Role of the PI3K-Akt Signaling Pathway in the Pathogenesis of Polycystic Ovary Syndrome

MicroRNA-126 Targeting PIK3R2 Inhibits NSCLC A549 Cell Proliferation, Migration, and Invasion by Regulation of PTEN/PI3K/AKT Pathway

(2016) Lei Song et al.   Clinical Lung Cancer

Combination of Rapamycin and Resveratrol for Treatment of Bladder Cancer

(2016) Anya Alayev et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Metformin improves hepatic IRS2/PI3K/Akt signaling in insulin-resistant rats of NASH and cirrhosis

(2016) Hong Xu et al.   JOURNAL OF ENDOCRINOLOGY

Metabolic profile in women with polycystic ovary syndrome across adult life

(2016) Bárbara Echiburú et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hypoglycemic effect of D-chiro-inositol in type 2 diabetes mellitus rats through the PI3K/Akt signaling pathway

(2016) Yun-feng Gao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Delphinidin suppresses proliferation and migration of human ovarian clear cell carcinoma cells through blocking AKT and ERK1/2 MAPK signaling pathways

(2016) Whasun Lim et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Glucoregulatory, endocrine and morphological effects of [P5K]hymenochirin-1B in mice with diet-induced glucose intolerance and insulin resistance

(2016) Bosede O. Owolabi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The incretin system ABCs in obesity and diabetes - novel therapeutic strategies for weight loss and beyond

(2016) A. L. João et al.   Obesity Reviews

The Role of Heat Shock Protein 90B1 in Patients with Polycystic Ovary Syndrome

(2016) Li Li et al.   PLoS One

Impaired insulin signaling pathway in ovarian follicles of cows with cystic ovarian disease

(2015) G.J. Hein et al.   ANIMAL REPRODUCTION SCIENCE

N-Oleoyl glycine, a lipoamino acid, stimulates adipogenesis associated with activation of CB1 receptor and Akt signaling pathway in 3T3-L1 adipocyte

(2015) Songbo Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Curcumin Promotes Cell Cycle Arrest and Inhibits Survival of Human Renal Cancer Cells by Negative Modulation of the PI3K/AKT Signaling Pathway

(2015) Hao Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

New strategy for in vitro activation of primordial follicles with mTOR and PI3K stimulators

(2015) Xinhui Sun et al.   CELL CYCLE

MiR-499-5p Contributes to Hepatic Insulin Resistance by Suppressing PTEN

(2015) Lei Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Krüppel-like factor 14 increases insulin sensitivity through activation of PI3K/Akt signal pathway

(2015) Min Yang et al.   CELLULAR SIGNALLING

FSH stimulates IRS-2 expression in human granulosa cells through cAMP/SP1, an inoperative FSH action in PCOS patients

(2015) G. Anjali et al.   CELLULAR SIGNALLING

PI3K/Akt signaling in osteosarcoma

(2015) Jian Zhang et al.   CLINICA CHIMICA ACTA

Metabolic response to selenium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial

(2015) Mehri Jamilian et al.   CLINICAL ENDOCRINOLOGY

Cell Autonomous Phosphoinositide 3-Kinase Activation in Oocytes Disrupts Normal Ovarian Function Through Promoting Survival and Overgrowth of Ovarian Follicles

(2015) So-Youn Kim et al.   ENDOCRINOLOGY

Phase II study of the PI3K inhibitor pilaralisib (SAR245408; XL147) in patients with advanced or recurrent endometrial carcinoma

(2015) Ursula Matulonis et al.   GYNECOLOGIC ONCOLOGY

Involvement of the PI3K/Akt signal pathway in the hypoglycemic effects of tea polysaccharides on diabetic mice

(2015) Shuqin Li et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Up-Regulated Expression of WNT5a Increases Inflammation and Oxidative Stress via PI3K/AKT/NF-κB Signaling in the Granulosa Cells of PCOS Patients

(2015) Yue Zhao et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytes

(2015) Bhesh Sharma et al.   Journal of Translational Medicine

Phosphatidylinositide 3-kinase inhibition: A new potential target for the treatment of polycystic ovarian syndrome

(2015) Krushangi N. Shah et al.   PHARMACEUTICAL BIOLOGY

Long-Term Over-Expression of Neuropeptide Y in Hypothalamic Paraventricular Nucleus Contributes to Adipose Tissue Insulin Resistance Partly via the Y5 Receptor

(2015) Min Long et al.   PLoS One

PI3K-C2γ is a Rab5 effector selectively controlling endosomal Akt2 activation downstream of insulin signalling

(2015) Laura Braccini et al.   Nature Communications

The CNS glucagon-like peptide-2 receptor in the control of energy balance and glucose homeostasis

(2014) Xinfu Guan   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Metformin modulates PI3K and GLUT4 expression and Akt/PKB phosphorylation in human endometrial stromal cells after stimulation with androgen and insulin

(2014) Gustavo Dias Ferreira et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Gallic acid attenuates high-fat diet fed-streptozotocin-induced insulin resistance via partial agonism of PPARγ in experimental type 2 diabetic rats and enhances glucose uptake through translocation and activation of GLUT4 in PI3K/p-Akt signaling pathway

(2014) Gopalsamy Rajiv Gandhi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Bifurcation analysis of a menstrual cycle model reveals multiple mechanisms linking testosterone and classical PCOS

(2014) Angelean O. Hendrix et al.   JOURNAL OF THEORETICAL BIOLOGY

Inhibition of phosphatase and tensin homologue (PTEN) in human ovary in vitro results in increased activation of primordial follicles but compromises development of growing follicles

(2014) M. McLaughlin et al.   MOLECULAR HUMAN REPRODUCTION

Metabolic response to folate supplementation in overweight women with polycystic ovary syndrome: A randomized double-blind placebo-controlled clinical trial

(2014) Zatollah Asemi et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Enhancement of a robust arcuate GABAergic input to gonadotropin-releasing hormone neurons in a model of polycystic ovarian syndrome

(2014) Aleisha M. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PIK3R1 Mutations Cause Syndromic Insulin Resistance with Lipoatrophy

(2013) Christel Thauvin-Robinet et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Central GLP-2 Enhances Hepatic Insulin Sensitivity via Activating PI3K Signaling in POMC Neurons

(2013) Xuemei Shi et al.   Cell Metabolism

Metformin augments the levels of molecules that regulate the expression of the insulin-dependent glucose transporter GLUT4 in the endometria of hyperinsulinemic PCOS patients

(2013) R. Carvajal et al.   HUMAN REPRODUCTION

Prevalence of polycystic ovary syndrome in women in China: a large community-based study

(2013) R. Li et al.   HUMAN REPRODUCTION

The relationship between gut and adipose hormones, and reproduction

(2013) Alexander N. Comninos et al.   HUMAN REPRODUCTION UPDATE

Metabolic Inflexibility Is a Feature of Women With Polycystic Ovary Syndrome and Is Associated With Both Insulin Resistance and Hyperandrogenism

(2013) Daniela Di Sarra et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Phosphoinositide 3-Kinase p110δ Mediates Estrogen- and FSH-Stimulated Ovarian Follicle Growth

(2013) Qian Li et al.   MOLECULAR ENDOCRINOLOGY

Different Patterns of Akt and ERK Feedback Activation in Response to Rapamycin, Active-Site mTOR Inhibitors and Metformin in Pancreatic Cancer Cells

(2013) Heloisa P. Soares et al.   PLoS One

Molecular Analysis of a Mutated FSH Receptor Detected in a Patient with Spontaneous Ovarian Hyperstimulation Syndrome

(2013) Sayaka Uchida et al.   PLoS One

Higher ghrelin and lower leptin secretion are associated with lower LH secretion in young amenorrheic athletes compared with eumenorrheic athletes and controls

(2012) Kathryn E. Ackerman et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gankyrin plays an essential role in estrogen-driven and GPR30-mediated endometrial carcinoma cell proliferation via the PTEN/PI3K/AKT signaling pathway

(2012) Jiawen Zhang et al.   CANCER LETTERS

Loss of PKB /Akt2 predisposes mice to ovarian cyst formation and increases the severity of polycystic ovary formation in vivo

(2012) D. F. Restuccia et al.   Disease Models & Mechanisms

Differential Gene Expression in Granulosa Cells from Polycystic Ovary Syndrome Patients with and without Insulin Resistance: Identification of Susceptibility Gene Sets through Network Analysis

(2012) Surleen Kaur et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

KRAS, BRAF and PIK3CA Mutations and the Loss of PTEN Expression in Chinese Patients with Colorectal Cancer

(2012) Chen Mao et al.   PLoS One

PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells

(2012) M. E. Hunzicker-Dunn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein expression of PKCZ (Protein Kinase C Zeta), Munc18c, and Syntaxin-4 in the insulin pathway in endometria of patients with polycystic ovary syndrome (PCOS)

(2012) Rodrigo Rivero et al.   Reproductive Biology and Endocrinology

Hepatic Suppression ofFoxo1andFoxo3Causes Hypoglycemia and Hyperlipidemia in Mice

(2011) Kebin Zhang et al.   ENDOCRINOLOGY

Body mass index does not influence post-treatment survival in early stage endometrial cancer: Results from the MRC ASTEC trial

(2011) Emma J. Crosbie et al.   EUROPEAN JOURNAL OF CANCER

Consensus on women’s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE/ASRM-Sponsored 3rd PCOS Consensus Workshop Group

(2011) Bart C.J.M. Fauser et al.   FERTILITY AND STERILITY

Adipokines: New Emerging Roles in Fertility and Reproduction

(2011) Chiara Tersigni et al.   OBSTETRICAL & GYNECOLOGICAL SURVEY

AMP-activated protein kinase inhibits IL-6-stimulated inflammatory response in human liver cells by suppressing phosphorylation of signal transducer and activator of transcription 3 (STAT3)

(2010) A. Nerstedt et al.   DIABETOLOGIA

Altered aquaporin expression in women with polycystic ovary syndrome: hyperandrogenism in follicular fluid inhibits aquaporin-9 in granulosa cells through the phosphatidylinositol 3-kinase pathway

(2010) F. Qu et al.   HUMAN REPRODUCTION

Regulation of Adipocyte Differentiation by Distinct Subcellular Pools of Protein Kinase B (PKB/Akt)

(2010) Tamara Maiuri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway

(2010) S. M. Choi et al.   MOLECULAR AND CELLULAR BIOLOGY

AMP-Activated Protein Kinase Inhibits IGF-I Signaling and Protein Synthesis in Vascular Smooth Muscle Cells via Stimulation of Insulin Receptor Substrate 1 S794 and Tuberous Sclerosis 2 S1345 Phosphorylation

(2010) Junyu Ning et al.   MOLECULAR ENDOCRINOLOGY

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(2010) Romina Fornes et al.   MOLECULAR MEDICINE

Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats

(2010) Anjali Priyadarshani et al.   Journal of Ovarian Research

Chronic 17β-estradiol treatment improves skeletal muscle insulin signaling pathway components in insulin resistance associated with aging

(2009) M. Moreno et al.   AGE

Ovarian control of pituitary sensitivity of luteinizing hormone secretion to gonadotropin-releasing hormone in women with the polycystic ovary syndrome

(2009) Konstantinos Dafopoulos et al.   FERTILITY AND STERILITY

Intrabursal injection of vascular endothelial growth factor trap in eCG-treated prepubertal rats inhibits proliferation and increases apoptosis of follicular cells involving the PI3K/AKT signaling pathway

(2009) Dalhia Abramovich et al.   FERTILITY AND STERILITY

Involvement of Akt, Ras and cell cycle regulators in the potential development of endometrial hyperplasia in women with polycystic ovarian syndrome

(2009) A. Villavicencio et al.   GYNECOLOGIC ONCOLOGY

Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

(2009) D. Adhikari et al.   HUMAN MOLECULAR GENETICS

IGF1 induces up-regulation of steroidogenic and apoptotic regulatory genes via activation of phosphatidylinositol-dependent kinase/AKT in bovine granulosa cells

(2009) Arul Murugan Mani et al.   REPRODUCTION

Luteinizing hormone-induced Akt phosphorylation and androgen production are modulated by MAP Kinase in bovine theca cells

(2009) Shin Fukuda et al.   Journal of Ovarian Research