Article
Agriculture, Dairy & Animal Science
Zifang Wu, Jiawei Nie, Deyuan Wu, Shuangbo Huang, Jianzhao Chen, Huajin Liang, Xiangyu Hao, Li Feng, Hefeng Luo, Chengquan Tan
Summary: The study investigated the effect of adenosine supplementation on placental angiogenesis and the occurrence of intrauterine growth restriction (IUGR) in piglets. Adenosine supplementation was found to increase birth weight and placental efficiency, while decreasing the rate of IUGR piglets. The placenta of IUGR piglets showed impaired angiogenesis and down-regulated expression of adenosine A2a receptor (ADORA2A), but adenosine treatment could activate ADORA2A expression and improve placental angiogenesis, ultimately reducing the occurrence of IUGR in piglets.
Article
Biochemistry & Molecular Biology
Lina Qi, Jingle Jiang, Ge Yu, Xin Zhang, Xi Qi, Jingfei Zhang, Lili Zhang, Tian Wang
Summary: The study found that daily curcumin supplementation alleviated placental inflammation in rat models of IUGR by inhibiting the NF-kappa B signaling pathway. Curcumin supplementation increased fetal weight and placental total protein levels, normalized changes induced by low protein diet, and regulated levels of serum lipids and inflammatory cytokines.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Jing Long, Yan Huang, Gang Wang, Zhengshan Tang, Yali Shan, Shiping Shen, Xin Ni
Summary: In this study, it was found that increased maternal glucocorticoid levels were a risk factor for the development of preeclampsia (PE). Pregnant rats exposed to dexamethasone (DEX) exhibited features of PE, impaired spiral artery remodeling, and elevated levels of certain circulatory markers. Abnormal mitochondrial morphology and dysfunction were observed in placentas of DEX rats. The use of a mitochondria-targeted antioxidant alleviated maternal hypertension and renal damage in the DEX-induced PE model. However, scavenging excess ROS did not improve intrauterine growth retardation (IUGR) and elevated levels of certain markers in DEX rats. These findings suggest that excess mitochondrial ROS contributes to trophoblast dysfunction, impaired spiral artery remodeling, reduced uteroplacental blood flow, and maternal hypertension in the DEX-induced PE model, while inflammation and impaired energy metabolism and IGF system may be associated with elevated levels of certain markers and IUGR.
Article
Virology
Daria Bortolotti, Valentina Gentili, Erica Santi, Cristina Taliento, Amerigo Vitagliano, Giovanna Schiuma, Silvia Beltrami, Sabrina Rizzo, Giovanni Lanza, Roberta Rizzo, Roberta Gafa, Pantaleo Greco
Summary: Late-onset IUGR is associated with higher levels of HLA-G expression and HHV-6 presence in placenta samples, suggesting a potential involvement of HHV-6 infection in HLA-G deregulation that may affect vessel remodeling and pregnancy outcome in IUGR condition.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chengjun Hu, Zifang Wu, Zihao Huang, Xiangyu Hao, Shuqi Wang, Jinping Deng, Yulong Yin, Chengquan Tan
Summary: The study reveals that Nox2 deficiency facilitates angiogenesis by inhibiting the VEGF-A and STAT3 pathway, and reducing VEGF-A expression through inducing ROS production in pigs' vascular endothelial cells. The findings suggest that Nox2 could be a potential therapeutic target for increasing VEGF-A expression to promote angiogenesis, and also serve as a prognostic indicator for fetus with IUGR.
Review
Medicine, Research & Experimental
Sandra Kannampuzha, Madurika Ravichandran, Anirban Goutam Mukherjee, Uddesh Ramesh Wanjari, Kaviyarasi Renu, Balachandar Vellingiri, Mahalaxmi Iyer, Abhijit Dey, Alex George, Abilash Valsala Gopalakrishnan
Summary: Placental complications arising from various risk factors during pregnancy have led to an increased morbidity rate. Disorders related to the placenta, such as pre-eclampsia and intra-uterine growth restriction, are major causes of pregnancy-related complications. Recent studies have identified specific non-coding RNAs (ncRNAs) in fetal tissues, including the placenta, and their aberrant expression has been linked to disorders like pre-eclampsia. Abnormal expression of ncRNAs, which play a significant role in regulating biological processes in the placenta, can result in complications such as spontaneous pregnancy loss. This review article focuses on the association of ncRNAs (miRNAs, lncRNAs, and CircRNAs) with placental complications and discusses different therapy options based on ncRNAs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Environmental Sciences
Fatemeh Amereh, Nooshin Amjadi, Anoushiravan Mohseni-Bandpei, Siavash Isazadeh, Yadollah Mehrabi, Akbar Eslami, Zahra Naeiji, Mohammad Rafiee
Summary: This study is the first to detect microplastic particles in fresh human placenta and found their presence in both intrauterine growth restriction (IUGR) pregnancies and normal pregnancies. The study also observed inverse associations between MPs exposure and birth outcomes.
ENVIRONMENTAL POLLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
Caizai Zhang, Zhimin Wu, Guangling Hu, Yiyu Zhang, Zheng Ao
Summary: This study compared the placental morphology, transcriptome, and cord serum metabolome between Kele piglets with low birth weight (LBW) and normal birth weight (NBW). It found that LBW placentas had inferior villus development, insufficient nutrient supply, and abnormal immune function, which may be associated with the occurrence and development of LBW in Kele pigs.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2023)
Article
Reproductive Biology
Pauline B. Guidoni, J. Alex Pasternak, Glenn Hamonic, Daniel J. MacPhee, John C. S. Harding
Summary: Understanding the gene expression of tight junction proteins in IUGR and N-IUGR fetuses exposed to PRRSV-2 infection may provide insights into their differential susceptibility. This study found that IUGR fetuses showed similar gene expression profiles to N-IUGR fetuses, regardless of infection status. However, the expression of specific tight junction proteins varied with disease progression. Overall, the integrity of tight junctions was primarily affected following PRRSV-2 infection.
Article
Reproductive Biology
Barbara Denkl, Nada Cordasic, Hanna Huebner, Carlos Menendez-Castro, Marius Schmidt, Alexander Mocker, Joachim Woelfle, Andrea Hartner, Fabian B. Fahlbusch
Summary: The study investigates the roles of placental UPR and oxidative stress in IUGR and PE, finding that placental ER stress is not induced in rat and mouse models, while oxidative stress is significantly increased in female IUGR rat placentas.
BIOLOGY OF REPRODUCTION
(2021)
Article
Developmental Biology
Shiva Shafiei, Daniel Dufort
Summary: The study found that maternal Cripto deletion leads to defective placentation, decreased vascularization, resulting in fetal death. Downregulation of VEGF and Notch signaling pathways may contribute to defects in vascular development at the maternal-fetal interface.
Article
Biochemistry & Molecular Biology
Zhimin Wu, Guangling Hu, Ting Gong, Qun Hu, Linjun Hong, Yiyu Zhang, Zheng Ao
Summary: Intrauterine growth restriction (IUGR) is a severe complication that affects pig production. This study investigated the relationship between fetal growth and placental morphologies and functions using histomorphological analysis, RNA sequencing, and in vitro experiments. Results showed that the LW placentas had poor development compared to MW placentas, and the downregulation of RACK1 gene in LW placentas may be involved in abnormal development of placental folds. These findings suggest that RACK1 may play a vital role in the development of placental folds and could be a potential target for improving pig production.
MOLECULAR REPRODUCTION AND DEVELOPMENT
(2023)
Review
Obstetrics & Gynecology
Nikita P. Joshi, Aditi R. Mane, Akriti S. Sahay, Deepali P. Sundrani, Sadhana R. Joshi, Chittaranjan S. Yajnik
Summary: Maternal nutrient availability and transport through the placenta are essential for fetal development, particularly the transfer of glucose which is crucial for fetal growth and development. Glucose transport across the placenta is influenced by maternal glucose concentrations and mediated by glucose transporter family proteins. Alterations in these transporters can impact fetal growth and body composition, potentially leading to future metabolic risks for the baby.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Amanda Antonelli, Silvia Capuani, Giada Ercolani, Miriam Dolciami, Sandra Ciulla, Veronica Celli, Bernd Kuehn, Maria Grazia Piccioni, Antonella Giancotti, Maria Grazia Porpora, Carlo Catalano, Lucia Manganaro
Summary: This study aimed to evaluate the potential of Intravoxel Incoherent Motion (IVIM) Imaging in identifying and discriminating different forms of intrauterine growth restriction (IUGR) and normal fetuses pregnancies through the quantification of placental micro-perfusion and microstructural features. The results showed that IVIM parameters are effective in discriminating between small for gestational age (SGA) and fetal growth restriction (FGR), and in detecting microvascular subtle impairment. Additionally, the perfusion IVIM parameter (fp) was found to predict fetuses' body weight in IUGR pregnancies, while the diffusion IVIM parameter (D) reflected more rapid microstructural rearrangement in the placenta due to aging processes in the IUGR group.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Reproductive Biology
Faten AbdelHafez, Christian Klausen, Hua Zhu, Peter C. K. Leung
Summary: This study found that myostatin can increase trophoblast cell invasion by upregulating N-cadherin, and this effect is mediated by the SMAD2/3-SMAD4 signaling pathway.
BIOLOGY OF REPRODUCTION
(2022)
Correction
Biochemistry & Molecular Biology
Wei-Bin Wu, Yuan-Yuan Chen, Bo Zhu, Xiao-Min Peng, Song-Wen Zhang, Mei-Ling Zhou
Article
Biochemistry & Molecular Biology
Wei-Bin Wu, Yuan-Yuan Chen, Bo Zhu, Xiao-Min Peng, Song-Wen Zhang, Mei-Ling Zhou
Article
Developmental Biology
W. -B. Wu, Y. -Y. Xu, W-W Cheng, Y. -X. Wang, Y. Liu, D. Huang, H. -J. Zhang
Article
Oncology
Ya-Xin Wang, Jiu-Ru Zhao, Yue-Ying Xu, Wei-Bin Wu, Hui-Juan Zhang
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2017)
Article
Cell Biology
Jiu-Ru Zhao, Wei-Wei Cheng, Ya-Xin Wang, Mei Cai, Wei-Bin Wu, Hui-Juan Zhang
CELL DEATH & DISEASE
(2018)
Article
Biochemistry & Molecular Biology
Xiaomin Peng, Weibin Wu, Bo Zhu, Zhichao Sun, Lingling Ji, Yuanyuan Ruan, Meiling Zhou, Lei Zhou, Jianxin Gu
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2014)
Article
Biochemistry & Molecular Biology
Lingling Ji, Ruyi Xue, Wenqing Tang, Weibin Wu, Tingting Hu, Xijun Liu, Xiaomin Peng, Jianxin Gu, She Chen, Si Zhang
Article
Developmental Biology
W. Wu, Y. Wang, Y. Xu, Y. Liu, Y. Wang, H. Zhang
Article
Multidisciplinary Sciences
Wei-Bin Wu, Ramkumar Menon, Yue-Ying Xu, Jiu-Ru Zhao, Yan-Lin Wang, Yuan Liu, Hui-Juan Zhang
SCIENTIFIC REPORTS
(2016)
Article
Cell Biology
Weibin Wu, Qing Wu, Xinmei Liu
Article
Developmental Biology
Juan Li, Yuan Liu, Ruihong Xue, Hong Shen, Ying Wu, Martin Quinn, Huijuan Zhang, Weibin Wu
Article
Medicine, General & Internal
Fuzhen Song, Yuanyuan Chen, Lei Chen, Huan Li, Xiajin Cheng, Weibin Wu
Summary: This study found that gestational hypercholanemia was associated with an increased risk of LBW and IUGR, especially in pregnant individuals with hypertensive disorders in pregnancy. Monitoring sTBA concentration during the follow-up of pregnancies with potential IUGR could be meaningful.
Article
Cell Biology
Xi Yang, Yulai Zhou, Huan Li, Fuzhen Song, Juan Li, Yong Zhang, Yi Lin, Huijuan Zhang, Jianxia Fan, Weibin Wu
Summary: This study revealed the complex interaction among excessive bile acids induced autophagic flux, mitochondrial dysfunction, and cellular apoptosis in placental trophoblasts, which may play a critical role in the pathogenesis of intrahepatic cholestasis of pregnancy (ICP).
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Developmental Biology
Wei-Bin Wu, Yue-Ying Xu, Wei-Wei Cheng, Bo Yuan, Jiu-Ru Zhao, Yan-Lin Wang, Hui-Juan Zhang