Article
Biochemistry & Molecular Biology
Iveta Yotova, Quanah J. Hudson, Florian M. Pauler, Katharina Proestling, Isabella Haslinger, Lorenz Kuessel, Alexandra Perricos, Heinrich Husslein, Rene Wenzl
Summary: LINC01133 is upregulated in endometriosis and may affect pathogenesis through cellular proliferation and migration pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Radhika Kapoor, Christina Anna Stratopoulou, Marie-Madeleine Dolmans
Summary: Endometriosis is a female reproductive disorder with a low rate of early detection, the treatment mainly involves hormone therapies, thus there is a need to study alternative strategies that are more effective and have fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Vaishnavi Balasubramanian, Roshni Saravanan, Leena Dennis Joseph, Bhawna Dev, Shanmugasundaram Gouthaman, Bhuvana Srinivasan, Arun Dharmarajan, Suresh Kumar Rayala, Ganesh Venkatraman
Summary: Endometriosis is a common disease affecting some women of reproductive age, characterized by infertility and pelvic pain. Although the exact pathogenesis is not fully understood, exploring the molecular elements involved may lead to breakthroughs in treatment of the illness.
CELLULAR SIGNALLING
(2021)
Article
Biotechnology & Applied Microbiology
Yi Sun, Rui Du, Yulong Shang, Changhao Liu, Linhua Zheng, Ruiqing Sun, Yuanyong Wang, Guofang Lu
Summary: This study reveals the significant role of ARHGAP35 in gastric cancer, specifically in regulating cell morphology and motility through cytoskeletal reorganization and EMT, respectively. Targeting the ARHGAP35/RhoA/E-cadherin pathway could be a potential therapeutic approach for treating gastric cancer.
Review
Oncology
Arpita Datta, Shuo Deng, Vennila Gopal, Kenneth Chun-Hong Yap, Clarissa Esmeralda Halim, Mun Leng Lye, Mei Shan Ong, Tuan Zea Tan, Gautam Sethi, Shing Chuan Hooi, Alan Prem Kumar, Celestial T. Yap
Summary: The cellular process of EMT is a critical mechanism in cancer metastasis, involving reorganization of the cytoskeleton composed of actin filaments, microtubules, and intermediate filaments. Understanding the physiological functions of the cytoskeleton and targeting key components for EMT regulation may offer promising approaches for cancer therapy, particularly in tackling multidrug-resistant cancer cells.
Article
Cell Biology
Qin Yu, Jianzhang Wang, Tiantian Li, Xinyue Guo, Shaojie Ding, Xuan Che, Libo Zhu, Yangying Peng, Xinxin Xu, Gen Zou, Xinmei Zhang
Summary: RON, a receptor tyrosine kinase, promotes endometriosis development by facilitating epithelial-mesenchymal transition (EMT) of endometrial epithelial cells. Inhibition or knockdown of RON expression suppresses the migration and invasion of endometrial epithelial cells. Targeting RON may offer a new therapeutic approach for endometriosis.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Xiaoxu Liu, Jing Wu, Bo Yang, Yuanyuan Zhao, Yafan Wang, Shuhong Pan, Suibing Miao, Xiaohua Wu
Summary: This study found that the hsa_circ_0005991/miR-30b-3p/Cdc42EP1 axis promotes the epithelial-mesenchymal transition process in endometriosis, providing a theoretical basis for the mechanism exploration and therapy of this disease.
Article
Medicine, Research & Experimental
Soad L. Kabil, Hayam E. Rashed, Noura Mostafa Mohamed, Nisreen E. Elwany
Summary: The study showed that parthenolide inhibited the PI3K/AKT/GSK-30/n0-catenin cascade in a dose dependent manner through enhancement of PTEN, leading to increased expression of the epithelial marker E-cadherin and decreased expression of the mesenchymal marker vimentin. It also reversed the invasion and migration properties of epithelial endometriotic cell lines.
Review
Cell Biology
Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah, Leszek Kotula
Summary: Despite over a century of scientific inquiry since the discovery of v-SRC, there is still no final judgement on SRC function. However, Src family kinases have been defined as key players in tumor progression, invasion and metastasis. Understanding the role of SFKs in mediating invasion and metastasis processes has grown along with the evidence supporting epithelial-mesenchymal transition (EMT) in these processes. This article describes key mechanisms through which SFKs play critical roles in epithelial homeostasis and propagate invasive signals.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Emergency Medicine
Young In Lee, Jung Eun Shim, Jihee Kim, Won Jai Lee, Jae Woo Kim, Kee Hyun Nam, Ju Hee Lee
Summary: This study identified a partial mechanism of keloid pathogenesis, which involves intercellular communication via the WNT5A and STAT pathways leading to the occurrence of EMT-like phenomena. Improving our understanding of keloid development and the role of WNT5A in EMT could promote the development of targeted treatments for keloid scars.
Article
Endocrinology & Metabolism
Qingli Quan, Jiabao Wu, Meixing Yu, Jia Tang
Summary: EMT was found to be promoted by stroma cell infiltration and inhibited by immune cell infiltration in peritoneal endometriosis. The EMT classification showed potential in precise diagnosis and treatment of peritoneal endometriosis, with drug candidates targeting specific pathways for different clusters.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Dandan Wang, Liangyi Cui, Qing Yang, Jiao Wang
Summary: The up-regulated circZFPM2 in ectopic endometrial tissues can induce EMT through the miR-205-5p /ZEB1 signaling pathway, promoting cell proliferation, migration, and invasion. This may serve as a promising biomarker in the diagnosis and treatment of endometriosis.
CELLULAR SIGNALLING
(2021)
Article
Medicine, General & Internal
Zhipeng Fan, Hongfei Song, Rongli Yuan, Yangzhi Peng, Yong Jiang
Summary: Using a two-sample Mendelian Randomization approach, this study found a causal relationship between female infertility and an increased risk of epithelial ovarian cancer, but no causal relationship between infertility and endometrial cancer.
POSTGRADUATE MEDICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Denise Paulin, Alain Lilienbaum, Sareen Kardjian, Onnik Agbulut, Zhenlin Li
Summary: Vimentin, an abundant cytoplasmic intermediate filament protein, plays important roles in stabilizing intracellular structure, cell plasticity, and signaling regulation. It can also be found outside the cell, exhibiting novel functions such as secretion, cell surface presence, and involvement in viral entry. The expression of vimentin is regulated by a complex network of promoter elements and epigenetic mechanisms.
Review
Veterinary Sciences
Federico Armando, Federico Mazzola, Luca Ferrari, Attilio Corradi
Summary: This review discusses the general concept of epithelial-mesenchymal transition (EMT) and its regulation by various factors. It covers the role of transcription factors, microRNAs, reactive oxygen species, exosomes, microvesicles, and viruses in EMT. The review also examines EMT in embryonic development, fibrosis, and cancer metastasis, including discussions on the tumor microenvironment, pre-metastatic niches, and cancer stem cells. Additionally, it explores the use of EMT as a prognostic marker and provides insights into mesenchymal-epithelial transition (MET) in sarcomas. Therapeutic approaches for targeting EMT and MET are also addressed.
VETERINARY SCIENCES
(2023)