期刊
REJUVENATION RESEARCH
卷 19, 期 5, 页码 394-405出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/rej.2015.1779
关键词
Woohwangchungsimwon; kainic acid; seizure behavior; anti-inflammation
资金
- Kwang Dong Pharmaceutical Co., Ltd.
- Basic Science Research Program through the National Research Foundation of Korea (NRF)
- Ministry of Science, ICT and Future Planning [2014R1A2A1A11051240]
- National Research Foundation of Korea [2014R1A2A1A11051240] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Woohwangchungsimwon (WCW) is an oriental medicine that has been extensively prescribed in Asia to patients with apoplexy, high blood pressure, acute/chronic convulsion, and so on. However, the potential therapeutic value of WCW in treating the pathologic brain has not yet been fully investigated. In the present study, we evaluated whether WCW has beneficial effects on kainic acid (KA)-induced excitotoxicity. An intraperitoneal injection of KA (40mg/kg) and an intracerebroventricular injection of KA (0.2g) produced typical seizure behavior and neuronal cell death in the CA1 and CA3 pyramidal layers of the hippocampus, respectively. However, the systemic administration of WCW significantly attenuated the seizure behavior and neuronal cell death. WCW was found to exert the best protective effect when it was administrated 2 hours before a KA injection. Moreover, this WCW-induced neuroprotection was accompanied by a reduction in microglia activation and tumor necrosis factor-alpha, interleukin (IL)-1, IL-6, inducible nitric oxide synthase, and cyclooxyganase-2 in the hippocampus. These results suggest that WCW has therapeutic potential to suppress KA-induced pathogenesis in the brain by inhibiting inflammation.
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