Article
Biochemistry & Molecular Biology
Franccesco P. P. Boeno, Jay Patel, Ryan N. N. Montalvo, Stephanie S. S. Lapierre-Nguyen, Claire M. M. Schreiber, Ashley J. J. Smuder
Summary: Doxorubicin (DOX) is an effective chemotherapy drug for cancer treatment, but its clinical use is limited due to off-target toxicity. DOX accumulation in the liver and kidneys causes inflammation and oxidative stress, leading to cytotoxicity. Endurance exercise preconditioning may help prevent liver and kidney damage caused by DOX treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hyoung-Yun Han, Mi-Sun Choi, Seokjoo Yoon, Je-Won Ko, Sang-Kyum Kim, Tae-Won Kim
Summary: This study confirmed kidney-biased organ toxicity of ifosfamide in rats, with identically altered genes in both the liver and kidney. Interferon regulatory factor 7 was identified as the main upstream regulator that changed in both organs. Further toxicogenomic studies are needed to fully understand the relationship between ifosfamide-induced genes and organ toxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Gurleen Kour, Syed Assim Haq, Bijender Kumar Bajaj, Prem N. Gupta, Zabeer Ahmed
Summary: Phytochemicals have long been known for their therapeutic potential in autoimmune disorders such as rheumatoid arthritis, but their combination with DMARDs can increase the efficacy of treatment while reducing toxic side effects. Studies have shown promising results in experimental and clinical settings when combining phytochemicals with DMARDs, highlighting the importance of this approach in future RA therapy.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, Research & Experimental
Nermeen N. Welson, Remon R. Rofaeil, Sabreen Mahmoud Ahmed, Shereen S. Gaber, Gaber El-Saber Batiha, Mary Girgis Shahataa
Summary: The study demonstrates that vitamin E exhibits significant protection against gabapentin-induced liver and kidney injury, improving biochemical markers and partially inhibiting apoptosis, with notable reparative effects on liver and kidney tissue.
Article
Environmental Sciences
Hsing-Kang Chen, Shu-Li Wang, Yu-Hsun Chang, Chien-Wen Sun, Ming-Tsang Wu, Mei-Lien Chen, Yu-Jie Lin, Chia -Jung Hsieh
Summary: This study examines the associations between prenatal phthalate exposure and neonatal neurobehavioral development. It found that phthalate exposure was negatively associated with neurobehaviors in female infants and positively associated with neurobehaviors in male infants. These findings highlight the gender-specific effects of maternal phthalate exposure on the neurodevelopment of newborns.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Bilal Hussain, Muhammad Sajad, Hassan Usman, Khalid A. Al-Ghanim, Mian Nadeem Riaz, Aydin Berenjian, Shahid Mahboob, Pau Loke Show
Summary: Cytotoxicity induced by industrial effluents and dyes is a global issue for freshwater fishes. This study aims to determine the sub-lethal effects of trypan blue dye in fish. The results showed that exposure to trypan blue dye can cause liver and kidney tissue damage in freshwater fish.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Sefa Kucukler, Fatih Mehmet Kandemir, Selcuk Ozdemir, Selim Comakli, Cuneyt Caglayan
Summary: The study evaluated the protective effects of rutin against deltamethrin-induced liver and kidney toxicities in rats. Rutin significantly improved liver and kidney function damage, oxidative stress, inflammation, and apoptosis in the rats.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Fatih Mehmet Kandemir, Cuneyt Caglayan, Ekrem Darendelioglu, Sefa Kucukler, Ebubekir Izol, Ozge Kandemir
Summary: Carvacrol (CRV) has been shown to modulate cadmium (Cd)-induced toxic effects on liver and kidney tissues by enhancing antioxidant enzymes' activities and reversing changes in inflammatory biomarkers and apoptotic genes. Additionally, CRV treatment reduced Cd content and increased levels of essential minerals in tissues, suggesting it as a promising strategy to protect against Cd-induced oxidative damage, inflammation, and apoptosis.
Article
Medicine, Research & Experimental
Danilo B. M. Lucchi, Gisela R. S. Sasso, Leticia S. Sena, Diego D. Santos, Paulo C. Franco, Izabella Lice, Fernanda T. Borges, Sonia M. Oliani, Cristiane D. Gil
Summary: In this study, the pharmacological treatment with AnxA1-derived peptide Ac2-26 was evaluated in an experimental model of cisplatin-induced toxicity. The results showed that Ac2-26 treatment could alleviate the inflammatory response induced by cisplatin and protect the liver and kidneys from cisplatin-induced damage. However, the peptide treatment had no significant effect on kidney morphology injury.
Review
Pediatrics
Jogender Kumar, Bharti Yadav, Jitendra Meena, Jaivinder Yadav, Jitendra Kumar Sahu
Summary: This study reviewed whether levetiracetam is non-inferior to phenobarbital as the first-choice medication for neonatal seizures. The results showed that levetiracetam had similar efficacy in seizure control compared to phenobarbital, but had better safety profile and slightly improved short-term neurodevelopment. Therefore, levetiracetam may be considered as an initial choice for managing neonatal seizures.
INDIAN JOURNAL OF PEDIATRICS
(2023)
Article
Environmental Sciences
Mustafa Ileriturk, Fatih Mehmet Kandemir
Summary: The protective effect of carvacrol on lambda-Cyhalothrin-induced hepatotoxicity and nephrotoxicity was investigated. Carvacrol reduced oxidative stress, inflammation, apoptosis, endoplasmic reticulum stress, and autophagy caused by lambda-Cyhalothrin, protecting liver and kidney tissues from damage.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Toxicology
Ege Arzuk, Mehmet Tokdemir, Hilmi Orhan
Summary: Mitochondria are the major target of paracetamol-induced hepatotoxicity. This study found that mitochondrial CYPs can catalyze the formation of toxic metabolite NAPQI from paracetamol, leading to the transmission of death signals. However, in the kidneys, there is no correlation between the formation of NAPQI and kidney CYP2E1 activity, suggesting a different toxicity mechanism compared to the liver.
TOXICOLOGY LETTERS
(2022)
Review
Physiology
Julia K. Gunn-Charlton
Summary: Preterm infants and those born with congenital anomalies share common risk factors for neurodevelopmental impairment, including prolonged hospitalization, feeding difficulties, pain exposure, and medication use. Congenital heart disease and specific anomalies such as esophageal atresia, diaphragmatic hernia, and abdominal wall defects are more likely to result in neurodevelopmental impairment in preterm infants.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Mehdi Khaksari, Samira Esmaili, Reyhane Abedloo, Hossein Khastar
Summary: Palmatine can alleviate hepatotoxicity and nephrotoxicity induced by gentamicin mainly through inhibiting oxidative stress and apoptosis.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Yue Qiu, Xinlu Chen, Zhangxi Chen, Xuejun Zeng, Tianli Yue, Yahong Yuan
Summary: Selenium nanoparticles can effectively alleviate oxidative damage caused by patulin, but their effectiveness in preventing gastrointestinal damage is limited.
Review
Pharmacology & Pharmacy
Anne Smits, Pieter Annaert, Giacomo Cavallaro, Pieter A. J. G. De Cock, Saskia N. de Wildt, Jenny M. Kindblom, Florian B. Lagler, Carmen Moreno, Paula Pokorna, Michiel F. Schreuder, Joseph F. Standing, Mark A. Turner, Benedetto Vitiello, Wei Zhao, Annelie-Martina Weingberg, Raffaella Willmann, John van den Anker, Karel Allegaert
Summary: Developmental pharmacology focuses on the impact of maturation on drug metabolism and effects in pediatric patients, providing insights into drug development strategies and highlighting the importance of considering developmental pharmacodynamics. This paper summarizes current knowledge, identifies remaining gaps, and suggests innovative approaches for studying drug disposition and effects in children.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pediatrics
Charalampos Kotidis, David Wertheim, Michael Weindling, Heike Rabe, Mark A. Turner
Summary: Monitoring patent ductus arteriosus (PDA) in premature infants using standard neonatal monitoring, including ECG and blood pressure waveform analysis, may provide potential biomarkers for continuous evaluation of PDA diameter and function. The study found significant correlations between PDA diameter and various parameters derived from ECG and blood pressure waveforms, suggesting a promising approach for assessing PDA status.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Review
Pediatrics
Rian Hayes, Jack Hartnett, Gergana Semova, Cian Murray, Katherine Murphy, Leah Carroll, Helena Plapp, Louise Hession, Jonathan O'Toole, Danielle McCollum, Edna Roche, Elinor Jenkins, David Mockler, Tim Hurley, Matthew McGovern, John Allen, Judith Meehan, Frans B. Plotz, Tobias Strunk, Willem P. de Boode, Richard Polin, James L. Wynn, Marina Degtyareva, Helmut Kuester, Jan Janota, Eric Giannoni, Luregn J. Schlapbach, Fleur M. Keij, Irwin K. M. Reiss, Joseph Bliss, Joyce M. Koenig, Mark A. Turner, Christopher Gale, Eleanor J. Molloy
Summary: Neonatal sepsis, a leading cause of infant mortality, has diverse definitions based on microbiological culture, laboratory tests, and clinical signs. An international consensus-based definition could improve research comparability and clinical outcomes.
PEDIATRIC RESEARCH
(2023)
Article
Pediatrics
Benjamin Dudoignon, Isabelle Denjoy, Maxime Patout, Boris Matrot, Jorge Gallego, Plamen Bokov, Christophe Delclaux
Summary: This study investigated heart rate variability (HRV) in children with congenital central hypoventilation syndrome (CCHS) and its relationship with ambulatory blood pressure (BP) and ECG monitoring. The study found that CCHS children have a higher prevalence of hypertension and sinus pauses. The modifications of cardiac autonomic nervous system were associated with these manifestations.
PEDIATRIC RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Zhen-Hai Shang, Yue-E Wu, Dong-Mei Lv, Wei Zhang, Wen-Qiang Liu, John van den Anker, Yan Xu, Wei Zhao
Summary: This study evaluated the pharmacokinetics of cefotaxime in newborns with early-onset sepsis using real-world data and found that a dose of 50 mg/kg, BID had favorable efficacy and an acceptable safety profile in neonates.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zeming Wang, Jing Bi, Dianping You, Yu Tang, Gang Liu, Jinqian Yu, Zhipeng Jin, Tingting Jiang, Xue Tian, Hui Qi, Lei Dong, Lili Dong, Qunqun Zhang, Wei Zhao, Adong Shen
Summary: This study evaluated the relationship between the time in which the plasma free concentration of meropenem exceeds the minimum inhibitory concentration of pathogens during therapy and the clinical outcome of treatment. It found that sufficient target attainment of meropenem can improve the antibacterial efficacy of treatment without causing any adverse events.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yi-Ning Dong, Ya-Kun Wang, Qian Li, Bo-Hao Tang, John van den Anker, Guo-Xiang Hao, Yi Zheng, Li-Yuan Tian, Dian-Ping You, Yue-E Wu, Wei Zhao
Summary: This study found that the concentration of ceftriaxone in epithelial lining fluid is 12 times higher than in plasma in children.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Zi-Xuan Guo, Yue-E Wu, Hai-Yan Shi, John van den Anker, Ping Liang, Ying Zheng, Xue-Wei Zhao, Rui Feng, Wei Zhao
Summary: This study developed and validated a multi-component analysis method based on LC-MS/MS technology for the simultaneous determination of concentrations of 39 TKIs in plasma. The method showed good accuracy and precision and can be used for therapeutic drug monitoring in patients with different types of TKIs.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Pediatrics
Karel Allegaert, Heidrun Hildebrand, Kanwaljit Singh, Mark A. A. Turner
Summary: The International Neonatal Consortium aims to define reference ranges for commonly used laboratory values in neonates, but there is a lack of standardized and complete published information on these values. This hinders treatment comparison, safety monitoring, and clinical management.
PEDIATRIC RESEARCH
(2023)
Article
Peripheral Vascular Disease
Benjamin Dudoignon, Plamen Bokov, Nathalie Couque, Isabelle Denjoy, Boris Matrot, Christophe Delclaux
Summary: This study investigated children with congenital central hypoventilation syndrome (CCHS) using ambulatory blood pressure monitoring (ABPM) and found that their cardiac autonomic nervous system dysfunction worsened during sleep, correlating with blood pressure and nighttime PCO2 levels. Decreased heart rate variability while awake was associated with higher daytime systolic blood pressure percentiles, while decreased SD1/SD2 ratio was associated with higher nighttime systolic blood pressure percentiles. These findings suggest the presence of neurogenic hypertension in CCHS and its correlation with autonomic dysfunction and alveolar ventilation during mechanical ventilation.
JOURNAL OF HYPERTENSION
(2023)
Letter
Anesthesiology
Boris Lacarra, Guillaume Geslain, Arielle Maroni, Jerome Naudin, Boris Matrot, Stephane Dauger
MINERVA ANESTESIOLOGICA
(2023)
Article
Endocrinology & Metabolism
Alexis Casciato, Lola Bianchi, Manon Reverdy, Fanny Joubert, Roman Delucenay-Clarke, Sandrine Parrot, Nelina Ramanantsoa, Eleonore Sizun, Boris Matrot, Christian Straus, Thomas Similowski, Florence Cayetanot, Laurence Bodineau
Summary: Congenital Central Hypoventilation Syndrome, a rare disease caused by PHOX2B mutation, is associated with absent or blunted CO2/H+ chemosensitivity due to the dysfunction of PHOX2B neurons. Clinical observations have reported non-systematic CO2/H+ chemosensitivity recovery under desogestrel. This study used a preclinical mouse model to investigate the restoration of chemosensitivity by etonogestrel acting on serotonin neurons or residual PHOX2B cells.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Tiphaine Adam de Beaumais, Simon Lorrain, Naura Mamhoudi, Mathieu Simonin, Christine Martinez Vinson, Yves Medard, Arnaud Petit, Evelyne Jacqz-Aigrain
Summary: This study investigates the factors affecting the concentrations of red blood cell metabolites in children to facilitate therapeutic drug monitoring. The results show that many children did not reach the target concentration range, and adjusting the dosage may help improve treatment outcomes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Physiology
Plamen Bokov, Benjamin Dudoignon, Maxime Patout, Boris Matrot, Jorge Gallego, Christophe Delclaux
Summary: This study aimed to evaluate both peripheral and central CO2 chemosensitivity in patients with congenital central hypoventilation syndrome (CCHS) and their correlations with daytime PCO2 and arterial desaturation during exercise. The results showed that peripheral CO2 chemosensitivity is altered in some patients with CCHS, and daytime PETCO2 level is dependent on central and peripheral chemoreceptor responses.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Physiology
Plamen Bokov, Claudine Peiffer, Jorge Gallego, Jade Pautrat, Boris Matrot, Christophe Delclaux
Summary: The aim of this study was to assess whether children with dysfunctional breathing (DB) exhibit decreased plant gain and examine the relationships between HVPT characteristics and plant gain. The results showed that children with DB, regardless of subtype, deplete their CO2 stores (decreased plant gain), which may be due to intermittent alveolar hyperventilation, suggesting the futility of subtype classification.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Medicine, Legal
Fiona Sewell, Ian Ragan, Graham Horgan, David Andrew, Thomas Holmes, Irene Manou, Boris P. Mueller, Tim Rowan, Barbara G. Schmitt, Marco Corvaro
Summary: There are currently three test guidelines for acute oral toxicity studies, but the subjectivity of one guideline may be hindering its wider use. In order to address this, the NC3Rs and EPAA collaborated to analyze historical data and provide recommendations on the recognition of 'evident toxicity'.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)
Article
Medicine, Legal
Michael DeVito, Bas Bokkers, Majorie B. M. van Duursen, Karin van Ede, Mark Feeley, Elsa Antunes Fernandes Gaspar, Laurie Haws, Sean Kennedy, Richard E. Peterson, Ron Hoogenboom, Keiko Nohara, Kim Petersen, Cynthia Rider, Martin Rose, Stephen Safe, Dieter Schrenk, Matthew W. Wheeler, Daniele S. Wikoff, Bin Zhao, Martin van den Berg
Summary: In October 2022, the World Health Organization reevaluated the toxic equivalency factors (TEFs) for chlorinated dioxin-like compounds in a panel convened in Lisbon. This effort utilized an updated database, Bayesian dose response modeling, and meta-analysis to derive Best-Estimate TEFs. Applying these new TEFs may result in lower total toxic equivalents for dioxin-like chemicals.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2024)