Article
Veterinary Sciences
Grigorios Maleas, Mahmoud Mageed
Summary: The long-term outcomes of treatment with LR-PRP or BMAC are significantly better than conventional treatment for hindlimb chronic PSD in horses. Additionally, BMAC yields better lameness scores compared to LR-PRP in both short- and long-term follow-up.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Medicine, General & Internal
Angelo Boffa, Alberto Poggi, Iacopo Romandini, Emanuela Asunis, Valeria Pizzuti, Alessandro Di Martino, Stefano Zaffagnini, Giuseppe Filardo
Summary: This study indicates that the presence of bone marrow edema does not influence the clinical outcomes of intra-articular PRP injections in knee osteoarthritis patients. The area and site of bone marrow edema do not affect the treatment results, but patients with higher grades of bone marrow edema have a higher failure rate.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Orthopedics
Adam W. Anz, Hillary A. Plummer, Achraf Cohen, Peter A. Eyerts, James R. Andrews, Joshua G. Hackel
Summary: This study compares the efficacy of BMC and PRP in treating knee osteoarthritis and finds that both treatments have similar outcomes up to 24 months, with no significant difference.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Review
Cell & Tissue Engineering
Jose Fabio Santos Duarte Lana, Lucas Furtado da Fonseca, Rafael da Rocha Macedo, Tomas Mosaner, William Murrell, Ashok Kumar, Joseph Purita, Marco Antonio Percope de Andrade
Summary: The use of orthobiologics, such as PRP and BMAC, as novel therapies for musculoskeletal disorders has expanded in the past decade. While both products show potential for tissue repair, standardized protocols and their synergistic effects need further evaluation to consolidate their efficacy in orthopedics.
WORLD JOURNAL OF STEM CELLS
(2021)
Review
Polymer Science
Jose Fabio Lana, Joseph Purita, Peter Albert Everts, Palmerindo Antonio Tavares De Mendonca Neto, Daniel de Moraes Ferreira Jorge, Tomas Mosaner, Stephany Cares Huber, Gabriel Ohana Marques Azzini, Lucas Furtado da Fonseca, Madhan Jeyaraman, Ignacio Dallo, Gabriel Silva Santos
Summary: Platelet- and fibrin-rich orthobiologic products, such as autologous platelet concentrates, have been extensively studied and appreciated for their beneficial effects in musculoskeletal disorders. These products stimulate biological pathways that promote inflammation modulation, neovascularization, cell recruitment, and differentiation. The combination of platelet-rich fibrin with other orthobiologic products, such as hyaluronic acid, shows promise in improving cell activity and may be a cost-effective approach in regenerative medicine.
Article
Orthopedics
Abed El-Hakim El-Kadiry, Carlos Lumbao, Natasha Salame, Moutih Rafei, Riam Shammaa
Summary: In this retrospective comparative study, intra-articular autologous bone marrow aspirate concentrate (BMAC) and platelet-rich plasma (PRP) injections for knee osteoarthritis patients were compared in terms of pain and functional improvements. It was found that BMAC injections significantly improved pain and functionality scores, while PRP injections did not show significant improvement.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Rheumatology
Marcel Niemann, Melanie Ort, Luis Lauterbach, Mathias Streitz, Andreas Wilhelm, Gerald Gruetz, Florian N. Fleckenstein, Frank Graef, Antje Blankenstein, Simon Reinke, Ulrich Stoeckle, Carsten Perka, Georg N. Duda, Sven Geissler, Tobias Winkler, Tazio Maleitzke
Summary: This study compared the leukocyte and cytokine distributions of different PRP products and assessed the effect of pro-inflammatory cytokines on chondrocytes. The results showed that all three PRP products contained elevated levels of leukocytes, and the nSTRIDE APS product had significantly higher concentrations of the pro-inflammatory cytokines IFN-gamma and TNF-alpha. Furthermore, treatment with IFN-gamma and TNF-alpha negatively affected chondrocyte proliferation and cartilage formation. These findings suggest that both the individual's immune profile and the concentration method impact the composition of PRP products.
ARTHRITIS RESEARCH & THERAPY
(2023)
Review
Orthopedics
Justin P. Chan, Michael Vrla, Claire Thompson, David P. Trofa, Xinning Li, Dean Wang, Robert L. Parisien
Summary: This article systematically reviewed randomized controlled trials (RCTs) evaluating the efficacy of platelet-rich plasma (PRP) for knee osteoarthritis (OA), and calculated the fragility index (FI) and fragility quotient (FQ). The results suggested that the literature evaluating PRP use for knee OA may lack statistical stability, and recommended reporting both FI and FQ in addition to P value analysis in research reports.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Rafael Gonzalez dos Santos, Gabriel Silva Santos, Natasha Alkass, Tania Liana Chiesa, Gabriel Ohana Azzini, Lucas Furtado da Fonseca, Antonio Fernando dos Santos, Bruno Lima Rodrigues, Tomas Mosaner, Jose Fabio Lana
Summary: Orthobiologics, particularly platelet-rich plasma derivatives, are gaining popularity in medical science, showing promising results in accelerating tissue growth and healing processes. Utilizing the high platelet concentration above basal levels, these biologic products stimulate and enhance tissue repair, particularly in areas where standard healing is disrupted.
Review
Biochemistry & Molecular Biology
Edilson Silva Machado, Fabiano Pasqualotto Soares, Ernani Vianna de Abreu, Tais Amara da Costa de Souza, Robert Meves, Hans Grohs, Mary A. Ambach, Annu Navani, Renato Bevillaqua de Castro, Daniel Humberto Pozza, Jose Manuel Peixoto Caldas
Summary: This systematic review evaluated the efficacy of platelet-rich plasma (PRP) injections in managing low back pain. The analysis of 13 randomized clinical trials and 27 nonrandomized trials or case series showed that PRP was generally effective and safe for degenerative low back pain. Positive results were found in almost all studies, although there were some biases in the research. Large-scale, multicenter randomized clinical trials are still needed to confirm these findings.
Article
Medicine, General & Internal
Oliver Dulic, Predrag Rasovic, Ivica Lalic, Vaso Kecojevic, Gordan Gavrilovic, Dzihan Abazovic, Dusan Maric, Mladen Miskulin, Marko Bumbasirevic
Summary: The study compared three biological treatments for knee osteoarthritis, showing that bone marrow aspirate concentrate may be better than platelet-rich plasma and hyaluronic acid in clinical improvement up to 12 months, with platelet-rich plasma providing better outcomes than hyaluronic acid during the observation period.
MEDICINA-LITHUANIA
(2021)
Article
Orthopedics
A. Lychagin, M. Lipina, A. Garkavi, O. Islaieh, P. Timashev, K. Ashmore, E. Kon
Summary: The study evaluated the short-term effectiveness of intraosseous PRP injections in individuals with OA, showing a significant reduction in pain, improvement in WOMAC and overall KOOS scores. Serum marker levels initially increased significantly, but remained stable at six and 12 months post-operatively, indicating positive results in pain reduction and knee function improvement.
INTERNATIONAL ORTHOPAEDICS
(2021)
Review
Biochemistry & Molecular Biology
Eva Kubrova, Gabriel A. Martinez Alvarez, Yeng F. Her, Robert Pagan-Rosado, Wenchun Qu, Ryan S. D'Souza
Summary: Back pain with radicular symptoms is a common condition that affects physical, emotional, and economic well-being. Current conservative treatments may not provide long-term relief, leading to the exploration of regenerative medicine options such as Platelet Rich Plasma (PRP) injections. However, there is a lack of evidence supporting the effectiveness of PRP injections in treating radicular pain.
Article
Anesthesiology
Christopher Centeno, Cameron Cartier, Ian Stemper, Ehren Dodson, Michael Freeman, Ugochi Azuike, Christopher Williams, Matthew Hyzy, Otono Silva, Neven Steinmetz
Summary: The study found that treating knee bone marrow lesions with either intraarticular injections of bone marrow concentrate and platelet products alone, or intraosseous plus intraarticular injections, did not significantly impact patient reported outcomes.
Article
Cell & Tissue Engineering
Luca Cevolani, Giuseppe Bianchi, Errani Costantino, Eric Staals, Enrico Lucarelli, Benedetta Spazzoli, Tommaso Frisoni, Davide M. Donati
Summary: Percutaneous injection of DBM, BMC, and PRF is an effective treatment for long-bone non-unions. Most patients achieved bone union within about 7 months and resumed full weight bearing on average after 9 months. This minimally invasive approach allows for bone healing with a relatively short hospitalization period.
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2021)
