Review
Public, Environmental & Occupational Health
Yan Teng, Yong Yu, Sujing Li, Youming Huang, Danfeng Xu, Xiaohua Tao, Yibin Fan
Summary: Ultraviolet radiation, particularly UVB, is a significant environmental risk factor for the development of basal cell carcinoma (BCC) by promoting uncontrolled cell replication. UVR can activate oncogenes, inhibit tumor suppressor genes, and lead to aberrant proliferation and survival of keratinocytes. In addition to DNA damage, inflammatory responses in the tumor microenvironment also play a crucial role in skin tumorigenesis induced by UVR.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Biochemistry & Molecular Biology
Ye-Ram Kim, Ah-Reum Han, Jin-Baek Kim, Chan-Hun Jung
Summary: Dendrobine inhibits IR-induced migration and invasion of NSCLC cells by suppressing SULF2 expression, demonstrating its potential as a therapeutic enhancer to overcome the malignant effects of radiation therapy.
Article
Environmental Sciences
Hao Bai, Jufang Wang, Qiaojuan Wang, Yaxiong Chen, Guoying Miao, Tongshan Zhang, Junrui Hua, Yanan Zhang, Jinpeng He, Nan Ding, Heng Zhou, Li Sui, Wenjun Wei
Summary: The study suggests that circulating IGFBP-3 may serve as a promising universal biomarker for complex environmental radiation exposure, and its upregulation is influenced by MKC in a P53-dependent manner. Circulating IGFBP-3 assays could provide rapid, convenient and effective dose and toxicity assessment methods in occupational exposure or radiation disaster management.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Oncology
Puja Upadhaya, Nathan Ryan, Peyton Roth, Travis Pero, Felipe Lamenza, Anna Springer, Pete Jordanides, Hasan Pracha, Darrion Mitchell, Steve Oghumu
Summary: This study demonstrates that tumor-targeted radiation therapy can generate tumor antigens that induce strong immune responses. These responses show comparable sensitivity but greater specificity for T cell activation compared to conventional antibodies. This information can be utilized to predict patient responses to radiation and immune therapy.
Article
Environmental Sciences
Farshad Bahrami Asl, Mahdi Islami-seginsara, Mohammad Ebrahimi Kalan, Rasoul Hemmatjo, Mousa Hesam, Vahid Shafiei-Irannejad
Summary: Long-term exposure to ionizing radiation, even below dose limits, is associated with significantly increased levels of IL-6 and eosinophils.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biology
Xiaohong Zhang, Xin Li, Chunyan Zheng, Chunzhi Yang, Rui Zhang, Ailian Wang, Jundong Feng, Xiaodan Hu, Shuquan Chang, Haiqian Zhang
Summary: This review summarizes the findings on ionizing radiation-induced ferroptosis, highlighting the increase of hydroxyl radicals, free iron, and lipid metabolic enzymes as well as the role of iron metabolism in regulating ferroptosis. The study suggests that ferroptosis may be the primary form of cell death in the bone marrow under hematopoietic acute radiation syndrome and that DNA damage is not involved in ionizing radiation-induced ferroptosis.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2022)
Article
Environmental Sciences
Michael Peleg, Elliot M. Berry, Mora Deitch, Or Nativ, Elihu Richter
Summary: This study reports a group of young cancer patients exposed to high-intensity RFR during military service. The results show a high prevalence of HL cancers in this group, consistent with previous studies. The study also reveals an increased risk of other types of cancer and sarcoma associated with occupational RFR exposure.
ENVIRONMENTAL RESEARCH
(2023)
Article
Orthopedics
Ashley B. Anderson, Julio A. Rivera, Edmund P. Mullin, Collin J. Harrington, Benjamin K. Potter, Jonathan A. Forsberg, Scott M. Tintle
Summary: Patients with complex polytrauma in military and civilian settings are exposed to substantial diagnostic medical radiation, increasing the risk of subsequent malignancy. Currently, there is no coordinated effort to track radiation exposure or long-term surveillance for such patients. This study aims to quantify radiation exposure for combat-wounded servicemembers and determine its correlation with the Injury Severity Score (ISS).
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yuxiao Sun, Lianying Fang, Mengmeng Yang, Ningning He, Jinhan Wang, Manman Zhang, Kaihua Ji, Qin Wang, Yang Liu, Liqing Du, Yan Wang, Chang Xu, Qiang Liu
Summary: RMI1 knockdown leads to increased radiosensitivity and apoptosis, with differentially expressed circRNAs identified in response to IR, indicating the important role of RMI1 in the cellular response to IR and the regulatory mechanism of circRNAs in the radiation response.
DNA AND CELL BIOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Xiaoji Hao, Anfang Ye, Shunfei Yu, Qianying Ni, Jiadi Guo, Xiangguo Wang, Shenyong Gao, Zhongjun Lai, Yaoxian Zhao, Zhiqiang Xuan
Summary: This study followed the case of a worker who developed acute radiation disease and eventually died of leukemia, providing key practical information for understanding the clinical effects of radiation on workers' health. Results showed significant effects of radiation on chromosomal morphology, white blood cell count, and sperm count in the patient. Despite initial improvements after treatment, the patient ultimately succumbed to leukemia, highlighting the long-term risks of ionizing radiation-induced malignancies and the need for enhanced occupational protection for workers in radiographic inspection.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Cell Biology
Emily M. Bertucci, Marilyn W. Mason, Olin E. Rhodes, Benjamin B. Parrott
Summary: Epigenetic alterations are important in biological aging, with age-related DNA methylation changes being used to predict age. Environmental exposures can influence DNA methylation patterns and disrupt the normal aging process, providing insights into the interactions between environment and epigenetic aging.
Article
Multidisciplinary Sciences
Yasukazu Hijikata, Masayuki Nakahara, Akira Kusumegi, Junji Morii, Naoki Okubo, Nozomi Hatano, Yuichi Takahashi
Summary: Occupational radiation exposure may lead to a lower male sex ratio, with specific testicular radiation exposure possibly contributing to this phenomenon. Larger studies are needed to confirm these findings.
Article
Biochemistry & Molecular Biology
Duling Xu, Hongyan Li, Takanori Katsube, Guomin Huang, Jiadi Liu, Bing Wang, Hong Zhang
Summary: Concurrent exposure to ionizing radiation and psychological stress did not cause renal fibrosis in the Trp53-heterozygous mice in this study, as revealed by histopathological and immunohistochemical analysis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Xijuan Yao, Hui Chen, Bing Xu, Jing Lu, Junjie Gu, Fangyu Chen, Mengyang Ju, Xinchen Sun
Summary: This study aimed to investigate the role of ATP6V1C1 in radiotherapy resistance in esophageal squamous cell carcinoma (ESCC) cells. The results showed that suppressing ATP6V1C1 increased the sensitivity of ESCC cells to radiotherapy, while also inhibiting autophagy by activating the mTOR signaling pathway to suppress radiosensitivity. These findings suggest that ATP6V1C1 may serve as a potential therapeutic target to enhance radiation sensitivity in ESCC.
Review
Oncology
Eun Kyung Ko, Brian C. Capell
Summary: Although the underlying mechanisms of skin cancers like keratinocyte cancers are still emerging, recent evidence suggests that alterations in DNA, RNA, and histone methylation may play a critical role in disrupting gene expression. While methylation modifiers are frequently dysregulated in keratinocyte cancers, the molecular and mechanistic changes are just beginning to be understood, with extensive cross-talk among these distinct methylation processes. These discoveries may lead to novel therapeutic approaches for these common cancers.