Article
Psychology, Clinical
Kavinash Loganathan
Summary: Value-based decision-making plays a crucial role in drug dependency by biasing cognitive systems towards the motivated pursuit of addictive drugs, affecting learning, attention, and memory functions. This bias leads to the excessive valuation of drugs as the preferred means of achieving a desired internal state, narrowing one's focus towards the pursuit and consumption of addictive drugs.
ADDICTIVE BEHAVIORS
(2021)
Review
Biochemistry & Molecular Biology
Carla Occhipinti, Raffaele La Russa, Naomi Iacoponi, Julia Lazzari, Andrea Costantino, Nicola Di Fazio, Fabio Del Duca, Aniello Maiese, Vittorio Fineschi
Summary: This article provides an overview of the role of miRNAs in substance addiction, evaluating their regulatory role in neuroadaptation and synaptic plasticity. It also explores the potential diagnostic role of miRNAs in various stages of drug and substance addiction, and discusses future prospects for miRNAs as potential novel therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Behavioral Sciences
Avinash Veerappa, Gurudutt Pendyala, Chittibabu Guda
Summary: This review attempts to coalesce data points from experimental studies in the field of SUDs, revealing a 'core addictome' pathway and proposing several important observations and hypotheses for addressing addiction issues effectively.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Francesco Dernie, Harrison S. France, Elizabeth T. Thomas, Maja Bilip, Nicholas J. DeVito, Robin E. Ferner, Anthony R. Cox, Carl Heneghan, Jeffrey K. Aronson, Georgia C. Richards
Summary: Opioid deaths have increased in England and Wales. Coroners' reports provide important insights to prevent future deaths, but opioid-related reports have not been synthesized. This study aimed to identify opioid-related reports and explore coroners' concerns.
JOURNAL OF PUBLIC HEALTH
(2023)
Review
Pharmacology & Pharmacy
Patrycja Kleczkowska, Dorota Sulejczak, Malgorzata Zaremba
Summary: Disulfiram is a well-known anti-alcohol agent that also shows potential in treating other forms of drug addiction, but it carries the greatest risk of pharmacological interactions compared to other drugs used in alcohol dependence.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Leisheng Shi, Yan Wang, Chong Li, Kunlin Zhang, Quansheng Du, Mei Zhao
Summary: AddictGene is a resource that integrates multidimensional data related to commonly abused substances, including gene expression, gene-gene interaction, gene-drug interaction, and epigenetic regulatory information. This database provides detailed information about differentially expressed genes, offering a valuable resource for studying the molecular mechanisms underlying addiction.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Review
Neurosciences
Briana Lees, Alexis M. Garcia, Jennifer Debenham, Anna E. Kirkland, Brittany E. Bryant, Louise Mewton, Lindsay M. Squeglia
Summary: It has been found that aberrant neural structure and function can precede the initiation, escalation, and disorder of substance use in adolescence, with individuals having smaller fronto-parietal and amygdala volume and larger ventral striatal volume being more prone to future substance misuse. Neurobehavioral data is useful in predicting future substance use behaviors, but there is currently a lack of empirical research testing the underlying assumptions of widely used theoretical frameworks.
Article
Pharmacology & Pharmacy
Joanna Hockenhull, Elise Amioka, Joshua C. Black, Alyssa Forber, Colleen M. Haynes, David M. Wood, Richard C. Dart, Paul I. Dargan
Summary: The prevalence of non-medical use of benzodiazepines and GABA analogues varies among European countries, with Germany having a high incidence of GABA analogue NMU and Spain having a high incidence of benzodiazepine NMU. Further research is needed to identify factors and motivations behind these differences and inform public health policies.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Suzanne J. van den Toren, Amy van Grieken, Hein Raat
Summary: Research shows that adolescent nitrous oxide use is associated with factors such as ethnic background, education levels, mental health issues, binge drinking, and cannabis use.
Article
Psychiatry
Mark A. Smith, Shannon L. Ballard, Clarise F. Ballesteros, Samantha A. Bonge, Alexander T. Casimir, Lauren M. Childs, Max A. Feinstein, Annie K. Griffith, Alexandra N. Johansen, Daegeon Lee, A. Caroline Mauser, Cassidy M. Moses, Ian J. Robertson, Javier U. Robles, Justin C. Strickland, Mary E. Walters, Seeley J. Yoo
Summary: This study examined the role of an opioid's relative efficacy at the mu receptor in altering the behavioral effects of dextroamphetamine. The results indicated that opioids possessing different relative efficacy at the mu receptor significantly increased the locomotor effects of dextroamphetamine.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Olga Wronikowska-Denysiuk, Weronika Mrozek, Barbara Budzynska
Summary: Drug abuse is a global problem that has negative consequences on physical, mental, and economic aspects. The oxytocin (OT) and vasopressin (AVP) systems have shown potential as therapeutic targets for drug abuse treatment. Both OT and AVP can reduce drug consumption and ameliorate their rewarding effects. Additionally, these neuropeptides are involved in social and reward behaviors. Therefore, understanding the relationship between OT and AVP and the behavioral effects of drugs of abuse may contribute to more successful drug development.
Article
Multidisciplinary Sciences
Yang Chen, Guibin Wang, Wen Zhang, Ying Han, Libo Zhang, Hubo Xu, Shiqiu Meng, Lin Lu, Yanxue Xue, Jie Shi
Summary: This study found that rats with compulsive cocaine use showed increased neural activity in the anterior insular cortex and enhanced orbitofrontal cortex-anterior insular cortex circuit. Manipulating the activity of anterior insular cortex glutamatergic neurons and the orbitofrontal cortex-anterior insular cortex circuit bidirectionally regulated compulsive cocaine intake.
Review
Environmental Sciences
Ekaterina Georgieva, Krasimira Benkova, Nadya Vlaeva, Yanka Karamalakova, Radostina Miteva, Hristo Abrashev, Galina Nikolova
Summary: This study focuses on the relationship between the use of different psychostimulants and gender, identifying gender-specific patterns in illicit substance use in the general population. It aims to provide guidance for developing gender-specific treatment and prevention methods, including pharmacological and behavioral therapies, based on the analysis of research up to 2022.
Article
Pharmacology & Pharmacy
Joanna Hockenhull, Joshua C. Black, Alex Bletz, Zachary Margolin, Rick Olson, David M. Wood, Richard C. Dart, Paul I. Dargan
Summary: The study found substantial online discussions about nonmedical use of prescription opioids in the UK, including for hydrocodone which is not medically available. The most common theme in discussions was sharing experiences or opinions, with mentions also involving polysubstance use and drug diversion.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Psychology, Clinical
Erynn Christensen, Lucy Albertella, Samuel R. Chamberlain, Maja Brydevall, Chao Suo, Jon E. Grant, Murat Yucel, Rico Sze Chun Lee
Summary: This study evaluated the neurocognitive correlates of problem alcohol use and three non-substance-related addictive behaviors using a large community sample. The results showed differential associations between neurocognition and each addictive behavior, highlighting the need for a more nuanced understanding of non-substance addiction.
ADDICTIVE BEHAVIORS
(2024)
Article
Clinical Neurology
Martine Skumlien, Claire Mokrysz, Tom P. Freeman, Vincent Valton, Matthew B. Wall, Michael Bloomfield, Rachel Lees, Anna Borissova, Kat Petrilli, Manuela Giugliano, Denisa Clisu, Christelle Langley, Barbara J. Sahakian, H. Valerie Curran, Will Lawn
Summary: This study examined the association between cannabis use and anhedonia, apathy, pleasure, and effort-based decision-making for reward, and explored the moderating effect of age group.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinran Wu, Lena Palaniyappan, Gechang Yu, Kai Zhang, Jakob Seidlitz, Zhaowen Liu, Xiangzhen Kong, Gunter Schumann, Jianfeng Feng, Barbara J. Sahakian, Trevor W. Robbins, Edward Bullmore, Jie Zhang
Summary: This study constructed a whole-brain morphometric similarity network and found that developmental dissimilarities between cortical and subcortical regions were associated with cognitive and psychiatric status during preadolescence.
MOLECULAR PSYCHIATRY
(2023)
Article
Neurosciences
Christelle Langley, Sophia Armand, Qiang Luo, George Savulich, Tina Segerberg, Anna Sondergaard, Elisabeth B. Pedersen, Nanna Svart, Oliver Overgaard-Hansen, Annette Johansen, Camilla Borgsted, Rudolf N. Cardinal, Trevor W. Robbins, Dea S. Stenbaek, Gitte M. Knudsen, Barbara J. Sahakian
Summary: This study aimed to investigate the chronic effects of the SSRI escitalopram on cognition in healthy volunteers. The findings revealed that escitalopram decreased reinforcement sensitivity but had no significant impact on "cold" cognition and decision-making ability. These findings suggest that serotonin reuptake inhibition plays a role in reinforcement learning in healthy individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Karmele Lopez-de-Ipina, Jon Iradi, Elsa Fernandez, Pilar M. Calvo, Damien Salle, Anujan Poologaindran, Ivan Villaverde, Paul Daelman, Emilio Sanchez, Catalina Requejo, John Suckling
Summary: The workplace is shifting towards a more interactive role between humans and intelligent machines, while the aging workforce brings about new risks due to health disorders, necessitating intelligent intervention for production management and worker support. This study presents HUMANISE, an intelligent system for risk management targeting workers with disease conditions, based on Computer Vision, Machine Learning and Intelligent Agents. The results demonstrate the system's potential in coordinating and monitoring industrial scenarios with worker health information for successful risk management.
Article
Clinical Neurology
Roxanne W. Hook, Masanori Isobe, George Savulich, Jon E. Grant, Konstantinos Ioannidis, David Christmas, Barbara J. Sahakian, Trevor W. Robbins, Samuel R. Chamberlain
Summary: This study found that single-dose istradefylline can impact human cognition, particularly in the social information preference task with emotional loading. This indicates the under-studied role of the adenosine neurochemical system in human cognition, which requires further exploration.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Sameer Jauhar, Danilo Arnone, David S. Baldwin, Michael Bloomfield, Michael Browning, Anthony J. Cleare, Phillip Corlett, J. F. William Deakin, David Erritzoe, Cynthia Fu, Paolo Fusar-Poli, Guy M. Goodwin, Joseph Hayes, Robert Howard, Oliver D. Howes, Mario F. Juruena, Raymond W. Lam, Stephen M. Lawrie, Hamish McAllister-Williams, Steven Marwaha, David Matuskey, Robert A. McCutcheon, David J. Nutt, Carmine Pariante, Toby Pillinger, Rajiv Radhakrishnan, James Rucker, Sudhakar Selvaraj, Paul Stokes, Rachel Upthegrove, Nefize Yalin, Lakshmi Yatham, Allan H. Young, Roland Zahn, Philip J. Cowen
Summary: A recent umbrella review found no consistent evidence linking serotonin to the pathophysiology of depression. However, we argue that this conclusion is overstated due to methodological weaknesses, selective reporting of data, oversimplification, and errors in the interpretation of neuropsychopharmacological findings. We use the examples of tryptophan depletion and serotonergic molecular imaging, the two most relevant research areas, to support our argument.
MOLECULAR PSYCHIATRY
(2023)
Article
Psychiatry
Michal M. Graczyk, Barbara J. Sahakian, Trevor W. Robbins, Karen D. Ersche
Summary: Not everyone who uses drugs loses control over their intake, which is a hallmark of addiction. Although familial risk studies suggest significant addiction heritability, the genetic basis of vulnerability to drug addiction remains largely unknown. In this study, the researchers examined the relationship between self-control, cocaine use, and a specific gene variant (rs36024) associated with the noradrenaline transporter gene. They found that individuals carrying the C-allele of this gene exhibited impaired self-control, particularly in the context of chronic cocaine use. Patients with cocaine use disorder who had the CC genotype showed longer stop-signal reaction time and fewer successful stops compared to healthy controls and patients with the TT genotype. These findings suggest that rs36024 may be a potential genetic vulnerability marker for cocaine addiction.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Julia Sinclair, Thomas R. E. Barnes, Anne Lingford-Hughes, Colin Drummond, Ignatius Loubser, Olivia Rendora, Carol Paton
Summary: A comparison of medically assisted alcohol withdrawal (MAAW) between acute adult wards and specialist addiction units reveals that the involvement of clinicians with specialist addiction training leads to higher quality care, including comprehensive assessment and treatment interventions. This has implications for improving the provision of MAAW in acute adult mental health settings.
Letter
Psychiatry
Noham Wolpe, Shanquan Chen, Brian Kirkpatrick, Peter B. Jones, Christopher Jenkins, Rudolf N. Cardinal, Emilio Fernandez-Egea
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Editorial Material
Psychiatry
Emilio Fernandez-Egea, Armida Mucci, Jimmy Lee, Brian Kirkpatrick
Summary: This article presents the recent advancements in the research on negative symptoms in schizophrenia, including new concepts, epidemiology, pathophysiology, and therapeutic options for management.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Kim Donoghue, Sadie Boniface, Eileen Brobbin, Sarah Byford, Rachel Coleman, Simon Coulton, Edward Day, Ranjita Dhital, Anum Farid, Laura Hermann, Amy Jordan, Andreas Kimergard, Maria-Leoni Koutsou, Anne Lingford-Hughes, John Marsden, Joanne Neale, Aimee O'Neill, Thomas Phillips, James Shearer, Julia Sinclair, Joanna Smith, John Strang, John Weinman, Cate Whittlesea, Kideshini Widyaratna, Colin Drummond
Summary: This study aimed to evaluate the effectiveness of Medication Management in enhancing adherence to acamprosate. The results showed that Medication Management enhanced with Contingency Management is more beneficial for supporting patients to take acamprosate. However, there was no significant difference compared to Medication Management alone.
HEALTH TECHNOLOGY ASSESSMENT
(2023)
Article
Clinical Neurology
R. Rodrigues, E. Z. Mehesz, A. Lingford-Hughes, M. Di Simplicio
Summary: This study used a Dot Probe Task to investigate attentional biases in individuals with self-harm. The results showed that the self-harm group had a higher level of avoidance towards self-harm cues, while the negative affect group had less difficulty disengaging from these cues. The study also suggested that further research is needed to determine whether these attentional biases can serve as markers for treatment response or susceptibility to relapse in individuals with self-harm.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Bence Bruncsics, Gabor Hullam, Bence Bolgar, Peter Petschner, Andras Millinghoffer, Kinga Gecse, Nora Eszlari, Xenia Gonda, Debra J. Jones, Sorrel T. Burden, Peter Antal, Bill Deakin, Gyorgy Bagdy, Gabriella Juhasz
Summary: Manipulation of tryptophan intake can rapidly induce and alleviate depression symptoms. This study investigates the effect of habitual tryptophan intake on mood symptoms and the influence of genetic factors. High dietary tryptophan ratio provides a protective effect against depression. Genetic associations with depression are found in the low tryptophan ratio group, particularly in serotonin and kynurenine pathways. Understanding the interaction between genetics and diet can lead to personalized prevention and intervention for mood disorders.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Shitong Xiang, Tianye Jia, Chao Xie, Zhichao Zhu, Wei Cheng, Gunter Schumann, Trevor W. Robbins, Jianfeng Feng
Summary: How to retrieve latent neurobehavioural processes from complex neurobiological signals is a challenge that has not been fully addressed. This study presents a novel approach, DeCoP, that outperforms traditional decoding methods in terms of false inference and robustness. The research reveals distinct evaluation and readiness processes during reward/punishment anticipation, modulated by different dopamine systems. Only a few brain regions encode exact input information, while others encode abstract information.
Article
Pharmacology & Pharmacy
Carmen Jimenez-Mesa, Juan E. Arco, Francisco Jesus Martinez-Murcia, John Suckling, Javier Ramirez, Juan Manuel Gorriz
Summary: The integration of PET and SPECT imaging techniques with ML algorithms, including DL models, is a promising approach that enhances diagnostic and treatment strategies, as well as provides invaluable insights into disease mechanisms.
PHARMACOLOGICAL RESEARCH
(2023)