期刊
PSYCHOPHARMACOLOGY
卷 233, 期 19-20, 页码 3639-3646出版社
SPRINGER
DOI: 10.1007/s00213-016-4394-7
关键词
Unilateral hippocampus; Bilateral hippocampus; Fear memory; Recent memory; Remote memory
资金
- National Basic Research Program of China from the Ministry of Science and Technology of China [2013CB835103]
- Strategic Priority Research Program of the Chinese Academy of Science [XDB02020002]
- National Science Foundation of China [31371141]
- Science and Technology Program of Yunnan Province [2013GA003]
Contextual fear memory depends on the hippocampus, but the role of unilateral hippocampus in this type of memory remains unclear. Herein, pharmacological inactivation or excitotoxic lesions were used to study the role of unilateral hippocampus in the stages of contextual fear memory. The pharmacological experiments revealed that compared with the control groups, unilateral hippocampal blockade did not impair 1-day recent memory following learning, whereas bilateral hippocampal blockade significantly impaired this memory. The lesion experiments showed that compared with the control groups, the formed contextual fear memory was retained for 7 days and that 30-day remote memory was markedly reduced in unilateral hippocampal lesion groups. These results indicate that an intact bilateral hippocampus is required for the formation of remote memory and that unilateral hippocampus is sufficient for recent contextual fear memory.
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