Article
Biochemistry & Molecular Biology
Qingxia Yang, Qiaowen Xing, Qingfang Yang, Yaguo Gong
Summary: Schizophrenia, bipolar disorder, and major depressive disorder are the most common psychiatric disorders. Diagnosing these disorders is difficult due to overlaps in genetic epidemiology and molecular genetics. This study used transcriptomic data to identify key genes and construct a classification model for differentiating these disorders. The model showed potential for improving the diagnoses of these psychiatric disorders.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Xue Mei Song, Xi-Wen Hu, Zhe Li, Yuan Gao, Xuan Ju, Dong-Yu Liu, Qian-Nan Wang, Chuang Xue, Yong-Chun Cai, Ruiliang Bai, Zhong-Lin Tan, Georg Northoff
Summary: The study found a specific deficit in visual perception among patients with acute major depressive disorder, which is correlated with symptom severity and decreased GABA concentration in the brain. These findings highlight the importance of reduced occipital GABA in altered visual perception and psychopathological symptoms in acute MDD.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Elisabeth M. Weiss, Eberhard A. Deisenhammer, Andreas Fink, Josef Marksteiner, Markus Canazei, Ilona Papousek
Summary: This study compared self-perceived abilities in emotional functioning between patients with schizophrenia, major depressive disorder, and healthy participants. The results showed that both patient groups had lower overall levels of self-perceived emotional functioning compared to the control group. There were also significant differences in profile patterns between the two patient groups.
Review
Clinical Neurology
Kody G. Kennedy, Megan Mio, Benjamin I. Goldstein, Paolo Brambilla, Giuseppe Delvecchio
Summary: This review and meta-analysis found that individuals with severe mental illness, especially schizophrenia, have wider retinal venules compared to controls, indicating a potential connection between cerebrovascular health and mental illness.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
S. Rupprechter, A. Stankevicius, Q. J. M. Huys, P. Series, J. D. Steele
Summary: The study focused on reward valuation and decision-making processes in individuals with major depressive disorder. Results showed abnormal reward value encoding in depression, leading to impaired decision-making processes and increased activity in the rostral anterior cingulate cortex. Additionally, decreased event-related connectivity between the anterior mid-cingulate cortex and rostral cingulate regions was observed in depression, indicating impaired communication between neural substrates related to expected value estimation and decision-making.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Zongchang Li, David Li, Xiaogang Chen
Summary: This study shows differences in genetic association between bipolar I disorder (BD-I) and bipolar II disorder (BD-II) with schizophrenia (SCZ) and major depressive disorder (MDD). The study finds that BD-II is more polygenic compared to BD-I, SCZ, and MDD, and there is substantial polygenic overlap between BD-I and SCZ, as well as between BD-I and MDD. The study also identifies specific shared genetic loci between BD subtypes and SCZ or MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Po-Han Chou, Wen-Chun Liu, Wei-Hao Lin, Chih-Wei Hsu, Shao-Cheng Wang, Kuan-Pin Su
Summary: Near-infrared spectroscopy (NIRS) can be used to differentiate major depressive disorder (MDD), bipolar disorder (BPD), and schizophrenia (SZ) at the individual level by analyzing the spatiotemporal characteristics of hemodynamic responses. This can provide diagnostic support in clinical settings.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Cell Biology
Shiwan Tao, Yamin Zhang, Qiang Wang, Chunxia Qiao, Wei Deng, Sugai Liang, Jinxue Wei, Wei Wei, Hua Yu, Xiaojing Li, Mingli Li, Wanjun Guo, Xiaohong Ma, Liansheng Zhao, Tao Li
Summary: This study identified transdiagnostic subtypes of schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics abnormalities. The two subtypes differed in clinical diagnosis, functional impairment, and brain white matter abnormalities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Chao Li, Mengshi Dong, Fay Y. Womer, Shaoqiang Han, Yi Yin, Xiaowei Jiang, Yange Wei, Jia Duan, Ruiqi Feng, Luheng Zhang, Xizhe Zhang, Fei Wang, Yanqing Tang, Ke Xu
Summary: The study utilized DFC analysis to investigate transdiagnostic dysconnectivity across SZ, BD, and MDD, revealing more common dysconnectivity than previously expected, with SZ showing the most pronounced changes.
HUMAN BRAIN MAPPING
(2021)
Review
Neurosciences
Jiaqi Zhou, Miao Li, Xueying Wang, Yuwen He, Yan Xia, John A. Sweeney, Richard F. Kopp, Chunyu Liu, Chao Chen
Summary: Pharmacotherapy is the most common treatment for SCZ, BD, and MDD, but pharmacogenetic studies have limited clinical utility. DNAm, an epigenetic modification, has been proposed to be involved in the pathogenesis and drug treatment of these disorders. BDNF DNAm shows promise as a predictor of antidepressant treatment response for MDD, while more pharmacoepigenetic studies are needed for a variety of diseases. Future research should utilize system-wide analysis and strict analytical procedures.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychology, Multidisciplinary
Yun Wang, Xiaoling Li, Haohao Yan, Qinqin Zhang, Yangpan Ou, Weibin Wu, Webo Shangguan, Wensheng Chen, Yang Yu, Jiaquan Liang, Wanting Wu, Hairong Liao, Zishan Liu, Xiancong Mai, Guojun Xie, Wenbin Guo
Summary: This study aimed to investigate the relationships between regional neural activity and multiple related indicators in patients with major depressive disorder (MDD). The results suggested that the decreased regional homogeneity (ReHo) of the salience network might be the underpinning of cognitive impairments in patients with MDD.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Weiliang Yang, Yuting Wang, Wen Qin, Meijuan Li, Huan Mao, Chi Zhou, Xueying Liu, Jie Li
Summary: This study investigated the changes in temporal properties of dynamic functional network connectivity (dFNC) in first-episode, drug-naive patients with major depressive disorder (MDD). The results showed that these changes in temporal properties could serve as potential biomarkers for MDD, with good diagnostic performance.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Yahui Liu, Jiajia Zhang, Meng Zhang, Xianrui Li, Kun Li, Bi Wang, Yongfeng Yang, Ruize Song, Yajing Si, Tianjun Ni, Xueke Wang, Yibo Geng, Qiaohua Chang, Haisan Zhang, Zhijun Zhang, Hongxing Zhang
Summary: This study found that patients with major depressive disorders have abnormalities in the frontal-limbic structures of the brain, specifically decreased gray matter volume in the right middle frontal and precentral gyri. Childhood trauma may be a contributing factor to these structural abnormalities and increased susceptibility to depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychiatry
Qi Liu, Bo Zhou, Xiaodong Zhang, Peng Qing, Xinqi Zhou, Feng Zhou, Xiaolei Xu, Siyu Zhu, Jing Dai, Yulan Huang, Jinyu Wang, Zhili Zou, Keith M. Kendrick, Benjamin Becker, Weihua Zhao
Summary: This study aims to explore the comorbidity between generalized anxiety disorder (GAD) and major depressive disorder (MDD) and the common and distinct alterations in functional brain networks. The findings suggest abnormal dynamic brain connectivity in both GAD and MDD patients compared to healthy controls.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Neurosciences
Sitong Chen, Xiaoya Liu, Zhenni Huang, Fangyue Su, Wenquan Zhang, Jie Li, Shuang Liu, Dong Ming
Summary: This study aimed to investigate the disruption of spatiotemporal dynamics underlying gamma-ASSR in patients with major depressive disorder (MDD). Dynamic directed brain networks were constructed based on graph theory. The results showed patterns of hypofunction in the parietal-to-frontal regions associated with gamma oscillations, providing novel insights into the neuropathological mechanism underlying gamma oscillations in MDD.
Article
Psychiatry
Paul H. Lysaker, Leonor Irarrazaval, Emily C. Gagen, Ivan Armijo, Massimo Ballerini, Milena Mancini, Giovanni Stanghellini
PSYCHIATRY RESEARCH
(2018)
Article
Psychiatry
Guilherme Messas, Melissa Tamelini, Milena Mancini, Giovanni Stanghellini
FRONTIERS IN PSYCHIATRY
(2018)
Article
Psychiatry
Alessandra D'Agostino, Milena Mancini, Mario Rossi Monti
Article
Psychiatry
Giovanni Stanghellini, Massimo Ballerini, Milena Mancini
FRONTIERS IN PSYCHIATRY
(2019)
Article
Psychiatry
Giovanni Stanghellini, Anthony Vincent Fenrandez, Massimo Ballerini, Stefano Blasi, Erika Belfiore, John Cutting, Milena Mancini
SCHIZOPHRENIA BULLETIN
(2020)
Article
Psychiatry
Frank Rohricht, Savitha Eranti, Massimo Ballerini, Milena Mancini, Josephine Neale, Athanasios Tsoumpris, Giovanni Stanghellini
Article
Psychiatry
Milena Mancini, Cecilia Maria Esposito
Summary: According to phenomenological perspective, the lived body disorder is a core feature of feeding and eating disorders. Individuals with FEDs experience their own body as an object looked by others, leading to alienation, disgust, shame, and exaggerated preoccupation with appearance. The gaze of the Other plays a crucial role in this disorder, as individuals with FEDs rely on external perception of their body.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2021)
Article
Psychiatry
Eleonora Rossi, Giovanni Castellini, Emanuele Cassioli, Carolina Sensi, Milena Mancini, Giovanni Stanghellini, Valdo Ricca
Summary: This study demonstrates the pivotal role of embodiment disorder in eating disorders, with higher levels predicting increased diagnostic instability. Improvement of embodiment disorder was found to reduce ED-specific psychopathology and body uneasiness, highlighting the importance of integrating CBT-E with a phenomenological model of EDs.
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2021)
Meeting Abstract
Psychiatry
E. Rossi, E. Cassioli, G. Castellini, M. Franzago, S. Bagnoli, L. Lelli, M. Balsamo, M. Mancini, B. Nacmias, V. Ricca, S. Sorbi, I. Antonucci, L. Stuppia, G. Stanghellini
EUROPEAN PSYCHIATRY
(2020)
Meeting Abstract
Urology & Nephrology
E. Rossi, E. Cassioli, G. Castellini, C. Sensi, M. Mancini, L. Lelli, A. M. Monteleone, V Ricca, G. Stanghellini
JOURNAL OF SEXUAL MEDICINE
(2020)
Article
Psychiatry
Emanuele Cassioli, Eleonora Rossi, Giovanni Castellini, Carolina Sensi, Milena Mancini, Lorenzo Lelli, Alessio Maria Monteleone, Valdo Ricca, Giovanni Stanghellini
EATING AND WEIGHT DISORDERS-STUDIES ON ANOREXIA BULIMIA AND OBESITY
(2020)
Article
Psychiatry
Jerome Englebert, Eugenie Minguet, Adam Helinski, Francoise Domine, Sandra Gebhard, Catherine Zdrojewski, Giovanni Castellini, Valdo Ricca, Milena Mancini, Friedrich Stiefel, Giovanni Stanghellini, Adelaide Blavier
EVOLUTION PSYCHIATRIQUE
(2019)
Article
Philosophy
Giovanni Stanghellini, Milena Mancini
PHENOMENOLOGY AND THE COGNITIVE SCIENCES
(2019)
Article
Psychology, Clinical
Alessio Maria Monteleone, Giovanni Castellini, Valdo Ricca, Umberto Volpe, Francesco De Riso, Massimiliano Nigro, Francesco Zamponi, Milena Mancini, Giovanni Stanghellini, Palmiero Monteleone, Janet Treasure, Mario Maj
EUROPEAN EATING DISORDERS REVIEW
(2017)
Article
Psychology, Clinical
Milena Mancini, Giovanni Stanghellini
RESEARCH IN PSYCHOTHERAPY-PSYCHOPATHOLOGY PROCESS AND OUTCOME
(2020)