Review
Behavioral Sciences
Anka Bernhard, Jutta S. Mayer, Nikola Fann, Christine M. Freitag
Summary: This systematic review investigated the cortisol stress response to psychosocial stress in ADHD compared to Conduct Disorder (CD) and Major Depressive Disorder (MDD). The study found that alterations of cortisol stress response in ADHD were less pronounced compared to CD and MDD, and were primarily driven by comorbidity with disruptive behavior disorders such as CD and ODD.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Clinical Neurology
Gunild M. Vulpius, Kristin Kohler-Forsberg, Brice Ozenne, Soren Larsen, Arafat Nasser, Claus Svarer, Nic Gillings, Sune H. Keller, Martin B. Jorgensen, Gitte M. Knudsen, Vibe G. Frokjaer
Summary: This study investigates the correlation between brain 5-HT4R availability and cortisol dynamics in untreated patients with MDD. The results suggest a link between serotonergic disturbances and cortisol dynamics in MDD, but cortisol dynamics did not predict treatment outcome.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Song Yue, Linlin Luo, Yutao Feng, Debiao Liu, Fengting Wang, Rongbo Che, Jin Zhu, Ximing Duan, Yunfeng Tang, JianLi Wang, Yan Liu
Summary: This study provides evidence that the combined effect of rs768705 (TMEM161B) and rs35936514 (LHPP) may modulate the risk of MDD. The study also finds that the 2-year incidence of MDD in Chinese college students is 3.75%.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Ana Salome Correia, Armando Cardoso, Nuno Vale
Summary: Both stress and immune responses are recognized as important factors in various neurological disorders, with neurotransmitters such as serotonin playing a key role in connecting these factors to diseases. Imbalances in stressors may promote neuropsychiatric or neurodegenerative pathologies. Investigations into the connections between stress, immune responses, and serotonergic signaling could lead to new and improved treatments for conditions like major depressive disorder, Alzheimer's, and Parkinson's, ultimately enhancing the quality of life for patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Peijun Tian, Renying Zou, Luyao Wang, Ying Chen, Xin Qian, Jianxin Zhao, Hao Zhang, Long Qian, Qun Wang, Gang Wang, Wei Chen
Summary: This study investigated the potential psychotropic effects of a combined three-strain probiotic intervention for human MDD patients. The results showed that multi-probiotics significantly reduced depression symptoms and improved gastrointestinal functions, with serotonergic system modification as the key mechanism.
JOURNAL OF ADVANCED RESEARCH
(2023)
Review
Food Science & Technology
Agata Fijalkowska, Karol Jedrejko, Katarzyna Sulkowska-Ziaja, Marek Ziaja, Katarzyna Kala, Bozena Muszynska
Summary: This article explores the possibility of using edible medicinal mushrooms as an adjunctive treatment for major depressive disorder (MDD) and provides relevant background and research findings. It highlights the potential impact of Lion's mane on human well-being, the inconsistent clinical results of Reishi, and the ongoing research on Caterpillar Mushroom. Additionally, edible mushrooms contain 5-hydroxy-L-tryptophan (5-HTP), a precursor of serotonin, the neurotransmitter targeted in MDD pharmacotherapy.
Article
Psychology, Clinical
Shabaz Sendi, Susanne Fischer, Andrew Papadopoulos, Lucia Poon, Lena J. J. Rane, Abebaw Fekadu, Valeria Mondelli, Anthony J. J. Cleare
Summary: This study found that patients with major depressive disorder have higher cortisol levels after awakening compared to healthy controls, but this difference only exists in patients reporting childhood trauma. The results suggest that early life stress may impact the biological markers of individuals with major depressive disorder. Therefore, tailored treatments may be needed for this population.
PSYCHOLOGICAL MEDICINE
(2023)
Review
Chemistry, Analytical
Xin Zhang, Zhiheng Zhang, Weize Diao, Chuangxin Zhou, Yetong Song, Renzhi Wang, Xiaoguang Luo, Guozhen Liu
Summary: Major depressive disorder, or depression, is a common mental illness worldwide, and the current clinical diagnosis methods have limitations. Therefore, it is crucial to search for high-quality depression biomarkers and develop accurate and convenient early diagnosis methods. This review summarizes various potential biomarkers for the diagnosis of depression, discusses their advantages and disadvantages in early diagnosis, and explores the feasibility of applying these biomarkers for depression diagnosis. Additionally, disposable devices and wearable devices for detecting these biomarkers are introduced and analyzed, and future perspectives for early diagnosis of depression, especially in a point-of-care scenario, are proposed.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Psychiatry
Evgenia E. Psarraki, Flora Bacopoulou, Eustathios Panagoulias, Maria Michou, Panagiotis Pelekasis, Artemios Artemiadis, George P. Chrousos, Christina Darviri
Summary: A randomized clinical trial implemented a holistic stress management program, PSAI, for adults with MDD, showing that the intervention group had greater reductions in depressive symptoms, perceived stress, and negative affect, along with improvements in visual memory and healthy lifestyle compared to the control group.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neuroimaging
Darren Roddy, John R. Kelly, Chloe Farrell, Kelly Doolin, Elena Roman, Anurag Nasa, Thomas Frodl, Andrew Harkin, Shane O'Mara, Erik O'Hanlon, Veronica O'Keane
Summary: The study identified larger right medial nuclei volumes in MDD compared to healthy controls, as well as relatively increased right compared to left whole and substructure volume ratios in MDD. This suggests that amygdala substructure volumes may be involved in the pathophysiology of depression.
NEUROIMAGE-CLINICAL
(2021)
Review
Medicine, General & Internal
Ming-Zhe Zhao, Xu-Sheng Song, Jing-Song Ma
Summary: Major depressive disorder (MDD) is a multifactorial disorder influenced by multiple susceptibility genes and environmental factors, with childhood adversities and stressful life events playing crucial roles; the differential susceptibility theory challenges the diathesis-stress conceptualization in GxE studies, highlighting the need to consider complex interactions between genes and environments in MDD research.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Psychiatry
Kelly J. Heard, Maxim N. Shokhirev, Caroline Becronis, Callie Fredlender, Nadia Zahid, Amy T. Le, Yuan Ji, Michelle Skime, Timothy Nelson, Daniel Hall-Flavin, Richard Weinshilboum, Fred H. Gage, Krishna C. Vadodaria
Summary: The study explores the impact of chronic stress on cortisol-induced neuropathology, finding unique differences at the transcriptomic level between chronic and acute cortisol treatment, and investigates the stress response transcriptome of astrocytes from MDD patient iPSCs. These data emphasize the unique role of astrocytes in the central nervous system and present potential genes for further research on the relationship between chronic stress and MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Peter Zhukovsky, Michael Wainberg, Milos Milic, Shreejoy J. Tripathy, Benoit H. Mulsant, Daniel Felsky, Aristotle N. Voineskos
Summary: This study compared the neural mechanisms underlying major depressive disorder (MDD), anxiety, and stress-related disorders. The results showed that MDD had the greatest differences in neural signatures, followed by anxiety and stress-related disorders. The neural signatures of MDD and anxiety disorders were highly similar, while stress-related disorders showed a distinct pattern. Controlling for genetic risk decreased the similarity between stress-related disorders and MDD/anxiety disorders. Cognitive impairment was associated with reduced within-network connectivity and increased between-network connectivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
C. Sophia Albott, Kelvin O. Lim, Christopher Erbes, Paul Thuras, Joseph Wels, Susanna J. Tye, Paulo R. Shiroma
Summary: This study examined the neurocognitive effects of repeated ketamine in participants with comorbid PTSD and MDD, finding that repeated ketamine infusions did not worsen cognition, but instead showed significant improvement in working memory. Additionally, certain neurocognitive performances at baseline can predict the response to ketamine for symptoms of PTSD and MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Thiemo Knaust, Matthias B. D. Siebler, Dagmar Tarnogorski, Philipp Skiberowski, Helge Hoellmer, Christian Moritz, Holger Schulz
Summary: This study compared hippocampal subfield volumes among soldiers with PTSD, MDD, and AdjD using routine clinical data. The results showed no significant volume differences between these stress-related mental disorders.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Biological
Maria Ditcheva, Suzanne Vrshek-Schallhorn, Anna Batista
BIOLOGICAL PSYCHOLOGY
(2018)
Article
Endocrinology & Metabolism
Suzanne Vrshek-Schallhorn, Bradley M. Avery, Maria Ditcheva, Vaibhav R. Sapuram
PSYCHONEUROENDOCRINOLOGY
(2018)
Article
Psychology, Clinical
Suzanne Vrshek-Schallhorn, Catherine B. Stroud, Leah D. Doane, Susan Mineka, Richard E. Zinbarg, Eva E. Redei, Michelle G. Craske, Emma K. Adam
DEPRESSION AND ANXIETY
(2019)
Letter
Psychiatry
Suzanne Vrshek-Schallhorn, Gail M. Corneau, Lisa R. Starr
AMERICAN JOURNAL OF PSYCHIATRY
(2019)
Article
Endocrinology & Metabolism
Catherine B. Stroud, Suzanne Vrshek-Shallhorn, Emily M. Norkett, Leah D. Doane
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Psychiatry
Lisa R. Starr, Suzanne Vrshek-Schallhorn, Catherine B. Stroud
JOURNAL OF PSYCHIATRIC RESEARCH
(2019)
Article
Psychology, Clinical
Meghan Vinograd, Alexander Williams, Michael Sun, Lyuba Bobova, Kate B. Wolitzky-Taylor, Suzanne Vrshek-Schallhorn, Susan Mineka, Richard E. Zinbarg, Michelle G. Craske
CLINICAL PSYCHOLOGICAL SCIENCE
(2020)
Article
Endocrinology & Metabolism
Travis Anderson, Gail Corneau, Laurie Wideman, Kari Eddington, Suzanne Vrshek-Schallhorn
Summary: The study found that prior day sleep duration and physical activity levels can interact to predict the cortisol awakening response (CAR) the following morning, with short sleep duration and high levels of physical activity resulting in an augmented CAR. The effects of sleep and physical activity on CAR demonstrate an interactive effect.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Family Studies
Anne C. Fletcher, Michaeline Jensen, Suzanne Vrshek-Schallhorn
Summary: First-generation college students are less likely to complete their degrees compared to continuing-generation students. This is partly due to experiences of educational and socioeconomic adversity, which influence stress responding and academic avoidance behaviors. A cognitive processing characteristic called trait rumination and levels of enacted family support during college play a role in the strength of this pathway. Interventions that target decreasing rumination, increasing family support, and reducing academic avoidance behaviors may be particularly important for first-generation students.
EMERGING ADULTHOOD
(2023)
Article
Psychology, Clinical
Brian A. Feinstein, N. Keita Christophe, Cindy J. Chang, Paul J. Silvia, Lisa R. Starr, Gabriela Livas Stein, Suzanne Vrshek-Schallhorn
Summary: Sexual minority individuals have a higher risk of suicidal thoughts and behaviors compared to heterosexuals. The interpersonal theory of suicide suggests that perceived burdensomeness and thwarted belongingness play a central role in the desire to die, and both factors are associated with suicidal ideation in sexual minority populations. The Interpersonal Needs Questionnaire (INQ) is commonly used to measure these risk factors, but its measurement properties across different subgroups of sexual minority individuals are unknown. This study aimed to examine the measurement invariance of the 15-item version of the INQ across sexual orientation, gender identity, and race/ethnicity. The results showed that the INQ-15 demonstrated strict invariance across all three dimensions of identity, indicating that it can be used and compared among diverse samples of sexual minority young adults. It was also found that transgender/gender diverse individuals and people of color reported greater perceived burdensomeness and thwarted belongingness compared to cisgender individuals and non-Latinx White individuals, respectively. Additional research is needed to understand the factors contributing to these group differences.
PSYCHOLOGICAL ASSESSMENT
(2022)
Article
Psychology, Clinical
Vaibhav R. Sapuram, Suzanne Vrshek-Schallhorn, Lori M. Hilt, Catherine B. Stroud
Summary: The study found that dopaminergic genetic variation is associated with the reward-related personality trait of sensation-seeking, but not with social drive. Further research is needed to explore whether sensation seeking may be a pathway through which this genetic variation confers depression risk.
RESEARCH ON CHILD AND ADOLESCENT PSYCHOPATHOLOGY
(2021)
Article
Psychology, Clinical
Susan Mineka, Alexander L. Williams, Kate Wolitzky-Taylor, Suzanne Vrshek-Schallhorn, Michelle G. Craske, Constance Hammen, Richard E. Zinbarg
JOURNAL OF ABNORMAL PSYCHOLOGY
(2020)
Article
Psychology, Experimental
Suzanne Vrshek-Schallhorn, Elizabeth A. Velkoff, Richard E. Zinbarg
COGNITION & EMOTION
(2019)
Article
Psychology, Biological
Frances R. Chen, Catherine B. Stroud, Suzanne Vrshek-Schallhorn, Leah D. Doane, Douglas A. Granger
BIOLOGICAL PSYCHOLOGY
(2017)
Article
Behavioral Sciences
Shauna C. Kushner, Kathrin Herzhoff, Suzanne Vrshek-Schallhorn, Jennifer L. Tackett
AGGRESSIVE BEHAVIOR
(2018)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)