期刊
PSYCHONEUROENDOCRINOLOGY
卷 73, 期 -, 页码 166-176出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.psyneuen.2016.08.002
关键词
T helper bias; Cytokine; Microglia; Brain; Cognition
资金
- National Natural Science Foundation of China [31371130]
- Special Foundation of Education Department of Guangdong Province
- Medical Scientific Research Foundation of Guangdong Province, China [2013-159]
- Foundation of Medical Science and Technology Research of Guangdong Province [A2016273]
The immune system plays a vital role in brain development. The hepatitis B vaccine (HBV) is administered to more than 70% of neonates worldwide. Whether this neonatal vaccination affects brain development is unknown. Newborn C57BL/6 mice were injected intraperitoneally with HBV or phosphate-buffered saline. HBV induced impaired behavioral performances and hippocampal long-term potentiation at 8 weeks (w) of age without influence at 4 or 12w. At 6w, there was decreased neurogenesis, M1 microglial activation and a neurotoxic profile of neuroimmune molecule expression [increased tumor necrosis factor-a and reduced interferon (IFN)-gamma, brain-derived neurotrophic factor and insulin-like growth factor-1] in the hippocampus of the HBV-vaccinated mice. In the serum, HBV induced significantly higher levels of interleukin (IL)-4, indicating a T helper (Th)-2 bias. Moreover, the serum IFN-gamma/IL-4 ratio was positively correlated with the levels of neurotrophins and neurogenesis in the hippocampus at the individual level. These findings suggest that neonatal HBV vaccination of mice results in neurobehavioral impairments in early adulthood by inducing a proinflammatory and low neurotrophic milieu in the hippocampus, which follows the HBV-induced systemic Th2 bias. (C) 2016 Elsevier Ltd. All rights reserved.
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