Article
Endocrinology & Metabolism
Emily Jane Meyer, Marni Anne Nenke, Michael Laurence Davies, Marianne Chapman, Wayne Rankin, R. Louise Rushworth, David James Torpy
Summary: The study found that patients with septic shock who had a CBG concentration of <200 nmol/L had higher ICU mortality rates. This suggests that severe CBG deficiency is associated with an increased risk of death in septic shock patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Sean Bankier, Lingfei Wang, Andrew Crawford, Ruth A. Morgan, Arno Ruusalepp, Ruth Andrew, Johan L. M. Bjorkegren, Brian R. Walker, Tom Michoel
Summary: Genome-wide association meta-analysis identified a genetic association between plasma cortisol, cardiovascular disease, and the SERPINA6/SERPINA1 locus. The study explored the mechanisms by which variations in corticosteroid-binding globulin (CBG) lead to cardiovascular disease using transcriptomic data and causal inference. The findings suggest that liver CBG production may perturb cortisol-regulated gene networks in peripheral tissues and promote cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Cathy Degroote, Roland von Kanel, Livia Thomas, Claudia Zuccarella-Hackl, Nadine Messerli-Burgy, Hugo Saner, Roland Wiest, Petra H. Wirtz
Summary: Research shows that patients with coronary heart disease (CHD) and hypertension have decreased activity in the hypothalamus-pituitary-adrenal (HPA) axis, which may contribute to an increased risk of cardiovascular disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Yannuo Li, Ioannis P. Androulakis
Summary: The suprachiasmatic nucleus (SCN) synchronizes physiological rhythms and adapts to changes in photoperiod, affecting the phase distribution of neuron activities. Elevated glucocorticoid levels in short photoperiods are associated with peak disease incidence. Topological changes in the SCN network may influence seasonal variations in disease incidence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhen Jiang, Selma Z. Elsarrag, Qiming Duan, Edward L. LaGory, Zhe Wang, Michael Alexanian, Sarah McMahon, Ingrid C. Rulifson, Sarah Winchester, Yi Wang, Christian Vaisse, Jonathan D. Brown, Mattia Quattrocelli, Charles Y. Lin, Saptarsi M. Haldar
Summary: This study reveals that hepatocyte KLF15 controls plasma corticosteroid transport and inflammatory responses through direct transcriptional activation of Serpina6. Moreover, KLF15 is predominantly enriched in the promoter regions of liver cells, regulating gene transcription activity through binding specific DNA sequences, with minimal associated gene repression.
Article
Endocrinology & Metabolism
Ryan E. Adams, Jonathan Bruce Santo, William M. Bukowski
Summary: This study examines the indirect effects of HPA axis dysregulation on the link between adolescent peer victimization and depressive symptoms, finding that blunted cortisol reactivity is associated with depressive symptoms, particularly in cases of chronic peer victimization. These findings suggest that interventions targeting peer victimization may need to focus on those who experience chronic peer victimization over time.
PSYCHONEUROENDOCRINOLOGY
(2021)
Review
Clinical Neurology
Raphael J. Dressle, Bernd Feige, Kai Spiegelhalder, Christine Schmucker, Fee Benz, Nina C. Mey, Dieter Riemann
Summary: This study aimed to evaluate the differences in cortisol levels, the hormonal end product of the HPA axis, between patients with insomnia and good sleeper controls. The results suggested that patients with insomnia showed moderately increased cortisol levels, with higher effect sizes found when analyzing studies that used blood samples. There was a positive but insignificant association between the extent of objective sleep loss in insomnia patients and group differences in cortisol levels.
SLEEP MEDICINE REVIEWS
(2022)
Review
Zoology
Hai-Yan Lin, Gang Song, Fumin Lei, Dongming Li, Yanhua Qu
Summary: CBG is a high-affinity plasma protein that plays a crucial role in birds by regulating the biological activities of glucocorticoids and helping them adapt to various stresses and environments. The structural and functional properties of CBG are important for understanding the biological actions of glucocorticoids in mediating stress responses and adaptive mechanisms in birds.
FRONTIERS IN ZOOLOGY
(2021)
Article
Psychology, Biological
Sarah Glier, Alana Campbell, Rachel Corr, Andrea Pelletier-Baldelli, Mae Yefimov, Carina Guerra, Kathryn Scott, Louis Murphy, Joshua Bizzell, Aysenil Belger
Summary: Dysregulations in autonomic and endocrine stress responses in adolescence are associated with the emergence of psychopathology. This study comprehensively evaluated the coordination of parasympathetic, sympathetic, and hypothalamic pituitary adrenal axis components in 72 typically developing adolescents. The findings supported the predictions of the Adaptive Calibration Model and highlighted the importance of studying multisystem dynamics in understanding stress response regulation.
Article
Environmental Sciences
Jith Thomas, Errol M. Thomson
Summary: Strain differences in glucocorticoid response to ozone are accompanied by changes in regulatory factors, collectively associated with the inflammatory response to ozone.
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychology, Experimental
Belma Isakovic, Bridget Bertoldi, Catherine Tuvblad, Sara Cucurachi, Adrian Raine, Laura Baker, Shichun Ling, Brittany E. Evans
Summary: This study examined the association between HPA axis responsivity in mid-adolescence and psychopathic personality traits in early adulthood, and determined whether the association was moderated by sex. The results showed that HPA axis responsivity in mid-adolescence did not serve as a biological marker for psychopathic personality traits among young adults from the general population.
Article
Psychology, Biological
Dilara Yuksel, Orsolya Kiss, Devin Prouty, Nicole Arra, Laila Volpe, Fiona C. Baker, Massimiliano de Zambotti
Summary: This study investigated the relationship between insomnia, stress, HPA axis activity, and ANS function in adolescence. The results showed that participants in the insomnia group reported higher stress levels from school performance and work overload, with insomnia girls experiencing more stress from peer pressure and future uncertainty. However, there were no group differences in physiological stress responses overall, although there was a potential sex by insomnia interaction.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Psychology, Developmental
Casey D. Calhoun, Megan W. Patterson, Jason Jose Bendezu, Sarah W. Helms, Sarah A. Owens, Karen D. Rudolph, Paul D. Hastings, Mitchell J. Prinstein
Summary: The study found that girls who displayed more pronounced cortisol reactivity expressed greater vulnerability and received more support from their close friend. Expressed vulnerability was associated with more efficient cortisol recovery. Close friend support was not significantly associated with cortisol recovery, and did not influence the connection between expressed vulnerability and cortisol recovery.
JOURNAL OF ADOLESCENCE
(2021)
Article
Psychology, Developmental
Casey D. Calhoun, Megan W. Patterson, Jason Jose Bendezu, Sarah W. Helms, Sarah A. Owens, Karen D. Rudolph, Paul D. Hastings, Mitchell J. Prinstein
Summary: The study found that girls are more likely to express vulnerability to close friends when under stress, and receive more support in return. The expression of vulnerability is associated with more efficient cortisol recovery, while close friend support does not significantly influence cortisol recovery.
JOURNAL OF ADOLESCENCE
(2021)
Article
Pediatrics
Jennifer M. Lye, Julia A. Knight, Jasleen Arneja, Ryan A. Seeto, Jody Wong, Nadya Adel Khani, Jennifer D. Brooks, Robert D. Levitan, Stephen G. Matthews, Stephen J. Lye, Rayjean J. Hung
Summary: This study aimed to investigate the relationship between maternal acetaminophen use during pregnancy and cognitive development at 4 years old. Through data analysis and regression models, the study found no association between acetaminophen use and cognitive development in offspring.
PEDIATRIC RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Phillip E. E. Melton, M. A. Burton, K. A. Lillycrop, K. M. Godfrey, S. Rauschert, D. Anderson, G. C. Burdge, T. A. Mori, L. J. Beilin, O. T. Ayonrinde, J. M. Craig, J. K. Olynyk, J. D. Holbrook, C. E. Pennell, W. H. Oddy, E. K. Moses, L. A. Adams, R. C. Huang
Summary: Through DNA methylation epigenome-wide association study, we identified novel DNA methylation loci associated with NAFLD and serum liver biochemistry markers during adolescence, implicating putative dmCpG/gene regulatory pathways and providing insights for future mechanistic studies.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Jun Yang, Stella May Gwini, Lawrence J. Beilin, Markus Schlaich, Michael Stowasser, Morag J. Young, Peter J. Fuller, Trevor A. Mori
Summary: Oral contraception can increase the aldosterone to renin ratio, leading to false positive results in the screening for primary aldosteronism. Until more reliable criteria for primary aldosteronism screening in oral contraception users are established, alternative contraception methods should be considered.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cardiac & Cardiovascular Systems
Sultana Monira Hussain, Peter R. R. Ebeling, Anna L. L. Barker, Lawrence J. J. Beilin, Andrew M. M. Tonkin, John J. J. McNeil
Summary: This study examines the association between higher levels of HDL-C and increased fracture risk in healthy older adults. The results show that each 1-SD increment in HDL-C level is associated with a 14% higher risk of fractures, independent of common risk factors. The findings suggest that HDL-C may play a role in bone health and fracture risk.
Article
Multidisciplinary Sciences
Thao G. Pham, John B. McNeil, Anna Barker, Suzanne E. Orchard, Anne Newman, Catherine L. Robb, Michael R. Ernst, Sara Espinoza, Robyn Woods, Mark Nelson, Lawrence Beilin, Sultana Monira Hussain
Summary: This study explored the association between grip strength, gait speed, and falls risk in older adults. Lower grip strength was found to be associated with a higher risk of falls, while the association between gait speed and falls risk was weaker. These findings can aid in the early identification of falls.
Article
Obstetrics & Gynecology
Joanna Y. X. Fu, Carol A. Wang, Ge Liu, Elyse Mead, Jason Phung, Maria Makrides, Craig E. Pennell
Summary: The study aimed to develop a non-invasive tool to identify individuals with total n-3 serum levels above 4.3% in early pregnancy. The tool had moderate predictive ability in identifying pregnant women with elevated n-3 levels, but it is not yet suitable for clinical use.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Multidisciplinary Sciences
Prudence R. Carr, Katherine L. Webb, Johannes T. Neumann, Le T. P. Thao, Lawrence J. Beilin, Michael E. Ernst, Bernadette Fitzgibbon, Danijela Gasevic, Mark R. Nelson, Anne B. Newman, Suzanne G. Orchard, Alice Owen, Christopher M. Reid, Nigel P. Stocks, Andrew M. Tonkin, Robyn L. Woods, John J. McNeil
Summary: Body mass index (BMI) and waist circumference are recognized risk factors for several chronic diseases and all-cause mortality in the general population. However, this study found that the associations between BMI, waist circumference and mortality risk are different in older men and women. For men, being overweight was associated with a lower risk of all-cause and cardiovascular mortality, while being underweight was associated with a higher risk. For women, the lowest BMI was associated with the highest risk of all-cause mortality. Waist circumference had little association with mortality risk.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Sophia Zoungas, Andrea Curtis, Simone Spark, Rory Wolfe, John J. McNeil, Lawrence Beilin, Trevor T-J Chong, Geoffrey Cloud, Ingrid Hopper, Alissia Kost, Mark Nelson, Stephen J. Nicholls, Christopher M. Reid, Joanne Ryan, Andrew Tonkin, Stephanie A. Ward, Anthony Wierzbicki
Summary: This paper presents the protocol for the STAtins in Reducing Events in the Elderly (STAREE) trial, which aims to study the effects of statins in community dwelling older people without CVD, diabetes or dementia. The trial will be a double-blind, randomised placebo-controlled trial with people aged 70 and over. The main endpoints are disability-free survival and major cardiovascular events, while secondary endpoints include all-cause death, dementia, physical disability, and quality of life. The results of this trial will provide valuable information about the preventive effects of statins in older populations.
Article
Psychology, Educational
Filippo Abbondanza, Philip S. Dale, Carol A. Wang, Marianna E. Hayiou-Thomas, Umar Toseeb, Tanner S. Koomar, Karen G. Wigg, Yu Feng, Kaitlyn M. Price, Elizabeth N. Kerr, Sharon L. Guger, Maureen W. Lovett, Lisa J. Strug, Elsje van Bergen, Conor V. Dolan, J. Bruce Tomblin, Kristina Moll, Gerd Schulte-Koerne, Nina Neuhoff, Andreas Warnke, Simon E. Fisher, Cathy L. Barr, Jacob J. Michaelson, Dorret I. Boomsma, Margaret J. Snowling, Charles Hulme, Andrew J. O. Whitehouse, Craig E. Pennell, Dianne F. Newbury, John Stein, Joel B. Talcott, Dorothy V. M. Bishop, Silvia Paracchini
Summary: The association between handedness and language-related disorders has been extensively studied. However, the inconsistent findings may be attributed to factors such as small sample sizes, publication bias, and variation in study criteria. This study examined the frequency of non-right-handedness (NRH) in individuals with reading and/or language impairment and found a higher prevalence compared to controls. Meta-analysis results further supported the association between NRH and language/reading impairments, suggesting shared underlying pathways between brain lateralization, handedness, and cognitive functions.
Review
Obstetrics & Gynecology
Elyse C. Mead, Carol A. Wang, Jason Phung, Joanna Y. X. Fu, Scott M. Williams, Mario Merialdi, Bo Jacobsson, Stephen Lye, Ramkumar Menon, Craig E. Pennell
Summary: Preterm birth (PTB), defined as the birth of a child before 37 completed weeks gestation, is a major health issue affecting about 11% of live births and is the leading cause of death in children under 5 years old. Genetic studies have identified genes within various pathways that may be involved in PTB, but many of the published data are inconclusive and have limited power to detect associations. On the other hand, some large hypothesis-free approaches have identified multiple novel genetic variants associated with PTB. Attempts to predict PTB using single -omics datasets have mostly been unsuccessful, while integrating data from multiple -omics datasets has shown promising results.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Tegan Grace, Joshua Fisher, Carol Wang, Sarah R. Valkenborghs, Roger Smith, Jonathan J. Hirst, Joerg Mattes, Vanessa E. Murphy, Craig E. Pennell
Summary: Multiple cohort studies in Australia, established over 20 years ago, need to be updated due to changes in socioeconomic, environmental and cultural influences over time. The Newcastle 1000 Study aims to investigate the impact of early life factors on health outcomes by collecting repeated biological samples and in-depth phenotype data across the first 1000 days of life from conception.
Review
Obstetrics & Gynecology
Anne -Marie Aubin, Liam McAuliffe, Kimberley Williams, Ashad Issah, Rosanna Diacci, Jack E. McAuliffe, Salma Sabdia, Jason Phung, Carol A. Wang, Craig E. Pennell
Summary: This study aimed to determine the efficacy of combining cervical cerclage and vaginal progesterone in the prevention of preterm birth. The results showed that combined therapy was associated with a lower risk of preterm birth and better outcomes compared to single therapy.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Meeting Abstract
Obstetrics & Gynecology
Carol A. Wang, Stephen J. Lye, Wendy H. Oddy, Lawrence Beilin, Trevor A. Mori, Craig E. Pennell
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Ashish Yadav, Lawrence J. Beilin, Rae-Chi Huang, John P. Newnham, Scott W. White, Trevor A. Mori
Summary: This study investigated the relationship between serial ultrasound-derived fetal growth trajectories and markers of insulin resistance in young adults in an Australian pregnancy cohort. The study found that restricted fetal head circumference and abdominal circumference from early pregnancy are associated with higher relative insulin resistance in offspring during adulthood. These findings enhance our understanding of the importance of the intrauterine environment and its impact on the risk of adult diabetes and related metabolic disorders.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Letter
Cardiac & Cardiovascular Systems
J. Ball, J. T. Neumann, A. M. Tonkin, P. Kirchhof, B. Freedman, A. Brodtmann, C. Reid, M. R. Nelson, L. J. Beilin, S. Fitzgerald, D. Stub, R. L. Woods, J. J. McNeil
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2023)
Article
Endocrinology & Metabolism
Shanshan Xiao, Natalie C. Ebner, Amirhossein Manzouri, Tie-Qiang Li, Diana S. Cortes, Kristoffer N. T. Mansson, Hakan Fischer
Summary: The mechanisms through which intranasal oxytocin affects the brain are not fully understood, but recent research suggests that brain regions with a higher density of oxytocin receptors may play a key role. This study used resting-state fMRI to investigate the effects of intranasal oxytocin administration on connectivity between these receptor-enriched regions and other regions in the brain, and found that the effects varied depending on the age of the participants.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Lisa Haase, Antonia Vehlen, Julia Strojny, Gregor Domes
Summary: This study found no significant changes in the cortisol awakening response (CAR) over the menstrual cycle, and no significant association with variations in estradiol and progesterone. These results suggest that CAR is largely robust against hormonal variations across the menstrual cycle.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Derek Schaeuble, Tyler Wallace, Sebastian A. Pace, Shane T. Hentges, Brent Myers
Summary: Depression and cardiovascular disease are influenced by daily life stress, but the biological mechanisms behind this connection are not well understood. This study shows that the ventromedial prefrontal cortex (vmPFC) plays a role in regulating stress responses and behavior, with sex-specific effects. In males, the vmPFC-PH circuitry promotes positive motivation and reduces stress responses, while in females it elevates stress responses. This suggests that cortical regulation of stress reactivity and behavior is mediated by projections to the hypothalamus in a sex-specific manner.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Jose M. Guzman, Montana H. Boone, Gabriela L. Suarez, Colter Mitchell, Christopher S. Monk, Luke W. Hyde, Nestor L. Lopez-Duran
Summary: The COVID-19 pandemic has led to increased life stress and internalizing disorders, with a disproportionate impact on women. This study focused on the neuroendocrinology of stress-related disorders and found that women have lower cortisol responses and higher DHEA responses to stress. However, lower cortisol and higher DHEA are associated with internalizing disorders in women, while the opposite is true in men. The study also examined the relationship between COVID-related stress and internalizing symptoms and found gender differences in the association between DHEA and cortisol and internalizing outcomes. These findings suggest distinct neuroendocrine pathways for stress-related disorders in young men and women.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meriah L. Dejoseph, Keira B. Leneman, Alyssa R. Palmer, Emily R. Padrutt, Otiti A. Mayo, Daniel Berry
Summary: Childhood and adolescence are critical periods for the development of the stress response system. This study found a modest positive relation between the adrenocortical and sympathetic systems, as well as between the adrenocortical and parasympathetic systems. The strength of these associations varied based on methodological and sociodemographic characteristics.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Qiong Xiang, Jia-Sheng Tao, Shuai Dong, Xiao-Lin Liu, Liang Yang, Li-Ni Liu, Jing Deng, Xian-Hui Li
Summary: Chronic hyperglycemia accelerates the pathological process of cognitive dysfunction, but the heterogeneity of hippocampal cells under long-term high glucose conditions is not well known. In this study, single-cell RNA sequencing was performed on diabetic mice, and distinct cell sub-clusters and important genes involved in neuroplasticity regulation were identified.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Roger Mcintosh, Hannah Hoogerwoerd, Salman S. Ahmad, Cassandra Michel, Kaitlyn Dillon, Mahendra Kumar, Gail Ironson
Summary: The study found that a 4-session guided written emotional disclosure intervention led to significant reductions in total output and concentration of epinephrine in urine for up to 6 months in individuals living with HIV. This effect was especially pronounced in women. However, there were no significant changes in norepinephrine output in urine.
PSYCHONEUROENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Meredith Gruhn, Adam Bryant Miller, Tory A. Eisenlohr-Moul, Sophia Martin, Matthew G. Clayton, Matteo Giletta, Paul D. Hastings, Matthew K. Nock, Karen D. Rudolph, George M. Slavich, Mitchell J. Prinstein, Margaret A. Sheridan
Summary: This study investigates how early life adversity characterized by threat impacts the association between neural activity and cortisol production during emotion processing. The results suggest that threat exposure may moderate the relationship between neural activation and cortisol response.
PSYCHONEUROENDOCRINOLOGY
(2024)
