Article
Chemistry, Medicinal
Liqiang Hu, Huixin Yang, Tao Yu, Fangfang Chen, Runqiu Liu, Shuyuan Xue, Shuangzhan Zhang, Wuyu Mao, Changge Ji, Hao Wang, Hexin Xie
Summary: This study demonstrates the effectiveness of stereochemically altered cephalosporins as potent inhibitors against NDM-1, a major cause of antibiotic resistance. The findings provide a new approach to combat antibiotic resistance.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Han Gao, Jia-Qi Li, Peng-Wei Kang, Jia-Zhu Chigan, Huan Wang, Lu Liu, Yin-Sui Xu, Le Zhai, Ke-Wu Yang
Summary: This study constructed and characterized an effective M beta L inhibitor, which showed preferential inhibition against NDM-1, potential antibacterial activities, and synergistic effects with meropenem. The research provided a new framework for the development of NDM-1 inhibitors.
BIOORGANIC CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Vikram Khipple Mulligan, Sean Workman, Tianjun Sun, Stephen Rettie, Xinting Li, Liam J. Worrall, Timothy W. Craven, Dustin T. King, Parisa Hosseinzadeh, Andrew M. Watkins, P. Douglas Renfrew, Sharon Guffy, Jason W. Labonte, Rocco Moretti, Richard Bonneau, Natalie C. J. Strynadka, David Baker
Summary: This study presents a structure-guided computational method for designing peptide macrocycles using a mixture of L- and D-amino acids to inhibit therapeutic targets. The experimental results show that this method can effectively predict peptide binding propensity and inhibitory activity, as demonstrated in the interaction with NDM-1.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Dennis Nurjadi, Kaan Kocer, Quan Chanthalangsy, Sabrina Klein, Klaus Heeg, Sebastien Boutin
Summary: This study found that the emergence of resistance to Cefiderocol in metallo-beta-lactamase-producing bacteria is facilitated by mutations in the CirA siderophore receptor, which are induced by the New Delhi metallo-beta-lactamase. However, inhibiting the metallo-beta-lactamase activity using dipicolinic acid can successfully prevent the development of Cefiderocol-resistant mutants. Therefore, caution should be taken when using Cefiderocol to treat infections caused by metallo-beta-lactamase-producing bacteria.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Health Care Sciences & Services
Narcisa Muresu, Giovanna Deiana, Marco Dettori, Alessandra Palmieri, Maria Dolores Masia, Andrea Cossu, Cristina D'Avino, Illari Sechi, Arcadia Del Rio, Andrea Piana, Paolo Castiglia
Summary: The spread of multi-drug resistant organisms (MDROs) is increasing globally. This report presents two independent cases of patients from Ukraine infected with Carbapenemase-producing Klebsiella pneumoniae, and the infection prevention control (IPC) strategies implemented to prevent further contamination. These cases highlight the importance of early recognition of multidrug-resistant bacteria, effective inter-hospital communication, antimicrobial stewardship protocols, and adequate IPC policies. Improvement in screening procedures is necessary to prevent potential nosocomial outbreaks and endemization.
Article
Biochemistry & Molecular Biology
Lalitha Cheepurupalli, Aathithya Diaz, Adithya Conjeevaram Gopal, Sudarshan Singh Rathore, Vigneshwar Ramakrishnan, Jayapradha Ramakrishnan
Summary: The increase in drug resistance poses a major threat to public health, with carbapenem-resistant bacteria being a significant concern leading to higher morbidity and mortality rates. Inhibiting the activity of New Delhi metallo-beta-lactamase-1 is seen as a potential way to treat multidrug-resistant pathogens. The study identified potential inhibitors for New Delhi metallo-beta-lactamase-1, providing insights into novel treatment strategies for combating drug resistance.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Pharmacology & Pharmacy
Yan Guo, Hongtao Liu, Mengge Yang, Rui Ding, Yawen Gao, Xiaodi Niu, Xuming Deng, Jianfeng Wang, Haihua Feng, Jiazhang Qiu
Summary: The study identified dexrazoxane, embelin, candesartan cilexetil, and nordihydroguaiaretic acid as promising carbapenem adjuvants against metallo-β-lactamase-producing carbapenem-resistant bacterial pathogens. These drugs inhibit the activity of metallo-β-lactamases and show in vitro synergistic bactericidal effect with meropenem.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Le Zhai, Yue Jiang, Yang Shi, Miao Lv, Ya-Li Pu, Hua-Lei Cheng, Jia-Yu Zhu, Ke-Wu Yang
Summary: The irregular use of antibiotics has led to the development of antibiotic-resistant bacteria, specifically metallo-beta-lactamases. This study identified eight compounds that have strong inhibitory effects on NDM-1, with one compound being the most effective inhibitor. The presence of a hydroxyl group in the compounds was found to improve their inhibitory activity. Additionally, these compounds demonstrated antibacterial effects on NDM-1-producing bacteria and showed low cytotoxicity in cell experiments.
BIOORGANIC CHEMISTRY
(2022)
Article
Immunology
Jacqueline Findlay, Laurent Poirel, Julie Kessler, Andreas Kronenberg, Patrice Nordmann
Summary: The study in Switzerland found that NDM-positive CPE, primarily consisting of Klebsiella pneumoniae and Escherichia coli, were prevalent, with NDM-1 and NDM-5 variants being the most common. Some isolates also co-produced a second carbapenemase and a 16S rRNA methylase. Successful plasmids and global lineages were identified as major factors contributing to the increasing prevalence of NDMs in Switzerland.
EMERGING INFECTIOUS DISEASES
(2021)
Article
Microbiology
Xiaoxia Gu, Mengzhu Zheng, Lixia Chen, Hua Li
Summary: This article summarizes NDM-1 inhibitors developed since 2018, classifies these compounds by chemical scaffolds, and points out inconsistencies and notable problems in these studies, which are expected to benefit future research.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Infectious Diseases
Shamsi Khalid, Antonella Migliaccio, Raffaele Zarrilli, Asad U. Khan
Summary: Investigation on multidrug-resistant New Delhi metallo-beta-lactamase-producing strains found three antibiotic combinations that showed synergistic effects, providing effective treatment options against highly drug-resistant strains.
Article
Biochemistry & Molecular Biology
Jia-Qi Li, Le-Yun Sun, Zhihui Jiang, Cheng Chen, Han Gao, Jia-Zhu Chigan, Huan-Huan Ding, Ke-Wu Yang
Summary: A new scaffold was constructed for inhibiting NDM-1, showing promising results in combating bacterial infections and providing important insights for the development of anti-NDM-1 drugs.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jia-Zhu Chigan, Zhenxin Hu, Lu Liu, Yin-Sui Xu, Huan-Huan Ding, Ke-Wu Yang
Summary: The superbug infection caused by metallo-beta-lactamases (M beta Ls) has become an urgent health threat. In this study, compounds were synthesized and tested for their inhibitory effect on M beta L NDM-1. Among them, 1e and 1f showed the strongest inhibition, with an IC50 value of 0.02 mu M against NDM-1. This study provides potential lead compounds for further development of clinically useful inhibitors targeting NDM-1.
BIOORGANIC CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Ying Ge, Peng-Wei Kang, Jia-Qi Li, Han Gao, Le Zhai, Le-Yun Sun, Cheng Chen, Ke-Wu Yang
Summary: The study demonstrated that thiosemicarbazones are valuable scaffolds for developing inhibitors of NDM-1 and drug-resistant bacteria carrying NDM-1, and they also exhibit synergistic antimicrobial effects with other antibiotics, showing strong activity against bacteria harboring NDM-1.
JOURNAL OF ANTIBIOTICS
(2021)
Article
Multidisciplinary Sciences
Azhar Salari-jazi, Karim Mahnam, Parisa Sadeghi, Mohamad Sadegh Damavandi, Jamshid Faghri
Summary: The study conducted multi-step virtual screening in the NPASS database to identify potential metallo-beta -lactamase inhibitors. The efficacy of these compounds was evaluated through molecular docking and molecular dynamics simulations, while protein sequence alignment and pharmacophore modeling revealed conserved residues.
SCIENTIFIC REPORTS
(2021)
Article
Virology
Tianyu Lu, Nouredine Behloul, Yi Zhou, Sarra Baha, Zhenzhen Liu, Wenjuan Wei, Rui-Hua Shi, Jihong Meng
Summary: This study demonstrates the potential of utilizing the truncated HEV capsid as an antigen-presenting platform for the development of chimeric VLP immunogens. The chimeric VLPs, produced in Escherichia coli, show similar morphology and physicochemical properties to native virus particles, and the presented foreign antigen has stronger antigenicity and immunogenicity. In mouse experiments, antibodies induced by the chimeric VLPs appear earlier, increase faster, and maintain higher levels compared to the antigen alone or an inactivated virus vaccine.
Article
Cell & Tissue Engineering
Xunhui Guo, Jiayi Wang, Wei Zou, Wenjuan Wei, Xin Guan, Jing Liu
Summary: Mesenchymal stem cells (MSCs) play an important role in cell therapy and tissue regeneration, but replicative senescence during long-term in vitro culture is a challenge. Constructing a microenvironment to delay MSCs replicative senescence is a feasible strategy, and there has been progress in research and clinical trials.
STEM CELLS AND DEVELOPMENT
(2022)
Article
Microbiology
Sarra Baha, Min Zhang, Nouredine Behloul, Zhenzhen Liu, Wenjuan Wei, Jihong Meng
Summary: This study reports the production of stable HEV-PCV2 chimeric virus-like particles (VLPs) with optimal antigenicity and immunogenicity, potentially applicable in diagnostics and vaccine development.
VETERINARY MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wen-Juan Wei, Hong-Qiang Gao, Xiao-Hua Luo, Yun-Zhi Tang
Summary: This study successfully synthesized a halide semiconductor containing antimony, which exhibits dielectric relaxation behavior and the ability to function as a dielectric switch. The compound shows promising adjustable switch temperature and enriches the family of dielectric switches.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Wenjuan Wei, Hongqiang Gao, Ming Fang, Yang Yang, Yan Guan, Yen Wei, Yunzhi Tang
Summary: Inorganic relaxor ferroelectric solid solution single crystals have superior properties that make them suitable for high performance electromechanical devices. However, relaxor ferroelectric single crystals found in organic-inorganic hybrid perovskites are limited, but achieving these properties in them is significant for functional materials design. Fortunately, the first two-dimensional (2D) organic-inorganic hybrid relaxor ferroelectric single crystal, [Br(CH2)(3)NH3](2)PbBr4 (BPA(2)-PbBr4), demonstrates some of these superior properties, including large relaxation temperature change, low energy loss, and strong second harmonic generation effect. It also exhibits temperature-dependent luminescence with adjustable emitted light color, making it compatible with relaxor ferroelectricity.
SCIENCE CHINA-CHEMISTRY
(2023)
Review
Construction & Building Technology
Minh Tien Tran, Wenjuan Wei, Claire Dassonville, Christophe Martinsons, Pascal Ducruet, Corinne Mandin, Valerie Hequet, Pawel Wargocki
Summary: As the importance of indoor environmental quality (IEQ) in schools becomes more recognized, a systematic strategy for assessing IEQ needs to be developed. This paper provides a summary of parameters measured in school classrooms to characterize the quality of thermal, acoustic, visual environments, and indoor air quality (IAQ). The review of literature from Europe and North America over the past ten years identified 88 papers that described measurements in schools. The review reveals inconsistencies in measurement methods, parameters, and concentrations, suggesting the need for a standardized rating scheme and protocols for assessing classroom IEQ.
Article
Physics, Applied
Yuming Lai, Jiahua Ma, Honggui Wen, Huilu Yao, Wenjuan Wei, Lingyu Wan, Xiaodong Yang
Summary: In this paper, a neural network method for wave height detection is proposed, which trains the voltage waveform to achieve high-precision measurement and eliminate the influence of external factors on sensor performance.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Cardiac & Cardiovascular Systems
Jianzhen Huang, Xinyi Yang, Yumeng Hu, Huibin Li, Xiaochang Leng, Jianping Xiang, Wenjuan Wei
Summary: AccuFFRivus, based on IVUS images, is an alternative method for functional assessment of coronary stenosis compared to FFR. Its prognostic impact in PCI patients was investigated in this retrospective study. AccuFFRivus was calculated based on postoperative angiographic and IVUS images, and the occurrence of VOCE at 2 years was recorded and analyzed. The study found that lower post-AccuFFRivus values were associated with a higher risk of VOCE during the follow-up period.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Chemistry, Physical
Xudong Tang, Yani Liu, Mingyang Li, Wangyang Ding, Haihua Chen, Wenjuan Wei, Jiayu Li
Summary: In this study, the stable molecular structure of monolayer TPPA-COF was obtained and its optical absorption properties were investigated. The monolayer band gap width of TPPA-COF was found to be 1.52 eV, and all excited states showed obvious π→π* delocalized excitation characteristics. The simulated UV-vis spectra demonstrated that TPPA-COF has a potential as a light-absorbing material.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Physical
Xudong Tang, Yani Liu, Mingyang Li, Wangyang Ding, Haihua Chen, Wenjuan Wei, Jiayu Li
Summary: In this study, the stable molecular structure of monolayer TPPA-COF was obtained through first-principles calculation, and it was found to have a band gap width of 1.52 eV. The spatial distribution analysis of electron-hole pairs in the excited states of the TPPA-COF showed localized excitation characteristics. The simulated UV-vis spectra indicated that the TPPA-COF had a potential for light absorption.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Mengshi Wang, Youzhi Song, Wenjuan Wei, Hongmei Liang, Yanyan Yi, Xiaolin Wang, Dongsheng Ren, Li Wang, Jianlong Wang, Yen Wei, Xiangming He, Yang Yang
Summary: A novel solid-state fluorescence probe, TPECatechol, was designed for graphite anodes, which can visually observe the uneven intercalation and morphology of lithium plating, and quantitatively measure the state of charge (SOC) of graphite anodes based on fluorescence intensity differences. Solid-state fluorescence imaging provides a valid experimental means for understanding the electrochemical processes of lithium-ion batteries (LIBs).
Article
Public, Environmental & Occupational Health
Minh-Tien Tran, Jean-Marie Alessandrini, Bernard Collignan, Ambre Delater, Virginie Desvignes, Corinne Mandin, Aya Mansouri, Pierre Martinache, Melanie Nicolas, Frederic Thevenet, Liselotte Tinel, David Umba, Marie Verriele, Wenjuan Wei
ENVIRONNEMENT RISQUES & SANTE
(2023)
Article
Chemistry, Multidisciplinary
Wen-Juan Wei, Hong-Qiang Gao, Ming Fang, Yun-Zhi Tang, Yen Wei
Summary: In this study, two new supramolecular compounds were constructed and their phase transitions were characterized using various techniques such as DSC, X-ray analysis, and Raman spectroscopy.
Article
Cell Biology
Yang Jiao, Yue-Tong Sun, Nai-Fei Chen, Li-Na Zhou, Xin Guan, Jia-Yi Wang, Wen-Juan Wei, Chao Han, Xiao-Lei Jiang, Ya-Chen Wang, Wei Zou, Jing Liu
Summary: In this study, the administration of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) was investigated as a potential treatment for neonatal hypoxic/ischemic brain injury associated with maternal immune activation. The study found that hUC-MSCs inhibited the expression of PTBP-1 and activated astrocytes, leading to a reduction in inflammation and promotion of neuronal plastic regeneration, thereby improving brain function.
NEURAL REGENERATION RESEARCH
(2022)
Article
Oncology
Hua Cao, Xiaofei Ji, Qi Wang, Xin Guan, Wenjuan Wei, Ying Li, Wei Zou, Jing Liu
Summary: The transplantation of hUC-MSCs was found to have a protective effect on neurons, promote myelin repair, and control glial scar formation in mice with spinal cord hemisection.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
