期刊
PSYCHIATRY RESEARCH
卷 245, 期 -, 页码 116-118出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2016.08.024
关键词
Autism; STOP/MAP6 protein; Hypothesis
类别
资金
- National Natural Science Foundation of China [81201061]
- Outstanding Youth Talents Program of Shanxi Province
Autism is a neurodevelopmental disorder characterized by abnormal reciprocal social interactions, communication deficits and repetitive behaviors with restricted interests. A previous quantitative proteomic profiling study demonstrated that microtubule-associated stable tubule only polypeptide (STOP; also known as MAP6) protein was significant reduced in the cerebral cortex from BTBR mouse model of autism compared to the C57BL/6J mice. In the present study, the result showed that the concentration of STOP/MAP6 protein was significantly reduced in the plasma of autistic subjects than that in healthy controls. Finally, a possible mechanism of STOP/MAP6 protein in the pathogenesis of autism was proposed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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