Article
Clinical Neurology
M. Alemany-Navarro, M. Tubio-Fungueirino, S. Diz-de Almeida, R. Cruz, A. Lombroso, E. Real, V. Soria, S. Bertolin, M. Fernandez-Prieto, P. Alonso, J. M. Menchon, A. Carracedo, C. Segalas
Summary: This study analyzed the association of SNPs with neurocognitive variables in a sample of 133 OCD probands. The results suggest that studying neurocognitive variables in GWAS may provide more insight into the genetic basis of OCD and facilitate the development of individualized treatment approaches.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Xin Yuan, Yanyan Zhu, Li Xiao, Zi Chuan Liu, Jingzhi Zou, Zhizhong Hu, Yunhong Wu, Pan Li, Maorong Hu, Fuqing Zhou
Summary: This study aimed to investigate the brain functional impairment of patients with obsessive-compulsive disorder (OCD) with and without depressive symptoms. The results showed abnormal regional homogeneity values in specific brain regions of the patients with OCD and depression, which were correlated with the severity of symptoms.
NEUROSCIENCE LETTERS
(2023)
Editorial Material
Clinical Neurology
Trevor. W. Robbins
Summary: This scientific commentary discusses the research conducted by Kim et al. on the unbalanced fronto-pallidal neurocircuit underlying set shifting in patients with obsessive-compulsive disorder, published in the journal Brain.
Article
Psychiatry
Huicong Ren, Haibin Li, Jin Huang, Nan Zhang, Ruiqin Chen, Wenjuan Liu, Zhaohui Zhang, Chencheng Zhang
Summary: Studies have shown that Chinese patients with OCD do not exhibit significant differences in executive functioning compared to healthy controls, and cognitive performance does not vary significantly between patients with relatively mild symptoms and those with severe symptoms.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychiatry
Alexandra E. Dingemans, S. Alida Volkmer, Sandra Mulkens, Richard Vuijk, Yanda R. van Rood
Summary: Several studies have found that OCD, ED, ASD, and BDD share common symptoms and often co-occur, suggesting a common etiological basis. The study found that executive functioning skills such as attention switching and social communication skills were central in individuals with these disorders. Difficulty with cognitive flexibility and social factors are key factors in OC-spectrum disorders.
PSYCHIATRY RESEARCH
(2022)
Article
Neurosciences
Haohao Yan, Xiaoxiao Shan, Huabing Li, Feng Liu, Wenbin Guo
Summary: This study investigated early brain functional changes induced by pharmacotherapy in patients with OCD and their relation to drug treatment and improvement of symptoms. The study found that patients with OCD had higher regional homogeneity values in specific brain regions at baseline, which significantly decreased after treatment. The reduction rate of regional homogeneity values was positively correlated with the reduction rates of OCD symptoms and total scores.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neuroimaging
Qianqian Ye, Zongfeng Zhang, Wanqing Sun, Qing Fan, Yao Li
Summary: This study investigated the heterogeneous functional connectivities of the precuneus subregions in unmedicated OCD patients and healthy subjects. It revealed a tripartite functional parcellation of the precuneus with distinct connectivity patterns with the whole brain. The decreased functional connectivity between the dorsal posterior precuneus and vermis in OCD patients was negatively correlated with compulsions score, suggesting its role in compulsive behavior inhibition in OCD.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Ziwen Peng, Tingxin He, Ping Ren, Lili Jin, Qiong Yang, Chuanyong Xu, Rongzhen Wen, Jierong Chen, Zhen Wei, Tom Verguts, Qi Chen
Summary: This study found an imbalance in striatal connectivity, specifically increased connectivity in the caudate, in OCD patients. The imbalance in connectivity was only observed in the OCD patient group and was negatively associated with task-switch performance. These findings suggest that the abnormal increase in caudate activity may serve as a clinical characteristic for OCD.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Catarina Raposo-Lima, Pedro Moreira, Ricardo Magalhaes, Sonia Ferreira, Nuno Sousa, Maria Pico-Perez, Pedro Morgado
Summary: This study investigates the impact of stress on resting-state functional connectivity in OCD patients and finds a correlation between stress levels and connectivity in specific networks.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2022)
Article
Psychiatry
K. Deepthi, Bangalore N. Roopesh, Srinivas Balachander, John K. Vijay Sagar, Thennarasau Kandavel, Y. C. Janardhan Reddy
Summary: This study found that youth with OCD performed significantly worse in neuropsychological functions compared to controls, particularly in the 'behavioral reversal' test. Certain comorbid disorders, medication use, and age of onset did not have a significant impact on neuropsychological performance.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Silvia Fornaro, Antonino Vallesi
Summary: Obsessive-compulsive disorder (OCD) is associated with cognitive abnormalities in executive processes. Neuroimaging studies have shown functional abnormalities in the executive fronto-parietal network (FPN), default-mode network (DMN), and prefrontal cortex (PFC) in OCD patients. This systematic review found reduced DMN functional connectivity, increased FPN intra-network connectivity, and hyper-connectivity of right-sided prefrontal links in OCD patients. These findings may represent endophenotypes reflecting computational impairments and difficulties in self-referential processes and cognitive control.
CURRENT PSYCHOLOGY
(2023)
Article
Psychiatry
Sharon Morein-Zamir, Michael Kasese, Samuel R. Chamberlain, Estherina Trachtenberg
Summary: Research has found a high frequency of hoarding symptoms in patients with ADHD, with inattention being a significant predictor of hoarding severity. Despite the potential impact on everyday functioning, individuals with ADHD do not typically disclose associated difficulties, highlighting the importance of routine assessment for HD in this population. Further research on HD in younger adults with ADHD is needed, as they differ in demographics from typical HD samples.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Psychiatry
Louise Destree, Mary-Ellen E. Brierley, Lucy Albertella, Laura Jobson, Leonardo F. Fontenelle
Summary: This study conducted a systematic review on the relationships between childhood trauma and obsessive-compulsive symptoms (OCS) severity. The results showed a significant relationship between exposure to childhood trauma and OCS severity in both clinical and non-clinical populations. It was also found that a range of childhood trauma types, rather than a single type, was associated with OCD.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Lekai Luo, Qian Li, Wanfang You, Yuxia Wang, Wanjie Tang, Bin Li, Yanchun Yang, John A. Sweeney, Fei Li, Qiyong Gong
Summary: The study revealed aberrant dynamic brain activity in OCD patients, characterized by increased functional segregation among networks and impaired flexibility in connections. These findings may play important roles in the neuropathology of OCD.
HUMAN BRAIN MAPPING
(2021)
Review
Psychology, Clinical
Behrang Mahjani, Katharina Bey, Julia Boberg, Christie Burton
Summary: Obsessive-compulsive disorder (OCD) is a heritable, polygenic disorder with contributions from both common and rare genetic variants. Genetics play an important role in the susceptibility to OCD, with discrete OCD symptom dimensions having both shared and unique genetic risks. Genome-wide studies show that OCD shares genetic risk with its comorbid conditions.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Clinical Neurology
Xia Yang, Wan-Jun Guo, Yu-Jie Tao, Ya-Jing Meng, Hui-Yao Wang, Xiao-Jing Li, Ya-Min Zhang, Jin-Kun Zeng, Wan-Jie Tang, Qiang Wang, Wei Deng, Lian-Sheng Zhao, Xiao-Hong Ma, Ming-Li Li, Jia-Jun Xu, Jing Li, Yan-Song Liu, Zhen Tang, Xiang-Dong Du, Wei Hao, Jeremy W. Coid, Sing Lee, Andrew J. Greenshaw, Tao Li
Summary: This study surveyed 12,043 undergraduates on Internet addiction and depression, finding an association between the two. Baseline depression predicted follow-up Internet addiction, and baseline Internet addiction predicted follow-up depression.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Environmental Sciences
Belinda Agyapong, Ejemai Eboreime, Reham Shalaby, Hannah Pazderka, Gloria Obuobi-Donkor, Medard K. Adu, Wanying Mao, Folajinmi Oluwasina, Ernest Owusu, Andrew J. Greenshaw, Vincent I. O. Agyapong
Summary: This study compared the mental health of employees of the school board and other employees in Fort McMurray. The results showed that other employees had significantly higher symptoms of potential PTSD. Greater exposure to traumatic events and a perceived lack of support from other employers may have contributed to this difference.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Psychiatry
Jeff Sawalha, Muhammad Yousefnezhad, Zehra Shah, Matthew R. G. Brown, Andrew J. Greenshaw, Russell Greiner
Summary: Rates of PTSD have increased due to the COVID-19 pandemic, and telehealth has emerged as a means to monitor symptoms. Using machine learning and sentiment analysis, individuals with PTSD can be identified through virtual mediums, providing an important, accessible, and inexpensive tool for detecting mental health abnormalities during the pandemic.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Sunil Vasu Kalmady, Animesh Kumar Paul, Janardhanan C. Narayanaswamy, Rimjhim Agrawal, Venkataram Shivakumar, Andrew J. Greenshaw, Serdar M. Dursun, Russell Greiner, Ganesan Venkatasubramanian, Y. C. Janardhan Reddy
Summary: In this study, a transparent and explainable multiparcellation ensemble learning framework was applied to predict OCD, achieving better accuracy than neural networks. Transfer learning using features effective for schizophrenia also improved OCD prediction without loss in performance.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2022)
Review
Pharmacology & Pharmacy
Fernanda Talarico, Sucheta Chakravarty, Yang S. Liu, Andrew J. Greenshaw, Ives Cavalcante Passos, Bo Cao
Summary: This article provides a systematic review of the psychiatric adverse effects of chloroquine and hydroxychloroquine, comparing clinical trials, populational studies, and case report studies. The current literature suggests that both drugs carry a risk of short-term psychiatric adverse effects.
ANNALS OF PHARMACOTHERAPY
(2023)
Article
Psychiatry
Yang S. Liu, Lawrence Kiyang, Jake Hayward, Yanbo Zhang, Dan Metes, Mengzhe Wang, Lawrence W. Svenson, Fernanda Talarico, Pierre Chue, Xin-Min Li, Russell Greiner, Andrew J. Greenshaw, Bo Cao
Summary: A machine learning model based on representative large-scale health data was developed and prospectively validated for predicting individual OUD cases.
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Editorial Material
Psychiatry
Jonathan Jin, Lisa Burback, Andrew J. Greenshaw, Olga Winkler
CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE
(2023)
Article
Cell Biology
Zhichao Wang, Lin Su, Tong Wu, Lei Sun, Zhenghai Sun, Yuchen Wang, Ping Li, Guangcheng Cui
Summary: This study found that miR-182 and miR-183 were highly expressed in both SZ patients and rats, and the miR-182/183 cluster regulated the progression of SZ through targeting DCC. Inhibition of the miR-182/183 cluster improved SZ symptoms, potentially through the activation of the axon guidance pathway.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Editorial Material
Psychiatry
Eric Vermetten, Chelsea Jones, Lorraine Smith MacDonald, Jackie June ter Heide, Andrew James Greenshaw, Suzette Bremault-Phillips
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Sugai Liang, Bo Cao, Wei Deng, Xiangzhen Kong, Liansheng Zhao, Yan Jin, Xiaohong Ma, Yingcheng Wang, Xiaojing Li, Qiang Wang, Wanjun Guo, Xiangdong Du, Pak C. Sham, Andrew J. Greenshaw, Tao Li
Summary: This study investigated the aberrant resting-state functional connectivity of anterior cingulate cortex (ACC) in schizophrenia and bipolar disorder (BP), and its relationship with clinical manifestations. The results showed that different subregions of ACC exhibited varying connectivity patterns in patients with schizophrenia, psychotic BP, and nonpsychotic BP. Transdiagnostic dysconnectivity was found in ACC subregions associated with cortical, limbic, striatal, and cerebellar regions. The study also identified disorder-specific dysconnectivity in patients with schizophrenia and psychotic BP, which were correlated with specific clinical symptoms.
SCHIZOPHRENIA RESEARCH
(2023)
Article
Medicine, General & Internal
Belinda Agyapong, Reham Shalaby, Wesley Vuong, April Gusnowski, Shireen Surood, Andrew J. Greenshaw, Yifeng Wei, Vincent Israel Opoku Agyapong
Summary: This study assessed the impact of the online mental health service Text4Hope on the psychological well-being of young adults. The results showed that young adults who received daily supportive text messages for six weeks experienced a significant reduction in stress, anxiety, and depression. This service is an effective tool for supporting young adult mental health and preventing suicide.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Medard Kofi Adu, Reham Shalaby, Ejemai Eboreime, Adegboyega Sapara, Mobolaji A. Lawal, Corina Chew, Shelley Daubert, Liana Urichuck, Shireen Surood, Daniel Li, Mark Snaterse, Mike Mach, Pierre Chue, Andrew J. Greenshaw, Vincent I. O. Agyapong
Summary: This study aimed to evaluate the initial clinical effectiveness of rTMS treatment with and without iCBT for TRD patients. The results showed that there was no significant difference in the impact on depression severity, suicidal ideations, subjective depression, and health quality between the two interventions. Therefore, the use of combined rTMS + iCBT treatment for TRD management is not supported.
Article
Health Care Sciences & Services
Gloria Obuobi-Donkor, Reham Shalaby, Wesley Vuong, Belinda Agyapong, Marianne Hrabok, April Gusnowski, Shireen Surood, Andrew J. Greenshaw, Vincent I. O. Agyapong
Summary: This study evaluated the impact of a daily supportive text message program, Text4Hope-Addiction Support, on cravings and mental health symptoms in subscribers. The results showed that receiving supportive text messages reduced the desire to use drugs and improved mental well-being. This study suggests that mobile-based supportive strategies can be used as complementary treatments for addiction.
JMIR FORMATIVE RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Jonathan Jin, Rachel Goud, Huda Al-Shamali, Anja Dzunic, Tirzah Lyons, Matthew Reeson, Hanna Pazderka, Liz Dennett, Wanda Polzin, Yifeng Wei, Peter H. Silverstone, Andrew J. Greenshaw
Summary: This review examines the value of reflective functioning assessment and intervention studies in caregiver-child dyads. The findings indicate significant health disparities in these studies, highlighting the need for further research to address these gaps.
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
(2023)
Article
Psychology, Clinical
Bonnie K. Lee, Samuel M. Ofori Dei, Matthew M. R. Brown, Olu A. Awosoga, Yanjun Shi, Andrew J. Greenshaw
Summary: A randomized trial conducted at outpatient addiction clinics in Canada compared the effectiveness of systemic congruence couple therapy (CCT) and individual-based treatment-as-usual (TAU) on multiple clinical outcomes. The results showed that CCT was more effective than TAU in both primary and secondary outcomes. Additionally, the improvement in primary clients and partners was largely equivalent between the two treatments.