Article
Clinical Neurology
Maya Kuperberg, Douglas Katz, Sophie L. A. Greenebaum, Nevita George, Louisa G. Sylvia, Gustavo Kinrys, Astrid Desrosiers, Andrew A. Nierenberg
Summary: This study examined the relationship between psychotic symptoms during bipolar depressive episodes and suicidal ideation among outpatients with bipolar disorder. The results indicated that patients with psychotic symptoms were more likely to report active suicidal thoughts, including specific plans and methods.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Daniel Guinart, Renato de Filippis, Stella Rosson, Bhagyashree Patil, Lara Prizgint, Nahal Talasazan, Herbert Meltzer, John M. Kane, Robert D. Gibbons
Summary: The study developed CAT-Psychosis test, which can quickly and reliably assess the severity of psychosis and discriminate psychotic patients from healthy controls. The development and calibration study included 649 psychotic patients, while the validation study involved 160 patients and 40 healthy controls.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Psychiatry
Weijia Gao, Dong Cui, Qing Jiao, Linyan Su, Guangming Lu, Rongwang Yang
Summary: The study aimed to investigate brain functional differences between pediatric bipolar disorder (PBD) patients with and without psychotic symptoms. The results showed distinct brain functional patterns in these two groups of PBD patients, providing empirical evidence for different clinical outcomes based on the presence or absence of psychotic symptoms.
Article
Clinical Neurology
Adrian Andrzej Chrobak, Zbigniew Soltys, Dominika Dudek, Marcin Siwek
Summary: The aim of this study was to evaluate the effect of BD type, stage, and the history of psychotic symptoms (HoPS) on the severity of neurological and cerebellar soft signs (NSS and CSS). The results showed that staging was closely related to CSS and NSS scores, while the history of psychotic symptoms was associated with oculomotor deficits. The study found that late-stage BD had more severe CSS and NSS than the control group, while early-stage BD only showed differences in posture and gait disturbances compared to the control group.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Review
Psychology, Clinical
S. R. Aminoff, I. N. Onyeka, M. Odegaard, C. Simonsen, T. Lagerberg, O. A. Andreassen, K. L. Romm, I Melle
Summary: This systematic review and meta-analysis examined the prevalence rates of psychotic symptoms in bipolar disorders. The findings showed a high prevalence of psychotic symptoms in BD type I, with a lifetime prevalence of 63% and a point prevalence of 54%. More research is needed in BD type II and other subtypes.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychiatry
Alyson Zwicker, Janice M. Fullerton, Niamh Mullins, Frances Rice, Danella M. Hafeman, Neeltje E. M. van Haren, Nikita Setiaman, John A. Merranko, Benjamin I. Goldstein, Alessandra G. Ferrera, Emma K. Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergio Mas Herrero, Gloria Roberts, Claudio Toma, Peter R. Schofield, Howard J. Edenberg, Holly C. Wilcox, Melvin G. McInnis, Victoria Powell, Lukas Propper, Eileen Denovan-Wright, Guy Rouleau, Josefina Castro-Fornieles, Manon H. J. Hillegers, Boris Birmaher, Anita Thapar, Philip B. Mitchell, Cathryn M. Lewis, Martin Alda, John I. Nurnberger, Rudolf Uher
Summary: The authors found that polygenic scores (PGSs) can complement family history to improve identification of risk for major mood and psychotic disorders. PGSs for neuroticism and subjective well-being are significantly associated with the onsets of disorders, and PGSs for psychiatric illness have limited predictive power when family history is known.
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Weijia Gao, Dong Cui, Qing Jiao, Linyan Su, Rongwang Yang, Guangming Lu
Summary: This study found structural brain differences between pediatric bipolar disorder patients with and without psychotic symptoms, with psychotic patients showing more extensive brain lesions in the prefrontal-limbic-striatum circuit. These findings suggest that psychotic symptoms in bipolar disorder may be associated with more severe symptoms due to underlying brain structural abnormalities.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Sang Jin Rhee, Dongyoon Shin, Daun Shin, Yoojin Song, Eun-Jeong Joo, Hee Yeon Jung, Sungwon Roh, Sang-Hyuk Lee, Hyeyoung Kim, Minji Bang, Kyu Young Lee, Se Hyun Kim, Minah Kim, Jihyeon Lee, Jaenyeon Kim, Yeongshin Kim, Jun Soo Kwon, Kyooseob Ha, Youngsoo Kim, Yong Min Ahn
Summary: Data-driven approaches are crucial for understanding the heterogeneity and overlap in transdiagnostic samples. This study used plasma proteomics-based clustering to subtype patients with psychotic-affective disorders. Significant differences were found between patients and healthy controls in terms of pathologic peptides. Latent class analysis revealed distinct classes of patients, with the negative symptom factor being significantly different between the classes. This highlights the significance of negative symptoms in understanding the heterogeneity and overlap of psychotic-affective disorders.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Emma M. Parrish, Samantha A. Chalker, Mayra Cano, Raeanne C. Moore, Amy E. Pinkham, Philip D. Harvey, Thomas Joiner, Amy Lieberman, Eric Granholm, Colin A. Depp
Summary: This study used ecological momentary assessment to investigate the relationship between perceived burdensomeness (PB) and thwarted belonginess (TB) with suicidal ideation (SI) in individuals with psychotic disorders. The results showed that burdensomeness varied less within participants compared to belongingness, and participants with SI had higher burdensomeness ratings and lower belongingness ratings. Social context, psychotic symptoms, mood, and SI were all found to be related to these interpersonal suicide-related risk factors.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Medicine, General & Internal
Ernest Swora, Monika Boberska, Ewa Kulis, Nina Knoll, Jan Keller, Aleksandra Luszczynska
Summary: This study found a consistent pattern of associations between higher levels of physical activity and lower positive, negative, and general psychopathology symptoms in individuals with schizophrenia and other psychotic disorders.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Sandeep Grover, Ajit Avasthi, Rahul Chakravarty, Amitava Dan, Kaustav Chakraborty, Rajarshi Neogi, Avinash Desouza, Omkar Nayak, Samir Kumar Praharaj, Vikas Menon, Ramandeep, Manish Bathla, Alka A. Subramanyam, Naresh Nebhinani, Prasonjit Ghosh, Bhavesh Lakdawala, Ranjan Bhattacharya
Summary: The presence of psychotic symptoms in patients with bipolar disorder is associated with a more severe course of the illness, including lower age of onset, higher episode rates, and higher rates of suicide attempts and hospitalizations. However, the presence of psychotic symptoms is also associated with better cognitive functioning.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Developmental
Madelaine R. Abel, Aude Henin, Jordan Holmen, Elana Kagan, Antonia Hamilton, Nestor Noyola, Dina R. Hirshfeld-Becker
Summary: This study examined the contribution of parental bipolar disorder and psychiatric comorbidities in predicting psychiatric symptoms and disorders in 2-5-year-old children. The results showed that children of parents with bipolar disorder had significant elevations in behavioral, mood, and anxiety disorders and symptoms. Parental bipolar disorder predicted child disruptive behavioral symptoms, while comorbid parental anxiety was a stronger predictor of child anxiety symptoms.
JOURNAL OF ATTENTION DISORDERS
(2023)
Article
Medicine, General & Internal
Cecilia Maria Esposito, Jennifer L. Barkin, Alessandro Ceresa, Guido Nosari, Martina Di Paolo, Francesca Legnani, Luisa Cirella, Teresa Surace, Ilaria Tagliabue, Enrico Capuzzi, Alice Caldiroli, Antonios Dakanalis, Pierluigi Politi, Massimo Clerici, Massimiliano Buoli
Summary: Patients with psychotic BD showed more severe clinical features, fewer metabolic alterations, and higher levels of inflammation compared to those without psychotic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Psychiatry
Yingying Li, Huiqian Yuan, Xianlin Liu, Langjun Su, Chunhong Yang, Chao Chen, Chunyang Li
Summary: This study analyzed the impact of psychotic symptoms on olfactory function in patients with bipolar disorder and compared olfactory function between the episode and remission phases. The results indicate that olfactory function is impaired in patients with episodic bipolar disorder, regardless of the presence of psychotic symptoms. Olfactory identification may be a characteristic marker of bipolar disorder, while olfactory sensitivity may be a state marker to distinguish between episodic and euthymic bipolar disorder.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Psychiatry
Subho Chakrabarti, Navdeep Singh
Summary: This article systematically reviews the impact of psychotic symptoms on bipolar disorder (BD). The findings suggest that psychotic symptoms are common in BD, with delusions being more prevalent than hallucinations. Psychotic symptoms can affect the course and outcome of BD, but the impact is not always adverse.
WORLD JOURNAL OF PSYCHIATRY
(2022)
Review
Pharmacology & Pharmacy
Alice Caldiroli, Enrico Capuzzi, Ilaria Tagliabue, Luisa Ledda, Massimo Clerici, Massimiliano Buoli
Summary: This review summarizes the efficacy of unlabeled molecules for the treatment of social anxiety disorder (SAD). Pregabalin at high doses appears to be a reliable alternative strategy for SAD treatment. Among the SSRIs not labeled for SAD, citalopram showed the most promising results.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Anna Maria Auxilia, Massimiliano Buoli, Alice Caldiroli, Greta Silvia Carnevali, Agnese Tringali, Roberto Nava, Massimo Clerici, Enrico Capuzzi
Summary: Treatment discontinuation is a challenge in clinical settings. Long acting injectable (LAI) antipsychotics are underutilized despite their potential benefits. This study aimed to identify the factors associated with LAI discontinuation in a real-world setting.
Article
Psychiatry
Cecilia Maria Esposito, Anna Maria Auxilia, Alessandro Ceresa, Francesco Giuseppe Zanvit, Francesco Zanelli Quarantini, Enrico Capuzzi, Alice Caldiroli, Massimo Clerici, Massimiliano Buoli
Summary: The aim of this study was to examine the factors associated with duration of untreated illness (DUI) in borderline personality disorder (BPD). A chart review of 152 patients followed up by community psychiatry services in Milan and Monza, Italy was conducted. Pearson correlation and analyses of variances were used to analyze the association between DUI and socioeconomic and clinical variables. The results showed that a longer DUI was associated with several variables, but these associations were not maintained in the regression analyses. Therefore, DUI does not appear to be significantly associated with specific clinical aspects of BPD or the course and outcome of the disorder. Larger studies are needed to confirm these findings.
EARLY INTERVENTION IN PSYCHIATRY
(2023)
Article
Nutrition & Dietetics
Alice Caldiroli, Davide La Tegola, Letizia Maria Affaticati, Francesca Manzo, Francesca Cella, Alberto Scalia, Enrico Capuzzi, Monica Nicastro, Fabrizia Colmegna, Massimiliano Buoli, Massimo Clerici, Antonios Dakanalis
Summary: Compared to mildly severe anorexia, patients with severe anorexia were older, engaged in more frequent substance misuse, and had a lower neutrophil-to-lymphocyte ratio (NLR). Only a lower NLR was predictive of severe manifestations of anorexia nervosa (AN).
Review
Medicine, General & Internal
Teresa Surace, Cecilia Quitadamo, Alice Caldiroli, Enrico Capuzzi, Fabrizia Colmegna, Guido Nosari, Elisa Borroni, Luca Fedrizzi, Valentina Bollati, Angela Cecilia Pesatori, Michele Carugno, Massimo Clerici, Massimiliano Buoli
Summary: The aim of this study was to summarize available data on the link between air pollution exposure and the onset and severity of psychiatric disorders in pregnant women during the perinatal period. Nine studies were included in the analysis, with most focusing on the association between air pollutant exposure and postpartum depression (PPD) onset. The results showed a significant association between PM2.5 and NO2 exposure and PPD onset, as well as an association between PBDE blood levels and more severe depressive symptoms. One study also observed a link between exposure to PM2.5, PM10 during pregnancy and stressful symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Alice Caldiroli, Lia Colzani, Enrico Capuzzi, Cecilia Quitadamo, Davide La Tegola, Teresa Surace, Stefania Russo, Mauro Capetti, Silvia Leo, Agnese Tringali, Matteo Marcatili, Francesco Zanelli Quarantini, Fabrizia Colmegna, Antonios Dakanalis, Massimiliano Buoli, Massimo Clerici
Summary: Generalized Anxiety Disorder (GAD) and Panic Disorder (PD) share similar neurobiological mechanisms and clinical features, leading to potential misdiagnosis and delayed treatment. This study aimed to assess the relationship between clinical and socio-demographic markers and GAD/PD diagnosis. Out of 290 outpatients identified with PD or GAD in mental health services in Italy, post-onset psychiatric and medical comorbidities were associated with GAD, while treatment with selective serotonin reuptake inhibitors (SSRIs) was associated with PD. GAD patients had a worse prognosis due to higher comorbidity rates, relapses, and poorer treatment compliance. The association between GAD and psychodynamic psychotherapy was a unique finding of this study.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Enrico Capuzzi, Alice Caldiroli, Cecilia Quitadamo, Francesco Butturini, Teresa Surace, Massimo Clerici, Massimiliano Buoli
Summary: This article provides an updated overview of novel pharmacotherapy targeting positive symptoms in schizophrenia. Promising compounds include lamotrigine, pro-cognitive compounds, and drugs acting partially or totally outside the Central Nervous System. The effectiveness of these compounds suggests that other biological systems may be potential targets for future research.
EXPERT OPINION ON PHARMACOTHERAPY
(2023)
Review
Nutrition & Dietetics
Alice Caldiroli, Davide La Tegola, Francesca Manzo, Alberto Scalia, Letizia Maria Affaticati, Enrico Capuzzi, Fabrizia Colmegna, Marios Argyrides, Constantinos Giaginis, Leonardo Mendolicchio, Massimiliano Buoli, Massimo Clerici, Antonios Dakanalis
Summary: The aim of this systematic review was to examine the impact of the COVID-19 pandemic on binge eating disorder, including new onset and clinical changes. Twelve studies with 4326 participants were included, and the findings suggest an increase in BED diagnoses and worsening of symptoms during the pandemic. However, the quality of the included studies was weak to moderate, and there was high heterogeneity among the studies, indicating a need for further research to validate these findings and develop preventive strategies and personalized treatments.
Article
Medicine, General & Internal
Cecilia Maria Esposito, Jennifer L. Barkin, Alessandro Ceresa, Guido Nosari, Martina Di Paolo, Francesca Legnani, Luisa Cirella, Teresa Surace, Ilaria Tagliabue, Enrico Capuzzi, Alice Caldiroli, Antonios Dakanalis, Pierluigi Politi, Massimo Clerici, Massimiliano Buoli
Summary: Patients with psychotic BD showed more severe clinical features, fewer metabolic alterations, and higher levels of inflammation compared to those without psychotic symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alice Caldiroli, Enrico Capuzzi, Letizia M. M. Affaticati, Teresa Surace, Carla L. L. Di Forti, Antonios Dakanalis, Massimo Clerici, Massimiliano Buoli
Summary: Social anxiety disorder (SAD) is a common psychiatric condition that requires prompt treatment to prevent psychiatric comorbidity and impairment in social and occupational functioning. This study systematically reviewed the literature on potential biomarkers for SAD. While some preliminary evidence suggests the role of certain genes and neuroimaging findings in SAD, the results overall remain inconsistent and need further investigation on larger samples to identify more specific biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Letizia Maria Affaticati, Massimiliano Buoli, Nadia Vaccaro, Francesca Manzo, Alberto Scalia, Sara Coloccini, Tommaso Zuliani, Davide La Tegola, Enrico Capuzzi, Monica Nicastro, Fabrizia Colmegna, Massimo Clerici, Antonios Dakanalis, Alice Caldiroli
Summary: Severe forms of Anorexia Nervosa (AN) are associated with low BMI, higher vitamin B12 and total cholesterol levels, later age at onset, and treatment with medication or poly-therapy. These findings contribute to the early identification of patients at higher risk.
