Article
Geriatrics & Gerontology
Elena Milanesi, Catalina Anca Cucos, Jordi A. Matias-Guiu, Gerard Pinol-Ripoll, Gina Manda, Maria Dobre, Antonio Cuadrado
Summary: Regulator of G protein signaling 2 (RGS2) is involved in neuronal plasticity and synaptic signaling, and its expression levels were found to be downregulated in the blood of Alzheimer's disease (AD) patients. Despite disease-specific therapy, RGS2 transcript levels continued to decrease at 1 year. These findings suggest that RGS2 may play a role in the pathology and progression of AD, serving as a potential blood biomarker for the disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Medicine, General & Internal
Zihan Ding, Tsz-Lok Lee, Agnes S. Chan
Summary: The current systematic review aims to identify digital cognitive biomarkers from computerized tests for detecting dementia and mild cognitive impairment (MCI), and evaluates their diagnostic performance. Results showed that digital cognitive biomarkers achieved comparable or better diagnostic performance than traditional tests, and have the potential to be sensitive markers for MCI and dementia.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemical Research Methods
Jianbo Fu, Qingxia Yang, Yongchao Luo, Song Zhang, Jing Tang, Ying Zhang, Hongning Zhang, Hanxiang Xu, Feng Zhu
Summary: Label-free quantification (LFQ) is an important technique in proteomics due to its broad proteome coverage and enhanced reproducibility. In this study, an R package EVALFQ was developed to evaluate and discover well-performing LFQ chains from over 3000 options.
BRIEFINGS IN BIOINFORMATICS
(2022)
Article
Biochemical Research Methods
Jianbo Fu, Qingxia Yang, Yongchao Luo, Song Zhang, Jing Tang, Ying Zhang, Hongning Zhang, Hanxiang Xu, Feng Zhu
Summary: The label-free quantification (LFQ) is a powerful technique in proteomics due to its broad proteome coverage, great dynamic ranges, and enhanced analytical reproducibility. However, determining the well-performing LFQ chain is challenging due to the dependence on data and the diverse possibilities. In this study, a unique R package EVALFQ was developed for performance evaluation of >3000 LFQ chains, utilizing multiple criteria, spiking proteins, and comprehensive assessment. This package is expected to attract broad interests in the field of proteomic quantification.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Chieh-Hsin Lin, Hsien-Yuan Lane
Summary: This study longitudinally monitored plasma GSH levels and cognitive function in MCI patients, showing a significant decline over a 2-year period, while these levels remained relatively stable in healthy individuals. Both baseline GSH levels and changes in GSH levels were found to significantly influence cognitive decline in MCI patients, suggesting that blood GSH concentration may be a potential biomarker for monitoring cognitive changes in MCI.
Review
Cell Biology
Yi-Jun Ge, Wei Xu, Ya-Nan Ou, Yi Qu, Ya-Hui Ma, Yu-Yuan Huang, Xue-Ning Shen, Shi-Dong Chen, Lan Tan, Qian-Hua Zhao, Jin-Tai Yu
Summary: The study systematically evaluated retinal imaging and electrophysiological markers in patients with Alzheimer's disease, mild cognitive impairment, and preclinical AD. It found that these retinal biomarkers hold great potential for the diagnosis, prognosis, and risk assessment of AD and MCI. Further development of these biomarkers, especially in diagnostic test accuracy and longitudinal studies, is warranted in the future.
AGEING RESEARCH REVIEWS
(2021)
Review
Psychology, Multidisciplinary
Alexandra Wolf, Kornkanok Tripanpitak, Satoshi Umeda, Mihoko Otake-Matsuura
Summary: Mild cognitive impairment (MCI) is a transitional zone between normal cognition and dementia, and has become a novel topic in clinical research. Early detection is crucial but logistically challenging, and technological advancements in cognitive scoring methodologies are needed. Non-invasive eye-tracking-based paradigms may contribute to early AD detection, but further longitudinal investigations are necessary for clinical applications.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Cell Biology
Michael K. Yeung, Anson Kwok-yun Chau, Jason Yin-chuen Chiu, Jay Tsz-lok Shek, Jody Po-yi Leung, Toby Chun-ho Wong
Summary: The study found significant differences in neuroimaging abnormalities between amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI), with aMCI showing more and more significant abnormalities, while naMCI showing more limited abnormalities, with shared features but unique neuroimaging abnormalities in aMCI.
AGEING RESEARCH REVIEWS
(2022)
Article
Geriatrics & Gerontology
Fardin Nabizadeh, Mohammad Balabandian, Mohammad Reza Rostami, Richard T. Ward, Niloufar Ahmadi, Mahsa Pourhamzeh
Summary: Alzheimer's disease is a progressive neurodegenerative disease associated with dementia that poses a serious threat to individuals and global healthcare systems. Identifying biomarkers for early brain structural changes associated with the disease is crucial for diagnosis and monitoring disease progression. Recent findings suggest that the plasma level of p-tau181 can serve as a diagnostic marker for early AD and neurodegeneration-related brain structural changes.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Review
Biology
Angelica E. Ramirez, Natalia Gil-Jaramillo, Maria Alejandra Tapias, Yeimy Gonzalez-Giraldo, Andres Pinzon, Pedro J. Puentes-Rozo, Andres Felipe Aristizabal-Pachon, Janneth Gonzalez
Summary: Neurodegenerative diseases are complex disorders affecting older people worldwide, with high incidence and expensive treatments. In this review, possible factors and biomarkers for mild cognitive impairment (MCI) diagnosis based on miRNAs are compiled. miRNAs can affect cellular behavior and play an important role in the early stages of neurodegenerative diseases. Further research into biomarkers is encouraged to improve the understanding of cognitive impairment in cellular models such as astrocytes. This review highlights the importance of miRNAs in maintaining brain balance and improving early diagnosis and treatment of neurodegenerative diseases.
Article
Clinical Neurology
Bin Jiao, Rihui Li, Hui Zhou, Kunqiang Qing, Hui Liu, Hefu Pan, Yanqin Lei, Wenjin Fu, Xiaoan Wang, Xuewen Xiao, Xixi Liu, Qijie Yang, Xinxin Liao, Yafang Zhou, Liangjuan Fang, Yanbin Dong, Yuanhao Yang, Haiyan Jiang, Sha Huang, Lu Shen
Summary: This study aimed to identify effective EEG biomarkers for distinguishing early-stage AD patients and monitoring disease progression. The results showed that EEG biomarkers can be used for the diagnosis and evaluation of MCI and AD.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Chao Gao, Binyin Li, Yixi He, Pai Huang, Juanjuan Du, Guiying He, Pingchen Zhang, Huidong Tang, Shengdi Chen
Summary: This study aims to compare fecal levels of short-chain fatty acids (SCFAs) in patients with mild cognitive impairment (MCI) and normal controls (NC) and investigate their potential as biomarkers for MCI identification. The study also examines the relationship between fecal SCFAs and A beta deposition in the brain.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Songmei Ma, Tong Xia, Xinyi Wang, Haiyun Wang
Summary: By analyzing gene expression data of patients with mild cognitive impairment (MCI), 8 cell senescence-related genes were identified as key gene signatures for MCI, and it was found that these genes play important roles in the regulation of response to DNA damage stimulus, Sin3 complex, and transcription corepressor activity. The constructed machine learning model showed high accuracy and reliability in diagnosing MCI, providing a theoretical basis for targeted therapy against MCI through these hub genes.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Kym McNicholas, Maxime Francois, Jian-Wei Liu, James D. Doecke, Jane Hecker, Jeff Faunt, John Maddison, Sally Johns, Tara L. Pukala, Robert A. Rush, Wayne R. Leifert
Summary: This study identified biomarkers in saliva that can be used for early detection of cognitive impairment and Alzheimer's disease. The findings suggest that combinations of specific proteins can effectively distinguish patients with cognitive impairment and Alzheimer's disease from cognitively normal individuals.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
T. C. Ooi, A. Meramat, N. F. Rajab, S. Shahar, R. Sharif
Summary: This study found that oxidative stress, DNA damage, inflammation, and certain metabolic biomarkers may mediate the improvements in cognitive function among older adults with MCI who practice Islamic Sunnah intermittent fasting.
JOURNAL OF NUTRITION HEALTH & AGING
(2022)