A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces
出版年份 2016 全文链接
标题
A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces
作者
关键词
-
出版物
PROTEIN ENGINEERING DESIGN & SELECTION
Volume -, Issue -, Pages -
出版商
Oxford University Press (OUP)
发表日期
2016-09-14
DOI
10.1093/protein/gzw050
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Hydrophobic CDR3 residues promote the development of self-reactive T cells
- (2016) Brian D Stadinski et al. NATURE IMMUNOLOGY
- How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
- (2016) Sydney J. Blevins et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry
- (2016) Daniel T. Harris et al. STRUCTURE
- Differential utilization of binding loop flexibility in T cell receptor ligand selection and cross-reactivity
- (2016) Cory M. Ayres et al. Scientific Reports
- T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules
- (2015) Jamie Rossjohn et al. Annual Review of Immunology
- Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity
- (2015) Jarrett J Adams et al. NATURE IMMUNOLOGY
- TCR contact residue hydrophobicity is a hallmark of immunogenic CD8+T cell epitopes
- (2015) Diego Chowell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TCR Scanning of Peptide/MHC through Complementary Matching of Receptor and Ligand Molecular Flexibility
- (2014) W. F. Hawse et al. JOURNAL OF IMMUNOLOGY
- Specific Increase in Potency via Structure-Based Design of a TCR
- (2014) Karolina Malecek et al. JOURNAL OF IMMUNOLOGY
- Backbone Flexibility of CDR3 and Immune Recognition of Antigens
- (2014) Jaafar N. Haidar et al. JOURNAL OF MOLECULAR BIOLOGY
- Deep mutational scanning: a new style of protein science
- (2014) Douglas M Fowler et al. NATURE METHODS
- Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor
- (2014) Brian G. Pierce et al. PLoS Computational Biology
- Exploring the role of receptor flexibility in structure-based drug discovery
- (2013) Ferran Feixas et al. BIOPHYSICAL CHEMISTRY
- Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma
- (2013) G. P. Linette et al. BLOOD
- PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
- (2013) Daniel R. Roe et al. Journal of Chemical Theory and Computation
- Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 2. Explicit Solvent Particle Mesh Ewald
- (2013) Romelia Salomon-Ferrer et al. Journal of Chemical Theory and Computation
- Cancer Regression and Neurological Toxicity Following Anti-MAGE-A3 TCR Gene Therapy
- (2013) Richard A. Morgan et al. JOURNAL OF IMMUNOTHERAPY
- Computational Design of a Protein-Based Enzyme Inhibitor
- (2013) Erik Procko et al. JOURNAL OF MOLECULAR BIOLOGY
- Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions
- (2013) Rocco Moretti et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Highly confined ions store charge more efficiently in supercapacitors
- (2013) C. Merlet et al. Nature Communications
- Multi-Faceted Functions of Secretory IgA at Mucosal Surfaces
- (2013) Blaise Corthésy Frontiers in Immunology
- ImmTACs
- (2013) Joanne Oates et al. OncoImmunology
- Limitations of Time-Resolved Fluorescence Suggested by Molecular Simulations: Assessing the Dynamics of T cell Receptor Binding Loops
- (2012) Daniel R. Scott et al. BIOPHYSICAL JOURNAL
- Accounting for Receptor Flexibility and Enhanced Sampling Methods in Computer-Aided Drug Design
- (2012) William Sinko et al. Chemical Biology & Drug Design
- Structural and dynamic control of T-cell receptor specificity, cross-reactivity, and binding mechanism
- (2012) Brian M. Baker et al. IMMUNOLOGICAL REVIEWS
- Routine Microsecond Molecular Dynamics Simulations with AMBER on GPUs. 1. Generalized Born
- (2012) Andreas W. Götz et al. Journal of Chemical Theory and Computation
- Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing
- (2012) Timothy A Whitehead et al. NATURE BIOTECHNOLOGY
- Prediction of protein-protein binding free energies
- (2012) Thom Vreven et al. PROTEIN SCIENCE
- A comparison of successful and failed protein interface designs highlights the challenges of designing buried hydrogen bonds
- (2012) P. Benjamin Stranges et al. PROTEIN SCIENCE
- Epitope Flexibility and Dynamic Footprint Revealed by Molecular Dynamics of a pMHC-TCR Complex
- (2012) Cyril F. Reboul et al. PLoS Computational Biology
- Loss of T Cell Antigen Recognition Arising from Changes in Peptide and Major Histocompatibility Complex Protein Flexibility
- (2011) Francis K. Insaidoo et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms
- (2011) O. Y. Borbulevych et al. JOURNAL OF IMMUNOLOGY
- Community-Wide Assessment of Protein-Interface Modeling Suggests Improvements to Design Methodology
- (2011) Sarel J. Fleishman et al. JOURNAL OF MOLECULAR BIOLOGY
- Disparate Degrees of Hypervariable Loop Flexibility Control T-Cell Receptor Cross-Reactivity, Specificity, and Binding Mechanism
- (2011) Daniel R. Scott et al. JOURNAL OF MOLECULAR BIOLOGY
- Flexibility and binding affinity in protein-ligand, protein-protein and multi-component protein interactions: limitations of current computational approaches
- (2011) P. Tuffery et al. Journal of the Royal Society Interface
- Practically Useful: What the RosettaProtein Modeling Suite Can Do for You
- (2010) Kristian W. Kaufmann et al. BIOCHEMISTRY
- PyRosetta: a script-based interface for implementing molecular modeling algorithms using Rosetta
- (2010) S. Chaudhury et al. BIOINFORMATICS
- T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis
- (2010) Maria R Parkhurst et al. MOLECULAR THERAPY
- The IMGT/HLA database
- (2010) J. Robinson et al. NUCLEIC ACIDS RESEARCH
- Do salt bridges stabilize proteins? A continuum electrostatic analysis
- (2010) Zachary S. Hendsch et al. PROTEIN SCIENCE
- Role of conformational sampling in computing mutation-induced changes in protein structure and stability
- (2010) Elizabeth H. Kellogg et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- The Importance of Being Tyrosine: Lessons in Molecular Recognition from Minimalist Synthetic Binding Proteins
- (2009) Shohei Koide et al. ACS Chemical Biology
- Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner
- (2009) Kurt H. Piepenbrink et al. BIOCHEMICAL JOURNAL
- Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
- (2009) L. A. Johnson et al. BLOOD
- T Cell Receptor Cross-reactivity Directed by Antigen-Dependent Tuning of Peptide-MHC Molecular Flexibility
- (2009) Oleg Y. Borbulevych et al. IMMUNITY
- Engineering the binding properties of the T cell receptor:peptide:MHC ternary complex that governs T cell activity
- (2009) Natalie A. Bowerman et al. MOLECULAR IMMUNOLOGY
- Assessing computational methods for predicting protein stability upon mutation: good on average but not in the details
- (2009) V. Potapov et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Macromolecular Modeling with Rosetta
- (2008) Rhiju Das et al. Annual Review of Biochemistry
- Conformational changes and flexibility in T-cell receptor recognition of peptide–MHC complexes
- (2008) Kathryn M. Armstrong et al. BIOCHEMICAL JOURNAL
- Control of HIV-1 immune escape by CD8 T cells expressing enhanced T-cell receptor
- (2008) Angel Varela-Rohena et al. NATURE MEDICINE
- Structure-based design of a T-cell receptor leads to nearly 100-fold improvement in binding affinity for pepMHC
- (2008) Jaafar N. Haidar et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now