Article
Behavioral Sciences
Tong Zhao, XiaoLei Gao, Guang-Biao Huang
Summary: The study found that a portion of 6-OHDA lesioned mice exhibited more prominent stress response and social cognitive impairment under chronic social defeat stress, possibly due to decreased selectivity of D1 receptors in the amygdala.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Vsevolod V. V. Nemets, Alex L. L. Deal, Vladislav E. E. Sobolev, Vladimir P. P. Grinevich, Raul R. R. Gainetdinov, Evgeny A. A. Budygin
Summary: The study found that a single exposure to social defeat in rats resulted in profound alterations in dopamine release in the nucleus accumbens, as measured by fast-scan cyclic voltammetry. The defeated rats showed enhanced dopamine responses compared to control animals, which was associated with increased immobility time in the forced swim test. The administration of a dopamine D2 receptor antagonist resulted in increased dopamine release, but the effect was less pronounced in defeated rats compared to control animals. These findings suggest a promising path for understanding the neurobiological mechanisms underlying stress-induced behavioral abnormalities.
Article
Physiology
Gessynger Morais-Silva, Lucas Gomes-de-Souza, Willian Costa-Ferreira, Jacqueline C. Pavan, Carlos C. Crestani, Marcelo T. Marin
Summary: Prolonged and heightened responses to stress can affect the development of mood disorders and cardiovascular diseases. This study aimed to investigate how susceptible and resilient rats respond to a new stressor after exposure to social defeat stress. The results showed that susceptible rats had increased cardiovascular reactivity, indicating a higher risk for cardiovascular diseases.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Alisson Pinto de Almeida, Alicia Moraes Tamais, Carolina Zerbini, Fernando Falkenburger Melleu, Newton Sabino Canteras, Simone Cristina Motta
Summary: This study reveals the neural mechanisms involved in mediating social defensive responses. The dorsal pre-mammillary nucleus projects to the rostral dorsomedial PAG, and through ascending paths mediated by the cuneiform nucleus, it influences prosencephalic circuits to mediate passive social defensive responses. This study provides further support for the role of the PAG in the modulation of behavioral responses.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Clinical Neurology
Axel Fogaca Rosado, Laura Menegatti Bevilacqua, Eduardo Luiz Gasnhar Moreira, Manuella Pinto Kaster
Summary: This study aimed to evaluate if variability in baseline flexibility can enable differences in coping strategies, changes in neuroplasticity, and behavioral outcomes in responses to chronic social defeat stress (CSDS). The results showed that animals with high behavioral flexibility exhibited changes in their coping strategies during the CSDS protocol, and they also displayed higher dendritic complexity in certain cortical areas. Moreover, high flexibility was associated with better emotional responses and motivation. However, exposure to CSDS reversed the beneficial effects of high flexibility in male mice.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2023)
Article
Immunology
Fernando Gonzalez Ibanez, Torin Halvorson, Kaushik Sharma, Chloe Grace Mckeec, Micael Carrier, Katherine Picard, Nathalie Vernoux, Kanchan Bisht, Jessica Deslauriers, Maciej Lalowski, Marie-Eve Tremblay
Summary: Psychological stress increases the risk of various diseases, while the ketogenic diet (KD) has positive effects on mood and health. This study reveals that KD may improve resistance to psychological stress by its anti-inflammatory effects on the brain and behavior, as well as its impact on microglial morphology and function.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Neurosciences
Mikio Yoshida, Sho Hasegawa, Masayuki Taniguchi, Akihiro Mouri, Chiharu Suzuki, Akira Yoshimi, Takayoshi Mamiya, Norio Ozaki, Yukihiro Noda
Summary: Juveniles are more sensitive to stress, and exposure to stress can prolong psychiatric symptoms and cause treatment resistance. This study found that memantine can attenuate impaired social behavior in juveniles by regulating the NMDA receptor and ERK1/2 signaling activation mechanism.
Article
Environmental Sciences
Yi-Hong Wang, Ya-Qian Wang, Xiao-Gang Yu, Yin Lin, Jun-Xia Liu, Wei-Ye Wang, Chong-Huai Yan
Summary: Juvenile zebrafish exposed to environmental arsenic showed behavioral abnormalities, including anxiety and social deficits, along with increased oxidative stress in the brain, decreased dopamine content, and altered gene transcription related to dopamine metabolism. However, treatment with N-acetylcysteine helped reduce oxidative stress and improve social behavior, dopamine levels, monoamine oxidase activity, and gene transcription in zebrafish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Yuka Takahata, Waka Yoshimoto, Eri Kuwagaki, Yukie Yamada, Kazuki Nagasawa
Summary: Anhedonia is a key symptom of depression, but its underlying mechanism is unknown. This study found that in socially defeat stress (SDS)-subjected mice, susceptible BALB/c mice showed an increase in the expression of sweet taste receptors in their circumvallate papillae (CP) but a decrease in sweet taste preference. This suggests that the upregulation of sweet taste receptors may compensate for the stress-induced increase in energy expenditure in susceptible BALB/c mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Neurosciences
Princewill Ikechukwu Ugwu, Benneth Ben-Azu, Sandra Ugonne Ugwu, Christian Uruaka, Chinemerem Choice Nworgu, Pamela Onyinye Okorie, Kizito Oluchukwu Okafor, Kenneth Kelechi Anachuna, Melford Uche Elendu, Amogechukwu Onyinye Ugwu, Ugochukwu Bond Anyaehie, Azubuike A. Nwankwo, Eme Effiom Osim
Summary: The study found that quercetin can improve anxiety, depression, and cognitive defects induced by psychosocial stress through multiple mechanisms, including regulation of neurochemical release, increasing BDNF, etc. Additionally, quercetin can also reduce neuronal inflammation, oxidative stress, and apoptotic pathway, and improve stress-induced impairments by normalizing the HPA-axis.
BRAIN RESEARCH BULLETIN
(2022)
Article
Neurosciences
Wenjuan Hou, Shuying Huang, Lu Li, Xing Guo, Zhixiong He, Shufeng Shang, Ziyan Jia, Lizi Zhang, Yishan Qu, Caihong Huang, Yin Li, Yitong Li, Zijian Lv, Fadao Tai
Summary: Chronic social stress can lead to psychological diseases. Oxytocin has been found to modulate the effects of chronic social defeat stress on emotional and social behaviors, but its role in mediating the effects of CSDS on emotional and social abnormalities is still unclear. Repeated administration of oxytocin during CSDS prevented the decrease of oxytocin receptors in the nucleus accumbens in females, but had no effect on males.
Article
Multidisciplinary Sciences
Melanie R. Florkowski, Jessica L. Yorzinski
Summary: Animals experience stress and show physiological and behavioral responses to cope with it. This study investigates the effects of activating the D2 dopamine receptor on coping behavior in wild sparrows, and finds that it increases their biting behavior towards inanimate objects, suggesting it as a mechanism for stress coping.
Article
Plant Sciences
Bo-Ram Lee, Ju-Hyun Lee, Yong-Hyun Ko, Jee-Yeon Seo, Kwang-Hyun Hur, Young-Jung Kim, Seon-Kyung Kim, Seong-Eon Kim, Seok-Yong Lee, Choon-Gon Jang
Summary: Korean Red Ginseng (KRG) treatment alleviated anxiety-like behaviors and reduced social avoidance behavior induced by chronic social defeat stress (CSDS) in mice. It also recovered N-methyl-D-aspartate receptor protein levels in the hippocampus, indicating a therapeutic effect on CSDS-induced mood disorders.
JOURNAL OF GINSENG RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Gui-ying Zan, Xiang Sun, Yu-jun Wang, Rui Liu, Chen-yao Wang, Wei-jia Du, Liu-bin Guo, Jing-rui Chai, Qing-lin Li, Zhi-qiang Liu, Jing-gen Liu
Summary: The study shows that upregulated dynorphin/kappa opioid receptor system in the amygdala leads to the emergence of depression following chronic social defeat stress, and suggests kappa opioid receptor antagonists as potential therapeutic agents for the prevention and treatment of depression following chronic stress.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biochemistry & Molecular Biology
Yuta Yoshida, Misa Miyazaki, Yuhei Yajima, Atsushi Toyoda
Summary: This study utilized a mouse model to investigate the effects of psychosocial stress on peripheral taste-sensing systems, revealing that psychosocial stress can downregulate the mRNA levels of sweet and umami taste receptor subunits.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)