Article
Multidisciplinary Sciences
Akiko Maruko, Koichi M. Iijima, Kanae Ando
Summary: This study investigates the molecular pathways involved in the generation of daily feeding patterns in Drosophila. The results show that quasimodo (qsm) and CLK play important roles in regulating feeding rhythms, and the generation of feeding/fasting episodes is independent of the molecular clock machinery.
Article
Biochemistry & Molecular Biology
Xinyu Zhao, Shu Huang, Peng Zhang, Xue Qiao, Yu Liu, Miren Dong, Qilin Yi, Lingling Wang, Linsheng Song
Summary: This study identified the role of EsCry in regulating the expression of cytokines in Chinese mitten crab, showing that it negatively regulates TNF and IL-16 through inhibiting their transcription factors LITAF and ILF.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Multidisciplinary Sciences
Chip Sisson, Michael Seifu Bahiru, Emily N. C. Manoogian, Eric L. Bittman
Summary: The study reveals the role of Cry1 in phase shifting and longevity in the face of heart disease. The Cry1-deficient animals show increased phase volatility but not accelerated circadian clock. Additionally, phase shifts can eliminate the shortened lifespan effect of cardiomyopathy in these mutants.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Yong Uk Jeong, Hyo-Eon Jin, Hye Young Lim, Goyeong Choi, Hansol Joo, Bohun Kang, Ga-Hyun Lee, Kwang-Hyeon Liu, Han-Joo Maeng, Sooyoung Chung, Gi Hoon Son, Jong-Wha Jung
Summary: Non-ethoxypropanoic acid-type inhibitors were developed as potent enhancers of E-box-mediated transcription, showing promising metabolic and pharmacokinetic profiles. These inhibitors directly bound to both CRY1 and 2, and exhibited significant effects on molecular circadian rhythmicity as circadian clock-enhancers.
Review
Biochemistry & Molecular Biology
Evrim Yildirim, Rachel Curtis, Dae-Sung Hwangbo
Summary: Biological clocks are essential mechanisms that synchronize physiological and behavioral processes with external cues to ensure organisms' fitness and survival. While the central clock in the brain drives daily activity rhythms, peripheral tissues have their own clock systems generating metabolic and physiological rhythms. The fruit fly Drosophila melanogaster has been a widely studied model organism for investigating the mechanism and functions of circadian clocks.
Review
Cell Biology
Namasthee Harris-Gauthier, Shashank Bangalore Srikanta, Nicolas Cermakian
Summary: Living organisms have evolved to synchronize and adapt to daily environmental cycles through circadian rhythms. These rhythms are driven by a molecular clock composed of clock genes and proteins, which regulate the expression of numerous genes. Ubiquitination and deubiquitination play important roles in the regulation of clock proteins and their functions within the circadian clock.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marrit Putker, David C. S. Wong, Estere Seinkmane, Nina M. Rzechorzek, Aiwei Zeng, Nathaniel P. Hoyle, Johanna E. Chesham, Mathew D. Edwards, Kevin A. Feeney, Robin Fischer, Nicolai Peschel, Ko-Fan Chen, Michael Vanden Oever, Rachel S. Edgar, Christopher P. Selby, Aziz Sancar, John S. O'Neill
Summary: CRY proteins are considered essential components of the cellular clock mechanism, but studies show that circadian rhythms can still exist in the absence of CRY, albeit with variable expression and shorter periods. The classic circadian hallmarks like temperature compensation and period determination by specific activities are maintained even without CRY-mediated feedback repression. The sustained PER2 protein rhythms and circadian variation in protein stability suggest a post-translational core mechanism for biological clocks.
Review
Endocrinology & Metabolism
Ferdinando Fusco, Nicola Longo, Marco De Sio, Davide Arcaniolo, Giuseppe Celentano, Marco Capece, Roberto La Rocca, Francesco Mangiapia, Gianluigi Califano, Simone Morra, Carmine Turco, Gianluca Spena, Lorenzo Spirito, Giovanni Maria Fusco, Luigi Cirillo, Luigi De Luca, Luigi Napolitano, Vincenzo Mirone, Massimiliano Creta
Summary: The impact of circadian desynchrony on spermatogenesis is significant but current evidence is insufficient due to study heterogeneity.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Cell Biology
Jonathan S. Yi, Nicolas M. Diaz, Shane D'Souza, Ethan D. Buhr
Summary: Most organisms have self-sustained circadian clocks that can be synchronized by environmental stimuli or oscillate indefinitely. In mammals, this is true at the molecular level for most cell types, with a core set of clock genes forming a transcriptional/translational feedback loop (TTFL) with a 24-hour period. The TTFL mechanism varies slightly in different cell types, but all involve similar core clock genes. The clock has unique outputs in different tissues, as cells convert the TTFL timing signals into orchestrated transcriptional oscillations of clock-controlled genes and cellular processes.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2022)
Review
Physiology
Siska Wilantri, Hanna Grasshoff, Tanja Lange, Timo Gaber, Luciana Besedovsky, Frank Buttgereit
Summary: Research on 24-h rhythms over the past four decades has revealed their significance for immunity and various diseases through genetic, molecular, and physiological findings. Disruption and misalignment of circadian rhythms have been linked to diseases and abnormal physiological functioning, highlighting their fundamental importance to mammals. This article provides an overview of the molecular regulation of 24-h rhythms, their impact on immunity, the detrimental effects of misalignment, the association between pathological rhythms and rheumatoid arthritis (RA), and the potential use of chronobiological rhythms for chronotherapy in inflammatory autoimmune diseases like RA.
Review
Nutrition & Dietetics
Lauren N. Woodie, Kaan T. Oral, Brianna M. Krusen, Mitchell A. Lazar
Summary: Obesity and metabolic diseases are common in industrialized societies due to circadian disruption caused by shift work, jet lag, and social obligations. The circadian rhythm of the hypothalamic suprachiasmatic nucleus (SCN) plays a critical role in regulating physiological, metabolic, and behavioral processes. However, disruptions in external cues or metabolic flexibility can lead to the development of obesity and metabolic disease. This review explores the circadian rhythm of nutrient metabolism and discusses obesity as a circadian disease.
Article
Neurosciences
Elizabeth S. Maywood, Johanna E. Chesham, Raphaelle Winsky-Sommerer, Michael H. Hastings
Summary: This study demonstrates the importance of the suprachiasmatic nucleus (SCN) in regulating circadian rhythms and sleep. By restoring molecular circadian functions in the SCN, improvements in sleep quality and enhanced sleep-dependent memory were observed.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Leo Nava Piorsky Dominici Cruz, Rayane Teles-de-Freitas, Maria Eduarda Barreto Resck, Andresa Borges de Araujo Fonseca, Karine Pedreira Padilha, Luana Cristina Farnesi, Luciana Ordunha Araripe, Rafaela Vieira Bruno
Summary: This study investigated the expression of clock genes in the ovaries of Aedes aegypti and the impact of insemination and light conditions on their expression. The results indicate the absence of a functional circadian clock in the ovaries of A. aegypti, but differential mean expression changes suggest other roles beyond circadian rhythms in this mosquito's ovaries.
Article
Multidisciplinary Sciences
Xuemei Cao, Yanyan Yang, Christopher P. Selby, Zhenxing Liu, Aziz Sancar
Summary: The mammalian circadian clock is regulated by a transcription-translation feedback loop involving CLOCK-BMAL1 activators and CRY-PER repressors. Previous studies have shown that CRY and CRY-PER inhibit CLOCK-BMAL1 in different mechanisms. This study reveals the involvement of CRY-PER in displacing CLOCK-BMAL1 by recruiting CK1 delta, leading to the dissociation of CLOCK-BMAL1 from the E-box.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Xiwu Rao, Lizhu Lin
Summary: Circadian disruption is closely associated with colorectal cancer (CRC) development, with abnormal expression of certain genes found in patients. Some genes have tumor suppressor properties, while others may aggravate CRC progression. Circadian scheduling also benefits chemotherapy for CRC patients. Dysfunction of the molecular clock system disrupts cellular processes and accelerates colon tumorigenesis.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Psychology, Clinical
Hanna M. van Loo, Lian Beijers, Martijn Wieling, Trynke R. de Jong, Robert A. Schoevers, Kenneth S. Kendler
Summary: This study investigates the impact of age and sex on the point prevalence of different mood and anxiety disorders, internalizing symptoms, and neuroticism. The findings suggest that the point prevalence of internalizing disorders is typically highest between the ages of 30 and 50, and women report more internalizing disorders than men. However, the relative difference between the sexes remains stable across age.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Ymkje Anna de Vries, Robert A. Schoevers, Julian P. T. Higgins, Marcus R. Munafo, Jojanneke A. Bastiaansen
Summary: Statistical power is generally low in trials of psychotherapy, pharmacotherapy, and complementary and alternative medicine for mood, anxiety, and psychotic disorders. Underpowered studies tend to produce larger effect sizes, indicating the presence of reporting bias. Increasing sample sizes and reducing bias are necessary to improve the reliability of published literature in this field.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Anthropology
Madelien H. van de Beek, Erwin Landman, Wim Veling, Robert A. Schoevers, Lian van der Krieke
Summary: Migrants and their offspring are more prone to mental disorders, and the social factors play a significant role in their mental health. Young Moroccan-Dutch people feel isolated and discriminated against in their social environment. They explain mental health problems using religious and medical explanations.
TRANSCULTURAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Merve Atli, James C. Bennett, Megan Croal, Charles DeBattista, Boadie W. Dunlop, David Feifel, David J. Hellerstein, Muhammad Ishrat Husain, John R. Kelly, Molly R. Lennard-Jones, Rasmus W. Licht, Lindsey Marwood, Sunil Mistry, Tomas Palenicek, Ozlem Redjep, Dimitris Repantis, Robert A. Schoevers, Batya Septimus, Hollie J. Simmons, Jair C. Soares, Metten Somers, Susan C. Stansfield, Jessica R. Stuart, Hannah H. Tadley, Nisha K. Thiara, Joyce Tsai, Mourad Wahba, Sam Williams, Rachel I. Winzer, Allan H. Young, Matthew B. Young, Sid Zisook, Ekaterina Malievskaia
Summary: This study explores the efficacy of COMP360, a synthetic formulation of psilocybin, in treating treatment-resistant depression (TRD). Results show that a single dose of psilocybin at 25 mg and 10 mg can significantly improve symptoms of depression. This study expands on previous research on the use of psilocybin in treating TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biochemistry & Molecular Biology
Tina Drincic, Jens H. van Dalfsen, Jeanine Kamphuis, Mike C. Jentsch, Sjoerd M. van Belkum, Marcus J. M. Meddens, Brenda W. J. H. Penninx, Robert A. Schoevers
Summary: Insomnia has a clinically relevant relationship with major depressive disorder (MDD), as it is associated with neurobiological alterations similar to the pathophysiology of MDD. This study aimed to investigate the relationship between insomnia and the main mechanisms of MDD in a clinical sample of MDD individuals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Psychology, Clinical
Iris Jonker, Janine Doorduin, Henderikus Knegtering, Erna Van't Hag, Rudi A. Dierckx, Erik F. J. de Vries, Robert A. Schoevers, Hans C. Klein
Summary: This study aimed to determine whether add-on treatment of schizophrenic patients with the anti-viral drug valaciclovir would reduce hippocampal neuroinflammation and improve cognitive symptoms. Results showed that valaciclovir treatment reduced neuroinflammation in multiple brain regions, but had no effect on psychotic symptoms or cognitive functioning.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Arja O. O. Rydin, Yuri Milaneschi, Rick Quax, Jie Li, Jos A. A. Bosch, Robert A. A. Schoevers, Erik J. J. Giltay, Brenda W. J. H. Penninx, Femke Lamers
Summary: Depression is associated with metabolic alterations, and the associations may vary across individual symptoms. Using a network perspective, this study found 28 associations between depressive symptoms and metabolites, with fatigue and hypersomnia symptoms consistently related to cholesterol and fatty acid measures.
PSYCHOLOGICAL MEDICINE
(2023)
Correction
Neurosciences
Nina Schimmers, Joost J. Breeksema, Sanne Y. Smith-Apeldoorn, Jolien Veraart, Wim van den Brink, Robert A. Schoevers
PSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Hilde de Kluiver, Rick Jansen, Brenda W. J. H. Penninx, Erik J. J. Giltay, Robert A. A. Schoevers, Yuri Milaneschi
Summary: Depression overlaps with cardiometabolic conditions in terms of metabolomic signature. The metabolomic signature is linked to atypical depression profiles characterized by energy alterations. This specific clustering of metabolomic signature with clinical profile identifies a subgroup of depressed patients at higher cardiometabolic risk, potentially serving as a valuable target for interventions to reduce the detrimental impact of depression on health.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Lino von Klipstein, Michelle N. Servaas, Robert A. Schoevers, Date C. van der Veen, Harriette Riese
Summary: This article presents a case study of integrating personalized experience sampling methodology (ESM) assessment and feedback into psychotherapy for depression. Through ESM questionnaires and feedback sessions, the patient and therapist collaboratively explore and analyze the patient's symptoms and concerns, finding the ESM module to be useful and insightful for treatment.
Article
Multidisciplinary Sciences
J. K. E. Veraart, M. van Westenbrugge, J. E. van Wulfften Palthe, A. van der Meij, R. A. Schoevers, J. de Jong
Summary: Ketamine and esketamine have shown potential as pharmacotherapeutic options for treatment resistant depression and other psychiatric disorders. This study explores the effects of repeated oral esketamine treatment in patients with TRD and comorbid PTSD. The results suggest that combining (es)ketamine treatment with psychotherapy may be promising for these patients.
Article
Psychiatry
David Wedema, Klaas J. Wardenaar, Manna A. Alma, Antoinette D. I. van Asselt, Eliza L. Korevaar, Robert A. Schoevers
Summary: This article introduces a recovery program called STAIRS for patients with major depressive disorder (MDD) and plans to conduct a study to assess the program's efficacy, patients' subjective experiences, and cost-effectiveness.
Article
Oncology
Lonneke A. van Tuijl, Maartje Basten, Kuan-Yu Pan, Roel Vermeulen, Luetzen Portengen, Alexander de Graeff, Joost Dekker, Mirjam I. Geerlings, Adriaan Hoogendoorn, Femke Lamers, Adri C. Voogd, Jessica Abell, Philip Awadalla, Aartjan T. F. Beekman, Ottar Bjerkeset, Andy Boyd, Yunsong Cui, Philipp Frank, Henrike Galenkamp, Bert Garssen, Sean Hellingman, Martijn Huisman, Anke Huss, Trynke R. de Jong, Melanie R. Keats, Almar A. L. Kok, Steinar Krokstad, Flora E. van Leeuwen, Annemarie I. Luik, Nolwenn Noisel, N. Charlotte Onland-Moret, Yves Payette, Brenda W. J. H. Penninx, Ina Rissanen, Annelieke M. Roest, Rikje Ruiter, Robert A. Schoevers, David Soave, Mandy Spaan, Andrew Steptoe, Karien Stronks, Erik R. Sund, Ellen Sweeney, Emma L. Twait, Alison Teyhan, W. M. Monique Verschuren, Kimberly D. van der Willik, Judith G. M. Rosmalen, Adelita V. Ranchor
Summary: A meta-analysis of individual participant data from 18 cohorts found no associations between depression or anxiety and most types of cancer, except for lung cancer and smoking-related cancers. The associations with lung and smoking-related cancers were attenuated when adjusting for known risk factors.
Article
Clinical Neurology
Lino von Klipstein, Michelle N. Servaas, Femke Lamers, Robert A. Schoevers, Klaas J. Wardenaar, Harriette Riese
Summary: Experience sampling studies show that depressed individuals react more strongly to positive and negative stimuli than non-depressed individuals, particularly on negative affect. However, these findings may be influenced by floor/ceiling effects and assumption violations. Using data from 346 participants, it was found that depressed individuals showed increased positive affect reactivity when accounting for assumption violations, but no evidence of increased negative affect reactivity. The results highlight the importance of considering modeling choices in affective reactivity studies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Nadia Deflorin, Ulrike Ehlert, Rita T. Amiel Castro
Summary: Changes in the gut microbiome of infants have been associated with maternal psychological symptoms during pregnancy. This study found that maternal prenatal depressive symptoms are associated with lower diversity of the infant's microbiome, while maternal saliva cortisol levels are linked to increased diversity and changes in specific bacterial groups. Further research is needed to understand the implications of these microbiota alterations for child health.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zheng Ma, Hui-Xia Zhou, Da-Chun Chen, Dong-Mei Wang, Xiang-Yang Zhang
Summary: The impaired glucose metabolism in drug-na & iuml;ve schizophrenia patients is strongly associated with suicidal behavior, suggesting that glucose metabolism abnormalities may be potential biomarkers of suicide in schizophrenia patients. Regular monitoring of glucose metabolism variables is essential for suicide prevention.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Katie M. Lavigne, Jiaxuan Deng, Delphine Raucher-Chene, Adele Hotte-Meunier, Chloe Voyer, Lisa Sarraf, Martin Lepage, Genevieve Sauve
Summary: Psychiatric disorders are characterized by cognitive deficits and cognitive biases, which are associated with specific symptoms. While cognitive biases are present across diagnoses, their severity varies.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Yong-Yu Yin, Jiao-Zhao Yan, Shi-Xin Lai, Qian-Qian Wei, Si-Rui Sun, Li-Ming Zhang, Yun-Feng Li
Summary: This study found that gamma oscillations are closely associated with depression and may serve as predictive biomarkers of depression. Chronic restraint stress and lipopolysaccharide induced significant depression-like behaviors in mice and reduced gamma oscillations in the medial prefrontal cortex. Administration of ketamine, scopolamine, or fluoxetine increased gamma oscillations and exhibited rapid-acting antidepressant effects.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Veronica Begni, Moira Marizzoni, Kerstin Camile Creutzberg, Diana Morena Silipo, Mariusz Papp, Annamaria Cattaneo, Marco Andrea Riva
Summary: Exposure to stressful experiences is a significant risk factor for mental disorders, and pharmacological interventions targeting stress-induced alterations can help restore brain function. Lurasidone, an antipsychotic drug, has been shown to normalize the impairments caused by stress exposure and could be a valuable treatment for stress-induced mental illnesses. However, the mechanisms underlying the therapeutic effects of lurasidone are not well understood. This study found that chronic lurasidone treatment counteracted some of the transcriptional changes induced by chronic mild stress exposure, providing new insights into the potential therapeutic effects of lurasidone.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Esther E. Palacios-Barrios, Kunal Patel, Jamie L. Hanson
Summary: This review examines the association between early life interpersonal stress (ELIS) and depression, as well as the underlying mechanisms. The research shows that ELIS affects how youth respond to social rewards, and similar impairments in social reward processing are observed in youth with depression. The authors propose a preliminary model that suggests neurobehavioral disruptions in social reward processing as a mediating factor in the connection between ELIS and depression.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Rui Li, Jiaming Tang, Yizhuo Wang, Ying Wang, Hua Yang, Hongen Wei
Summary: Restricted and repetitive behaviors (RRBs) are characteristic features of neuropsychiatric disorders. This study focused on repetitive self-grooming behavior and investigated the involvement of the Pax2 gene in its control. Through the use of Pax2 neuron-specific deletion mice, the study found that the deletion of Pax2 gene affects the expression of the Arc gene in the prefrontal cortex, leading to impaired synaptic plasticity and excitatory/inhibitory imbalance, thereby contributing to the occurrence of repetitive self-grooming behavior.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Sara Derosa, Paulina Misztak, Jessica Mingardi, Giulia Mazzini, Heidi Kaastrup Muller, Laura Musazzi
Summary: This study investigated the involvement of neurotrophic signaling pathways in stress vulnerability/resilience and fast antidepressant response/non-response to ketamine in a rat model of depression. The findings showed that stress and ketamine induced specific changes in these pathways in different brain areas and subcellular fractions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Georgia F. Caruana, Sean P. Carruthers, Michael Berk, Susan L. Rossell, Tamsyn E. Van Rheenen
Summary: Cognitive impairment is related to both white matter macrostructure and microstructure in bipolar disorder patients. However, there is inconsistency in the results of the studies examining this relationship. Some studies have found an association between higher fractional anisotropy in white matter and better complex attention skills and executive functioning in bipolar disorder patients, while others have found no associations. Further research with increased statistical power and standardized methods is needed.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Amanda J. Sales, Pedro H. Gobira, Joa F. C. Pedrazzi, Joao R. Silveia, Elaine Del Bel, Felipe V. Gomes, Francisco S. Guimaraes
Summary: The study found that doxycycline can inhibit metalloproteinase in the brain and attenuate the rewarding effects and locomotor sensitization of drug abuse. This suggests that doxycycline could be repurposed for the treatment of substance use disorders.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Alejandro Borrego-Ruiz, Juan J. Borrego
Summary: There is substantial evidence that the development of the nervous system is related to the composition and functions of the gut microbiome. The communication between the central nervous system (CNS) and the gut microbiota is bidirectional, with various routes such as immune, endocrine, and neural circuits. Dysbiosis of the gut microbiota has been associated with neuropsychiatric diseases and psychological disorders. Fecal microbiota transplantation (FMT) therapy has shown a causal-effect relationship between the gut microbiota and behavioral features. Interventions based on prebiotics, probiotics, or synbiotics have demonstrated their influence on neurological disorders through the synthesis of neuroactive compounds and regulation of inflammatory and endocrine processes. Further research is needed to explore the impact of gut microbiota dysbiosis on psychiatric and psychological disorders and the potential therapeutic role of microbiota-based interventions.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Zhinan Li, Zhuang Kang, Xiaowei Xia, Leijun Li, Junyan Wu, Jiamin Dai, Tong Liu, Cai Chen, Yong Qiu, Ming Chen, Yanxi Liu, Ziyi Zhang, Zili Han, Zhengjia Dai, Qinling Wei
Summary: This study found that patients with schizophrenia showed lower levels of resilience and cognitive functions compared to healthy controls, as well as abnormal global properties and nodal metrics in brain networks. Furthermore, characteristic path length might moderate the relationship between resilience and working memory in these patients.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
David H. Adamowicz, Tsung-Chin Wu, Rebecca Daly, Michael R. Irwin, Dilip Jeste, Xin M. Tu, Lisa T. Eyler, Ellen E. Lee
Summary: This study aimed to explore the relationship between executive functioning and inflammatory biomarkers in people with schizophrenia. The results showed that systemic inflammation did not predict long-term declines in executive functioning. This suggests the need for further research to better understand the relationship and mechanisms between inflammation and cognition in schizophrenia.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Clinical Neurology
Nina Walter, Julian Wenzel, Shalaila S. Haas, Letizia Squarcina, Carolina Bonivento, Anne Ruef, Dominic Dwyer, Theresa Lichtenstein, Oeznur Bastruek, Alexandra Stainton, Linda A. Antonucci, Paolo Brambilla, Stephen J. Wood, Rachel Upthegrove, Stefan Borgwardt, Rebekka Lencer, Eva Meisenzahl, Raimo K. R. Salokangas, Christos Pantelis, Alessandro Bertolino, Nikolaos Koutsouleris, Joseph Kambeitz, Lana Kambeitz-Ilankovic
Summary: Clinical and neuroimaging data can be used to predict the potential of cognitive training to improve social functioning in recent onset psychosis patients. The use of multivariate pattern analysis and support vector machine classifier allows for the prediction of social functioning improvement based on baseline cognitive data. The findings suggest that cognitive data can provide a robust individual estimate of future social functioning for patients with recent onset psychosis.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
