Article
Nutrition & Dietetics
Harry A. Smith, Jonathan D. Watkins, Jean-Philippe Walhin, Javier T. Gonzalez, Dylan Thompson, James A. Betts
Summary: Breakfast consumption, whether high in carbohydrates or enriched with whey protein isolate, attenuates insulinemic responses to a subsequent meal, indicating that a reduced-carbohydrate protein-enriched breakfast can achieve similar glucose control later in the day without causing hyperglycemia in the morning.
JOURNAL OF NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Florian Beignon, Naig Gueguen, Helene Tricoire-Leignel, Cesar Mattei, Guy Lenaers
Summary: Understanding temperature production and regulation in endotherm organisms is a crucial challenge. Mitochondria can act as cellular radiators, controlling heat production and cell temperature. Considering these new thermic paradigms, we discuss conventional wisdom linking mitochondrial functions to cellular thermogenesis.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Endocrinology & Metabolism
Leonie C. Ruddick-Collins, Alan Flanagan, Jonathan D. Johnston, Peter J. Morgan, Alexandra M. Johnstone
Summary: The differences in thermic effect of food (TEF) between morning and evening can be explained by the underlying circadian variability in resting metabolic rate (RMR), which is independent of the acute effect of eating.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Miguel Lopez, Manuel Fernandez-Real, Stanislav I. Tomarev
Summary: Classically, the regulation of energy balance has been based on central and peripheral mechanisms sensing energy, nutrients, metabolites, and hormonal cues. Recent data have added more complexity to the homeostatic regulation of metabolism by introducing the key role of olfaction in energy homeostasis. Olfactory inputs contribute to the regulation of feeding, energy expenditure, and whole body metabolism.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Review
Chemistry, Analytical
Ye Wang, Hanliang Zhu, Jianguo Feng, Pavel Neuzil
Summary: This review discusses microcalorimetry-based techniques for measuring Delta P-M and its extended applications, including improving device performance, measurement in microorganisms and mammalian cells, and applications in metabolism research and drug testing. Measurement of Delta P-M at single-cell level is challenging but sheds light on cellular processes and enhances our knowledge in this field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Nadejda Bozadjieva-Kramer, Rachel A. Ross, David Q. Johnson, Henning Fenselau, David L. Haggerty, Brady Atwood, Bradford Lowell, Jonathan N. Flak
Summary: The study reveals that PACAP plays crucial roles in regulating metabolic rate and energy balance through multiple effector systems on various time scales, highlighting the diverse functions of PACAP in overall energy homeostasis.
Review
Nutrition & Dietetics
Zimei Li, Liansu Huang, Yuheng Luo, Bing Yu, Gang Tian
Summary: The imbalance between energy intake and expenditure in a continuous food availability environment can increase the risk of obesity and chronic noncommunicable diseases. Intermittent fasting (IF) is a popular nonpharmacological intervention to combat these diseases. Rodent studies show that IF optimizes energy metabolism, prevents obesity, promotes brain health, improves immune and reproductive function, and delays aging. In humans, IF is relevant for the aging population and increasing life expectancy. However, the ideal model of IF is still unclear. This review summarizes the possible mechanisms of IF and discusses its potential drawbacks, providing new insights for nonpharmaceutical dietary intervention of chronic noncommunicable diseases.
Article
Endocrinology & Metabolism
Berengere Coupe, Corinne Leloup, Kwame Asiedu, Julien Maillard, Luc Penicaud, Tamas L. Horvath, Sebastien G. Bouret
Summary: The study investigated the importance of the autophagy-related gene Atg7 in Sf1-expressing neurons of the ventromedial nucleus of the hypothalamus (VMH) under normal and fasting conditions. It was found that autophagy is nutritionally regulated in VMH neurons and participates in controlling energy homeostasis during fasting.
MOLECULAR METABOLISM
(2021)
Article
Multidisciplinary Sciences
Adela Urisarri, Ismael Gonzalez-Garcia, Anxela Estevez-Salguero, Maria P. Pata, Edward Milbank, Noemi Lopez, Natalia Mandia, Carmen Grijota-Martinez, Carlos A. Salgado, Ruben Nogueiras, Carlos Dieguez, Francesc Villarroya, Jose-Manuel Fernandez-Real, Maria L. Couce, Miguel Lopez
Summary: The study uses non-invasive infrared thermography to reveal the correlation between BAT activity and body temperature in newborns, showing that mild cold stimulus promotes BAT activation. Additionally, a short-term cold stimulus on the first day of life improves body temperature adaptation to subsequent cold events in newborns.
NATURE COMMUNICATIONS
(2021)
Article
Endocrinology & Metabolism
Naira da Silva Mansano, Henrique Rodrigues Vieira, Roberta Araujo-Lopes, Raphael Escorsim Szawka, Jose Donato Jr, Renata Frazao
Summary: This study found that acute fasting can modulate the activity of the HPG axis and has gender-specific effects on Kisspeptin neurons. In female mice, fasting reduces the levels of luteinizing hormone and prolactin, while increasing follicle-stimulating hormone levels. Fasting also reduces Kisspeptin gene expression. Additionally, GABAergic transmission and the effects of neuropeptide Y on ARHKisspeptin neurons show gender differences.
Article
Endocrinology & Metabolism
Edward Milbank, Nathalia R. V. Dragano, Ismael Gonzalez-Garcia, Marcos Rios Garcia, Veronica Rivas-Limeres, Liliana Perdomo, Gregory Hilairet, Francisco Ruiz-Pino, Patricia Mallegol, Donald A. Morgan, Ramon Iglesias-Rey, Cristina Contreras, Luisa Vergori, Juan Cunarro, Begona Porteiro, Aleix Gavalda-Navarro, Rebecca Oelkrug, Anxo Vidal, Juan Roa, Tomas Sobrino, Francesc Villarroya, Carlos Dieguez, Ruben Nogueiras, Cristina Garcia-Caceres, Manuel Tena-Sempere, Jens Mittag, M. Carmen Martinez, Kamal Rahmouni, Ramaroson Andriantsitohaina, Miguel Lopez
Summary: Milbank et al. demonstrate that targeted delivery of AMPK alpha 1 in SF1 neurons of the VMH using small extracellular vesicles can lead to weight loss through increased brown adipose tissue thermogenesis, independent of feeding.
Article
Multidisciplinary Sciences
Paige Niepoetter, Carolyn Butts-Wilmsmeyer, Chaya Gopalan
Summary: This study evaluated the impact of intermittent fasting on the mental and physical fatigue of obese rats. The results showed that intermittent fasting led to slower weight gain and lower blood glucose levels compared to the ad libitum group. The type of diet also affected ketone levels. However, there was no significant difference in mental or physical fatigue between intermittent fasting and ad libitum feeding.
Review
Gastroenterology & Hepatology
Iulia Minciuna, Suchira Gallage, Mathias Heikenwalder, Shira Zelber-Sagi, Jean-Francois Dufour
Summary: NASH, a chronic liver disease that can progress to end-stage liver disease and HCC, can be effectively treated with intermittent fasting, which not only induces weight loss but also reduces inflammation and oxidative stress.
Article
Cell Biology
Xuekai Xiong, Weini Li, Ruya Liu, Pradip Saha, Vijay Yechoor, Ke Ma
Summary: The dissolution of actin cytoskeleton and loss of MRTF/SRF activity are required for the morphological transformation of adipogenic progenitors into mature adipocytes. While the circadian clock controls the temporal regulation of adipogenic differentiation, the actin cytoskeleton-MRTF/SRF signaling pathway transduces extracellular physical cues. In this study, we identified a novel circadian transcriptional control that modulates the actin cytoskeleton-MRTF/SRF cascade, which is involved in the regulation of beige fat thermogenic function.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2023)
Article
Endocrinology & Metabolism
Rahel Catherina Loeliger, Claudia Irene Maushart, Gani Gashi, Jael Rut Senn, Martina Felder, Anton S. Becker, Julian Mueller, Miroslav Balaz, Christian Wolfrum, Irene A. Burger, Matthias Johannes Betz
Summary: Cold-induced thermogenesis (CIT) is related to BAT activity, while diet-induced thermogenesis (DIT) is not associated with BAT activity. The increase in EE after glucose intake is not linked to stimulated BAT activity. Therefore, in humans, DIT may not be a function of BAT.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Jo E. Lewis, Ricardo J. Samms, Scott Cooper, Jeni C. Luckett, Alan C. Perkins, James D. Dunbar, Dennis P. Smith, Paul J. Emmerson, Andrew C. Adams, Francis J. P. Ebling, Kostas Tsintzas
Article
Neurosciences
Javier T. Gonzalez, Judith D. Richardson, Enhad A. Chowdhury, Francoise Koumanov, Geoffrey D. Holman, Scott Cooper, Dylan Thompson, Kostas Tsintzas, James A. Betts
JOURNAL OF PHYSIOLOGY-LONDON
(2018)
Review
Biochemistry & Molecular Biology
Francis B. Stephens, Kostas Tsintzas
BIOCHEMICAL SOCIETY TRANSACTIONS
(2018)
Article
Physiology
Biraj Parmar, Jo E. Lewis, Ricardo J. Samms, Francis J. P. Ebling, Christine C. Cheng, Andrew C. Adams, Joanne Mallinson, Scott Cooper, Tariq Taylor, Reza Ghasemi, Francis B. Stephens, Kostas Tsintzas
EXPERIMENTAL PHYSIOLOGY
(2018)
Article
Nutrition & Dietetics
Enhad A. Chowdhury, Judith D. Richardson, Kostas Tsintzas, Dylan Thompson, James A. Betts
JOURNAL OF NUTRITION
(2018)
Article
Medicine, Research & Experimental
Iain Templeman, Dylan Thompson, Javier Gonzalez, Jean-Philippe Walhin, Sue Reeves, Peter J. Rogers, Jeffrey M. Brunstrom, Leonidas G. Karagounis, Kostas Tsintzas, James A. Betts
Article
Biology
Laurent Perrin, Ursula Loizides-Mangold, Stephanie Chanon, Cedric Gobet, Nicolas Hulo, Laura Isenegger, Benjamin D. Weger, Eugenia Migliavacca, Aline Charpagne, James A. Betts, Jean-Philippe Walhin, Lain Templeman, Keith Stokes, Dylan Thompson, Kostas Tsintzas, Maud Robert, Cedric Howald, Howard Riezman, Jerome N. Feige, Leonidas G. Karagounis, Jonathan D. Johnston, Emmanouil T. Dermitzakis, Frederic Gachon, Etienne Lefai, Charna Dibner
Article
Multidisciplinary Sciences
Enhad A. Chowdhury, Max J. Western, Thomas E. Nightingale, Oliver J. Peacock, Dylan Thompson
Article
Multidisciplinary Sciences
Mary F. O'Leary, Graham R. Wallace, Edward T. Davis, David P. Murphy, Thomas Nicholson, Andrew J. Bennett, Kostas Tsintzas, Simon W. Jones
SCIENTIFIC REPORTS
(2018)
Article
Endocrinology & Metabolism
Enhad A. Chowdhury, Judith D. Richardson, Javier T. Gonzalez, Kostas Tsintzas, Dylan Thompson, James A. Betts
Article
Endocrinology & Metabolism
Harriet A. Carroll, Yung-Chih Chen, Iain S. Templeman, Phoebe Wharton, Sue Reeves, William V. Trim, Enhad A. Chowdhury, Jeff M. Brunstrom, Peter J. Rogers, Dylan Thompson, Lewis J. James, Laura Johnson, James A. Betts
Article
Sport Sciences
Richard S. Metcalfe, Matthew Thomas, Christopher Lamb, Enhad A. Chowdhury
Summary: Omitting breakfast can impair evening exercise performance, but this is more related to meal timing rather than the amount of carbohydrates consumed during lunch. Providing a high-carbohydrate breakfast in the morning may be beneficial for optimizing evening exercise performance.
EUROPEAN JOURNAL OF SPORT SCIENCE
(2021)
Article
Cell Biology
Iain Templeman, Harry Alex Smith, Enhad Chowdhury, Yung-Chih Chen, Harriet Carroll, Drusus Johnson-Bonson, Aaron Hengist, Rowan Smith, Jade Creighton, David Clayton, Ian Varley, Leonidas Georgios Karagounis, Andrew Wilhelmsen, Kostas Tsintzas, Sue Reeves, Jean-Philippe Walhin, Javier Thomas Gonzalez, Dylan Thompson, James Alexander Betts
Summary: This study found that daily fasting is less effective in reducing body fat mass compared to a matched degree of daily energy restriction, with no evidence of fasting-specific effects on metabolic regulation or cardiovascular health.
SCIENCE TRANSLATIONAL MEDICINE
(2021)