On the (un)predictability of a large intragenic fitness landscape

Adaptive Evolution: Don’t Fix What’s Broken

(2016) Gaowen Liu et al.   CURRENT BIOLOGY

Measuring epistasis in fitness landscapes: The correlation of fitness effects of mutations

(2016) Luca Ferretti et al.   JOURNAL OF THEORETICAL BIOLOGY

Accelerating Mutational Load Is Not Due to Synergistic Epistasis or Mutator Alleles in Mutation Accumulation Lines of Yeast

(2015) J.-N. Jasmin et al.   GENETICS

Properties of selected mutations and genotypic landscapes under Fisher's geometric model

(2014) François Blanquart et al.   EVOLUTION

A Bayesian MCMC Approach to Assess the Complete Distribution of Fitness Effects of New Mutations: Uncovering the Potential for Adaptive Walks in Challenging Environments

(2014) C. Bank et al.   GENETICS

Adaptation in Tunably Rugged Fitness Landscapes: The Rough Mount Fuji Model

(2014) J. Neidhart et al.   GENETICS

A Systematic Survey of an Intragenic Epistatic Landscape

(2014) Claudia Bank et al.   MOLECULAR BIOLOGY AND EVOLUTION

Empirical fitness landscapes and the predictability of evolution

(2014) J. Arjan G.M. de Visser et al.   NATURE REVIEWS GENETICS

Global epistasis makes adaptation predictable despite sequence-level stochasticity

(2014) S. Kryazhimskiy et al.   SCIENCE

The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing

(2014) Jaclyn K. Mann et al.   PLoS Computational Biology

Genetic and non-genetic instability in tumor progression: link between the fitness landscape and the epigenetic landscape of cancer cells

(2013) Sui Huang   CANCER AND METASTASIS REVIEWS

SHIFTING FITNESS LANDSCAPES IN RESPONSE TO ALTERED ENVIRONMENTS

(2013) Ryan T. Hietpas et al.   EVOLUTION

SELECTION BIASES THE PREVALENCE AND TYPE OF EPISTASIS ALONG ADAPTIVE TRAJECTORIES

(2013) Jeremy A. Draghi et al.   EVOLUTION

Quantitative analyses of empirical fitness landscapes

(2013) Ivan G Szendro et al.   JOURNAL OF STATISTICAL MECHANICS-THEORY AND EXPERIMENT

Evolutionary Accessibility of Modular Fitness Landscapes

(2013) B. Schmiegelt et al.   JOURNAL OF STATISTICAL PHYSICS

Patterns of Epistasis between Beneficial Mutations in an Antibiotic Resistance Gene

(2013) Martijn F. Schenk et al.   MOLECULAR BIOLOGY AND EVOLUTION

Comprehensive experimental fitness landscape and evolutionary network for small RNA

(2013) J. I. Jimenez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein structure alignment beyond spatial proximity

(2013) Sheng Wang et al.   Scientific Reports

A Hellinger distance approach to MCMC diagnostics

(2012) Edward L. Boone et al.   JOURNAL OF STATISTICAL COMPUTATION AND SIMULATION

Fitness analyses of all possible point mutations for regions of genes in yeast

(2012) Ryan Hietpas et al.   Nature Protocols

VISUALIZING FITNESS LANDSCAPES

(2011) David M. McCandlish   EVOLUTION

Experimental illumination of a fitness landscape

(2011) R. T. Hietpas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A biophysical protein folding model accounts for most mutational fitness effects in viruses

(2011) C. S. Wylie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Negative Epistasis Between Beneficial Mutations in an Evolving Bacterial Population

(2011) A. I. Khan et al.   SCIENCE

Evolutionary Accessibility of Mutational Pathways

(2011) Jasper Franke et al.   PLoS Computational Biology

The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts

(2010) R. Craig MacLean et al.   NATURE REVIEWS GENETICS

Mutational effects and the evolution of new protein functions

(2010) Misha Soskine et al.   NATURE REVIEWS GENETICS

The Genetic Landscape of a Cell

(2010) M. Costanzo et al.   SCIENCE

The Properties of Adaptive Walks in Evolving Populations of Fungus

(2009) Sijmen E. Schoustra et al.   PLOS BIOLOGY

Positive Epistasis Drives the Acquisition of Multidrug Resistance

(2009) Sandra Trindade et al.   PLoS Genetics

Synergistic Fitness Interactions and a High Frequency of Beneficial Changes Among Mutations Accumulated Under Relaxed Selection in Saccharomyces cerevisiae

(2008) W. J. Dickinson   GENETICS