Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Vasily N. Sukhorukov, Alexandra A. Melnichenko, Victoria A. Khotina, Alexander N. Orekhov
Summary: Selenium is a vital trace element necessary for metabolic processes, protection against oxidative stress, and cardiovascular system functioning. Deficiency in selenium has been linked to various cardiovascular diseases including Keshan's disease, heart failure, coronary heart disease, myocardial infarction, and atherosclerosis. Through selenoenzymes and selenoproteins, selenium is involved in important processes such as regulation of redox homeostasis, oxidative stress, calcium flux, and thyroid hormone metabolism; an imbalance in selenium supply may disrupt these processes.
Article
Biochemistry & Molecular Biology
Barbara Rita Cardoso, Larissa Lago, Aimee Linda Dordevic, Eugene Anthony Kapp, Anna M. Raines, Roger A. Sunde, Blaine Russel Roberts
Summary: The study identified candidate proteins in the liver regulated by dietary selenium intake, ranging from deficiency to toxic levels, and found a U-shaped dose-response relationship between selenium status and health outcomes. The results suggest that changes in selenium levels can impact the metabolism of glutathione, xenobiotics, and amino acids in the body.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Kaitlin Day, Lucia A. Seale, Ross M. Graham, Barbara R. Cardoso
Summary: Observational studies suggest that selenium may be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), with the possibility of lower selenium levels in the liver of NAFLD patients due to increased consumption. Variations in gene expression may be associated with the progressive risk of NAFLD, with differences in gene expression levels in certain selenoprotein pathways between NAFLD patients and healthy individuals.
FRONTIERS IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Claire Hogan, Anthony V. Perkins
Summary: Selenium is an essential trace element for human health, and deficiency can lead to various diseases. Selenium is incorporated into selenoproteins, which play important roles in antioxidant defense, signaling, hormone production, DNA synthesis, and protein response. This review highlights the importance of selenium for a healthy pregnancy and the role of placental selenoproteins in early life development.
Article
Plant Sciences
Tao Liu, Xiaoting Liu, Rangrang Zhou, Hong Chen, Huaigang Zhang, Bo Zhang
Summary: Selenium is shown to have a significant impact on gene expression in oats, particularly in key genes related to selenate metabolism. The study identified 27 unigenes associated with selenate metabolism, with key genes exhibiting dramatic upregulation under selenate treatment. The research provides insights into the mechanisms underlying selenium uptake and metabolism in oats under high-selenium conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Sarah P. Short, Jennifer M. Pilat, Caitlyn W. Barrett, Vishruth K. Reddy, Yael Haberman, Jared R. Hendren, Benjamin J. Marsh, Cody E. Keating, Amy K. Motley, Kristina E. Hill, Anne E. Zemper, M. Kay Washington, Chanjuan Shi, Xi Chen, Keith T. Wilson, Jeffrey S. Hyams, Lee A. Denson, Raymond F. Burk, Michael J. Rosen, Christopher S. Williams
Summary: Patients with inflammatory bowel disease (IBD) often have nutritional selenium deficiencies and are at higher risk of developing colon cancer. Research has shown that reduction of the antioxidant protein SELENOP can increase tumor development in colitis-associated cancer models, with epithelial-specific deletion of SELENOP leading to elevated oxidative stress and tumor initiation. This suggests that colonic SELENOP levels may serve as a biomarker for disease severity and cancer predisposition in IBD patients.
Review
Nutrition & Dietetics
Xin Huang, Yu-Lan Dong, Tong Li, Wei Xiong, Xu Zhang, Peng-Jie Wang, Jia-Qiang Huang
Summary: Selenium is essential for maintaining a healthy physiological state, but deficiencies or excesses can lead to various diseases related to cognitive decline, immune disorders, and metabolic risks. MiRNAs play crucial roles in regulating interactions between the environment and genes, but the mechanisms of selenium metabolism and miRNA regulation remain unclear.
Review
Biochemistry & Molecular Biology
Carmen Beatrice Dogaru, Corina Muscurel, Carmen Duta, Irina Stoian
Summary: This review discusses the identity and functions of several less-known selenoproteins, which play important roles in various physiological and pathogenic processes, including antioxidant defense, anti-inflammation, anti-apoptosis, and immune and inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Rannapaula Lawrynhuk Urbano Ferreira, Karine Cavalcanti Mauricio Sena-Evangelista, Eduardo Pereira de Azevedo, Francisco Irochima Pinheiro, Ricardo Ney Cobucci, Lucia Fatima Campos Pedrosa
Summary: Selenium plays a crucial role in various bodily functions and maintaining a healthy gut microbiota. Its symbiotic relationship with gut bacteria helps in improving the bioavailability of selenocompounds and balancing microbial flora to prevent health damage associated with dysbiosis. However, selenium deficiency can lead to a phenotype of gut microbiota that is more susceptible to certain diseases, highlighting the importance of adequate selenium intake for both human and bacterial health.
FRONTIERS IN NUTRITION
(2021)
Review
Neurosciences
Daniel J. Torres, Naghum Alfulaij, Marla J. Berry
Summary: The stress response is crucial for organisms to survive adverse environmental conditions, although high levels of stress hormone glucocorticoids can have negative effects on the brain. Selenium, an antioxidant micronutrient, has been shown to protect against the impact of external stress and normalize neurological function.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Ruihua Ye, Jiaqiang Huang, Zixu Wang, Yaoxing Chen, Yulan Dong
Summary: Selenium, as an essential trace element, has been proven effective in alleviating intestinal diseases such as inflammatory bowel diseases due to its excellent antioxidant function. Intestinal diseases caused by chronic inflammation are among the most important threats to human health, and selenium plays a role in mitigating their impact.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Briana K. Shimada, Naghum Alfulaij, Lucia A. Seale
Summary: Selenium is an essential trace element crucial for cardiovascular health through its incorporation into selenoproteins, which are key to maintaining proper cardiovascular function. Deficiency in selenium can lead to various cardiovascular diseases, and selenium may potentially serve as a complementary therapy for prevention or treatment of cardiovascular disease by interacting with microRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Giuseppe Genchi, Graziantonio Lauria, Alessia Catalano, Maria Stefania Sinicropi, Alessia Carocci
Summary: Selenium is a vital element for human and animal health, playing a significant role in various bodily functions. However, excessive intake of selenium can be harmful. It supports antioxidant defense systems, hormone metabolism, reproductive functions, and neuroprotection. Optimizing selenium intake is important for preventing diseases related to selenium deficiency or excess.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Nada F. Abo El-Magd, Priscila O. Barbosa, Julia Nick, Viviana Covalero, Giacomo Grignetti, Giovanna Bermano
Summary: The study showed that selenium as selenite prevented adipogenesis by increasing antioxidant selenoprotein expression, reducing inflammatory markers, leading to decreased differentiation and lipid deposition, providing potential insights for preventing obesity through novel dietary approaches.
Article
Biochemistry & Molecular Biology
Brenna Flowers, Allison Poles, Irida Kastrati
Summary: There is an urgent need for new and improved therapeutic strategies in breast cancer, and selenium supplementation may play a critical role in improving breast cancer survival rates. However, further research is needed to understand the tissue-specific mechanisms and genetic variations related to selenium's effects.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Ran Tian, Kai Han, Yuepan Geng, Chen Yang, Chengcheng Shi, Patrick Thomas, Coral Pearce, Kate Moffatt, Siming Ma, Shixia Xu, Guang Yang, Xuming Zhou, Vadim N. Gladyshev, Xin Liu, Diana O. Fisher, Lisa K. Chopin, Natalia O. Leiner, Andrew M. Baker, Guangyi Fan, Inge Seim
Summary: The 15 species of Antechinus exhibit a rare life-history strategy called semelparity, with males experiencing rapid aging during the breeding season. Genome research on these species provides insights into their genetic characteristics and aging mechanisms, aiding in the conservation of these unique animals.
MOLECULAR ECOLOGY RESOURCES
(2022)
Review
Cell Biology
Bohan Zhang, Alexandre Trapp, Csaba Kerepesi, Vadim N. Gladyshev
Summary: There are interventions proposed to reverse aging rather than just slow it down, but the criteria for achieving rejuvenation are still controversial. A key prerequisite for a rejuvenation intervention is a significant reduction in biological age, which can be assessed by biomarkers such as epigenetic clocks.
Review
Biochemistry & Molecular Biology
Petra A. Tsuji, Didac Santesmasses, Byeong J. Lee, Vadim N. Gladyshev, Dolph L. Hatfield
Summary: Selenium is an essential element in the diet and has many health benefits, such as preventing heart disease and cancer, supporting male reproduction, and boosting the immune system. It plays important roles in the molecular biology of organisms and its incorporation into proteins is a unique feature. Research has focused on selenium's role in cancer prevention and its potential involvement in various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Donghyun Kang, Jeeyeon Lee, Jisu Jung, Bradley A. Carlson, Moon Jong Chang, Chong Bum Chang, Seung-Baik Kang, Byung Cheon Lee, Vadim N. Gladyshev, Dolph L. Hatfield, Byeong Jae Lee, Jin-Hong Kim
Summary: Osteoarthritis is caused by the accumulation of oxidative stress. This study reveals that dysregulation of the selenium metabolic pathway disrupts redox homeostasis in chondrocytes, leading to the development of osteoarthritis. The downregulation of SEPHS1 impairs the synthesis of oxidoreductase selenoproteins, increases reactive oxygen species levels, and induces chondrocyte senescence.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Sylvain Garciaz, Andrew A. Guirguis, Sebastian Muller, Fiona C. Brown, Yih-Chih Chan, Ali Motazediani, Caitlin L. Rowe, James A. Kuzich, Kah Lok Chan, Kevin Tran, Lorey Smith, Laura MacPherson, Brian Liddicoat, Enid Y. N. Lam, Tatiana Caneque, Marian L. Burr, Veronique Litalien, Giovanna Pomilio, Mathilde Poplineau, Estelle Duprez, Sarah-Jane Dawson, Georg Ramm, Andrew G. Cox, Kristin K. Brown, David C. S. Huang, Andrew H. Wei, Kate McArthur, Raphael Rodriguez, Mark A. Dawson
Summary: Ironomycin is a drug that disrupts mitochondrial metabolism and induces cell death in cancer cells by reducing mitochondrial iron load and activating BAX/BAK. It exhibits synergy with BH3 mimetics and overcomes venetoclax resistance in cancers such as acute myeloid leukemia.
Article
Cell Biology
Srimayee Vaidyanathan, Talhah M. Salmi, Rasan M. Sathiqu, Malcolm J. McConville, Andrew G. Cox, Kristin K. Brown
Summary: The study demonstrates that YAP utilizes the SREBP-dependent lipogenic program to promote cell proliferation and tissue growth. YAP-dependent regulation of SGK1 is essential for activating lipid synthesis and stimulating de novo lipogenesis. Targeting de novo lipogenesis could disrupt YAP-dependent proliferation and tissue growth.
DEVELOPMENTAL CELL
(2022)
Article
Biochemistry & Molecular Biology
Lake-Ee Quek, Michelle van Geldermalsen, Yi Fang Guan, Kanu Wahi, Chelsea Mayoh, Seher Balaban, Angel Pang, Qian Wang, Mark J. Cowley, Kristin K. Brown, Nigel Turner, Andrew J. Hoy, Jeff Holst
Summary: This study reveals that glutamine-indispensable triple-negative breast cancer (TNBC) cells rely on a non-canonical glutamine-to-glutamate overflow, which increases TCA cycle fluxes and replenishes TCA cycle intermediates. The coupling of glucose and glutamine catabolism hampers TNBC cells' ability to oxidize glucose when glutamine is limiting.
Article
Endocrinology & Metabolism
Tiffany M. Richardson, Diane C. Saunders, Rachana Haliyur, Shristi Shrestha, Jean-Philippe Cartailler, Rachel B. Reinert, Jenna Petronglo, Rita Bottino, Radhika Aramandla, Amber M. Bradley, Regina Jenkins, Sharon Phillips, Hakmook Kang, Alejandro Caicedo, Alvin C. Powers, Marcela Brissova
Summary: The autonomic nervous system regulates pancreatic function. Islet capillaries and nerve fibers in islets play important roles in islet hormone secretion. In type 1 diabetes, beta cell loss results in a decline in intraislet capillaries and reduction of islet innervation, possibly contributing to abnormal glucagon secretion.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Oncology
Gio Fidelito, David P. De Souza, Birunthi Niranjan, William De Nardo, Shivakumar Keerthikumar, Kristin Brown, Renea A. Taylor, Matthew J. Watt
Summary: Cancer cells undergo metabolic reprogramming to meet increased bioenergetic demands. Glucose, glutamine, and fatty acid oxidation were upregulated in malignant PDXs compared with benign PDXs. Fatty acid uptake and oxidation are targetable metabolic dependencies in human prostate cancer.
MOLECULAR CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Athena Jessica S. Ong, Cerys E. Bladen, Tara A. Tigani, Anthony P. Karamalakis, Kimberley J. Evason, Kristin K. Brown, Andrew G. Cox
Summary: The maintenance of redox and metabolic homeostasis is crucial for embryonic development. The transcription factor NRF2 plays a central role in regulating redox balance and cellular metabolism and is repressed by KEAP1 under normal conditions. In this study, we show that loss of Keap1 leads to activation of Nrf2 and postdevelopmental lethality due to severe liver abnormalities characterized by an accumulation of lysosomes. We also demonstrate that loss of Keap1 promotes aberrant activation of transcription factors TFEB and TFE3, resulting in lysosomal biogenesis. The findings highlight the importance of the KEAP1-NRF2 pathway in regulating lysosomal homeostasis during embryonic development.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemical Research Methods
Ellen M. Quardokus, Diane C. Saunders, Elizabeth McDonough, John W. Hickey, Christopher Werlein, Christine Surrette, Presha Rajbhandari, Anna Martinez Casals, Hua Tian, Lisa Lowery, Elizabeth K. Neumann, Frida Bjoerklund, Taruna V. Neelakantan, Josh Croteau, Anne E. Wiblin, Jeremy Fisher, April J. Livengood, Karen G. Dowell, Jonathan C. Silverstein, Jeffrey M. Spraggins, Gloria S. Pryhuber, Gail Deutsch, Fiona Ginty, Garry P. Nolan, Simon Melov, Danny Jonigk, Michael A. Caldwell, Ioannis S. Vlachos, Werner Muller, Nils Gehlenborg, Brent R. Stockwell, Emma Lundberg, Michael P. Snyder, Ronald N. Germain, Jeannie M. Camarillo, Neil L. Kelleher, Katy Boerner, Andrea J. Radtke
Summary: Organ Mapping Antibody Panels are standardized antibody panels created by the community for multiplexed spatial imaging. This imaging technique allows detailed characterization of molecular and cellular organization in tissues. Although high-parameter data collection is now possible (>60 targets), constructing the necessary antibody panels requires expertise and capital. Organ Mapping Antibody Panels are community-validated resources that save time and money, enhance reproducibility, expedite discovery, and support the creation of a Human Reference Atlas.
Article
Multidisciplinary Sciences
John T. Walker, Diane C. Saunders, Vivek Rai, Hung-Hsin Chen, Peter Orchard, Chunhua Dai, Yasminye D. Pettway, Alexander L. Hopkirk, Conrad V. Reihsmann, Yicheng Tao, Simin Fan, Shristi Shrestha, Arushi Varshney, Lauren E. Petty, Jordan J. Wright, Christa Ventresca, Samir Agarwala, Radhika Aramandla, Greg Poffenberger, Regina Jenkins, Shaojun Mei, Nathaniel J. Hart, Sharon Phillips, Hakmook Kang, Dale L. Greiner, Leonard D. Shultz, Rita Bottino, Jie Liu, Jennifer E. Below, Stephen C. J. Parker, Alvin C. Powers, Marcela Brissova
Summary: Integration of multiomics data with functional analysis of pancreatic tissues from individuals with early-stage type 2 diabetes indicates that the genetic risk converges on RFX6, which regulates chromatin architecture at multiple risk loci.
Article
Cell Biology
Esther Meron, Maria Thaysen, Suzanne Angeli, Adam Antebi, Nir Barzilai, Joseph A. Baur, Simon Bekker-Jensen, Maria Birkisdottir, Evelyne Bischof, Jens Bruening, Anne Brunet, Abigail Buchwalter, Filipe Cabreiro, Shiqing Cai, Brian H. Chen, Maria Ermolaeva, Collin Y. Ewald, Luigi Ferrucci, Maria Carolina Florian, Kristen Fortney, Adam Freund, Anastasia Georgievskaya, Vadim N. Gladyshev, David Glass, Tyler Golato, Vera Gorbunova, Jan Hoejimakers, Riekelt H. Houtkooper, Sibylle Jager, Frank Jaksch, Georges Janssens, Martin Borch Jensen, Matt Kaeberlein, Gerard Karsenty, Peter de Keizer, Brian Kennedy, James L. Kirkland, Michael Kjaer, Guido Kroemer, Kai-Fu Lee, Jean-Marc Lemaitre, David Liaskos, Valter D. Longo, Yu-Xuan Lu, Michael R. MacArthur, Andrea B. Maier, Christina Manakanatas, Sarah J. Mitchell, Alexey Moskalev, Laura Niedernhofer, Ivan Ozerov, Linda Partridge, Emmanuelle Passegue, Michael A. Petr, James Peyer, Dina Radenkovic, Thomas A. Rando, Suresh Rattan, Christian G. Riedel, Lenhard Rudolph, Ruixue Ai, Manuel Serrano, Bjoern Schumacher, David A. Sinclair, Ryan Smith, Yousin Suh, Pam Taub, Alexandre Trapp, Anne-Ulrike Trendelenburg, Dario Riccardo Valenzano, Kris Verburgh, Eric Verdin, Jan Vijg, Rudi G. J. Westendorp, Alessandra Zonari, Daniela Bakula, Alex Zhavoronkov, Morten Scheibye-Knudsen
Summary: Aging is the biggest risk factor for most chronic diseases, attracting attention from industry and investors. This year's ARDD meeting featured presentations from 75 speakers and included a longevity workshop to discuss aging mechanisms and potential modifications.