Article
Gastroenterology & Hepatology
Kyle G. Williams, Ramya Kongala, Donna M. Shows, Andrew J. Konecny, Duncan C. Hindmarch, Astrid S. Clarke, James D. Lord
Summary: CD8 T-cell clones are found homogeneously throughout the length of the colon in patients with inflammatory bowel disease (IBD), regardless of inflammation. There is a high degree of repertoire overlap for T-cell receptor (TCR) between the colon and peripheral blood, suggesting T-cell trafficking plays a significant role in the pathogenesis of IBD, particularly in relation to the alpha 4 beta 7+ T-cell subpopulation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2024)
Article
Immunology
Christelle Harly, Jacques Robert, Francois Legoux, Olivier Lantz
Summary: Innate-like T cells display characteristics of both ILCs and mainstream alpha beta T cells, and are probably present in all vertebrates. Their main characteristics are better known in amphibians and mammals. These cells include both gamma delta and alpha beta T cells, and each subset fulfills nonredundant roles related to their Ag specificity.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Lucy C. Garner, Ali Amini, Michael E. B. FitzPatrick, Martin J. Lett, Gabriel F. Hess, Magdalena Filipowicz Sinnreich, Nicholas M. Provine, Paul Klenerman
Summary: Garner et al. analyzed the single-cell transcriptome and TCR repertoire of matched blood and liver, and resting and activated, human MAIT cells. They identify donor-specific TCR repertoires shared across tissues and a transcriptome that is largely homogeneous at rest, but highly adaptive to different tissue and stimulation environments.
Article
Immunology
Kristin Schubert, Isabel Karkossa, Jana Schor, Beatrice Engelmann, Lisa Maria Steinheuer, Tony Bruns, Ulrike Rolle-Kampczyk, Joerg Hackermueller, Martin von Bergen
Summary: Research on MAIT cells reveals that their activation can be achieved by recognizing bacterial metabolites via TCR or in a TCR-independent manner through cytokines. By using multi-omics approach including transcriptomics, proteomics and metabolomics, it was found that MAIT cells undergo distinct transcriptional reprogramming under different activation modes, affecting their effector molecules and phenotype. Full activation of MAIT cells is achieved only when both IL12/IL18 and anti-CD3/CD28 are used simultaneously, with key drivers including cytokines and transcription factors.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Kimberly G. Laffey, Robert J. Stiles, Melissa J. Ludescher, Tessa R. Davis, Shariq S. Khwaja, Richard J. Bram, Peter J. Wettstein, Venkataraman Ramachandran, Christopher A. Parks, Edwin E. Reyes, Alejandro Ferrer, Jenna M. Canfield, Cory E. Johnson, Richard D. Hammer, Diana Gil, Adam G. Schrum
Summary: During normal T cell development, a low-frequency population of early all TCR+ DN cells is present, which requires CD3δ for their generation/detection. These cells can respond to MHC and display coreceptor-independent MHC reactivity. It has been observed that these cells are susceptible to T-ALL transformation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Immunology
Sai Harsha Krovi, Vijay K. Kuchroo
Summary: Autoimmune diseases are characterized by dysfunctional immune systems causing tissue destruction. CD4(+) T lymphocytes play crucial roles, requiring activation through three signals. Disruption of these signals in autoimmunity leads to loss of tolerance in CD4(+) T cells.
IMMUNOLOGICAL REVIEWS
(2022)
Article
Multidisciplinary Sciences
Orsolya Vincze, Fernando Colchero, Jean-Francois Lemaitre, Dalia A. Conde, Samuel Pavard, Margaux Bieuville, Araxi O. Urrutia, Beata Ujvari, Amy M. Boddy, Carlo C. Maley, Frederic Thomas, Mathieu Giraudeau
Summary: The study analyzed data on adult zoo mammals and found that cancer is prevalent and has a high frequency in mammals, with significant differences in cancer mortality rates across different mammalian orders. The research also showed that diet is associated with cancer mortality, with carnivorous mammals facing the highest cancer-related mortality. Furthermore, the study provided unequivocal evidence that cancer mortality risk is largely independent of body mass and adult life expectancy across species.
Article
Immunology
Yang Wang, Alexandra Tsitsiklis, Stephanie Devoe, Wei Gao, H. Hamlet Chu, Yan Zhang, Wei Li, Wing Ki Wong, Charlotte M. Deane, David Neau, Jill E. Slansky, Paul G. Thomas, Ellen A. Robey, Shaodong Dai
Summary: Certain CD8 T cell responses, such as those found in individuals harboring HLA-B57 and controlling HIV infection, are highly effective. A study focused on a protective CD8 T cell response against a parasite-derived peptide called HF10 found that this response is characterized by a specific T cell receptor (TCR) repertoire dominated by V beta 2. The study also revealed an unusual structure of the TCR in complex with the peptide-presenting molecule (MHC), with both MHC and TCR contributing extensively to peptide specificity and leaving a parallel footprint on the TCR's pMHC ligand. These findings suggest that V beta 2 and the molecule H-2Ld may play specialized roles in antigen recognition, leading to strong and focused T cell responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Erin W. Meermeier, Christina L. Zheng, Jessica G. Tran, Shogo Soma, Aneta H. Worley, David Weiss, Robert L. Modlin, Gwendolyn Swarbrick, Elham Karamooz, Sharon Khuzwayo, Emily B. Wong, Marielle C. Gold, David M. Lewinsohn
Summary: Human lung-resident MAIT cells are polycytotoxic, secrete antimicrobial molecules, express genes associated with persistence, and selectively express cytokine and chemokine-related molecules. These characteristics make MAIT cells early sensors in the defense of the respiratory barrier.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marco Lepore, Deborah A. Lewinsohn, David M. Lewinsohn
Summary: MR1, a monomorphic MHC-class I-like molecule, presents small metabolites to T cells, and is the restriction element for microbe-reactive MAIT cells. Besides microbial metabolites, MR1 has the capacity to bind diverse chemical entities like folate-derivatives and drug-like molecules. Recent studies have identified non-canonical subsets of MR1-restricted T cells based on their reactivity to various microbes and non-microbial cellendogenous ligands.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Filippo Grazioli, Anja Moesch, Pierre Machart, Kai Li, Israa Alqassem, Timothy J. O'Donnell, Martin Renqiang Min
Summary: This study investigates the generalization ability of state-of-the-art deep learning models for TCR-peptide/-pMHC binding prediction to unseen peptides. The results show that these models fail to perform well on peptides that are not included in the training set, and provide an explanation for this phenomenon.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Lihua Deng, Cedric Ly, Sina Abdollahi, Yu Zhao, Immo Prinz, Stefan Bonn
Summary: This study provides a general method for collecting and preprocessing TCR-pMHC binding data and generates comprehensive datasets for comparing prediction models. The performance evaluation of five deep learning models reveals that they have limitations in generalization and robustness. These findings suggest that TCR-pMHC binding prediction remains challenging and requires further improvement in data quality and algorithmic approaches.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rajesh Lamichhane, Fran Munro, Thomas W. R. Harrop, Sara M. de la Harpe, Peter K. Dearden, Andrea J. Vernall, John L. McCall, James E. Ussher
Summary: MAIT cells from liver and blood show comparable responses to TCR signals, but liver MAIT cells exhibit greater polyfunctionality than blood MAIT cells following cytokine stimulation. Transcriptomic analysis reveals distinct effector programs in liver MAIT cells under different activation modes.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Ecology
Ke He, Ying Zhu, Shang-Chen Yang, Qing Ye, Sheng-Guo Fang, Qiu-Hong Wan
Summary: The study on the MHC gene structure of the Chinese alligator reveals the presence of Class I and Class II subregions, a unique CD1 subregion, multiple groups of MHC class I and class II duplicated loci, and a mechanism for polymorphism in antigen presentation.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Immunology
Marcela de Lima Moreira, Luana Oliveira Borges-Fernandes, Marcelo Antonio Pascoal-Xavier, Agata Lopes Ribeiro, Victoria Hellena Silva Pereira, Troi Pediongco, Marcio Sobreira da Silva Araujo, Andrea Teixeira-Carvalho, Andrea Lucchesi de Carvalho, Maria Vitoria Assumpcao Mourao, Flavia Alves Campos, Marineide Borges, Mariangela Carneiro, Zhenjun Chen, Eleanor Saunders, Malcolm McConville, Moriya Tsuji, James McCluskey, Olindo Assis Martins-Filho, Sidonia Barbara Guiomar Eckle, Jordana Grazziela Alves Coelho-dos-Reis, Vanessa Peruhype-Magalhaes
Summary: This study reveals the role of MAIT cells in protecting against visceral leishmaniasis, expanding our understanding of MAIT-cell immunity beyond bacterial and viral infections. The findings highlight the potential of MAIT-cell-based therapeutics and vaccines for the treatment and prevention of parasitic infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Andre Megarbane, Sami Bizzari, Asha Deepthi, Sandra Sabbagh, Hicham Mansour, Eliane Chouery, Ghassan Hmaimess, Rosette Jabbour, Cybel Mehawej, Saada Alame, Abeer Hani, Dana Hasbini, Ismat Ghanem, Salam Koussa, Mahmoud Taleb Al-Ali, Marc Obeid, Diana Bou Talea, Gerard Lefranc, Nicolas Levy, France Leturcq, Stephany El Hayek, Valerie Delague, J. Andoni Urtizberea
Summary: The occurrence and frequency of inherited neuromuscular disorders (NMD) in the Lebanese population are underreported. This study provides a retrospective overview of hereditary NMDs based on clinical consultations in Lebanon. A total of 506 patients were diagnosed with 62 different disorders, with motor neuron diseases and muscular dystrophies being the most common.
JOURNAL OF NEUROMUSCULAR DISEASES
(2022)
Article
Nutrition & Dietetics
Stanislas Mondot, Laurine Lachkar, Joel Dore, Herve M. Blottiere, Mouna Hanachi
Summary: Anorexia nervosa is a severe eating disorder with high mortality rates. This study found reduced abundance, diversity, and richness of Roseburia genus in the gut microbiota of patients with AN. Treatment during hospitalization did not fully restore these levels. Dietary habit did not affect the abundance of Roseburia.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2022)
Correction
Immunology
Haifa H. Jabara, Douglas R. McDonald, Erin Janssen, Michel J. Massaad, Narayanaswamy Ramesh, Arturo Borzutzky, Ingrid Rauter, Halli Benson, Lynda Schneider, Sachin Baxi, Mike Recher, Luigi D. Notarangelo, Rima Wakim, Ghassan Dbaibo, Majed Dasouki, Waleed Al-Herz, Isil Barlan, Safa Baris, Necil Kutukculer, Hans D. Ochs, Alessandro Plebani, Maria Kanariou, Gerard Lefranc, Ismail Reisli, Katherine A. Fitzgerald, Douglas Golenbock, John Manis, Sevgi Keles, Reuben Ceja, Talal A. Chatila, Raif S. Geha
Article
Immunology
Giovanna Linguiti, Vincenzo Tragni, Ciro Leonardo Pierri, Serafina Massari, Marie-Paule Lefranc, Rachele Antonacci, Salvatrice Ciccarese
Summary: This study investigates the 3D structure of human and dromedary γδ T cell receptors to understand how they recognize antigen in an antibody-like fashion. The results show that the interactions between the V domains of TRG and TRD, as well as between the V domains and CD1D G domains, are stable.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Kensuke Shibata, Takashi Shimizu, Mashio Nakahara, Emi Ito, Francois Legoux, Shotaro Fujii, Yuka Yamada, Makoto Furutani-Seiki, Olivier Lantz, Sho Yamasaki, Masahisa Watarai, Mutsunori Shirai
Summary: Intracellular pathogen Francisella tularensis can acquire immune evasion capacity by altering its metabolic programs, which affects host immune response.
LIFE SCIENCE ALLIANCE
(2022)
Correction
Biology
Kensuke Shibata, Takashi Shimizu, Mashio Nakahara, Emi Ito, Francois Legoux, Shotaro Fujii, Yuka Yamada, Makoto Furutani-Seiki, Olivier Lantz, Sho Yamasaki, Masahisa Watarai, Mutsunori Shirai
LIFE SCIENCE ALLIANCE
(2022)
Article
Immunology
Anastasia du Halgouet, Aurelie Darbois, Mansour Alkobtawi, Martin Mestdagh, Aurelia Alphonse, Virginie Premel, Thomas Yvorra, Ludovic Colombeau, Raphael Rodriguez, Dietmar Zaiss, Yara El Morr, Helene Bugaut, Francois Legoux, Laetitia Perrin, Selim Aractingi, Rachel Golub, Olivier Lantz, Marion Salou
Summary: Tissue repair processes are important for maintaining organ function after mechanical or infection-related damage. Mucosal associated invariant T (MAIT) cells not only possess antibacterial properties but also play a role in tissue repair and promote skin wound healing. In this study, a human-like mouse model was used to investigate the mechanisms behind the tissue repair function of MAIT cells. The results showed that skin MAIT cells already expressed a repair program at steady state and promoted keratinocyte proliferation to accelerate wound healing. MAIT cells migrated to the wound in a T cell receptor-independent but CXCR6 chemokine receptor-dependent manner and secreted Amphiregulin to facilitate wound healing. The expression of the repair function was likely independent of sustained TCR stimulation. Overall, this study provides insights into the mechanisms of MAIT cell wound healing function in the skin.
Correction
Immunology
Francois Legoux, Jules Gilet, Emanuele Procopio, Klara Echasserieau, Karine Bernardeau, Olivier Lantz
Article
Oncology
Edith Borcoman, Ana Lalanne, Jean-Pierre Delord, Philippe A. Cassier, Frederic Rolland, Sebastien Salasi, Jean-Marc Limacher, Olivier Capitain, Olivier Lantz, Christina Ekwegbara, Emmanuelle Jeannot, Joanna Cyrta, Carine Tran-Perennou, Zahra Castel-Ajgal, Gregoire Marret, Eliane Piaggio, Maud Brandely, Annette Tavernaro, Hakim Makhloufi, Kaidre Bendjama, Christophe Le Tourneau
Summary: This study evaluated the use of the TG4001 viral immunotherapeutic vaccine in combination with avelumab in HPV16+ cancer patients, and found that it was safe and effective in treating this type of cancer.
EUROPEAN JOURNAL OF CANCER
(2023)
Meeting Abstract
Oncology
Caroline Hoffmann, Floriane Noel, Maximilien Grandclaudon, Lucile Massenet-Regad, Paula Michea, Philemon Sirven, Lilith Faucheux, Aurore Surun, Olivier Lantz, Mylene Bohec, Jian Ye, Weihua Guo, Juliette Rochefort, Jerzy Klijanienko, Sylvain Baulande, Charlotte Lecerf, Maud Kamal, Christophe Le Tourneau, Maude Guillot-Delost, Vassili Soumelis
Meeting Abstract
Oncology
Matthew S. Block, Jean-Pierre Delord, Christian H. Ottensmeier, Christophe Le Tourneau, Ana Lalanne, Olivier Lantz, Keith L. Knutson, Gisele Lacoste, Annette Tavernaro, Maud Brandely, Nathalie Silvestre, Benoit Grellier, Yoshiko Yamashita, Onoue Kousuke, Naoko Yamagata, Eric Quemeneur, Kaidre Bendjama
Article
Immunology
Marie-Paule Lefranc, Gerard Lefranc
Summary: The constant region of immunoglobulin heavy chain can be engineered to modify therapeutic monoclonal antibodies' effector properties. These variants can affect various effector functions and structural features, and they are classified and identified using a naming system. Detailed amino acid changes are provided in the description of IMGT engineered variants for comprehensive analysis of genes, sequences, and structures.
Meeting Abstract
Oncology
Jean-Pierre Delord, Matthew Stephen Block, Christian Ottensmeier, Gerardo Colon-Otero, Christophe Le Tourneau, Ana Lalanne, Camille Jamet, Olivier Lantz, Keith L. Knutson, Gisele Lacoste, Annette Tavernaro, Maud Brandely-Talbot, Nathalie Silvestre, Benoit Grellier, Brandon Malone, Yuki Tanaka, Kousuke Onoue, Yoshiko Yamashita, Eric Quemeneur, Kaidre Bendjama
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Immunology
Olivier Lantz, Luc Teyton
Summary: Identifying antigens recognized by T cells, especially innate-like T cells, remains a challenge due to their inability to recognize peptides and instead rely on small metabolites or lipids presented by MHC-like or non-MHC restricted antigens. The low affinity of T cell receptors for their ligands and the degeneracy of binding to antigen presenting cell surfaces contribute to this challenge. In this article, we discuss various methods used to identify peptide antigens and highlight the role of serendipity in the discovery of molecules recognized by innate-like T cells (NKT, MAIT, and gamma delta T cells).
SEMINARS IN IMMUNOLOGY
(2022)
Article
Immunology
Christelle Harly, Jacques Robert, Francois Legoux, Olivier Lantz
Summary: Innate-like T cells display characteristics of both ILCs and mainstream alpha beta T cells, and are probably present in all vertebrates. Their main characteristics are better known in amphibians and mammals. These cells include both gamma delta and alpha beta T cells, and each subset fulfills nonredundant roles related to their Ag specificity.
JOURNAL OF IMMUNOLOGY
(2022)
