期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 35, 页码 E5153-E5162出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1602739113
关键词
Notch; lateral inhibition; EGF; reaction diffusion; proneural wave
资金
- Precursory Research for Embryonic Science and Technology from Japan Science and Technology Agency (JST)
- Ministry of Education, Culture, Sports, Science, and Technology
- Sekisui Chemical Grant Program
- Asahi Glass Foundation
- Core Research for Evolutional Science and Technology from JST
- Cooperative Research of Network Joint Research Center for Materials and Devices
- Grants-in-Aid for Scientific Research [15KT0104, 26247015] Funding Source: KAKEN
Notch-mediated lateral inhibition regulates binary cell fate choice, resulting in salt and pepper patterns during various developmental processes. However, how Notch signaling behaves in combination with other signaling systems remains elusive. The wave of differentiation in the Drosophila visual center or proneural wave accompanies Notch activity that is propagated without the formation of a salt and pepper pattern, implying that Notch does not form a feedback loop of lateral inhibition during this process. However, mathematical modeling and genetic analysis clearly showed that Notch-mediated lateral inhibition is implemented within the proneural wave. Because partial reduction in EGF signaling causes the formation of the salt and pepper pattern, it is most likely that EGF diffusion cancels salt and pepper pattern formation in silico and in vivo. Moreover, the combination of Notch-mediated lateral inhibition and EGF-mediated reaction diffusion enables a function of Notch signaling that regulates propagation of the wave of differentiation.
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