Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients

Constitutive activation of Pim1 kinase is a therapeutic target for adult T-cell leukemia

(2016) M. Bellon et al.   BLOOD

Emerging roles for the FBXW7 ubiquitin ligase in leukemia and beyond

(2015) Nikos Kourtis et al.   CURRENT OPINION IN CELL BIOLOGY

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia

(2015) Christophe Nicot   Journal of Oncology

Aberrant regulation of FBW7 in cancer

(2015) Lixia Wang et al.   Oncotarget

Tumor Suppression by the Fbw7 Ubiquitin Ligase: Mechanisms and Opportunities

(2014) Ryan J. Davis et al.   CANCER CELL

Tax impairs DNA replication forks and increases DNA breaks in specific oncogenic genome regions

(2014) Hassiba Chaib-Mezrag et al.   Molecular Cancer

Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence

(2013) Shoichiro Takeishi et al.   CANCER CELL

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

(2013) Bryan King et al.   CELL

Investigation of the atypicalFBXW7mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines

(2013) Hayley Davis et al.   GUT

FBXW7 regulates glucocorticoid response in T-cell acute lymphoblastic leukaemia by targeting the glucocorticoid receptor for degradation

(2012) A Malyukova et al.   LEUKEMIA

Impact of NOTCH1/FBXW7 mutations on outcome in pediatric T-cell acute lymphoblastic leukemia patients treated on the MRC UKALL 2003 trial

(2012) S Jenkinson et al.   LEUKEMIA

Fbw7 and p53 Cooperatively Suppress Advanced and Chromosomally Unstable Intestinal Cancer

(2012) J. E. Grim et al.   MOLECULAR AND CELLULAR BIOLOGY

p53 mutations in cancer

(2012) Patricia A. J. Muller et al.   NATURE CELL BIOLOGY

HTLV-I Tax Increases Genetic Instability by Inducing DNA Double Strand Breaks during DNA Replication and Switching Repair to NHEJ

(2012) Hicham H. Baydoun et al.   PLoS One

MicroRNA-223 Regulates Cyclin E Activity by Modulating Expression of F-box and WD-40 Domain Protein 7

(2010) Yanfei Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia

(2010) J. Pancewicz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deregulation of microRNA involved in hematopoiesis and the immune response in HTLV-I adult T-cell leukemia

(2009) M. Bellon et al.   BLOOD

p53-Altered FBXW7 Expression Determines Poor Prognosis in Gastric Cancer Cases

(2009) T. Yokobori et al.   CANCER RESEARCH

Definition, Prognostic Factors, Treatment, and Response Criteria of Adult T-Cell Leukemia-Lymphoma: A Proposal From an International Consensus Meeting

(2008) Kunihiro Tsukasaki et al.   JOURNAL OF CLINICAL ONCOLOGY