期刊
CHINESE JOURNAL OF CHEMISTRY
卷 33, 期 4, 页码 418-424出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cjoc.201400829
关键词
organocatalysis; squaramide; heterocycles; Michael addition; cyclization
资金
- National Natural Science Foundation of China [21272024]
Enantioselective synthesis of biologically active dihydropyrano[2,3-c]pyrazoles has been achieved through a squaramide-catalysed Michael addition/Thorpe-Ziegler type cyclization cascade reaction between arylidenepyrazolones and malononitrile. A series of optically active dihydropyano[2,3-c]pyrazoles were obtained in excellent yields (up to 99%) and moderate to good enantioselectivities (up to 79% ee) under mild reaction conditions.
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