RNA polymerase II senses obstruction in the DNA minor groove via a conserved sensor motif

CDK7-Dependent Transcriptional Addiction in Triple-Negative Breast Cancer

(2015) Yubao Wang et al.   CELL

TP53 loss creates therapeutic vulnerability in colorectal cancer

(2015) Yunhua Liu et al.   NATURE

Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex

(2015) Lanfeng Wang et al.   NATURE

Impact of template backbone heterogeneity on RNA polymerase II transcription

(2015) L. Xu et al.   NUCLEIC ACIDS RESEARCH

Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions

(2015) Celine Walmacq et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting transcription regulation in cancer with a covalent CDK7 inhibitor

(2014) Nicholas Kwiatkowski et al.   NATURE

Strand-specific (asymmetric) contribution of phosphodiester linkages on RNA polymerase II transcriptional efficiency and fidelity

(2014) L. Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetic Assay for Transcription Errors Reveals Multilayer Control of RNA Polymerase II Fidelity

(2014) Jordan D. Irvin et al.   PLoS Genetics

A Chemical Perspective on Transcriptional Fidelity: Dominant Contributions of Sugar Integrity Revealed by Unlocked Nucleic Acids

(2013) Liang Xu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Sequences That Interfere with Transcription: Implications for Genome Function and Stability

(2013) Boris P. Belotserkovskii et al.   CHEMICAL REVIEWS

Effect of a Monofunctional Phenanthriplatin-DNA Adduct on RNA Polymerase II Transcriptional Fidelity and Translesion Synthesis

(2013) Matthew W. Kellinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minor Groove Binder Distamycin Remodels Chromatin but Inhibits Transcription

(2013) Parijat Majumder et al.   PLoS One

Antitumor activity of a pyrrole-imidazole polyamide

(2013) F. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Basic mechanism of transcription by RNA polymerase II

(2012) Vladimir Svetlov et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Ubiquitylation and degradation of elongating RNA polymerase II: The last resort

(2012) Marcus D. Wilson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RNA polymerase II transcription: Structure and mechanism

(2012) Xin Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A Movie of RNA Polymerase II Transcription

(2012) Alan C.M. Cheung et al.   CELL

Synthesis of Cyclic Py-Im Polyamide Libraries

(2012) Benjamin C. Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Dissecting Chemical Interactions Governing RNA Polymerase II Transcriptional Fidelity

(2012) Matthew W. Kellinger et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

RNA Polymerase II Collision Interrupts Convergent Transcription

(2012) David J. Hobson et al.   MOLECULAR CELL

5-formylcytosine and 5-carboxylcytosine reduce the rate and substrate specificity of RNA polymerase II transcription

(2012) Matthew W Kellinger et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Microwave Assisted Synthesis of Py-Im Polyamides

(2012) James W. Puckett et al.   ORGANIC LETTERS

DNA damage response and transcription

(2011) Saskia Lagerwerf et al.   DNA REPAIR

Transcription Inhibition as a Therapeutic Target for Cancer

(2011) Christine M. Stellrecht et al.   Cancers

Transcript Elongation by RNA Polymerase II

(2010) Luke A. Selth et al.   Annual Review of Biochemistry

X-ray structure and mechanism of RNA polymerase II stalled at an antineoplastic monofunctional platinum-DNA adduct

(2010) D. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Basis of Transcriptional Mutagenesis at 8-Oxoguanine

(2009) Gerke E. Damsma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stability, Flexibility, and Dynamic Interactions of Colliding RNA Polymerase II Elongation Complexes

(2009) Hideaki Saeki et al.   MOLECULAR CELL

Allosteric modulation of DNA by small molecules

(2009) D. M. Chenoweth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repression of DNA-binding dependent glucocorticoid receptor-mediated gene expression

(2009) K. A. Muzikar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis of Transcription: Backtracked RNA Polymerase II at 3.4 Angstrom Resolution

(2009) D. Wang et al.   SCIENCE

Next Generation Hairpin Polyamides with (R)-3,4-Diaminobutyric Acid Turn Unit

(2008) Christian Dose et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY