期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 113, 期 12, 页码 3353-3358出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1518147113
关键词
prefrontal; antisaccade; monkey; neurophysiology; adolescence
资金
- Tab Williams Family Endowment Fund
- Harry O'Parker Neurosciences Fund
- National Institutes of Health (NIH) [R33MH86946, P51 RR000167]
- Research Facilities Improvement Program [RR15459-01, RR020141-01]
Executive functions including behavioral response inhibition mature after puberty, in tandem with structural changes in the prefrontal cortex. Little is known about how activity of prefrontal neurons relates to this profound cognitive development. To examine this, we tracked neuronal responses of the prefrontal cortex in monkeys as they transitioned from puberty into adulthood and compared activity at different developmental stages. Performance of the antisaccade task greatly improved in this period. Among neural mechanisms that could facilitate it, reduction of stimulus-driven activity, increased saccadic activity, or enhanced representation of the opposing goal location, only the latter was evident in adulthood. Greatly accentuated in adults, this neural correlate of vector inversion may be a prerequisite to the formation of a motor plan to look away from the stimulus. Our results suggest that the prefrontal mechanisms that underlie mature performance on the antisaccade task are more strongly associated with forming an alternative plan of action than with suppressing the neural impact of the prepotent stimulus.
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