Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

Phase I Study of the Aurora A Kinase Inhibitor Alisertib in Combination With Irinotecan and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma: A NANT (New Approaches to Neuroblastoma Therapy) Trial

(2016) Steven G. DuBois et al.   JOURNAL OF CLINICAL ONCOLOGY

Ubiquitin-Dependent Turnover of MYC Antagonizes MYC/PAF1C Complex Accumulation to Drive Transcriptional Elongation

(2016) Laura A. Jaenicke et al.   MOLECULAR CELL

Allosteric inhibition of Aurora-A kinase by a synthetic vNAR domain

(2016) Selena G. Burgess et al.   Open Biology

Myc and its interactors take shape

(2015) William B. Tu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Combined MYC and P53 Defects Emerge at Medulloblastoma Relapse and Define Rapidly Progressive, Therapeutically Targetable Disease

(2015) Rebecca M. Hill et al.   CANCER CELL

Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity

(2015) Sara Helander et al.   STRUCTURE

Taming of the beast: shaping Myc-dependent amplification

(2015) Elmar Wolf et al.   TRENDS IN CELL BIOLOGY

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

(2015) Selena G. Burgess et al.   PLoS Genetics

The structure of C290A:C393A Aurora A provides structural insights into kinase regulation

(2015) Selena G. Burgess et al.   Acta Crystallographica Section F-Structural Biology Communications

Drugging MYCN through an Allosteric Transition in Aurora Kinase A

(2014) William Clay Gustafson et al.   CANCER CELL

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma

(2013) Markus Brockmann et al.   CANCER CELL

New Strategies in Neuroblastoma: Therapeutic Targeting of MYCN and ALK

(2013) G. Barone et al.   CLINICAL CANCER RESEARCH

Emerging landscape of oncogenic signatures across human cancers

(2013) Giovanni Ciriello et al.   NATURE GENETICS

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Crystal structure of an Aurora-A mutant that mimics Aurora-B bound to MLN8054: insights into selectivity and drug design

(2010) Charlotte A. Dodson et al.   BIOCHEMICAL JOURNAL

Imidazo[4,5-b]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies toward the Identification of an Orally Bioavailable Preclinical Development Candidate

(2010) Vassilios Bavetsias et al.   JOURNAL OF MEDICINAL CHEMISTRY

Myc proteins as therapeutic targets

(2010) W C Gustafson et al.   ONCOGENE

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Stabilization of N-Myc Is a Critical Function of Aurora A in Human Neuroblastoma

(2009) Tobias Otto et al.   CANCER CELL

Modelling Myc inhibition as a cancer therapy

(2008) Laura Soucek et al.   NATURE