Article
Biochemical Research Methods
Jiande Zhou, Amaury Wei, Arnaud Bertsch, Philippe Renaud
Summary: The Poisson limit poses a major challenge for isolating single cells, but this article presents a passive microfluidic system that overcomes this limitation with high efficiency. It has a high throughput and low fault ratio, making it suitable for various cells and particles.
Article
Biochemical Research Methods
Chuanfeng An, Yujie Zhang, Hanting Li, Haoyue Zhang, Yonghao Zhang, Jiamian Wang, Yang Zhang, Fang Cheng, Kai Sun, Huanan Wang
Summary: A novel class of thermo-responsive fluorosurfactants was developed to control droplet status based on temperature. These surfactants can destabilize droplets above a specific temperature, allowing for demulsification.
Article
Chemistry, Analytical
Xiao Zhou, Yuanhang Mao, Miao Gu, Zhen Cheng
Summary: Researchers developed a microfluidic system embedded with a weakly supervised cell counting network (WSCNet) to generate microfluidic droplets, evaluate their quality, and accurately recognize the locations of encapsulated cells.
Article
Chemistry, Multidisciplinary
Ampol Kamnerdsook, Ekachai Juntasaro, Numfon Khemthongcharoen, Mayuree Chanasakulniyom, Witsaroot Sripumkhai, Pattaraluck Pattamang, Chamras Promptmas, Nithi Atthi, Wutthinan Jeamsaksiri
Summary: This paper presents a surface modification method for preparing PDMS microfluidic devices with partially hydrophilic-hydrophobic surfaces to generate double emulsion droplets, achieving high encapsulation efficiency. The key component is a permanent chemical coating using Pluronic surfactant, allowing the surface property of PDMS to be modified.
Article
Chemistry, Physical
Jean-Paul Douliez, Anais Arlaut, Laure Beven, Anne-Laure Fameau, Arnaud Saint-Jalmes
Summary: Water-in-oil-in-water emulsions (W/O/W) are emulsions where water droplets are embedded within oil droplets dispersed in a continuous water phase. This study describes a one-step method using hydrophilic polymers dispersed in polar oils to generate osmose-induced diffusion of water into oil droplets, forming polymer-rich aqueous droplets. The method allows for adjusting the water diffusion amplitude by varying the polymer concentration and enables the production of high internal phase emulsions. Additionally, a pH-induced transition from multiple to single core double emulsion was achieved. This method has potential applications in microencapsulation and materials chemistry.
Article
Nanoscience & Nanotechnology
Biao Huang, Xinjin Ge, Boris Y. Y. Rubinstein, Xianchun Chen, Lu Wang, Huiying Xie, Alexander M. M. Leshansky, Zhenzhen Li
Summary: By using gas-assisted coflow step-emulsification, uniform and high-production rate micron- and submicron-sized droplets can be produced, which have wide applications in biomedical diagnosis and drug delivery. The method utilizes air as the innermost phase, gradually diffusing out to form oil droplets, following the scaling laws of triphasic step-emulsification for droplet size and oil layer thickness.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Wei Zhan, Ziwei Liu, Shaokun Jiang, Chunying Zhu, Youguang Ma, Taotao Fu
Summary: In this study, the generation processes of bubbles and droplets in a step-emulsification microfluidic device are compared to show the similarities and differences in the emulsification process. By changing the placement of the microdevice, the effects of buoyancy and gravity on the generation of bubbles and droplets are introduced, and the feedback mechanism of the bubble layer and the effect of droplet accumulation on the emulsification process are clarified.
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2022)
Article
Biochemical Research Methods
Yuta Nakagawa, Shinsuke Ohnuki, Naoko Kondo, Kaori Itto-Nakama, Farzan Ghanegolmohammadi, Akihiro Isozaki, Yoshikazu Ohya, Keisuke Goda
Summary: Single-cell analysis is crucial in biotechnology, and the use of microfluidic compartments for cell cultivation raises the importance of assessing the impact of culture conditions on cellular function. This study showed that culturing cells in droplets can lead to morphological differences and delays in the cell cycle, highlighting the need to carefully evaluate and optimize microfluidic cultivation methods for unbiased single-cell studies.
Review
Biochemical Research Methods
Cheng-Kun He, Chia-Hsien Hsu
Summary: Microfluidic devices are widely used for single-cell capture and cell-cell interaction analysis, improving drug screening and cell signal transduction. This study reviews various microfluidic multiple- and single-cell capture methods, comparing their advantages and disadvantages, and providing suggestions for their application to multiple-cell capture. The results may serve as a reference for research on microfluidic multiple single-cell coculture technology.
Article
Chemistry, Analytical
Enrique Azuaje-Hualde, Marian M. de Pancorbo, Fernando Benito-Lopez, Lourdes Basabe-Desmonts
Summary: This study proposes a low-cost and user-friendly paper microfluidic device for the detection of cell secreted VEGF. The device integrates a fluorescent VEGF biosensor into cellulose paper, enabling the detection of VEGF at low concentrations. It has the potential to be used in cell biology research, specifically for the detection of VEGF in the supernatant of mesenchymal stem cells culture plates.
ANALYTICA CHIMICA ACTA
(2022)
Article
Chemistry, Analytical
Lili Cong, Yu Tian, Zepeng Huo, Weiqing Xu, Chunxi Hou, Wei Shi, Weigang Wang, Chongyang Liang, Shuping Xu
Summary: This study introduces a microfluidic droplet-based fluorescence imaging platform for analyzing single cell-secreted VEGF, exploring cellular physiological clues at the single-cell level. By developing silica nanoparticle-based immunoprobes and conducting immunosandwich assays, the method demonstrates cellular heterogeneity in cytokine secretion.
ANALYTICAL CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Dan Liu, Tingting Xuanyuan, Xufang Liu, Wenzhu Fu, Wenming Liu
Summary: This study presents a simple and efficient method for encapsulating single cells through the mass production of droplets and collagen-alginate microgels using a microfluidic device. The method achieved a single-cell encapsulation rate of up to 33.6% and introduced stromal material to simulate an in vivo microenvironment. The single-cell manipulation achievement provides a methodological approach for developing simple and miniaturized devices for high-throughput single-cell manipulation and analysis in a microenvironment-biomimetic manner.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomohiro Komatsu, Kazuki Hishii, Michiko Kimura, Satoshi Amaya, Hiroaki Sakamoto, Eiichiro Takamura, Takenori Satomura, Shin-ichiro Suye
Summary: In this study, a bioanode was developed that could extract six electrons from a single molecule of L-proline via a three-enzyme cascade reaction. By immobilizing enzymes and using self-assembled monolayers and a microfluidic system, efficient electron transfer was achieved. The bioanode showed higher current density compared to a gold disc electrode, indicating potential for developing high-performance BFCs in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Irina G. Koryakina, Maksim Naumochkin, Daria Markina, Soslan A. Khubezhov, Anatoly P. Pushkarev, Anatoly A. Evstrapov, Sergey Makarov, Mikhail Zyuzin
Summary: A novel approach has been developed for the one-step fabrication of high-quality CsPbBr3 nanolasers in the form of suspension obtained by rapid precipitation in a microfluidic chip, allowing control of nanostructure morphology and deposition on an arbitrary surface.
CHEMISTRY OF MATERIALS
(2021)
Article
Operations Research & Management Science
Patrick R. Johnstone, Jonathan Eckstein
Summary: This work describes a new variant of projective splitting that can solve maximal monotone inclusions and complicated convex optimization problems with a single forward step for processing cocoercive operators. The new method allows larger stepsizes for cocoercive operators by establishing a stepsize bound of 2 beta for a beta-cocoercive operator. The new method also allows for a backtracking procedure when the cocoercivity constant is unknown, unlike the previous forward-backward splitting method.
COMPUTATIONAL OPTIMIZATION AND APPLICATIONS
(2021)
Article
Chemistry, Analytical
Chun-Guang Yang, Miao Zhang, Zhang-Run Xu
ANALYTICAL METHODS
(2015)
Article
Chemistry, Physical
Mei Liu, Xiao-Ting Sun, Chun-Guang Yang, Zhang-Run Xu
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2016)
Article
Chemistry, Multidisciplinary
Xiao-Ting Sun, Chun-Guang Yang, Zhang-Run Xu
Article
Chemistry, Multidisciplinary
Xiran Jiang, Wenwen Jing, Xiaoting Sun, Qi Liu, Chunguang Yang, Sixiu Liu, Kairong Qin, Guodong Sui
Article
Nanoscience & Nanotechnology
Rui Guo, Chun-Guang Yang, Zhang-Run Xu
MICROFLUIDICS AND NANOFLUIDICS
(2017)
Article
Chemistry, Physical
Rui Guo, Xiao-Ting Sun, Ying Zhang, Dan-Ni Wang, Chun-Guang Yang, Zhang-Run Xu
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Chemistry, Physical
Xiao-Ting Sun, Rui Guo, Dan-Ni Wang, Yun-Yun Wei, Chun-Guang Yang, Zhang-Run Xu
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2019)
Article
Biochemical Research Methods
Wen-Qi Ye, Yi-Xuan Wei, Ying-Zhi Zhang, Chun-Guang Yang, Zhang-Run Xu
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2020)
Article
Chemistry, Physical
Chun-Guang Yang, Lin Cheng, Wen-Qi Ye, Dong-Hua Zheng, Zhang-Run Xu
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Chemistry, Analytical
Yingzhi Zhang, Wenqi Ye, Chunguang Yang, Zhangrun Xu
Article
Chemistry, Multidisciplinary
Yingzhi Zhang, Danni Wang, Shuai Yue, Yanbing Lu, Chunguang Yang, Jin Fang, Zhangrun Xu
Article
Chemistry, Multidisciplinary
Yue Wang, Jing Liu, Xueqi Zhao, Chunguang Yang, Yukihiro Ozaki, Zhangrun Xu, Bing Zhao, Zhi Yu
CHEMICAL COMMUNICATIONS
(2019)
Article
Biophysics
Xiao-Ting Sun, Ying Zhang, Dong-Hua Zheng, Shuai Yue, Chun-Guang Yang, Zhang-Run Xu
BIOSENSORS & BIOELECTRONICS
(2017)
Article
Chemistry, Multidisciplinary
Jiang Jian, Li Panpan, Ma Yingxue, Yang Chunguang, Xu Zhangrun
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
(2016)
Article
Chemistry, Multidisciplinary
Qian Wu, Yubo Cui, Guifeng Xia, Jinlong Yang, Shuming Du, Xinhong Xiong, Li Yang, Dong Xu, Xu Deng, Jiaxi Cui
Summary: Passive daytime radiative cooling (PDRC) technology, while promising for global spacing cooling, faces limitations in practical application due to reduced cooling effectiveness caused by wear and dirt contamination. Researchers have developed a renewable armor structure using fluorinated hollow glass microspheres to enhance the anti-fouling and cooling properties of PDRC coatings. The coatings exhibit high solar reflectance and thermal emittance, leading to significant temperature reduction below ambient temperature.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Qiang Bei, Bei Zhang, Kaifeng Wang, Shiming Zhang, Guichuan Xing, Clement Cabanetos
Summary: The power conversion efficiency (PCE) of organic solar cells (OSCs) has reached 20% in recent years, thanks to the advantages of organic photoactive materials. Benzothiadiazole (BT) has attracted significant research attention as a building block of OSCs. OSCs based on BT structure have shown diversity, and the increasing PCE values indicate a promising future for OSCs. This review analyzes the progress made in the last decades, focusing on effective BT small-molecules and BT polymers for OSCs. The structure-property relationships, donor-acceptor matching criteria, and morphology control approaches are discussed. The remaining challenges and a personal perspective on the future advancement of OSCs are summarized.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Rong He, Dandan Tang, Ningge Xu, Heng Liu, Kun Dou, Xuejun Zhou, Fabiao Yu
Summary: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck, with a high incidence in China and Southeast Asian countries. In this study, a novel near-infrared fluorescent probe, SNAFL-GSH, was designed and synthesized for the detection of glutathione (GSH). The probe showed selective detection of GSH and the ability to distinguish normal and cancer cells. It has great potential for application in the diagnosis and evaluation of NPC.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhukang Guo, Baijiang Jin, Yile Fang, Lian Jin, Song Li, Yan Deng, Zhu Chen, Hui Chen, Yuanying Zhang, Rabia Usman, Nongyue He
Summary: This study isolated primary cells that can be stably passaged from spontaneous tumors of genetically engineered pancreatic ductal adenocarcinoma model mice and used an autonomously developed automated screening instrument for efficient nucleic acid aptamer screening. The obtained aptamers were affinity verified at the cellular level. The study also investigated the impact of cell growth environment difference on the recognition ability of aptamers and confirmed the targeting ability and drug loading ability of the aptamer.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Zhongshan Yang, Qiqi Zhang, Hui Song, Xin Chen, Jiwei Cui, Yanhui Sun, Lequan Liu, Jinhua Ye
Summary: Methane chemistry is a significant area of research in catalysis. Converting methane into value-added chemicals is desirable but challenging due to its high C-H bonding energy and lack of pi bonding or unpaired electrons. Photocatalytic partial oxidation of methane to liquid oxygenates is a promising technology for achieving high efficiency and selectivity under mild conditions. The choice and activation of oxidants are crucial for its performance.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Peng Shan, Jing Liao, Jiayi Li, Chengyan Wang, Jie Zhou, Linqiang Mei, Yunlu Dai, Qiang Wang, Wenyan Yin
Summary: This study reports an oral radioprotectant Gel@GYY that combines a gelatin-based hydrogel and a pH-responsive hydrogen sulfide donor. Gel@GYY has excellent adhesion and sustained release properties, allowing it to release H2S in the gastrointestinal tract and effectively scavenge free radicals induced by radiation. It also reduces inflammation and has biodegradable properties.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lu Liu, Ziyi Liu, Jingnan Cui, Guiling Ning, Weitao Gong
Summary: The development of new metal-free heterogeneous catalysts has been the subject of extensive research. In this study, a new Troger's base (TB)-derived porous organic polymer (POPs) was designed and prepared by integrating multifunctional monomers. The resulting polymer, which combines the advantages of pillar[5]arene macrocycle and TB moiety, exhibited enhanced catalytic performance in Knoevenagel condensation and CO2 conversion, serving as an effective metal-free catalyst. This work provides a new strategy for fabricating metal-free heterogeneous catalysts based on macrocyclic POPs.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leyong Zhou, Changyin Yang, Weitao Dou, Tongxia Jin, Haibo Yang, Lin Xu
Summary: This review summarizes the application of micro/nanofluidic techniques in constructing supramolecular assemblies of different scales, and highlights the advantages of these techniques over conventional synthesis methods. Furthermore, it emphasizes the potential of micro/nanofluidic systems in improving our understanding of supramolecular self-assembly processes.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Yanchao Jin, Suixiaochen Chen, Peiwen Huang, Xiongjian Chen, Chun-Yan Lin, Li-Ping Li, Xiao Chen, Rui Ding, Jianxi Liu, Riyao Chen
Summary: In this study, magnesium and coconut shell carbon were used to disinfect water by adsorbing copper(II) and converting dissolved oxygen to hydrogen peroxide through Mg corrosion. The copper was enriched on the carbon surface and efficiently catalyzed the hydrogen peroxide to inactivate E.coli. The process showed promising disinfection performance both in laboratory experiments and real wastewater treatment.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Haihong Lai, Zehong Chen, Hao Zhuo, Yijie Hu, Xuan Zhao, Jiwang Yi, Hongzhi Zheng, Ge Shi, Yifan Tong, Ling Meng, Xinwen Peng, Linxin Zhong
Summary: By altering the pyrolysis route of cellulose nanofiber, the structural defects of carbon aerogels can be reduced, leading to improved compressibility and stress retention, as well as higher stress sensor sensitivity and temperature coefficient.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lina Guo, Jinsong Ding, Wenhu Zhou
Summary: Bacteria-based tumor therapy has resurfaced due to the revolution of tumor immunotherapy, offering unique solutions for traditional tumor treatments. Bacteria with active tropism can selectively colonize tumor sites and suppress tumor growth through various mechanisms, making them attractive tools for tumor treatment. This critical review introduces recent advances in bacteria-based tumor therapy, including bacterial properties, their benefits for tumor therapy, anti-tumor mechanisms, challenges, and future perspectives.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Lan Liang, Chuanbin Wang, Xukai Lu, Yunan Sun, Beibei Yan, Ning Li, Guanyi Chen, Li'an Hou
Summary: This study investigates the interactions between phenol and benzaldehyde in the ECH process through experiments and theoretical calculations. The results show that phenol can accelerate the conversion of benzaldehyde, while benzaldehyde inhibits the conversion of phenol. The research provides a theoretical basis for the application of ECH in practical bio-oil upgrading.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Pengcheng Fan, Yuhao He, Junan Pan, Ning Sun, Qiyu Zhang, Chen Gu, Kang Chen, Weinan Yin, Longlu Wang
Summary: This study focuses on the recent progress in hydrogen evolution reaction (HER) based on photothermal effect. It introduces the main pathways of photothermal conversions applied in H2 evolution, summarizes the functions of the photothermal effect, and presents a method to improve the catalytic system through thermal means. The study also discusses the challenges and outlook in this promising area.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Leiduo Lai, Hongyu Zhou, Yichen Hong, Mengfan Luo, Yang Shi, Heng Zhang, Zhaokun Xiong, Gang Yao, Bo Lai
Summary: In this study, a facile ammonia reduction strategy was proposed and a novel FeVO3-x catalyst was synthesized for the activation of peroxymonosulfate (PMS) to degrade the pharmaceutical carbamazepine (CBZ). The results showed that the system could rapidly degrade CBZ and generate various active species involved in the degradation process.
CHINESE CHEMICAL LETTERS
(2024)
Article
Chemistry, Multidisciplinary
Tangxin Xiao, Xiuxiu Li, Liangliang Zhang, Kai Diao, Zheng-Yi Li, Xiao-Qiang Sun, Leyong Wang
Summary: This study presents the construction of a supramolecular light harvesting system based on sequential energy transfer. The system demonstrates tunable fluorescence emission through self-assembly of polymers into nanoparticles, achieving efficient two-step light harvesting.
CHINESE CHEMICAL LETTERS
(2024)
