期刊
POLYMER CHEMISTRY
卷 7, 期 12, 页码 2192-2201出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6py00194g
关键词
-
资金
- Institute of Bioengineering and Nanotechnology (Biomedical Research Council, Singapore)
- IBM Almaden Research Center
- Institute of Bioengineering and Nanotechnology (JCO, Agency for Science, Technology and Research, Singapore)
In this study, cationic amphiphilic cyclic carbonates with varying hydrophobicity and structure were synthesized and grafted onto amine-containing silica surface via a ring-opening nucleophilic addition reaction to impart antimicrobial properties. The presence of the coated layer on silica surface was verified by X-ray photoelectron spectroscopy (XPS) and thermogravimetric analysis (TGA). The effects of the alkyl chain length and the cationic group structure of the surface-grafted carbonate on the antimicrobial efficacy against Gram-positive S. aureus, and Gram-negative E. coli and P. aeruginosa were examined to understand the structure-activity relationship of the surface-coated silica particles. Results indicated that an optimal chain length of the hydrophobic alkyl tail, and the position of the cationic center and benzyl group were crucial in imparting high antimicrobial efficacy especially against difficult-to-kill P. aeruginosa. These quaternary ammonium-functionalized silica particles have various potential antimicrobial applications.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据