Article
Environmental Sciences
Kaniz Fatima Binte Hossain, Md Mostafizur Rahman, Md Tajuddin Sikder, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: This study investigated the protective role of selenium (Se) against inorganic mercury (iHg) toxicity in PC12 cells. Results showed that Se co-treatment inhibited intrinsic apoptosis and oxidative stress induced by iHg through various mechanisms, suggesting that excessive ROS generation plays a critical role in iHg-induced oxidative stress and Se has potential in attenuating iHg cytotoxicity via its antioxidant properties.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Minyan Li, Sha Wang, Chunmei Fu, Hongyu Chen, Yuxia Su, Peng Wu, Xinhao Yan, Juanjuan Gao
Summary: Parkinson's disease (PD) is characterized by oxidative stress and this study investigated the neuroprotective effects of salidroside (Sal) on 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells. Sal effectively regulated oxidative stress and prevented the transmission of pathologic α-synuclein in the cells. These findings provide insights into potential protective mechanisms against neurodegenerative diseases and synucleinopathies.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
P. Aravind, Sarojini R. Bulbule, N. Hemalatha, R. L. Babu, K. S. Devaraju
Summary: The study analyzed the gene expression of major calcium binding proteins under oxidative stress, revealing enhanced expression of certain proteins and down-regulation of others. Additionally, Akt protein expression was enhanced in most stress inducers except under hyperglycemic conditions.
Article
Pharmacology & Pharmacy
Aijing Bi, Zhen Guo, Guocui Yang, Youfang Huang, Zhimin Yin, Lan Luo
Summary: The highly toxic environmental pollutant cadmium (Cd) can lead to the occurrence and development of multiple neurological diseases. Gamma-glutamylcysteine (gamma-GC) has been found to inhibit Cd-induced apoptosis in PC12 cells by reducing oxidative stress and inhibiting the activation of MAPK and PI3K/Akt signaling pathways. This suggests that gamma-GC could potentially be used as a protective agent against Cd neurotoxicity.
Article
Pharmacology & Pharmacy
Yan Tang, Ya Hou, Yong Zeng, Yao Hu, Yi Zhang, Xiaobo Wang, Xianli Meng
Summary: Salidroside alleviates hypoxic injury in PC12 cells by inhibiting oxidative stress, anti-apoptosis, and enhancing mitochondrial energy synthesis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hironao Nakayama, Masako Nakahara, Erina Matsugi, Midori Soda, Tomoka Hattori, Koki Hara, Ayuki Usami, Chiaki Kusumoto, Shigeki Higashiyama, Kiyoyuki Kitaichi
Summary: Ferulic acid has antioxidant and anti-apoptotic effects in PC12 cells, protecting neurons from damage by inhibiting apoptosis and reducing reactive oxygen species production. It regulates protein phosphorylation, apoptosis-related proteins, and microRNA expression to mitigate oxidative stress induced by H2O2 in rat pheochromocytoma cells.
Article
Biochemistry & Molecular Biology
Mersedeh Shayan, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: This study demonstrates that minocycline can protect cells against cadmium-induced oxidative stress and apoptotic cell death, and exhibits antioxidant and anti-apoptotic activity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Neurosciences
Heping Zhang, Wei Zhou, Jianling Li, Zhaohui Qiu, Xiaotong Wang, Hui Xu, Huadong Wang, Daxiang Lu, Renbin Qi
Summary: This study found that Sen exhibits strong neuroprotective activity against A beta(25-35) induced oxidative damage and lipid metabolic associated with ferroptosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Kexin Wang, Xinyue Zhang, Miaosi Zhang, Xin Li, Jiao Xie, Suwen Liu, Qun Huang, Jilite Wang, Qingbin Guo, Hao Wang
Summary: Traditional Chinese medicines with hyperoside such as Acanthopanax senticosus and Crataegus pinnatifida have demonstrated anti-oxidative stress properties. Hyperoside, the main component of antioxidant herbs, may delay the onset of neurodegenerative diseases. This study investigated the therapeutic mechanism of hyperoside as a natural antioxidant against Alzheimer's disease in Caenorhabditis elegans and PC12 cells, showing its ability to reduce reactive oxygen species levels and neurotoxicity induced by A beta 42.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaojie Liu, Ying Liu, Yatu Guo, Lin Xu, Hao Wang
Summary: Phlorizin, the main active ingredient in apple peel, has potential antioxidant capacity and protective effects on liver. It can improve antioxidant enzyme activities, increase total antioxidant capacity, reduce oxidative stress markers, modulate inflammatory cytokines, enhance cholinergic activities, and promote the Nrf2 pathway to delay aging and improve cellular viability.
Article
Biochemistry & Molecular Biology
Reyhaneh Ahmadian, Mahmoud Reza Heidari, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: This study investigated the protective effects of alpha-mangostin against neurotoxicity induced by arsenic and cadmium. The results demonstrated that alpha-mangostin could reduce the toxic effects of arsenic and cadmium on PC12 cells, and decrease oxidative stress and apoptosis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Mersedeh Shayan, Soghra Mehri, Bibi Marjan Razavi, Hossein Hosseinzadeh
Summary: Arsenic is a naturally occurring metalloid that can cause acute and chronic toxicity in humans. Neurotoxicity is a serious manifestation of arsenic toxicity. This study found that minocycline, an antimicrobial agent with antioxidant properties and the ability to cross the blood-brain barrier, can significantly attenuate arsenic-induced neurotoxicity by reducing oxidative stress and apoptosis. These findings suggest that minocycline could be a promising treatment for arsenic toxicity.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Ning Li, Liuding Wen, Fangyu Wang, Tianlin Wang, Tiange Li, Mingwu Qiao, Lianjun Song, Erkigul Bukyei, Xianqing Huang
Summary: This study demonstrated that wheat germ peptides (WGPs) can protect PC12 cells from lead-induced oxidative stress. WGPs were found to reverse the cell damage and oxidative stress caused by lead exposure. Furthermore, WGPs enhance the antioxidant capacity of PC12 cells by regulating the TXNIP/Keap1/Nrf2 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Environmental Sciences
Kaniz Fatima Binte Hossain, Toshiyuki Hosokawa, Takeshi Saito, Masaaki Kurasaki
Summary: The study confirmed that Zn pretreatment significantly improves Hg-induced cytotoxicity, mainly by enhancing cell viability, reducing cell membrane damage, decreasing DNA damage, replenishing glutathione levels, lowering ROS production, and reducing apoptotic cells. Furthermore, Zn pretreatment can activate the Nrf2-HO1 pathway, thereby suppressing cell apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Liwei Wang, Qian Chen, Rui Ma, Bikui Zhang, Ping Yang, Ting Cao, Shimeng Jiao, Hui Chen, Chenquan Lin, Hualin Cai
Summary: Clozapine, while considered as a last resort for treatment-resistant schizophrenia, has limited efficacy in cognition improvement and can induce metabolic side effects that worsen cognitive impairment. The neurotoxic mechanisms of clozapine remain unclear. This study found that high concentrations of clozapine and AG205 resulted in cytotoxicity, reactive oxygen species accumulation, and mitochondrial membrane potential collapse in PC12 cells. Overexpression of progesterone receptor membrane component 1 (PGRMC1) reversed these toxic effects. Clozapine and AG205 also downregulated the expression of PGRMC1, glucagon-like peptide-1 receptor (GLP-1R), and mitofusin2 (Mfn2), which were restored by overexpressing PGRMC1. The findings suggest that PGRMC1 activation could be a promising therapeutic strategy for clozapine-induced neurotoxicity.
Article
Chemistry, Medicinal
Maria Antonietta Dettori, Marina Pisano, Carla Rozzo, Giovanna Delogu, Davide Fabbri
Summary: A small collection of C-2-symmetric hydroxylated biphenyl derivatives containing alpha,beta-unsaturated ketone as a lead structure were prepared and assayed for antiproliferative activity against four human malignant melanoma cell lines. The prodrug approach was utilized to enhance delivery of the compounds into cells by modulating the phenolic hydroxy protecting group. The hydroxylated biphenyl structure with alpha,beta-unsaturated ketone and phenolic-O-prenylated chain facilitated molecule delivery and interactions with biological targets, resulting in four compounds showing antiproliferative activity with IC50 values ranging from 1.2 to 2.8 μM.
Article
Medicine, General & Internal
Jasmina Brboric, Aleksandra Klisic, Jelena Kotur-Stevuljevic, Giovanna Delogu, Darinka Gjorgieva Ackova, Kristina Kostic, Maria Antonietta Dettori, Davide Fabbri, Paola Carta, Luciano Saso
Summary: The aim of this study was to identify representatives of natural and natural-like phenol monomers and their C2-symmetric dimers with the strongest antioxidant activity and the lowest prooxidant activity. The results showed that dehydrozingerone derivatives (compounds 6 and 12) exhibited the highest antioxidant activity and could be potential precursors for the synthesis of novel polyphenolic molecules with therapeutic applications.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Ylenia Spissu, Antonio Barberis, Guy D'hallewin, Germano Orru, Alessandra Scano, Gavina Rita Serra, Milo Pinna, Cristian Pinna, Salvatore Marceddu, Pier Andrea Serra
Summary: This work provides companies in the fresh-cut produce sector with an Ascorbate Bluetooth(C) Analyzer (ABA) for ascorbic acid (AA) detection, allowing them to investigate the kinetics of AA decay and study the role of ascorbate oxidase (AOx) and ascorbate peroxidase (APx) in fresh and fresh-cut parsley. The ABA can be used in situ by unskilled personnel and can help remedy unexpected flaws in the cold chain during processing or transport.
Article
Biochemistry & Molecular Biology
Claudia Honisch, Matteo Gazziero, Roberto Dallocchio, Alessandro Dessi, Davide Fabbri, Maria Antonietta Dettori, Giovanna Delogu, Paolo Ruzza
Summary: This study analyzed the inhibitory capabilities of antamanide and its glycine derivatives on the activity of tyrosinase and performed computational docking studies to understand the interactions occurring with the tyrosinase catalytic site. The results showed that the glycine derivatives exhibited tyrosinase inhibitory activity, which is significant for the agricultural, cosmetic, and medicinal industries.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Virology
Elisabetta Coradduzza, Daria Sanna, Fabio Scarpa, Ilenia Azzena, Mariangela S. Fiori, Rosario Scivoli, Angela M. Rocchigiani, Roberto Bechere, Maria A. Dettori, Davide Pintus, Eloisa Evangelista, Marco Casu, Ciriaco Ligios, Giantonella Puggioni
Summary: This study used Italian whole genomes to infer the evolutionary history of ORFV. The results revealed that ORFV originated in Europe and Asia in the late 18th century and spread throughout the European continent in the early 20th century. The Italian strains isolated from Sardinia may represent early European forms of ORFV.
Article
Plant Sciences
Iman Ramli, Anna Maria Posadino, Sakina Zerizer, Ylenia Spissu, Antonio Barberis, Hanane Djeghim, Emanuela Azara, Chawki Bensouici, Zahia Kabouche, Khellaf Rebbas, Guy D'hallewin, Leonardo Antonio Sechi, Gianfranco Pintus
Summary: The weed plant Ambrosia maritima L., traditionally used in North African folk medicine, has been found to have potential as a natural alternative for Crohn's disease treatment. Its phenolic extract showed antioxidant activity and cytoprotective effect on human endothelial cells stressed with H2O2.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Gaia Rocchitta, Carla Rozzo, Marina Pisano, Davide Fabbri, Maria Antonietta Dettori, Paolo Ruzza, Claudia Honisch, Roberto Dallocchio, Alessandro Dessi, Rossana Migheli, PierAndrea Serra, Giovanna Delogu
Summary: This study synthesized three curcumin-inspired compounds and analyzed their activities. The results showed that these compounds have inhibitory effects on melanin synthesis and have high antioxidant activity.
Article
Virology
Angela Maria Rocchigiani, Luca Ferretti, Alice Ledda, Antonello Di Nardo, Matteo Floris, Piero Bonelli, Federica Loi, Maria Laura Idda, Pier Paolo Angioi, Susanna Zinellu, Mariangela Stefania Fiori, Roberto Bechere, Paola Capitta, Annamaria Coccollone, Elisabetta Coradduzza, Maria Antonietta Dettori, Maria Caterina Fattaccio, Elena Gallisai, Caterina Maestrale, Daniela Manunta, Aureliana Pedditzi, Ivana Piredda, Bruna Palmas, Sara Salza, Anna Maria Sechi, Barbara Tanda, Maria Paola Madrau, Maria Luisa Sanna, Simonetta Cherchi, Nicoletta Ponti, Giovanna Masala, Roberto Sirica, Eloisa Evangelista, Annalisa Oggiano, Giantonella Puggioni, Ciriaco Ligios, Silvia Dei Giudici
Summary: Understanding the impact of geography and human mobility on the spread of infectious diseases like COVID-19 is crucial for controlling future epidemics. The second wave of the COVID-19 epidemic in Europe was facilitated by the movement of tourists around the Mediterranean coast in summer 2020. The Italian island of Sardinia, a popular tourist destination, is believed to be the origin of the second wave. Genetic analysis reveals that most virus strains circulating in northern Sardinia during both waves were part of a single clade, suggesting limited spread despite high virus inflow.
Article
Biochemistry & Molecular Biology
Kristina Kostic, Jasmina Brboric, Giovanna Delogu, Milena R. Simic, Stevan Samardzic, Zoran Maksimovic, Maria Antonietta Dettori, Davide Fabbri, Jelena Kotur-Stevuljevic, Luciano Saso
Summary: A comparative study was conducted to evaluate the antioxidant potential of natural phenols (zingerone, curcumin, raspberry ketone, magnolol) and their synthesized derivatives. The study measured the antioxidant efficiency in blood serum obtained from healthy individuals, before and after adding the pro-oxidant tert-butyl hydroperoxide (TBH). It was found that curcumin, raspberry ketone, magnolol, and the synthesized derivative of zingerone demonstrated remarkable antioxidant effects in the blood serum of healthy individuals. Moreover, a combination of zingerone and curcumin exhibited synergistic antioxidant effects.
Article
Biochemistry & Molecular Biology
Myriam Caval, Maria Antonietta Dettori, Paola Carta, Roberto Dallocchio, Alessandro Dessi, Salvatore Marceddu, Pier Andrea Serra, Davide Fabbri, Gaia Rocchitta
Summary: This paper evaluates the performances of electrosynthesized polymers, layered by means of constant potential amperometry, for amperometric biosensors. The polymeric films of zingerone and its dimer dehydrozingerone showed excellent shielding characteristics against interfering species and an increased monitoring capability for hydrogen peroxide. Docking analyses and theoretical speculation on the molecular structures of the obtained polymers were also conducted.
Article
Chemistry, Applied
Alessandra Scano, Antonio Barberis, Germano Orru, Sara Fais, Francesca Puggioni, Ylenia Spissu, Pier Andrea Serra, Guy D'hallewin
Summary: The study investigated biofilm development of two Pseudomonas aeruginosa strains on fresh-cut lettuce, revealing a significant difference between mucoid and non-mucoid phenotypes. The results emphasized the need for developing specific detection methods and sanitation systems for modified atmosphere package ready-to-eat commodities based on the contamination risk posed by different P. aeruginosa phenotypes.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Masoume Malmir, Majid M. Heravi, Zahra Yekke-Ghasemi, Masoud Mirzaei
Summary: In this study, a tri-component composite consisting of Fe3O4 nanoparticles, Keggin-type polyoxometalate, and graphene oxide was prepared and investigated as a catalyst for the oxidation of sulfides to sulfoxides. The catalyst showed excellent stability, high yields, and recyclability, making it a promising choice for organic-inorganic hybrid catalytic reactions conducted under mild conditions.
Article
Chemistry, Inorganic & Nuclear
Samuel D. Juarez-Escamilla, Sriloy Dey, Bruno Donnadieu, T. Keith Hollis
Summary: In this study, a bidentate Mo complex was synthesized using metalation and transmetalation methodology. The synthesis was optimized to achieve a high yield. The crystal structure of the bidentate complex was determined. Additionally, alternative forms of ligands were discovered in the reaction.
Article
Chemistry, Inorganic & Nuclear
Mohamed H. Abdel-Rhman, Ghada Samir, Mostafa A. Hussien, Nasser M. Hosny
Summary: This study investigated the dissolution performance of hydrazine carbonate solution on zirconium dibutyl phosphate (Zr-DBP), and found that hydrazine carbonate solution could promote the dissolution of Zr-DBP. The effects of dissolution temperature and hydrogen peroxide concentration on the dissolution efficiency were also explored, and the corrosion effect on stainless steel by hydrazine carbonate solution was studied.
Article
Chemistry, Inorganic & Nuclear
Qiaofang Fu, Fangyu Tan, Wu Ying
Summary: This study successfully prepared vermiculite/g-C3N4/TiO2 composites and found that under specific conditions, the composites exhibited excellent degradation effects, with a high degradation rate for methylene blue. Additionally, the composites were able to enhance surface area, reduce carrier loading rate, improve light energy utilization, and enhance durability.
Article
Chemistry, Inorganic & Nuclear
Annabelle G. W. Hodson, Robert T. Mason
Summary: Functionalised polystyrene resins have been found to be efficient catalysts in the synthesis of specific complexes, with the conversion rate controlled by the polymer structure. The addition of amines or amino acids can further yield substituted 13-butadienyl complexes, which have been analyzed by NMR.
Article
Chemistry, Inorganic & Nuclear
C. Kavitha, S. Anbarasan, P. Subramaniam
Summary: The sulfoxidation of PMAAs by the oxo(salen)chromium(V) complex in aqueous acetonitrile medium was studied. The rate of the reaction is influenced by the polarity of the medium and the substituents on PMAA, with electron donating substituents accelerating the reaction and electron withdrawing substituents retarding the reaction.
Article
Chemistry, Inorganic & Nuclear
Qiang-Qiang Liu, Mithun Kumar Ghosh, Shu-Lan Cai, Xiao-Hong Liu, Lu Lu, Mohd. Muddassir, Tanmay Kumar Ghorai, Jun Wang
Summary: Three newly developed coordination polymers (CPs) with semiconducting properties were synthesized using hydrothermal methods. These CPs exhibit superior photocatalytic activity and can degrade organic pollutants effectively.
Article
Chemistry, Inorganic & Nuclear
Mehrnaz Aliahmadi, Ali Nemati Kharat, Jan Janczak
Summary: This study proposes a method for synthesizing allyl alcohol using cost-effective and renewable bio-resource glycerol. By utilizing catalysts, alcohol as a solvent, and a reducing agent, allyl alcohol with an efficiency of 100% was obtained. The structures of the newly synthesized complexes were determined using X-ray single crystallography.
Article
Chemistry, Inorganic & Nuclear
Ji-Yan Gao, Nan Zhang, Dong-Sheng Huang, Xiang-Rong Liu, Zai-Wen Yang, Shun-Sheng Zhao
Summary: Two new transition metal complexes I and II were synthesized and characterized. The complexes exhibited strong thermal stabilities and showed effective binding to CT-DNA and BSA. Complex II exhibited stronger inhibition activity against P. aeruginosa than gentamicin sulfate. These complexes have potential applications in drug research.
Article
Chemistry, Inorganic & Nuclear
Rishabh Ujjval, Hilal Ahmad Khan, Chinnappan Sivasankar, Natesan Thirupathi
Summary: In this study, a rigid 2-aminobenzimidazole type guanidine and its platinum complexes were synthesized through a series of reactions and characterized by various physical and chemical methods. The reaction mechanism was also explained through DFT calculations.
Article
Chemistry, Inorganic & Nuclear
Marcelo Carpes Nunes, Thais Zaboenco, Vinicius Kemper Melara, Gabriel Barros Baptistella, Andre Luiz Barboza Formiga, Andersson Barison, Fabio Souza Nunes
Summary: A new luminescent molecular thermometer has been developed, which uses the spin-crossover equilibrium of a nickelcyclen derivative to measure temperature. The sensor shows high sensitivity and accuracy.
Article
Chemistry, Inorganic & Nuclear
Yuyu Shan, Zhenqin Zhao, Xia Zhang, Zhan Wu, Xiu-Ling Li
Summary: In this study, a new bridging ligand was synthesized through refluxing, and two mononuclear Cu(I) complexes and two trinuclear Cu(I)-Eu(III) complexes were obtained through self-assembly. The Cu(I) antenna chromophores successfully transferred energy to the Eu(III) centers, achieving sensitized Eu(III) luminescence.
Article
Chemistry, Inorganic & Nuclear
Gabriela Sanchez-Lecuona, Mayra C. Vazquez-Nunez, Bruno Donnadieu, Miguel A. Munoz-Hernandez, Virginia Montiel-Palma
Summary: The reaction of RuHCl(PPh3)3 with GaMe3 has been studied and the obtained complexes were analyzed in detail. The results indicate the formation of a Ru-Ga bond, suggesting the generation of an in situ formed ambiphilic phosphinogallyl ligand. This is of significance for understanding the interaction between metal-halogen bonds and metal-small molecule bonds.
Article
Chemistry, Inorganic & Nuclear
Sevil Sener, Nursel Acar, Fatih Dumludag
Summary: The synthesis, characterization, spectroscopic and bonding features of a new Co (II) phthalocyanine compound containing two thiocarbohydrazone groups were explained. The compound showed semiconductor properties and potential as a temperature sensor.
Article
Chemistry, Inorganic & Nuclear
Ledja B. O. Davi, Aryanna S. P. N. Costa, Mariana S. Silva, Adriana S. Ribeiro, Cintya D. A. E. S. Barbosa, Julio C. S. Da Silva, Dimas J. P. Lima, Daniela S. Anunciacao
Summary: In this study, a dansyl derivative sensor called o-PDDS was prepared and used for the detection of Al3+ ions in water. The o-PDDS sensor exhibited high sensitivity and linear response towards Al3+ ions. Experimental and computational studies confirmed a 1:1 stoichiometry ratio between o-PDDS and Al3+ ions. Real sample analysis demonstrated the selectivity and detection performance of the sensor, indicating its potential for field use.