Article
Multidisciplinary Sciences
Emanuel Fabersani, Kevin Portune, Isabel Campillo, Inmaculada Lopez-Almela, Sergio Montserrat-de la Paz, Marina Romani-Perez, Alfonso Benitez-Paez, Yolanda Sanz
Summary: The study found that administration of Bacteroides uniformis CECT 7771 reduced weight gain and improved metabolic function in obese mice. The bacterium also modulated gut microbiota and immune alterations in obese mice.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Lidia Rodrigo-Torres, Jose Maria Landete, Pol Huedo, Angela Peiroten, Susana Langa, Eva Rodriguez-Minguez, Margarita Medina, David R. Arahal, Rosa Aznar, Juan L. Arques
Summary: The draft genome sequences and analysis of genetical content of L. paracasei INIA P272 and L. rhamnosus INIA P344 support their probiotic characteristics and safety for use in functional foods.
Article
Neurosciences
Ana Agusti, Isabel Campillo, Tiziano Balzano, Alfonso Benitez-Paez, Inmaculada Lopez-Almela, Marina Romani-Perez, Jeronimo Forteza, Vicente Felipo, Nicole M. Avena, Yolanda Sanz
Summary: Food addiction is associated with gut microbiota, which can control binge eating and anxiety by influencing the brain's reward response. Administration of a specific bacterium can improve these symptoms, potentially by impacting levels of dopamine, serotonin, and noradrenaline.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Microbiology
Olajide Emmanuel Adedeji, Seung A. Chae, O-Hyun Ban, Won Yeong Bang, Hayoung Kim, Hyeon Ji Jeon, Chiemela Enyinnaya Chinma, Jungwoo Yang, Young Hoon Jung
Summary: This study evaluated the safety and anti-inflammatory activity of Lactobacillus johnsonii IDCC 9203. The strain showed resistance to tetracycline and aminoglycosides, but had no virulence or antibiotic resistance genes except tetW. The strain also exhibited no beta-hemolytic or beta-glucuronidase activity, and did not produce biogenic amines. Treatment with L. johnsonii IDCC 9203 significantly decreased the production of nitric oxide and pro-inflammatory cytokines in LPS-induced RAW 264.7 cells.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wei Dai, Jiaxue Zhang, Lu Chen, Junhong Yu, Junyi Zhang, Hua Yin, Qingsen Shang, Guangli Yu
Summary: This study demonstrates for the first time the protective effect of Bacteroides uniformis F18-22, isolated from the healthy human colon, against dextran-sulfate-sodium-induced ulcerative colitis in mice. Oral intake of B. uniformis F18-22 improves colon contraction, intestinal bleeding, and mucosal damage in diseased mice. It also restores gut dysbiosis by increasing the abundance of anti-inflammatory acetate-producing bacterium Eubacterium siraeum and decreasing pro-inflammatory pathogenetic bacteria Escherichia-Shigella spp.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Han Sol Kim, Ji-Sun Kim, Min Kuk Suh, Mi Kyung Eom, Ju Huck Lee, Seung-Hwan Park, Se Won Kang, Dong Ho Lee, Hyuk Yoon, Je Hee Lee, Jung-Sook Lee
Summary: Two similar anaerobic bacteria were isolated from the feces of two Korean individuals. They belong to the genus Bacteroides and have the ability to utilize complex polysaccharides that cannot be digested by humans.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Pediatrics
Veronica Fabrizio, Cheryl L. Harris, Kelly R. Walsh, Jennifer L. Wampler, Weihong Zhuang, Steven S. Wu
Summary: This study evaluated the effect of a hydrolyzed protein formula with added prebiotics on stool consistency in infants. The results showed that infants fed the formula had softer and more frequent stools compared to the control group. Additionally, crying, fussing, and pain during stooling decreased in both groups. This study suggests that the formula may have a positive effect on improving stool consistency in infants with reported hard or infrequent stools.
FRONTIERS IN PEDIATRICS
(2022)
Article
Immunology
Seung A. Chae, Sudha Rani Ramakrishnan, Taeok Kim, So -Rim Kim, Won Yeong Bang, Chae-Rim Jeong, Jungwoo Yang, Soo -Jung Kim
Summary: L. rhamnosus IDCC 3201 exhibited anti-inflammatory activity by decreasing the expression of cytokines and inducible enzymes in LPS-induced macrophages, as well as anti-pathogenic activity against various pathogens.
MICROBIAL PATHOGENESIS
(2022)
Article
Microbiology
Katja C. W. van Dongen, Athanasia Ioannou, Sebastiaan Wesseling, Karsten Beekmann, Clara Belzer
Summary: This study compares the functional differences in microbial fructoselysine degradation between breast-fed and formula-fed infants and finds that formula-fed infants have higher fructoselysine degradation activity. The results suggest that the infant gut microbiota adapts to dietary fructoselysine exposure, which affects the bacterial composition and metabolic capacity.
FEMS MICROBIOLOGY ECOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaoying Wu, Bei Wu, Yue Li, Xiue Jin, Xiliang Wang
Summary: Enterococci have dual characteristics as opportunistic pathogens and promising probiotics. In this study, a newly identified Enterococcus species, Enterococcus sanguinicola, was found to pose potential hazards. Evaluation of the isolated strain Enterococcus thailandicus TC1 showed sensitivity to clinically relevant antibiotics and beta-hemolytic activity. Animal experiments revealed no adverse effects on translocation and internal organ indices, but significant changes in gut histology were observed.
Article
Nutrition & Dietetics
Rui Li, Yalin Zhou, Yajun Xu
Summary: Currently, there is limited knowledge about the amount and composition of oligosaccharides (OS) in breast-fed babies' feces and their metabolic fate. This study successfully utilized UPLC-QE-HF-MS to identify the profiles of human milk oligosaccharides (HMOs) in breast milk and fecal OS in infants' feces. Significant variations and differences were observed in both the number and composition of HMOs and fecal OS. The metabolism of early-life gut microbiota may play a role in the breakdown, synthesis, bioconversion, or redesign of HMOs. Comparing the OS profiles between breast milk and feces can provide valuable insights into the fate of HMOs in the gastrointestinal tract.
Article
Microbiology
Hanh Vu, Yoshinori Muto, Masahiro Hayashi, Hideki Noguchi, Kaori Tanaka, Yoshimasa Yamamoto
Summary: This article presents the complete genome sequences of three Phocaeicola vulgatus strains isolated from the same healthy individual, determined by hybrid assembly using Nanopore long-read sequencing and DNBseq short-read sequencing.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Nutrition & Dietetics
Clair-Yves Boquien, Helene Billard, Laure Simon, Cecile Boscher, Arnaud Legrand, Evelyne Joram, Thomas Moyon, Marie-Cecile Alexandre-Gouabau, Dominique Darmaun, Jean-Christophe Roze
Summary: This study aimed to investigate the relationship between protein content in native breast milk and the 2-year neurodevelopment outcome in preterm infants. The results showed that the protein content in breast milk was not associated with neurodevelopmental outcomes in preterm infants at 2 years of age.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Microbiology
Li Zhao, Song Wang, Jiahuan Dong, Jialu Shi, Jiaqi Guan, Deyu Liu, Fei Liu, Bailiang Li, Guicheng Huo
Summary: This study isolated and screened B. longum subsp. longum strains with potential antioxidant properties from the gut microbiota of infants, with strain K5 showing high antioxidant capacity and promoting intestinal epithelial cell proliferation. These findings suggest that B. longum subsp. longum K5 could be a probiotic candidate for infant nutrition.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Yuliang Zhao, Guohua Li, Shengli Xia, Qiang Ye, Lin Yuan, Hong Li, Jiangjiao Li, Jingjing Chen, Shuyuan Yang, Zhiwei Jiang, Guoqing Zhao, Rongcheng Li, Yanping Li, Jielai Xia, Zhen Huang
Summary: The study aimed to determine the non-inferiority of the seven common serotypes in PCV13 compared to PCV7, and the superiority of its six additional serotypes. The results showed that PCV13 was immunogenic for all serotypes and had a comparable safety profile to PCV7.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Paula Sancho, Amparo Andres-Borderia, Nerea Gorria-Redondo, Katia Llano, Dolores Martinez-Rubio, Maria Eugenia Yoldi-Petri, Luba Blumkin, Pablo Rodriguez de la Fuente, Fernando Gil-Ortiz, Leonor Fernandez-Murga, Ana Sanchez-Monteagudo, Vincenzo Lupo, Belen Perez-Duenas, Carmen Espinos, Sergio Aguilera-Albesa
Summary: This study identified a non-progressive congenital ataxia (NPCA) phenotype caused by mutations in the beta-III spectrin (SPTBN2) gene, which resembles spinocerebellar ataxia but has an inheritance pattern similar to autosomal dominant classical spinocerebellar ataxia. The patients displayed characteristic symptoms of NPCA, including hypotonia, developmental delay, cerebellar syndrome, and cognitive deficits, along with progressive cerebellar volume loss and cortical hyperintensities on imaging. The novel de novo SPTBN2 substitutions detected in the patients were found to potentially disrupt actin spectrin-based membrane skeleton organization and contribute to the disease mechanism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Laureano E. Carpio, Yolanda Sanz, Rafael Gozalbes, Stephen J. Barigye
Summary: There is a growing interest in healthy foods, nutraceuticals, and cosmeceuticals, but regulations across countries vary and there is controversy over the effectiveness and mode of action of these products. Computational approaches are being used to discover bioactive molecules in these products and provide biological plausibility.
MOLECULAR DIVERSITY
(2021)
Article
Neurosciences
Ana Agusti, Isabel Campillo, Tiziano Balzano, Alfonso Benitez-Paez, Inmaculada Lopez-Almela, Marina Romani-Perez, Jeronimo Forteza, Vicente Felipo, Nicole M. Avena, Yolanda Sanz
Summary: Food addiction is associated with gut microbiota, which can control binge eating and anxiety by influencing the brain's reward response. Administration of a specific bacterium can improve these symptoms, potentially by impacting levels of dopamine, serotonin, and noradrenaline.
MOLECULAR NEUROBIOLOGY
(2021)
Review
Oncology
Beatriz Honrubia-Peris, Javier Garde-Noguera, Jose Garcia-Sanchez, Nuria Piera-Molons, Antonio Llombart-Cussac, Maria Leonor Fernandez-Murga
Summary: Immune checkpoint inhibitors have revolutionized the treatment of advanced NSCLC, but current biomarkers such as PD-L1 and PD-L1 have limitations. New non-invasive biomarkers are urgently needed to improve patient selection. Recent advances have focused on developing novel soluble biomarkers for better prediction of treatment response and toxicity in NSCLC patients undergoing immunotherapy.
Review
Biochemical Research Methods
Annelein Meisner, Beatrix Wepner, Tanja Kostic, Leo S. van Overbeek, Christine J. Bunthof, Rafael Soares Correa de Souza, Marta Olivares, Yolanda Sanz, Lene Lange, Doreen Fischer, Angela Sessitsch, Hauke Smidt
Summary: Microbiomes are essential players in various ecosystems and have significant impacts on biotechnological applications and health. However, current research mostly focuses on individual ecosystems, and a systems approach is needed to fully understand and utilize microbiomes for sustainable bioeconomy.
CURRENT OPINION IN BIOTECHNOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Yolanda Sanz, Marta Olivares
Review
Gastroenterology & Hepatology
Eline Margrete Randulff Hillestad, Aina van der Meeren, Bharat Halandur Nagaraja, Ben Rene Bjorsvik, Noman Haleem, Alfonso Benitez-Paez, Yolanda Sanz, Trygve Hausken, Guelen Arslan Lied, Arvid Lundervold, Birgitte Berentsen
Summary: This comprehensive review discusses the major features of irritable bowel syndrome and its interaction with gut microbiota, clinical microbiota-altering treatments such as low FODMAP diet and fecal microbiota transplantation, neuroimaging and microbiota analysis methods, and current and future challenges in big data analysis in IBS.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Nutrition & Dietetics
Rebeca Liebana-Garcia, Marta Olivares, Sonia M. Rodriguez-Ruano, Veronica Tolosa-Enguis, Isabel Chulia, Lidia Gil-Martinez, Enrique Guillamon, Alberto Banos, Yolanda Sanz
Summary: In this study, propyl propane thiosulfinate (PTS) showed dose-dependent anti-obesogenic effects in a murine model of diet-induced obesity. PTS prevented weight gain, adipocyte enlargement, inflammation, and gut barrier dysfunction caused by the obesogenic diet. The higher dose of PTS also improved glucose metabolism, liver homeostasis, lipid metabolism, and thermogenic capacity of brown adipose tissue.
Article
Gastroenterology & Hepatology
Alfonso Benitez-Paez, Annick Hartstra, Max Nieuwdorp, Yolanda Sanz
Summary: This study analyzed the changes in the human gut microbiota during a fecal microbiota transplantation (FMT) trial using nanopore technology. The results show that the engraftment of donors' microbiota is correlated with the improvement of metabolic health in recipients. Furthermore, the study revealed that assessing nucleotide frequencies can successfully explore the engraftment of donor bacterial strains. The findings indicate that factors such as baseline gut microbiota configuration, sex, and age of donors should be considered for successful FMT in humans.
Review
Food Science & Technology
V Rossini, V Tolosa-Enguis, C. Frances-Cuesta, Y. Sanz
Summary: SARS-CoV-2 primarily affects the respiratory system, but it also targets the gastrointestinal tract. Prolonged gut disorders in COVID-19 patients are associated with decreased richness and diversity of the gut microbiota, immune deregulation, and delayed viral clearance. The composition and function of the gut microbiome may play a role in the progression of COVID-19. Strategies to modulate the gut microbiome are being investigated for population stratification and management of COVID-19 infection.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Nutrition & Dietetics
Ana Agusti, Femke Lamers, Maria Tamayo, Carlos Benito-Amat, Gara V. Molina-Mendoza, Brenda W. J. H. Penninx, Yolanda Sanz
Summary: Exposure to early life stress can significantly impact mental and physical health. The role of the intestinal microbiome in human health, particularly mental health, is becoming increasingly evident. This systematic review found a link between early life stress and the gut microbiome, but no consensus microbiome signatures were identified, highlighting the need for further studies with consistent stressors and validated measures to draw definitive conclusions.
Article
Oncology
Antonio Llombart-Cussac, Antonio Anton-Torres, Beatriz Rojas, Raquel Andres, Noelia Martinez, Cesar A. Rodriguez, Sara Marin, Teresa Puertolas, Alejandro Falcon Gonzalez, Maria Leonor Fernandez-Murga, Carlos Hagen, Manuel Ruiz-Borrego
Summary: The 21-gene Oncotype DX Breast Recurrence Score assay is predictive of chemotherapy benefit for patients with estrogen receptor-positive, HER2- early breast cancer. It has the potential to guide treatment decisions in high-risk patients with early breast cancer.
Article
Gastroenterology & Hepatology
Rebeca Liebana-Garcia, Marta Olivares, Carlos Frances-Cuesta, Teresa Rubio, Valerio Rossini, Guillermo Quintas, Yolanda Sanz
Summary: Hypercaloric diets disrupt the microbiome and epithelial cell functions, affecting glucose metabolism. In obese mice, intestinal proinflammatory group 1 innate lymphoid cells (ILC1s) play a role in obesity and metabolic disruption. Depletion of ILC1s leads to an increase in ILC3-IL-22 pathway, resulting in changes in gut hormones, insulin levels, and adiposity. ILC1s also affect the abundance of Akkermansia muciniphila and Bilophila spp. Intestinal ILC1s are important in connecting immunity, microbiome, enteroendocrine system, and glucose metabolism and adiposity control.
Editorial Material
Microbiology
Alejandra Flor-Duro, Marta Olivares, Yolanda Sanz
Summary: Tracking the journey of inulin, a soluble dietary fibre, reveals that it can alleviate liver disease in mice by undergoing transformation by the gut microbiota.
NATURE MICROBIOLOGY
(2023)
Article
Food Science & Technology
Marina Romani-Perez, Clara Bullich-Vilarrubias, Inmaculada Lopez-Almela, Yolanda Sanz
Summary: This study reveals sex-dependent differences in the regulation of energy metabolism by the sodium channel Nav1.8, and suggests that activation of these neurons can improve oral glucose tolerance in females and inhibit glucagon secretion induced by glucose.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)