Article
Ecology
Brendan A. Daisley, Andrew P. Pitek, Christina Torres, Robin Lowery, Bethany A. Adair, Kait F. Al, Bernardo Nino, Jeremy P. Burton, Emma Allen-Vercoe, Graham J. Thompson, Gregor Reid, Elina Nino
Summary: Optimizing delivery methods can effectively apply beneficial lactobacilli consortium (LX3) to protect honey bees and promote hive health, resulting in increased brood production and colony growth.
Article
Chemistry, Multidisciplinary
Jiarong Zhou, Christian J. Ventura, Yiyan Yu, Weiwei Gao, Ronnie H. Fang, Liangfang Zhang
Summary: In this study, a biomimetic nanotoxoid was designed using neutrophil membrane-coated nanoparticles to capture secreted A. baumannii factors. The nanovaccine formulation rapidly mobilizes innate immune cells and promotes pathogen-specific adaptive immunity. In murine models, vaccination with the nanovaccine offers significant protection against A. baumannii infections.
Article
Biochemistry & Molecular Biology
Shereen M. Hamdy, Amal W. Danial, Eman M. Halawani, Ahmed A. M. Shoreit, Abd El-Latif Hesham, Sanaa M. F. Gad El-Rab
Summary: This study describes wound dressing materials made from biodegradable polyhydroxybutyrate (PHB) combined with AgNPs and gelatin (AgNPs/Gelatin/PHB). The results show that AgNPs/Gelatin/PHB exhibits excellent antimicrobial efficacy against bacteria and facilitates a better wound healing process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Badriyah Shadid Alotaibi, Maryam Shoukat, Manal Buabeid, Abida Kalsoom Khan, Ghulam Murtaza
Summary: The use of neomycin-loaded CG/PAN/PU nanofibers can promote wound healing, especially in burn wounds, indicating great potential in this field.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amina El Ayadi, John R. Salsbury, Perenlei Enkhbaatar, David N. Herndon, Naseem H. Ansari
Summary: Topical application of LF lotion containing EDTA and MSM can protect against burn progression by reducing cell death depth and blood vessel blockages, as well as decreasing inflammatory markers and lipid aldehyde production. LF lotion may serve as a targeted treatment to mitigate burn wound conversion.
Review
Pharmacology & Pharmacy
Debajyoti Pal, Pritish Rath, Pratik Das, Biswanath Kundu, Samit Kumar Nandi
Summary: Severe burn injuries pose significant health challenges, leading to extensive damage to organs and high morbidity and mortality rates. While early debridement and graft application have improved the outcomes for burn patients, there are still drawbacks such as delayed healing, scarring, infection, and pain. New techniques and medications are needed to enhance healing quality. This review article discusses the latest treatments in burn wound management, including the use of antibiotics, metallic ions, nanotherapeutics, and tissue engineering.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Infectious Diseases
Xuan Wang, Dan Liao, Qiu-Ming Ji, Yu-Hong Yang, Ming-Chao Li, Xian-Yun Yi, Chi Li, Yu Chen, Hong-Bo Tao, Wen-Hui Zhai
Summary: The study revealed that ozone gas and oil groups were able to completely eliminate multidrug-resistant bacteria within 30 minutes, while the bactericidal effect of the ozone gas group was significantly better than the ozone water and oil groups at 5 and 10 minutes. There was no significant difference in bactericidal effect between the ozone water group and the ozone gas and oil groups after 30 minutes.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Medicine, General & Internal
Jia Wan, Xi Yu, Jia-Qi Niu, Le Qiu, Fei Wang, Xu-Lin Chen
Summary: This study aimed to investigate the role and molecular mechanisms of Bruton's tyrosine kinase (BTK) in burn sepsis-induced intestinal injury. The results showed that BTK activation is closely associated with the histopathological changes, cellular apoptosis, inflammatory cytokine release, and oxidative stress induced by burn sepsis in the intestine.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
P. R. Vanitha, Rakesh Somashekaraiah, S. Divyashree, Indranil Pan, M. Y. Sreenivasa
Summary: The primary objective of this study was to evaluate the probiotic attributes and antifungal activity of lactic acid bacteria (LAB) against Trichophyton tonsurans. Among the screened isolates, MYSN7 showed strong antifungal activity and had potential probiotic characteristics. The cell-free supernatant (CFS) of MYSN7 exhibited effective antibacterial activity and significant anti-Trichophyton activity. The CFS was found to contain organic acids, with succinic acid and lactic acid being the predominant components.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Infectious Diseases
Gayathri Vijayakumar, Hyung Joo Kim, Senthil Kumaran Rangarajulu
Summary: In this study, probiotic bacteria were used to synthesize silver nanoparticles with significant antioxidant and antibacterial activities. The biosynthesized AgNPs showed significant wound-healing capabilities, as observed through an in vitro scratch-wound assay. Cytotoxic experiments demonstrated that the biosynthesized AgNPs were not extremely hazardous to fibroblast cells.
Article
Microbiology
Yixin Zhang, Xiaolong Liu, Huamei Wen, Zhongle Cheng, Yanyu Zhang, Haichuan Zhang, Zhongwen Mi, Xinjiong Fan
Summary: Pseudomonas aeruginosa can form biofilms at burn wound sites, causing infection and treatment failure. Previous in vitro studies have shown that a combination of the quorum-quenching enzyme AidH(A147G) and the extracellular matrix hydrolase PslG effectively inhibits biofilm formation and enhances antibiotic effects. This study aimed to evaluate the efficacy of this enzyme combination in conjunction with tobramycin for treating P. aeruginosa-infected burn wounds. The results showed that simultaneous treatment with these enzymes and antibiotics reduced tissue damage severity, bacterial load, and inflammatory markers, indicating it as a potentially effective treatment for P. aeruginosa biofilm infections of burn wounds.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Yalda Mahjoory, Reza Mohammadi, Mohammad Amin Hejazi, Yousef Nami
Summary: The potential of two identified probiotic strains, ABRIIFBI-6 and ABRIIFBI-7, to inhibit the growth of aspergilli and reduce aflatoxin availability was investigated. Both strains survived in simulated gastrointestinal conditions and significantly inhibited Aspergillus growth. They also exhibited high auto-aggregation, hydrophobicity, and coaggregation abilities with other bacteria. These findings contribute to the understanding of LAB probiotic potential in dairy products and their use as biocontrol agents against aflatoxin-producing species.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Maria Laggner, Marie-Therese Lingitz, Dragan Copic, Martin Direder, Katharina Klas, Daniel Bormann, Alfred Gugerell, Bernhard Moser, Christine Radtke, Stefan Hacker, Michael Mildner, Hendrik Jan Ankersmit, Thomas Haider
Summary: Burn injuries elicit a unique stress response and can lead to burn injury progression. This study found that levels of neutrophil-derived factors were significantly elevated in burn victims, and leukocyte and neutrophil counts were increased while lymphocytes were decreased. These factors did not predict mortality, but were associated with higher burn severity scores in patients with third-degree burns.
SCIENTIFIC REPORTS
(2022)
Article
Pharmacology & Pharmacy
Weibin Zhang, Zhe An, Yuqi Bai, Ying Zhou, Fangyi Chen, Ke-Jian Wang
Summary: Antimicrobial resistance (AMR) is a significant global threat to human health. In this study, a novel cationic antimicrobial peptide (AMP) named Scyreptin1-30 was identified, which showed broad-spectrum antimicrobial activity against bacteria and fungi, including the clinically isolated multidrug-resistant bacteria Pseudomonas aeruginosa. Scyreptin1-30 exhibited rapid bactericidal kinetics and destroyed bacterial membranes. It also demonstrated no discernible cytotoxicity and promoted wound healing in vivo. The findings suggest that Scyreptin1-30 holds promise as an effective antibacterial agent against multidrug-resistant bacterial infections.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Songxue Guo, Quan Fang, Leilei Chen, Meirong Yu, Yike Chen, Nan Li, Chunmao Han, Xueqing Hu
Summary: The study found that burn-induced typical ischemia and histological deterioration in the zone of stasis were parallel with increases in oxidative stress and apoptosis, with mitochondrial damage playing a role in these changes. Additionally, mitophagy was detected in burn-wounds, contradicting the burn wound conversion. HIF-1 alpha expression was closely related to the level of mitophagy, while BNIP3 and PARKIN are involved downstream.
Article
Genetics & Heredity
Latha Satish, J. Michael Krill-Burger, Phillip H. Gallo, Shelley Des Etages, Fang Liu, Brian J. Philips, Sudheer Ravuri, Kacey G. Marra, William A. LaFramboise, Sandeep Kathju, J. Peter Rubin
BMC MEDICAL GENOMICS
(2015)
Article
Orthopedics
Latha Satish, Bradley Palmer, Fang Liu, Loukia Papatheodorou, Lora Rigatti, Mark E. Baratz, Sandeep Kathju
BMC MUSCULOSKELETAL DISORDERS
(2015)
Article
Orthopedics
Chaoming Zhou, Fang Liu, Phillip H. Gallo, Mark E. Baratz, Sandeep Kathju, Latha Satish
BMC MUSCULOSKELETAL DISORDERS
(2016)
Article
Critical Care Medicine
Jacqueline M. Bliley, Anne Argenta, Latha Satish, Meghan M. McLaughlin, Aaron Dees, Casey Tompkins-Rhoades, Kacey G. Marra, J. Peter Rubin
Article
Cell Biology
Richard J. Bodnar, Latha Satish, Cecelia C. Yates, Alan Wells
WOUND REPAIR AND REGENERATION
(2016)
Article
Infectious Diseases
Latha Satish, Phillip H. Gallo, Sandra Johnson, Cecelia C. Yates, Sandeep Kathju
SURGICAL INFECTIONS
(2017)
Article
Surgery
Isaac James, Debra Bourne, Mayara Silva, Emmanuelle Havis, Kassandra Albright, Liyong Zhang, Nataliya Kostereva, Sheri Wang, Gabriella DiBernardo, Rachel Guest, Jenny Lei, Aurora Almadori, Latha Satish, Kacey Marra, J. Peter Rubin
JOURNAL OF SURGICAL RESEARCH
(2018)
Editorial Material
Medicine, General & Internal
Latha Satish
Article
Cell & Tissue Engineering
Richard J. Bodnar, Tianbing Yang, Lora H. Rigatti, Fang Liu, Alexander Evdokiou, Sandeep Kathju, Latha Satish
Article
Orthopedics
Chaoming Zhou, Yael Zeldin, Mark E. Baratz, Sandeep Kathju, Latha Satish
BMC MUSCULOSKELETAL DISORDERS
(2019)
Meeting Abstract
Cell Biology
Alexander Evdokiou, Stephanie Gierek, Onur Kanisicak, Richard Bodnar, Latha Satish
WOUND REPAIR AND REGENERATION
(2019)
Meeting Abstract
Cell Biology
L. Satish, T. Yang, F. Liu, L. Rigatti, R. J. Bodnar, S. Kathju
WOUND REPAIR AND REGENERATION
(2016)
Meeting Abstract
Cell Biology
L. Satish, R. N. Kreft, T. Yang, P. H. Gallo, F. Liu, A. Argenta, J. Ziembicki, A. Corcos, S. Kathju
WOUND REPAIR AND REGENERATION
(2015)
Meeting Abstract
Cell Biology
Alexander Evdokiou, Richard Bodnar, Latha Satish
WOUND REPAIR AND REGENERATION
(2018)