Variation in Human Cytochrome P-450 Drug-Metabolism Genes: A Gateway to the Understanding of Plasmodium vivax Relapses

Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial

(2016) Pamela L. St Jean et al.   MALARIA JOURNAL

In silico functional dissection of saturation mutagenesis: Interpreting the relationship between phenotypes and changes in protein stability, interactions and activity

(2016) Douglas E. V. Pires et al.   Scientific Reports

Differential CYP 2D6 Metabolism Alters Primaquine Pharmacokinetics

(2015) Brittney M. J. Potter et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Twelve novel HGD gene variants identified in 99 alkaptonuria patients: focus on ‘black bone disease’ in Italy

(2015) Martina Nemethova et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Contributions of Ionic Interactions and Protein Dynamics to Cytochrome P450 2D6 (CYP2D6) Substrate and Inhibitor Binding

(2015) An Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Estimation of the Antirelapse Efficacy of Tafenoquine, UsingPlasmodium vivaxGenotyping

(2015) Hans-Peter Beck et al.   JOURNAL OF INFECTIOUS DISEASES

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

(2015) Douglas E. V. Pires et al.   JOURNAL OF MEDICINAL CHEMISTRY

ENCoM server: exploring protein conformational space and the effect of mutations on protein function and stability

(2015) Vincent Frappier et al.   NUCLEIC ACIDS RESEARCH

Flexibility and small pockets at protein–protein interfaces: New insights into druggability

(2015) Harry Jubb et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Germline Mutations in the CDKN2B Tumor Suppressor Gene Predispose to Renal Cell Carcinoma

(2015) M. Jafri et al.   Cancer Discovery

Strategies for Understanding and Reducing the Plasmodium vivax and Plasmodium ovale Hypnozoite Reservoir in Papua New Guinean Children: A Randomised Placebo-Controlled Trial and Mathematical Model

(2015) Leanne J. Robinson et al.   PLOS MEDICINE

Modeling the Dynamics of Plasmodium vivax Infection and Hypnozoite Reactivation In Vivo

(2015) Adeshina I. Adekunle et al.   PLoS Neglected Tropical Diseases

Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis

(2014) Ric N Price et al.   LANCET INFECTIOUS DISEASES

Estimates of adherence to treatment of vivax malaria

(2014) Eduardo D Almeida et al.   MALARIA JOURNAL

The clinical and public health problem of relapse despite primaquine therapy: case review of repeated relapses of Plasmodium vivax acquired in Papua New Guinea

(2014) R Joan H Ingram et al.   MALARIA JOURNAL

Platinum: a database of experimentally measured effects of mutations on structurally defined protein–ligand complexes

(2014) Douglas E.V. Pires et al.   NUCLEIC ACIDS RESEARCH

DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach

(2014) D. E. V. Pires et al.   NUCLEIC ACIDS RESEARCH

Distribution of CYP2D6 Alleles and Phenotypes in the Brazilian Population

(2014) Deise C. Friedrich et al.   PLoS One

mCSM: predicting the effects of mutations in proteins using graph-based signatures

(2013) Douglas E. V. Pires et al.   BIOINFORMATICS

The activation of vivax malaria hypnozoites by infectious diseases

(2013) G Dennis Shanks et al.   LANCET INFECTIOUS DISEASES

The metabolism of primaquine to its active metabolite is dependent on CYP 2D6

(2013) Brandon S Pybus et al.   MALARIA JOURNAL

Primaquine Failure and Cytochrome P-450 2D6 in Plasmodium vivax Malaria

(2013) Jason W. Bennett et al.   NEW ENGLAND JOURNAL OF MEDICINE

Postmortem Characterization of Patients With Clinical Diagnosis of Plasmodium vivax Malaria: To What Extent Does This Parasite Kill?

(2012) Marcus V. G. Lacerda et al.   CLINICAL INFECTIOUS DISEASES

Relapses Contribute Significantly to the Risk of Plasmodium vivax Infection and Disease in Papua New Guinean Children 1–5 Years of Age

(2012) Inoni Betuela et al.   JOURNAL OF INFECTIOUS DISEASES

CYP450 phenotyping and accurate mass identification of metabolites of the 8-aminoquinoline, anti-malarial drug primaquine

(2012) Brandon S Pybus et al.   MALARIA JOURNAL

Multiple-Clone Activation of Hypnozoites Is the Leading Cause of Relapse in Plasmodium vivax Infection

(2012) Flávia Carolina F. de Araujo et al.   PLoS One

High genetic polymorphism of relapsing P. vivax isolates in northwest Colombia

(2011) Eliana Restrepo et al.   ACTA TROPICA

Pharmacogenomics of CYP2D6: Molecular Genetics, Interethnic Differences and Clinical Importance

(2011) Lay Kek Teh et al.   Drug Metabolism and Pharmacokinetics

Human Genetic Variation Is Associated With Plasmodium falciparum Drug Resistance

(2011) G. M. Paganotti et al.   JOURNAL OF INFECTIOUS DISEASES

The First Plasmodium vivax Relapses of Life Are Usually Genetically Homologous

(2011) Mallika Imwong et al.   JOURNAL OF INFECTIOUS DISEASES

Adherence to Plasmodium vivax malaria treatment in the Brazilian Amazon Region

(2011) Elza A Pereira et al.   MALARIA JOURNAL

Activation of the hypnozoite: a part of Plasmodium vivax life cycle and survival

(2011) Lena Hulden et al.   MALARIA JOURNAL

Plasmodium vivax Sub-Patent Infections after Radical Treatment Are Common in Peruvian Patients: Results of a 1-Year Prospective Cohort Study

(2011) Peter Van den Eede et al.   PLoS One

How Much Remains Undetected? Probability of Molecular Detection of Human Plasmodia in the Field

(2011) Cristian Koepfli et al.   PLoS One

High Complexity of Plasmodium vivax Infections in Symptomatic Patients from a Rural Community in Central Vietnam Detected by Microsatellite Genotyping

(2010) Peter Van den Eede et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Multidrug-Resistant Plasmodium vivax Associated with Severe and Fatal Malaria: A Prospective Study in Papua, Indonesia

(2008) Emiliana Tjitra et al.   PLOS MEDICINE