Article
Biochemistry & Molecular Biology
Romain Ragimbeau, Leila El Kebriti, Salwa Sebti, Elise Fourgous, Abdelhay Boulahtouf, Giuseppe Arena, Lucile Espert, Andrei Turtoi, Celine Gongora, Nadine Houede, Sophie Pattingre
Summary: BAG6 is a nucleocytoplasmic shuttling protein involved in protein quality control and has been shown to play a crucial role in mitophagy by regulating PINK1/PARKIN signaling in a LIR-dependent manner. Its localization in the mitochondria and interaction with LC3 suggest that BAG6 acts as a novel mitophagy receptor or adaptor.
Review
Immunology
Guangyuan Du, Zherui Xing, Jue Zhou, Can Cui, Chenyuan Liu, Yiping Liu, Zheng Li
Summary: The RLR pathway is a significant pathway in cells for monitoring abnormal RNA, which activates inflammatory effects to combat infections and also participates in cancer development. Various modifications are involved in regulating the RLR pathway in cancer, either enhancing tumor suppression or promoting tumor development. This review summarizes epigenetic, post-transcriptional, and post-translational modifications of the RLR pathway in cancer cells, and provides an overview of therapeutic strategies targeting this pathway in cancers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Haixia Wen, Yunyan Zuo, Luxi Li, Lixuan Zhan, Jiahui Xue, Weiwen Sun, En Xu
Summary: Hypoxic postconditioning (HPC) enhances Parkin-catalyzed mitochondrial ubiquitination to restore mitophagy in hippocampal CA1 against transient global cerebral ischemia (tGCI). This study investigates the molecular mechanism of HPC-mediated mitophagy after tGCI. The results suggest that HPC maintains K63-linked poly-ubiquitination (K63-Ub) of TBK1 in a Parkin-dependent manner to promote TBK1 phosphorylation and activate p62, thus restoring mitophagy and alleviating neuronal damage in CA1 after tGCI.
NEUROBIOLOGY OF DISEASE
(2023)
Editorial Material
Cell Biology
Cecilia Gotor, Angeles Aroca, Luis C. Romero
Summary: This commentary highlights the recent findings on the H2S regulation of autophagy in mammalian cells and discusses the similarities/divergences with plant cells. The main outcome of the study is the conserved molecular mechanism involving the posttranslational modification of thiol groups on cysteine residues to form persulfides.
Article
Neurosciences
Maria Bichmann, Nuria Prat Oriol, Ebru Ercan-Herbst, David C. Schoendorf, Borja Gomez Ramos, Vera Schwaerzler, Marie Neu, Annabelle Schlueter, Xue Wang, Liang Jin, Chenqi Hu, Yu Tian, Janina S. Ried, Per Haberkant, Laura Gasparini, Dagmar E. Ehrnhoefer
Summary: This study identified novel lysine methylation events on Tau protein in human Alzheimer's disease (AD) brain tissue and a mouse model of Tauopathy, demonstrating that methylated Tau levels increase with Tau pathology stage. Methylated Tau is enriched in soluble brain extracts, preferentially localizes to the cell soma and nuclear fractions, and is not associated with hyperphosphorylated, high molecular weight Tau species. The identification of SETD7 as a novel lysine methyltransferase for Tau suggests that methylated Tau may play a role in translocation to different subcellular compartments, shedding light on disease-associated phenomena related to Tau mislocalization.
MOLECULAR NEURODEGENERATION
(2021)
Article
Multidisciplinary Sciences
Jinghong Xu, Takuya Hashino, Reiji Tanaka, Koichiro Kawaguchi, Hideki Yoshida, Takao Kataoka
Summary: BCL-RAMBO interacts with GRP75 and mortalin, and mediates apoptosis by activating caspases and cleaving PARP-1.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Shulin Zhao, Boyan Li, Rongrong Zhao, Ziwen Pan, Shouji Zhang, Wei Qiu, Qindong Guo, Yanhua Qi, Zijie Gao, Yang Fan, Hao Xu, Ming Li, Jian Zhang, Huizhi Wang, Jianye Xu, Shaobo Wang, Qingtong Wang, Jiawei Qiu, Lin Deng, Xing Guo, Ping Zhang, Hao Xue, Gang Li
Summary: In this study, a previously unreported circRNA named circADAMTS6 was found to be specifically upregulated in the hypoxic microenvironment of glioblastoma and was closely related to poor prognosis. CircADAMTS6 was shown to promote malignant progression of glioblastoma by enhancing cell proliferation, inhibiting apoptosis, and regulating the NF-kappa B pathway. Targeting circADAMTS6 could be a novel therapeutic strategy for glioblastoma.
Article
Medicine, Research & Experimental
Aneta Stachowicz, Alia Sadiq, Brian Walker, Niveda Sundararaman, Justyna Fert-Bober
Summary: This study revealed that the treatment with BB-Cl leads to increased expression of HO-1 through the Nrf2 pathway, which can prevent excessive tissue damage and provide substantial clinical benefits for the treatment of cardiac fibrosis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Yan Wang, Weichun He
Summary: A significant proportion of diabetes patients will develop kidney disease, with Diabetic Kidney Disease (DKD) being a major complication and leading cause of end-stage kidney disease worldwide. FoxO1 transcription factor plays a crucial role in the pathogenesis of DKD and may be a potential clinical target for prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yekatarina Gadasheva, Alexander Nolze, Claudia Grossmann
Summary: Cardiovascular aging leads to increased arterial stiffness and left ventricular hypertrophy, with the renin-angiotensin-aldosterone system playing a key role in regulating electrolyte balance and blood pressure. The mineralocorticoid receptor can undergo enzymatic and non-enzymatic modifications, impacting its activity independently of its ligand aldosterone. These modifications may have implications for cardiovascular aging and diseases.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Cell Biology
Hong-Yi Liu, Ying-Ying Liu, Yin-Ling Zhang, Yan Ning, Fang-Lin Zhang, Da-Qiang Li
Summary: The study found that NAT10 undergoes covalent PARylation modification following DNA damage, with PARP1 catalyzing PARylation on three conserved lysine residues within its C-terminal nucleolar localization signal. These findings reveal the key role of PARP1-mediated PARylation of NAT10 in controlling its nucleoplasmic translocation and function in response to DNA damage.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Virology
Atsuko Sugimoto, Yuichi Abe, Tadashi Watanabe, Kohei Hosokawa, Jun Adachi, Takeshi Tomonaga, Yasumasa Iwatani, Takayuki Murata, Masahiro Fujimuro
Summary: During Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication, the UBE1L2-FAT10 system is upregulated to promote FAT10ylation and contribute to viral propagation.
JOURNAL OF VIROLOGY
(2021)
Article
Agricultural Engineering
Guangjia Jiao, Hanjun Zhou, Xianzhen Li, Jing Liu, Diao She
Summary: In this study, high-performance Fe-Mn-modified industrial lignin-based biochar (FMBC) was successfully prepared to efficiently degrade oxytetracycline using a sulfate radical-based advanced oxidation process. The results showed that oxygenated functional groups, Fe and Mn synergistic effect, and defective structures in the industrial lignin-based biochar were the active sites for activation of peroxy-disulfate. A total of 38 intermediates were proposed for the first time, and oxytetracycline was degraded in 7 ways. This study provides a new perspective on the application of industrial lignin in the advanced oxidative degradation of organic pollutants.
BIORESOURCE TECHNOLOGY
(2023)
Article
Plant Sciences
Sheng Huang, Noriyuki Konishi, Naoki Yamaji, Ji Feng Shao, Namiki Mitani-Ueno, Jian Feng Ma
Summary: Boron uptake in rice is mediated by two transporters, OsLsi1 and OsBOR1, with polar localization cooperating for efficient uptake. OsBOR1 undergoes degradation in response to high B, while OsLsi1 remains unaffected. This distinct regulatory mechanism in rice involves clathrin-independent degradation of OsBOR1 in contrast to Arabidopsis thaliana.
Article
Multidisciplinary Sciences
Zhibin Lin, Peijun Yang, Yufeng Hu, Hao Xu, Juanli Duan, Fei He, Kefeng Dou, Lin Wang
Summary: This study reveals the important role of RNF13 protein in NAFLD progression, which can alleviate NAFLD phenotypes by facilitating TRIM29-mediated degradation of STING.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Maria Levchenko, Jan-Moritz Wuttke, Katharina Roempler, Bernhard Schmidt, Klaus Neifer, Lisa Juris, Mirjam Wissel, Peter Rehling, Markus Deckers
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Maria Levchenko, Yuci Gou, Florian Graef, Audrey Hamelers, Zhan Huang, Michele Ide-Smith, Anusha Iyer, Oliver Kilian, Jyothi Katuri, Jee-Hyub Kim, Nikos Marinos, Rakesh Nambiar, Michael Parkin, Xingjun Pi, Frances Rogers, Francesco Talo, Vid Vartak, Aravind Venkatesan, Johanna McEntyre
NUCLEIC ACIDS RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Matthew Thakur, Alex Bateman, Cath Brooksbank, Mallory Freeberg, Melissa Harrison, Matthew Hartley, Thomas Keane, Gerard Kleywegt, Andrew Leach, Mariia Levchenko, Sarah Morgan, Ellen M. McDonagh, Sandra Orchard, Irene Papatheodorou, Sameer Velankar, Juan Antonio Vizcaino, Rick Witham, Barbara Zdrazil, Johanna McEntyre
Summary: EMBL-EBI is one of the world's leading sources of public biomolecular data, offering sustainable, high-quality data that can serve as training sets for deep learning and artificial intelligence applications. The open availability of their extensive curated databases makes them ideal for research in the life sciences.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Christine Ferguson, Dayane Araujo, Lynne Faulk, Yuci Gou, Audrey Hamelers, Zhan Huang, Michele Ide-Smith, Maria Levchenko, Nikos Marinos, Rakesh Nambiar, Maaly Nassar, Michael Parkin, Xingjun Pi, Faisal Rahman, Frances Rogers, Yogmatee Roochun, Shyamasree Saha, Mohamed Selim, Zunaira Shafique, Shrey Sharma, David Stephenson, Francesco Talo', Arthur Thouvenin, Santosh Tirunagari, Vid Vartak, Aravind Venkatesan, Xiao Yang, Johanna McEntyre
Summary: Europe PMC is a research article database with a wide range of content available for free use. New developments since 2017 include the addition of life science preprint abstracts, a special collection of COVID-19-related preprints, and expanded links to content related to publications. The platform also offers a redesigned website with improved navigation and a figure browse feature, along with an expanded annotations platform containing a vast amount of text-mined biological terms and concepts.
NUCLEIC ACIDS RESEARCH
(2021)