Article
Cardiac & Cardiovascular Systems
Mehrdad Samadishadlou, Reza Rahbarghazi, Zeynab Piryaei, Mahdad Esmaeili, cigir Biray Avci, Farhad Bani, Kaveh Kavousi
Summary: By integrating bioinformatics and machine learning analysis, we identified a set of miRNA biomarkers for cardiovascular diseases. The study demonstrates that miRNA signatures derived from peripheral blood mononuclear cells can serve as valuable novel biomarkers for cardiovascular diseases.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zhengbao Zhu, Yan He, Mengyao Shi, Daoxia Guo, Kaixin Zhang, Liyun Ren, Yanbo Peng, Pinni Yang, Jing Chen, Yuhan Zang, Aili Wang, Tan Xu, Qunwei Li, Zhong Ju, Deqin Geng, Yonghong Zhang, Jiang He
Summary: Elevated plasma osteopontin levels at baseline were found to be associated with increased risks of adverse clinical outcomes at 1 year after ischemic stroke in this study.
Article
Cardiac & Cardiovascular Systems
Luis M. Rincon, Macarena Rodriguez-Serrano, Elisa Conde, Val F. Lanza, Marcelo Sanmartin, Paz Gonzalez-Portilla, Marta Paz-Garcia, Jose Manuel Del Rey, Miriam Menacho, Maria-Laura Garcia Bermejo, Jose L. Zamorano
Summary: This study evaluated the prognostic value of circulating miRNAs for heart failure-related events among MI patients. It found that several miRNAs reliably predicted HF hospitalizations, cardiovascular mortality, and poor long-term NYHA status, improving current risk prediction methods.
Article
Oncology
He-Guo Jiang, Chun-Hua Dai, Ya-Ping Xu, Qian Jiang, Xian-Bin Xia, Yang Shu, Jian Li
Summary: This study investigated the diagnostic and prognostic value of four plasma miRNAs in non-small cell lung cancer (NSCLC), confirming that miR-210, miR-1290, miR-150, and miR-21-5p were highly expressed in NSCLC patients. The four-miRNA panel showed high accuracy in distinguishing NSCLC patients from healthy controls and those with benign lung disease, suggesting their potential as useful biomarkers for early diagnosis and prognosis of NSCLC.
Review
Biochemistry & Molecular Biology
Priyanka Venugopal, Karthikeyan Balakrishnan, Sriram Damal Kandadai, Melvin George
Summary: Myocardial infarction is the leading cause of mortality and morbidity worldwide. While certain miRNAs are associated with MI, there is currently no conclusive evidence to suggest that these miRNAs can serve as ideal prognostic markers.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2022)
Review
Oncology
Md. Hafiz Uddin, Mohammed Najeeb Al-Hallak, Philip A. Philip, Ramzi M. Mohammad, Nerissa Viola, Kay-Uwe Wagner, Asfar S. Azmi
Summary: Pancreatic cancer is the fourth leading cause of cancer death in the United States, with PDAC accounting for over 90% of cases and a low survival rate. MiRNAs have been identified as sensitive biomarkers in pancreatic cancer and are found in stable forms within exosomes. Further research on exosomal miRNAs is necessary for improved diagnostic, prognostic, and therapeutic strategies.
Article
Pharmacology & Pharmacy
Bin Sheng, Niansheng Lai, Tao Tao, Xiangxin Chen, Sen Gao, Qi Zhu, Wei Li, Qingrong Zhang, Chunhua Hang
Summary: This study characterized plasma extracellular vesicles in patients with aSAH using microRNAs (miRNAs) as diagnostic tools. Next-generation sequencing identified four differentially expressed miRNAs, which were validated in a large cohort. The results showed that miR-369-3p, miR-410-3p, miR-193b-3p, and miR-486-3p could predict the neurological outcomes of aSAH patients and have potential clinical utility as prognostic biomarkers.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Ferran Moratalla-Navarro, Anna Diez-Villanueva, Ainhoa Garcia-Serrano, Adria Closa, David Cordero, Xavier Sole, Elisabet Guino, Rebeca Sanz-Pamplona, Xavier Sanjuan, Cristina Santos, Sebastiano Biondo, Ramon Salazar, Victor Moreno
Summary: In this study, a microRNA signature was identified to recognize patients at high recurrence risk in stage II colorectal cancer. The validity of these findings has been confirmed in an independent group of stage II microsatellite stable colon adenocarcinoma patients. Most of the microRNAs present in the signature have prognostic relevance in various other cancer types. Some of these microRNAs are involved in pivotal pathways of cancer progression.
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Review
Gastroenterology & Hepatology
Ming-He Zhang, Yu-Feng Yuan, Li-Juan Liu, Yu-Xin Wei, Wan-Yue Yin, Lan-Zhuo-Yin Zheng, Ying-Ying Tang, Zhao Lv, Fan Zhu
Summary: Hepatitis B virus (HBV) infection is a significant risk factor for hepatocellular carcinoma (HCC). MicroRNAs (miRNAs) have potential as biomarkers for early detection and therapy of HBV-associated HCC. This review summarizes the current progress on the role of miRNAs in the diagnosis and treatment of HBV-HCC, discussing the mechanism by which HBV regulates miRNAs and the exact effect of miRNAs on HCC promotion. In the near future, miRNA-based diagnostic, prognostic, and therapeutic applications will be integrated into clinical practice.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Microbiology
Gokulakannan Venkatesan, Wan Suriana Wan Ab Rahman, Wan Nazatul Shima Shahidan, Salfarina Iberahim, Alwi bin Muhd Besari Hashim
Summary: Early disease diagnosis is crucial for effective management and treatment. Diagnostic methods should be accurate, consistent, low-cost, and non-invasive. Exosomal microRNA (miRNA) has shown potential as biomarkers for various diseases, but its application in vector-borne diseases is limited. This review focuses on discussing miRNAs derived from exosomal plasma that may serve as disease biomarkers for early detection of vector-borne diseases.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Endocrinology & Metabolism
Huimin Jiang, Chen Zhou, Huimin Wei, Yan Wu, Yifan Zhou, Xuechun Xiao, Lu Liu, Ming Li, Jiangang Duan, Ran Meng, Xunming Ji
Summary: In this study, metabolomic analysis was performed on plasma samples from acute CVT patients and healthy controls to identify specific biomarkers with high predictive ability for the diagnosis of acute CVT. The results showed that the caffeine metabolism pathway and the biosynthesis pathway for the BCAAs valine, leucine, and isoleucine were significant pathways between the CVT and healthy cohorts. The concentrations of BCAAs demonstrated good diagnostic efficacy for differentiating patients with acute CVT from the control cohort.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Teodora Barbalata, Alina Scarlatescu, Gabriela M. Sanda, Laura Toma, Camelia S. Stancu, Maria Dorobantu, Miruna M. Micheu, Anca Sima, Loredan S. Niculescu
Summary: This study aimed to assess the potential of circulating microRNAs, cell-free DNA, and mitochondrial DNA as prognostic tools for unfavorable outcomes in ST-segment elevation myocardial infarction (STEMI). The results showed that the levels of miRNAs, cfDNA, and mtDNA were highest at hospital discharge, and these levels were increased in STEMI patients with major adverse cardiovascular events. Combination of mtDNA and miR-142-3p levels had the highest predictive value for MACE. These findings suggest that increased plasma levels of mtDNA, along with miR-142-3p, could be used as predictive markers for unfavorable outcomes in STEMI patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Yuling Cheng, Wei Kou, Dandan Zhu, Xinbo Yu, Yu Zhu
Summary: Adrenocortical carcinoma is a rare endocrine malignancy with frequent metastatic spread and poor prognosis. Despite the challenge in diagnosis, novel non-invasive biomarkers have been discovered and they may have important value in diagnosis, predicting prognosis, and disease monitoring.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell & Tissue Engineering
Guofeng Cai, Guoliang Cai, Haichun Zhou, Zhe Zhuang, Kai Liu, Siying Pei, Yanan Wang, Hong Wang, Xin Wang, Shengnan Xu, Cheng Cui, Manchao Sun, Sihui Guo, Kunping Jia, Xiuzhen Wang, Dianquan Zhang
Summary: The study investigated the potential of MSC-derived exosomes containing miR-542-3p in preventing ischemia-induced inflammatory response in glial cells by targeting TLR4. The results showed a decrease in miR-542-3p and an increase in TLR4 in MCAO mice, and overexpression of miR-542-3p alleviated cell apoptosis and inflammation induced by OGD. The delivery of exosome-miR-21-3p from MSCs also showed potential in relieving cerebral injury and inflammation caused by MCAO or OGD.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Clinical Neurology
Zi-Fu Li, Bo Hong, Yi Xv, Qing-Hai Huang, Wen-Yuan Zhao, Jian-Min Liu
CLINICAL NEUROLOGY AND NEUROSURGERY
(2015)
Article
Clinical Neurology
Zifu Li, Rui Zhao, Xinggen Fang, Jiahao Zhou, Guoquan Jiang, Qinghai Huang, Jianmin Liu
WORLD NEUROSURGERY
(2017)
Article
Neurosciences
Zi-Fu Li, Xing-Gen Fang, Peng-Fei Yang, Qing-Hai Huang, Wen-Yuan Zhao, Chong Liang, Rui Zhao, Jian-Min Liu
CNS NEUROSCIENCE & THERAPEUTICS
(2013)
Article
Clinical Neurology
Zifu Li, Yongwei Zhang, Bo Hong, Benqiang Deng, Yi Xu, Wenyuan Zhao, Jianmin Liu, Qinghai Huang
JOURNAL OF CLINICAL NEUROSCIENCE
(2014)
Article
Biochemistry & Molecular Biology
Zifu Li, Rui Zhao, Xinggen Fang, Qinghai Huang, Jianmin Liu
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2017)