Article
Neurosciences
Jan Korbecki, Donata Siminska, Dariusz Jezewski, Klaudyna Kojder, Patrycja Tomasiak, Maciej Tarnowski, Dariusz Chlubek, Irena Baranowska-Bosiacka
Summary: This study examines the expression of elongases in GBM tumor samples and finds that the synthesis of fatty acids in GBM tumors may be higher in men than in women.
Article
Biochemistry & Molecular Biology
Naoki Kabeya, Kazunori Kimura, Yoshiyuki Matsushita, Satoshi Suzuki, Yasuhiro Nagakura, Ryuhei Kinami, Hiroyuki Noda, Koji Takagi, Kazutoshi Okamoto, Misako Miwa, Yutaka Haga, Shuichi Satoh, Goro Yoshizaki
Summary: This study investigated the requirements of long-chain polyunsaturated fatty acids (LC-PUFAs) in the commercially important alfonsino fish, Beryx splendens. The results showed that B. splendens obtains substantial amounts of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) from its natural diet. The study also confirmed the enzymatic capabilities of fatty acid desaturase (Fads2) and elongases (Elovl5, Elovl4a, and Elovl4b) in LC-PUFA biosynthesis in B. splendens.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Fisheries
Ka-Kei Sam, P. Merosha, M. Janaranjani, Izyan Athirah, Alexander Chong Shu-Chien
Summary: The Malaysian mahseer has the complete machinery for the biosynthesis of LC-PUFA from C18 PUFA, allowing it to utilize dietary vegetable oils for growth and deposition of n-3 LC-PUFA.
Article
Nutrition & Dietetics
Huimin Tian, Haitao Yu, Yiqi Lin, Yueting Li, Wenhui Xu, Yiru Chen, Guoliang Liu, Lin Xie
Summary: This study found significant differences in the content of n-6 PUFA in breast milk based on the transcription levels of the FADS1 gene, highlighting the importance of developing new methods and diets to optimize infant feeding.
Article
Biochemistry & Molecular Biology
Rodrigo Valenzuela, Adam H. Metherel, Giulia Cisbani, Mackenzie E. Smith, Raphael Chouinard-Watkins, Brinley J. Klievik, Luis A. Videla, Richard P. Bazinet
Summary: This study assessed the activities and protein concentration levels of enzymes involved in the n-3 and n-6 PUFA synthesis pathways in various organs. It found that the liver had the highest capacity for PUFA biosynthesis, while the heart and lung showed no activity.
Article
Agriculture, Dairy & Animal Science
Wenying Zhang, Changhui Zhang, Jun Luo, Huifen Xu, Jianxin Liu, Juan J. Loor, Hengbo Shi
Summary: This study provides evidence of a physiological link between LXRB and SREBP1 in ruminant mammary cells, demonstrating their important role in the synthesis of PUFA by regulating genes encoding elongases and desaturases. Targeting this network may have broad effects on lipid homeostasis in the ruminant mammary gland.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Nutrition & Dietetics
Alexia Gomez Rodriguez, Emanuela Talamonti, Alba Naudi, Anastasia V. Kalinovich, Anna M. Pauter, Gustavo Barja, Tore Bengtsson, Anders Jacobsson, Reinald Pamplona, Irina G. Shabalina
Summary: The production of endogenous DHA is crucial for the normal function of mouse liver mitochondria and may be relevant for human metabolism as well.
Article
Biology
Mengxing Li, Suryavathi Viswanadhapalli, Bindu Santhamma, Uday P. Pratap, Yiliao Luo, Junhao Liu, Kristin A. Altwegg, Weiwei Tang, Zexuan Liu, Xiaonan Li, Behnam Ebrahimi, Hui Yan, Yi Zou, Swapna Konda, Gangadhara R. Sareddy, Zhenming Xu, Yidong Chen, Manjeet K. Rao, Andrew J. Brenner, Virginia G. Kaklamani, Rajeshwar R. Tekmal, Gulzar Ahmed, Ganesh Raj, Klaus J. Nickisch, Hareesh B. Nair, Ratna K. Vadlamudi
Summary: The study demonstrated that LIFR inhibitor EC359 could enhance the therapeutic efficacy of HDACi against TNBC, with RNA-seq studies showing that the combination therapy attenuated oncogenic/survival signaling pathways activated by HDACi. Importantly, the combination therapy showed potent inhibition of TNBC growth in vivo.
COMMUNICATIONS BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Min Chen, Zimeng Zheng, Jialu Shi, Jun Shao
Summary: Endometrial receptivity plays a crucial role in fertility and pregnancy outcomes. The role of lipids, particularly polyunsaturated fatty acids, has been recognized in influencing endometrial receptivity. They have a significant impact on cell proliferation, development, signaling, and function, and are involved in the production of hormones that affect the receptivity of the endometrium. They also play a role in immunity and regulating endometrial decidualization.
Article
Biochemistry & Molecular Biology
Ran Zhao, Ya-Xin Wang, Chen-Ru Yang, Shang-Qi Li, Jin-Cheng Li, Xiao-Qing Sun, Hong-Wei Wang, Qi Wang, Yan Zhang, Jiong-Tang Li
Summary: Two elovl5 genes were found in common carp, both of which showed elongase activity towards various polyunsaturated fatty acids. Elov15b had higher expression levels than elovl5a, suggesting it may be the dominantly expressed gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rushendhiran Kesavan, Timo Froemel, Sven Zukunft, Bernhard Bruene, Andreas Weigert, Ilka Wittig, Ruediger Popp, Ingrid Fleming
Summary: Studies suggest that the absence of soluble epoxide hydrolase (sEH) accelerates primary tumor growth and increases tumor macrophage count and angiogenesis in animals. However, there is no impact of sEH inhibition on the formation of metastases in the lymph node or lung.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Depeng Wang, Wei Xu, Minghua Huang, Wei Ma, Yulu Liu, Xingchen Zhou, Qingrui Yang, Kun Mu
Summary: Drug resistance is common in triple-negative breast cancer (TNBC) and leads to poor prognosis. Targeting the DNA damage response (DDR) has shown to be effective in overcoming chemotherapy resistance in TNBC. CENPF, a key regulator of cell cycle progression, is highly expressed in TNBC and is associated with chemotherapy resistance. Knockdown of CENPF increases cytotoxicity in TNBC cells and overcomes adriamycin resistance. CENPF targets the Chk1-mediated G2/M phase arrest and competes with E2F1 in TNBC, providing a novel mechanism to overcome chemotherapy resistance.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Zhaowei Xu, Shuyan Liu, Chun Feng, Fuyi Xu, Demin Kong, Jia Mi, Chunhua Yang, Guilong Zhang, Pengfei Wei, Buyan-Ochir Orgil, Jonas Bergquist, Geng Tian
Summary: This study found that the expression of checkpoint suppressor 1 (CHES1) is highly associated with triple-negative breast cancer (TNBC) and plays a role in promoting the proliferation and metastasis of TNBC. Acetylation of CHES1 enhances its stability and contributes to its high abundance in TNBC. These findings highlight the significance of CHES1 acetylation in breast cancer progression.
CELL DEATH DISCOVERY
(2022)
Review
Agricultural Engineering
Menghour Huy, Ann Kristin Vatland, Gopalakrishnan Kumar
Summary: Circular bioeconomy is a sustainable business model that allows for reuse, recycling, and recovery in the nutraceutical industry while considering environmental impact. Microalgae biotechnology has the potential to produce high-value compounds for various industries through bioremediation of waste streams. The focus has shifted from commercial strains to indigenous strains due to cost and climate limitations in Nordic regions. This review discusses the potential compounds and strains from a Nordic perspective.
BIORESOURCE TECHNOLOGY
(2022)
Article
Oncology
Bianca Cioni, Silvia Ratti, Annamaria Piva, Irene Tripodi, Matteo Milani, Francesca Menichetti, Tiziana Langella, Laura Botti, Loris De Cecco, Claudia Chiodoni, Daniele Lecis, Mario P. Colombo
Summary: Breast cancer, especially the luminal subtype, is a common and threatening disease due to therapy resistance. JMJD6, known for its epigenetic activity, is found to have a negative prognostic value in luminal breast cancer and can regulate cancer cell pathways. This study discovers a novel function of JMJD6, showing that its genetic inhibition in breast cancer cells reduces lipid droplet formation and ANXA1 expression, ultimately preventing tumor aggressiveness by inhibiting M2-type macrophage polarization in the tumor microenvironment.
MOLECULAR CANCER RESEARCH
(2023)