Myeloid Cell Prostaglandin E2 Receptor EP4 Modulates Cytokine Production but Not Atherogenesis in a Mouse Model of Type 1 Diabetes

Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors

(2015) Kohichi Kawahara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis

(2015) Arpeeta Sharma et al.   DIABETES

Prostaglandin E2Inhibits NLRP3 Inflammasome Activation through EP4 Receptor and Intracellular Cyclic AMP in Human Macrophages

(2015) Milena Sokolowska et al.   JOURNAL OF IMMUNOLOGY

EP4 Receptor–Associated Protein in Macrophages Ameliorates Colitis and Colitis-Associated Tumorigenesis

(2015) Masato Nakatsuji et al.   PLoS Genetics

miR33 Inhibition Overcomes Deleterious Effects of Diabetes Mellitus on Atherosclerosis Plaque Regression in Mice

(2014) Emilie Distel et al.   CIRCULATION RESEARCH

Role of bone-marrow- and non-bone-marrow-derived receptor for advanced glycation end-products (RAGE) in a mouse model of diabetes-associated atherosclerosis

(2014) Christine Koulis et al.   CLINICAL SCIENCE

COX-2 but Not mPGES-1 Contributes to Renal PGE2 Induction and Diabetic Proteinuria in Mice with Type-1 Diabetes

(2014) Zhanjun Jia et al.   PLoS One

Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice

(2014) L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testing the Role of Myeloid Cell Glucose Flux in Inflammation and Atherosclerosis

(2014) Tomohiro Nishizawa et al.   Cell Reports

PGE2/EP4 signaling in peripheral immune cells promotes development of experimental autoimmune encephalomyelitis

(2013) Susanne Schiffmann et al.   BIOCHEMICAL PHARMACOLOGY

Prostaglandin E2 regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells

(2013) Y. M. Ikushima et al.   BLOOD

Hyperglycemia Promotes Myelopoiesis and Impairs the Resolution of Atherosclerosis

(2013) Prabhakara R. Nagareddy et al.   Cell Metabolism

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

(2013) Stephen P. Gray et al.   CIRCULATION

Prostaglandin E2 Receptor, EP3, Is Induced in Diabetic Islets and Negatively Regulates Glucose- and Hormone-Stimulated Insulin Secretion

(2013) M. E. Kimple et al.   DIABETES

Relationship of Glycated Albumin to Blood Glucose and HbA1c Values and to Retinopathy, Nephropathy, and Cardiovascular Outcomes in the DCCT/EDIC Study

(2013) D. M. Nathan et al.   DIABETES

Chronic administration of EP4-selective agonist exacerbates albuminuria and fibrosis of the kidney in streptozotocin-induced diabetic mice through IL-6

(2013) Riyaz Mohamed et al.   LABORATORY INVESTIGATION

PGE2 differentially regulates monocyte-derived dendritic cell cytokine responses depending on receptor usage (EP2/EP4)

(2013) Neil J. Poloso et al.   MOLECULAR IMMUNOLOGY

Differential stem- and progenitor-cell trafficking by prostaglandin E2

(2013) Jonathan Hoggatt et al.   NATURE

Th17 cells in type 1 diabetes

(2012) Shiying Shao et al.   CELLULAR IMMUNOLOGY

PTGS-2-PTGER2/4 Signaling Pathway Partially Protects From Diabetogenic Toxicity of Streptozotocin in Mice

(2012) A. Vennemann et al.   DIABETES

Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1

(2012) J. E. Kanter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation and diabetes-accelerated atherosclerosis: myeloid cell mediators

(2012) Jenny E. Kanter et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

S100A9 Differentially Modifies Phenotypic States of Neutrophils, Macrophages, and Dendritic Cells

(2011) Michelle M. Averill et al.   CIRCULATION

Diabetes Adversely Affects Macrophages During Atherosclerotic Plaque Regression in Mice

(2011) S. Parathath et al.   DIABETES

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Deletion of EP4 on Bone Marrow–Derived Cells Enhances Inflammation and Angiotensin II–Induced Abdominal Aortic Aneurysm Formation

(2010) Eva H.C. Tang et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions

(2010) E. H. C. Tang et al.   CARDIOVASCULAR RESEARCH

Tumor-secreted PGE2Inhibits CCL5 Production in Activated Macrophages through cAMP/PKA Signaling Pathway

(2010) Xuesong Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PGE2 Induces IL-6 in Orbital Fibroblasts through EP2 Receptors and Increased Gene Promoter Activity: Implications to Thyroid-Associated Ophthalmopathy

(2010) Nupur Raychaudhuri et al.   PLoS One

Monocytes from Patients with Type 1 Diabetes Spontaneously Secrete Proinflammatory Cytokines Inducing Th17 Cells

(2009) E. M. Bradshaw et al.   JOURNAL OF IMMUNOLOGY

CCR7-specific migration to CCL19 and CCL21 is induced by PGE2 stimulation in human monocytes: Involvement of EP2/EP4 receptors activation

(2009) Sandra C. Côté et al.   MOLECULAR IMMUNOLOGY

Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

(2009) A. L. Hertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Discriminating Messenger RNA Signature for Bipolar Disorder Formed by an Aberrant Expression of Inflammatory Genes in Monocytes

(2008) Roos C. Padmos et al.   ARCHIVES OF GENERAL PSYCHIATRY

Macrophage EP4 Deficiency Increases Apoptosis and Suppresses Early Atherosclerosis

(2008) Vladimir R. Babaev et al.   Cell Metabolism

Elevated plasma prostaglandins and acetylated histone in monocytes in Type 1 diabetes patients

(2008) S. S. H. Chen et al.   DIABETIC MEDICINE

Prostaglandin E Receptor Type 4-associated Protein Interacts Directly with NF-κB1 and Attenuates Macrophage Activation

(2008) Manabu Minami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE