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Medicine, Research & Experimental
Feiye Zhou, Linlin Zhang, Kecheng Zhu, Mengyao Bai, Yuqing Zhang, Qin Zhu, Shushu Wang, Chunxiang Sheng, Miaomiao Yuan, Yun Liu, Jieli Lu, Li Shao, Xiao Wang, Libin Zhou
Summary: SIRT2 plays a crucial role in glucose homeostasis by regulating insulin secretion and glucose tolerance; its deficiency inhibits GSIS by affecting the degradation of GKRP and ALDOA proteins; SIRT2 overexpression enhances insulin secretion through deacetylation of GKRP in beta-cells and promoting its degradation.
Article
Pharmacology & Pharmacy
Maria Cristina Caroleo, Pierluigi Plastina, Alessia Fazio, Chiara La Torre, Fabrizio Manetti, Erika Cione
Summary: The study focused on the potential effects of natural lipophenols on insulin secretion in type 2 diabetes mellitus, and their role in modulating the FFAR1 receptor. The findings suggest that these compounds may play a role in the anti-diabetic properties associated with olive oil consumption.
Article
Cell Biology
Felix Wittig, Lino Henkel, Jan Lukas Prueser, Jutta Merkord, Robert Ramer, Burkhard Hinz
Summary: Inhibition of MAGL and elevation of 2-AG level can reduce the effects of lung cancer cells on the migration and tube formation of human umbilical vein endothelial cells, thus inhibiting tumor angiogenesis.
Article
Biotechnology & Applied Microbiology
Patricia Wu Jin, Nassim Rousset, Andreas Hierlemann, Patrick M. Misun
Summary: A new generation microfluidic hanging-drop-based islet perifusion platform was developed to study dynamic insulin secretion from individual pancreatic islets with high temporal resolution. The platform was redesigned to increase experimental throughput and simplify operation, achieving continuous insulin release observation with reproducible results. This device will be valuable in islet and diabetes research for studying alterations in insulin secretion dynamics.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Geetali Pradhan, Jong Han Lee, Chia-Shan Wu, Hongying Wang, Ligen Lin, Taraka Donti, Brett H. Graham, Arun S. Rajan, Ashok Balasubramanyam, Susan L. Samson, Shaodong Guo, Yuxiang Sun
Summary: This study investigated the role of the Ghrelin receptor (GHS-R) in glucose-stimulated insulin secretion (GSIS) and its interaction with the insulin signaling pathway in pancreatic islets. The findings suggest that GHS-R affects key components of the insulin signaling pathway, likely regulating GSIS via the Akt-Pdx1-GLUT2 pathway.
Article
Chemistry, Analytical
Yao Wang, Damilola I. Adeoye, Yue J. Wang, Michael G. Roper
Summary: Insulin from islets of Langerhans is the main hormone for reducing blood glucose, and there are functional differences in secretion patterns at the single islet level. Fluorescence anisotropy imaging immunoassays provide a relatively simple method for increased throughput of islet secretion measurements.
ANALYTICA CHIMICA ACTA
(2022)
Article
Biochemistry & Molecular Biology
Bo Ahren
Summary: This study investigated the relationship between glucose dose and insulin response in mice, both in vivo and in vitro. It was found that there was a curvilinear relationship between glucose concentrations and insulin secretion, with half maximal increase in insulin concentrations achieved at 12.5 mmol/L glucose and maximal increase at 21.5 mmol/L. These findings suggest that the glucose-insulin relation follows a similar pattern in mice in both in vivo and in vitro conditions.
Article
Environmental Sciences
Hai-Ming Xu, Meng-Yu Wu, Xin-Chen Shi, Ke-Liang Liu, Ying-Chi Zhang, Yin-Feng Zhang, Hong-Mei Li
Summary: This study investigated the impact of PFOS exposure on GSIS in INS-1 cells and the potential protective effects of PC. After 48 h of exposure, the effects of PFOS and/or PC on GSIS were examined. Results showed that PFOS exposure did not significantly affect cell viability but reduced insulin secretion and relative mRNA expression levels. Furthermore, PFOS exposure led to an increase in ROS activity, which was alleviated by PC intervention.
Article
Plant Sciences
Altaf Al-Romaiyan, Willias Masocha, Sunday Oyedemi, Sulaiman K. Marafie, Guo-Cai Huang, Peter M. Jones, Shanta J. Persaud
Summary: The aim of this study was to investigate the molecular mechanism of action of CM-induced insulin secretion. The findings suggest that CM directly stimulates insulin secretion by activating downstream effectors of insulin secretion. Specifically, CM activates PKC zeta, leading to the phosphorylation and activation of ERK1/2, which in turn induces insulin exocytosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Sophie Hallakou-Bozec, Micheline Kergoat, Pascale Fouqueray, Sebastien Bolze, David E. Moller
Summary: Imeglimin, a novel drug candidate, enhances glucose-stimulated insulin secretion in islets isolated from rodents with Type 2 diabetes through increasing the NAD(+) pool, raising ATP levels, and promoting cADPR production. This unique mode of action suggests a potential link between elevated NAD(+) and improved glucose-induced Ca2+ mobilization, leading to enhanced insulin secretion and providing a new approach for treating patients with Type 2 diabetes.
Article
Biochemistry & Molecular Biology
Yael E. Diaz-Lopez, Gloria Erandi Perez-Figueroa, Vicenta Cazares-Dominguez, Maria E. Frigolet, Ruth Gutierrez-Aguilar
Summary: Partial silencing of ETV5 in INS-1 (832/13) cells leads to decreased cell number and proliferation, without affecting cell viability or apoptosis, indicating that ETV5 regulates cell proliferation through modulation of inhibitors of the cyclin/CDKs complexes and cell cycle activators.
Article
Cell Biology
Jalal Taneera, Anila Khalique, Aissaoui Salima, Abdul Khader Mohammed, Ahmed Saad Sawan, Hamam Aneis, Peter Habib, Sham Abdrabh, Noha M. Elemam, Narjes Saheb Sharif-Askari, Eman Abu-Gharbieh, Maha Saber-Ayad, Waseem El-Huneidi
Summary: The study suggests that FAM105A plays a crucial role in pancreatic beta-cell function, including insulin release, glucose uptake, and cellular energy metabolism, and may be involved in the development of type 2 diabetes. Evaluation: 8 points.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Estela Lorza-Gil, Gabriele Kaiser, Christopher Carlein, Markus D. A. Hoffmann, Gabriele M. Koenig, Sieglinde Haug, Leticia Prates Roma, Elisabeth Rexen Ulven, Trond Ulven, Evi Kostenis, Andreas L. Birkenfeld, Hans-Ulrich Haering, Susanne Ullrich, Felicia Gerst
Summary: Research shows that NEFA plays an important role in the functional maturation and adaptive insulin secretion of neonatal beta cells, with FFA1 being a critical factor. FFA1 promotes insulin secretion and is essential in the adaptation of offspring beta cells to parental high-fat feeding.
Article
Plant Sciences
Dahae Lee, Ki Hyun Kim, Taesu Jang, Ki Sung Kang
Summary: The phytochemical examination of Cornus walteri led to the isolation of a tirucallane triterpenoid, (-)-leucophyllone, which was found to increase glucose-stimulated insulin secretion in rat INS-1 pancreatic beta-cells. Treatment with (-)-leucophyllone also resulted in increased expression of proteins related to insulin signaling, suggesting its potential as an antidiabetic agent.
Article
Environmental Sciences
Xiaoyu Duan, Weijie Sun, Hongwen Sun, Lianying Zhang
Summary: The study revealed that PFASs adversely affect insulin secretion, with exposure to PFOS inhibiting SIRT1 activity and leading to impairment of GSIS.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Karel A. Erion, Charles A. Berdan, Nathan E. Burritt, Barbara E. Corkey, Jude T. Deeney
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Multidisciplinary Sciences
Javier Pizarro-Delgado, Jude T. Deeney, Rafael Martin-del-Rio, Barbara E. Corkey, Jorge Tamarit-Rodriguez
Review
Biochemistry & Molecular Biology
Lucia E. Rameh, Jude T. Deeney
BIOCHEMICAL SOCIETY TRANSACTIONS
(2016)
Article
Multidisciplinary Sciences
Javier Pizarro-Delgado, Jude T. Deeney, Barbara E. Corkey, Jorge Tamarit-Rodriguez
Article
Cell Biology
Zhigang Xie, Albert Jones, Jude T. Deeney, Seong Kwon Hur, Vytas A. Bankaitis
Article
Biochemistry & Molecular Biology
Gilad Twig, Alvaro Elorza, Anthony J. A. Molina, Hibo Mohamed, Jakob D. Wikstrom, Gil Walzer, Linsey Stiles, Sarah E. Haigh, Steve Katz, Guy Las, Joseph Alroy, Min Wu, Benedicte F. Py, Junying Yuan, Jude T. Deeney, Barbara E. Corkey, Orian S. Shirihai
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Biochemistry & Molecular Biology
Nika N. Danial, Loren D. Walensky, Chen-Yu Zhang, Cheol Soo Choi, Jill K. Fisher, Anthony J. A. Molina, Sandeep Robert Datta, Kenneth L. Pitter, Gregory H. Bird, Jakob D. Wikstrom, Jude T. Deeney, Kirsten Robertson, Joel Morash, Ameya Kulkarni, Susanne Neschen, Sheene Kim, Michael E. Greenberg, Barbara E. Corkey, Orian S. Shirihai, Gerald I. Shulman, Bradford B. Lowell, Stanley J. Korsmeyer
Article
Endocrinology & Metabolism
Lisa Getty-Kaushik, Ann-Marie T. Richard, Jude T. Deeney, Sarah Krawczyk, Orian Shirihai, Barbara E. Corkey
Article
Endocrinology & Metabolism
Tong Wang, Yaguang Si, Orian S. Shirihai, Huiqing Si, Vera Schultz, Richard F. Corkey, Liping Hu, Jude T. Deeney, Wen Guo, Barbara E. Corkey
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Multidisciplinary Sciences
Marylana Saadeh, Thomas C. Ferrante, Ada Kane, Orian Shirihai, Barbara E. Corkey, Jude T. Deeney
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Multidisciplinary Sciences
Jude T. Deeney, Anna C. Belkina, Orian S. Shirihai, Barbara E. Corkey, Gerald V. Denis
Article
Biochemistry & Molecular Biology
Michael Trus, Richard F. Corkey, Rafael Nesher, Ann-Marie T. Richard, Jude T. Deeney, Barbara E. Corkey, Daphne Atlas
Article
Endocrinology & Metabolism
Ann-Marie T. Richard, Dominic-Luc Webb, Jessie M. Goodman, Vera Schultz, John N. Flanagan, Lisa Getty-Kaushik, Jude T. Deeney, Gordon C. Yaney, George A. Dunaway, Per-Olof Berggren, Keith Tornheim
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2007)
Article
Biochemistry & Molecular Biology
Jude T. Deeney, Robert Branstrom, Barbara E. Corkey, Olof Larsson, Per-Olof Berggren