Article
Cardiac & Cardiovascular Systems
Yuchen Gao, Xiaojie Liu, Lijuan Wang, Sudena Wang, Yang Yu, Yao Ding, Jingcan Wang, Hushan Ao
Summary: Machine learning methods were found to predict postoperative major bleeding after cardiac surgery successfully, with greater performance compared to previous scoring models. Modern machine learning models may enhance the identification of high-risk major bleeding subpopulations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Yu-Ting Cheng, Dong-Yi Chen, Victor Chien-Chia Wu, An-Hsun Chou, Shang-Hung Chang, Pao-Hsien Chu, Shao-Wei Chen
Summary: The effect of previous coronary stenting on subsequent coronary artery bypass graft is inconclusive. This retrospective study using Taiwan's National Health Insurance Database found that previous coronary stenting before multivessel coronary artery bypass graft significantly increased 30-day mortality but did not affect late survival. However, patients who had coronary stenting before coronary artery bypass graft experienced more revascularization events during late follow-up.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Donald S. Likosky, Raymond J. Strobel, Xiaoting Wu, Robert S. Kramer, Baron L. Hamman, James K. Brevig, Michael P. Thompson, Amir A. Ghaferi, Min Zhang, Eric J. Lehr
Summary: This study evaluated whether interhospital variation in mortality rates for coronary artery bypass grafting was driven by complications and failure to rescue. The study found a positive correlation between hospital failure to rescue rates and complications, suggesting that early recognition and management of complications are important factors in improving the success of coronary artery bypass grafting.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Editorial Material
Medicine, General & Internal
Marco Loffi, Gian B. Danzi
Summary: A 64-year-old woman presented with chest pain at rest and with exertion. Coronary angiography revealed an isolated coronary artery, as seen in a video.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Alexander Vladimirovich Ivanov, Mikhail Aleksandrovich Popov, Arkady Andreevich Metelkin, Valery Vasil'evich Aleksandrin, Evgeniy Gennad'evich Agafonov, Maria Petrovna Kruglova, Ekaterina Vladimirovna Silina, Victor Aleksandrovich Stupin, Ruslan Andreevich Maslennikov, Aslan Amirkhanovich Kubatiev
Summary: Coronary artery disease (CAD) and coronary artery bypass graft (CABG) are associated with a decrease in blood glutathione (bGSH) level. This study aimed to examine the associations of bGSH with glucose and plasma aminothiols in CAD patients before CABG and in the early postoperative period. The results showed that bGSH and its redox status were lower in CAD patients at admission, and CABG had no significant effect on these parameters except for an increase in the bGSH/hemoglobin ratio. Additionally, an association was found between an increase in oxidized GSH in the blood after surgery and fasting glucose levels.
Article
Cardiac & Cardiovascular Systems
Babak Sattartabar, Ali Ajam, Mina Pashang, Arash Jalali, Saeed Sadeghian, Hamideh Mortazavi, Soheil Mansourian, Jamshid Bagheri, Abbas-Ali Karimi, Kaveh Hosseini
Summary: Prior to undergoing coronary artery bypass grafting surgery, male patients have a lower incidence of MACE, while female patients are more likely to experience MACE post-surgery. Diabetes and hypertension are associated with higher mortality and MACE rates in both sexes.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Mats C. H. Lassen, Soren Lindberg, Flemming J. Olsen, Thomas Fritz-Hansen, Sune Pedersen, Allan Iversen, Soren Galatius, Rasmus Mogelvang, Tor Biering-Sorensen
Summary: E/e'sr is an independent predictor of all-cause mortality following CABG, especially in patients with preserved systolic function, and superior to E/e'.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Endocrinology & Metabolism
Donna Shu-Han Lin, Yu-Sheng Lin, Jen-Kuang Lee, Hsien-Li Kao
Summary: This study compares the outcomes of women and men with acute myocardial infarction (AMI) who underwent percutaneous coronary intervention (PCI) or coronary artery bypass graft surgery (CABG). It found that women had worse in-hospital and long-term outcomes, especially in the PCI group. Women who underwent PCI were more likely to be admitted for heart failure during follow-up.
BIOLOGY OF SEX DIFFERENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Stacey Matthews, Amanda Buttery, Adrienne O'Neil, Julie Sanders, Silvana Marasco, Suzanne Fredericks, Geraldine Martorella, Niamh Keenan, Anand Ghanes, Rochelle Wynne
Summary: There are contradictory findings regarding sex-specific differences in mortality after coronary artery bypass graft surgery (CABGS). Meta-analysis shows inconsistent results, highlighting the need for trials with sex-specific stratification to ensure appropriate gender-specific treatments for revascularization.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2022)
Article
Medicine, General & Internal
Tzu-Hsiang Lin, Chi-Wei Wang, Ching-Hui Shen, Keng-Hao Chang, Chih-Hung Lai, Tsun-Jui Liu, Kuan-Ju Chen, Yu-Wei Chen, Wen-Lieng Lee, Chieh-Shou Su
Summary: The study found that in real-world practice, robotic-assisted CABG (R-CABG) for patients with multivessel coronary artery disease (MVD) was associated with lower in-hospital and long-term mortalities compared to conventional CABG (C-CABG). However, there were no significant differences between the two groups in terms of target lesion revascularization, target vessel revascularization, myocardial infarction, and stroke.
Article
Health Care Sciences & Services
Po-Shun Hsu, Jia-Lin Chen, Shih-Ying Sung, Yi-Ting Tsai, Chih-Yuan Lin, Yi-Fan Wu, Chien-Sung Tsai
Summary: This study compares the hemorheological and inflammatory changes before and after coronary artery bypass graft (CABG) surgery and finds that hyperviscosity persists for almost one week after the surgery. Inflammatory markers are also correlated with hemorheological changes. Understanding the interplay between inflammation and hemorheological properties is crucial for patient care.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Psychology, Clinical
Wolfgang Linden, Sandra Young, Andrew Ignaszewski, Tavis Campbell
Summary: This study found that depression symptoms and household responsibility measured at 1-year post-CABG were significantly associated with long-term survival, with an interaction between depression symptoms and social support at year 1. Depression may contribute to increased event recurrence. Gender did not have a significant impact on long-term medical outcomes.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Respiratory System
Tomasz Urbanowicz, Michal Michalak, Anna Olasinska-Wisniewska, Assad Haneya, Ewa Straburzynska-Migaj, Michal Bocianski, Marek Jemielity
Summary: This study found that female patients had better overall late survival following surgical revascularization, despite smaller diameters of coronary arteries. Male sex was identified as a significant risk factor for all-cause mortality, despite having larger coronary artery diameters.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Masafumi Ono, Shigetaka Kageyama, Neil O'Leary, Mohammed S. El-Kurdi, Jochen Reinoehl, Eric Solien, Richard W. Bianco, Mirko Doss, Bart Meuris, Renu Virmani, Martijn Cox, Yoshinobu Onuma, Patrick W. Serruys
Summary: This study demonstrates the feasibility and effectiveness of a novel biorestorative graft in an ovine coronary artery bypass graft model, suggesting its potential as an alternative to saphenous vein grafts. These findings could pave the way for the first-in-man trial of using this new material for coronary artery bypass graft patients who struggle with harvesting SVGs.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2023)
Article
Cardiac & Cardiovascular Systems
Garry W. Hamilton, Diem Dinh, Julian Yeoh, Angela L. Brennan, Jordan Fulcher, Anoop N. Koshy, Matias B. Yudi, Christopher M. Reid, David L. Hare, Melanie Freeman, Dion Stub, William Chen, Stephen J. Duffy, Andrew Ajani, Jaishankar Raman, Omar Farouque, David J. Clark
Summary: This study reports the characteristics of arterial graft stenoses and evaluates the feasibility of radial artery percutaneous coronary intervention (PCI). The results show that patients undergoing radial artery PCI had earlier presentation, less frequent acute coronary syndrome, and more common intervention at the ostial or distal anastomosis compared with saphenous vein graft PCI. Patients undergoing radial artery PCI were more likely to have diabetes, peripheral vascular disease, and non-ST-segment elevation myocardial infarction compared with those undergoing native PCI.
JACC-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Sven T. Pleger, Nicolas Geis, Michael Kreusser, Haitham Abu-Sharar, Christian Sebening, Gabor Szabo, Hugo A. Katus, Philip W. J. Raake
Summary: This study found that treating patients with Carpentier type IIIb recurrent severe MV regurgitation using the MitraClip device resulted in significantly reduced MV regurgitation, improved functional state, and increased exercise capability. The procedure was safe with a 0% 30-day mortality rate.
Article
Cardiac & Cardiovascular Systems
Kalman Benke, David Kurszan Jasz, Agnes Lilla Szilagyi, Balint Barath, Eszter Tuboly, Anett Roxana Marton, Petra Varga, Arpad Mohacsi, Anna Szabo, Zsofia Szell, Mihaly Ruppert, Tamas Radovits, Gabor Szabo, Bela Merkely, Petra Hartmann, Mihaly Boros
Summary: Adding methane during cold storage of organs for transplantation has been shown to improve early graft function, reduce mitochondrial dysfunction and inflammation, as well as lower myocardial damage and proapoptotic signaling caused by heart transplantation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Lars Saemann, Folker Wenzel, Matthias Kohl, Sevil Korkmaz-Icoz, Fabio Hoorn, Sivakkanan Loganathan, Yuxing Guo, Qingwei Ding, Pengyu Zhou, Gabor Veres, Matthias Karck, Gabor Szabo
Summary: In the evaluation of hearts donated after circulatory death, monitoring myocardial microcirculation (mLDP) using Laser-Doppler-Perfusion may be superior to lactate (Lac) measurement for assessing perfusion and predicting contractility. The combination of mLDP and Lac showed the best results in predicting DCD-heart contractility.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cell & Tissue Engineering
Sevil Korkmaz-Icoez, Pengyu Zhou, Yuxing Guo, Sivakkanan Loganathan, Paige Brlecic, Tamas Radovits, Alex Ali Sayour, Mihaly Ruppert, Gabor Veres, Matthias Karck, Gabor Szabo
Summary: The study demonstrates that the use of CM from bone marrow MSCs can protect vascular grafts in BD rats, alleviating endothelial dysfunction caused by IR injury and reducing levels of inflammation and apoptosis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Gabor Veres, Yang Bai, Klara Aliz Stark, Harald Schmidt, Tamas Radovits, Sivakkanan Loganathan, Sevil Korkmaz-Icoez, Gabor Szabo
Summary: The results of the study demonstrated that pretreatment with cinaciguat protected vascular grafts against ischemia-reperfusion injury, improved vascular function, reduced DNA fragmentation and oxidative stress, increased the expression of endothelial nitric oxide synthase and cGMP, and decreased levels of apoptosis and cell adhesion molecules.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2021)
Article
Cell Biology
Sevil Korkmaz-Icoez, Xiaoxin Sun, Shiliang Li, Paige Brlecic, Sivakkanan Loganathan, Mihaly Ruppert, Alex Ali Sayour, Tamas Radovits, Matthias Karck, Gabor Szabo
Summary: The study revealed that adding conditioned medium from mesenchymal stem cells can protect vascular grafts from ischemia/reperfusion injury in aged rats, alleviating endothelial dysfunction.
Article
Geriatrics & Gerontology
Sevil Korkmaz-Icoez, Deniz Akca, Shiliang Li, Sivakkanan Loganathan, Paige Brlecic, Mihaly Ruppert, Alex Ali Sayour, Andreas Simm, Maik Brune, Tamas Radovits, Matthias Karck, Gabor Szabo
Summary: Using hearts with LVH from SHRSP rats as donors for cardiac transplantation may expand the donor pool. LVH in donors did not lead to graft dysfunction in the early phase of reperfusion after transplantation, although it was associated with alterations in myocardial gene expression.
Article
Cardiac & Cardiovascular Systems
Matthias Thielmann, David Corteville, Gabor Szabo, Madhav Swaminathan, Andre Lamy, Lukas J. Lehner, Craig D. Brown, Nicolas Noiseux, Mohamed G. Atta, Elizabeth C. Squiers, Shai Erlich, Daniel Rothenstein, Bruce Molitoris, C. David Mazer
Summary: In high-risk patients undergoing cardiac surgery, a single 10 mg/kg dose of teprasiran significantly reduced the incidence, severity, and duration of early AKI compared to placebo.
Article
Nutrition & Dietetics
Kristin Waechter, Alexander Navarrete Santos, Anne Grosskopf, Tim Baldensperger, Marcus A. Glomb, Gabor Szabo, Andreas Simm
Summary: Research showed that bread crust extract (BCE) activates antioxidant gene expression through the NRF2 signaling pathway, inducing the expression of antioxidative genes and enhancing cell resistance to oxidative stress, ultimately protecting tissues from oxidative stress-induced injury.
Review
Immunology
Jiale Li, Qinbao Peng, Ronghua Yang, Kunsheng Li, Peng Zhu, Yufeng Zhu, Pengyu Zhou, Gabor Szabo, Shaoyi Zheng
Summary: This review discusses the use of machine perfusion and mesenchymal stem cells to improve the quality and outcomes of marginal organs in transplantation. By continuously perfusing the organs to mimic physiological conditions, evaluating pre-transplant organ function, and treating the organs with pharmacological, gene, and stem cell therapy, the quality and adaptability of the organs can be enhanced. Promising preclinical results indicate the potential clinical translation of this innovative strategy to improve the quality of marginal grafts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Geriatrics & Gerontology
Miklos Fagyas, Viktor Banhegyi, Katalin uri, Attila Enyedi, Erzsebet Lizanecz, Ivetta Siket Manyine, Lilla Martha, Gabor aron Fulop, Tamas Radovits, Miklos Polos, Bela Merkely, Arpad Kovacs, Zoltan Szilvassy, Zoltan Ungvari, Istvan edes, Zoltan Csanadi, Judit Boczan, Istvan Takacs, Gabor Szabo, Jozsef Balla, Gyorgy Balla, Petar Seferovic, Zoltan Papp, Attila Toth
Summary: ACE2 levels in patients with severe COVID-19 comorbidities, such as hypertension, heart failure, and lung cancer, are influenced by factors including sex, weight, and age. The levels of ACE2 show a correlation with the severity of cardiovascular diseases, suggesting a potential role in the pathomechanisms and higher mortality of COVID-19. Abandoning RAS inhibitory medication may worsen cardiovascular status without affecting ACE2 levels.
Article
Biochemistry & Molecular Biology
Gabor Veres, Kalman Benke, Roland Stengl, Yang Bai, Klara Aliz Stark, Alex Ali Sayour, Tamas Radovits, Sivakkanan Loganathan, Sevil Korkmaz-Icoez, Matthias Karck, Gabor Szabo
Summary: Aspirin preconditioning may be beneficial for the patency of arterial bypass grafts in coronary artery bypass grafting (CABG), improving endothelial function and reducing ischemia-reperfusion injury.
Article
Chemistry, Medicinal
Sevil Korkmaz-Icoez, Belinda Ballikaya, Jasmin Soethoff, Patricia Kraft, Alex Ali Sayour, Tamas Radovits, Sivakkanan Loganathan, Matthias Karck, Gabor Szabo, Gabor Veres
Summary: DuraGraft(R) has been shown to improve vascular function of arterial grafts subjected to IRI, protecting endothelial function and enhancing vascular contractile ability.
Article
Cardiac & Cardiovascular Systems
Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Guenther, Gloria Faerber, Christoph Sponholz, Marcus Franz, Andre Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst
Summary: This study investigated the effect of hemoadsorption during cardiac surgery for infective endocarditis (IE) on postoperative organ dysfunction and found that hemoadsorption did not reduce the occurrence of organ dysfunction. Although hemoadsorption reduced cytokine levels during surgery, it did not have an impact on clinically relevant outcome measures.
Article
Cell Biology
Patrick R. Winterhalter, Mandy Wirkner, Babett Bartling, Kristin Waechter, Arina Urazova, Anne Grosskopf, Claudius Diez, Gabor Szabo, Andreas Simm
Summary: Increased expression of RAGE in cardiac tissue is well-known in the elderly, in diabetes mellitus, and after acute cardiac infarction or ischemia/reperfusion injuries. RAGE and its binding partners affect the clinical outcome of heart failure and may play a crucial role in accelerating the functional decline in cardiovascular aging. The study found that RAGE overexpression leads to negative effects on heart function, causing downregulation of energy metabolism-associated genes and decreased ATP production.
MECHANISMS OF AGEING AND DEVELOPMENT
(2022)
