Article
Dermatology
Yumiko Asanuma, Hironobu Ishimaru, Tetsuko Sato, Takenobu Yamamoto, Yumi Aoyama
Summary: This study established a mouse model of dry skin caused by sweating disturbance induced by HSV-1 infection and determined the impact of HSV-1 infection on sweat gland function.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Benoit Chapellier, Damien Guindolet, Daniel Pereira, Roman Galetto, Jose-Alain Sahel, Marc Labetoulle, Eric E. Gabison
Summary: Research has found that gene therapy may provide sustained protection against corneal blindness caused by herpes simplex virus (HSV) infection. Through the use of a specific meganuclease and a vector, experiments conducted in vitro and in vivo demonstrated that meganuclease treatment reduced the number of infected cells, protected against corneal opacification and edema, and genetically engineered corneas transplanted into animals provided protection against HSV-1 infection.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Review
Immunology
Iara M. M. Backes, David A. A. Leib, Margaret E. E. Ackerman
Summary: The fetal/neonatal period is a critical stage for interventions and also a vulnerable period for viral infections. Maternal transfer of antibodies can reduce the risk of neonatal herpes simplex virus (nHSV) infections. Exploring the combination of antibody-based interventions and antiviral therapy is important for reducing infant mortality and long-term morbidity.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Hongyan Guo, Heather S. Koehler, Richard D. Dix, Edward S. Mocarski
Summary: HSV1 is a common human pathogen that can cause oral and ocular diseases. Host immune mechanisms and cell death pathways play important roles in controlling HSV1 infection, while the virus has evolved strategies to evade host cell death.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Dor Rafael, Enosh Tomer, Oren Kobiler
Summary: Latent infection is a characteristic feature of herpesviruses, where the number of latent viral genomes reactivating per cell is limited and typically only one genome reactivates in each cell.
MICROBIOLOGY SPECTRUM
(2022)
Article
Immunology
Austin M. Jeffries, Alexander J. Suptela, Ian Marriott
Summary: This study found that ZBP1 serves as a restriction factor for HSV-1 infection and is associated with the induction of both necroptotic and apoptotic cell death pathways in primary murine astrocytes.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Virology
Abigail L. Whitford, Corinne A. Clinton, E. B. Lane Kennedy, Sara A. Dochnal, Jon B. Suzich, Anna R. Cliffe
Summary: The cellular protein DLK plays an essential role in the reactivation of herpes simplex virus, and the mechanisms of gene expression during reactivation are distinct from replication.
JOURNAL OF VIROLOGY
(2022)
Article
Critical Care Medicine
Tanguy Chaumette, Raphael Cinotti, Alice Molle, Pierre Solomon, Louise Castain, Cynthia Fourgeux, Hamish E. G. McWilliam, Barbara Misme-Aucouturier, Alexis Broquet, Cedric Jacqueline, Mickael Vourc'h, Delphine Fradin, Celine Bossard, Laurent David, Emmanuel Montassier, Cecile Braudeau, Regis Josien, Jose A. Villadangos, Karim Asehnoune, Celine Bressollette-Bodin, Jeremie Poschmann, Antoine Roquilly
Summary: Brain injury induces immunosuppression, increasing the risk of viral reactivations and impairing neurological recovery. This study found that lung replication of herpesviridae is associated with poor recovery after brain injury, and a specific monocyte signature can predict the neurological outcome at 6 months.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Review
Microbiology
Sajal Deea Shukla, Tibor Valyi-Nagy
Summary: HSV-1 is a human virus that causes lifelong infections and can lead to various diseases, including blindness and central nervous system diseases. Host molecules play important roles in the infection process, including immune response, autophagy, and inflammation. Understanding the interaction between the virus and host molecules is essential for developing effective treatments.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Kathleen A. Cashman, Eric R. Wilkinson, Jeffrey Posakony, Ikenna G. Madu, Eric J. Tarcha, Kurt H. Lustig, Marcus J. Korth, Kristin M. Bedard, Sean M. Amberg
Summary: LHF-535, a small molecule antiviral, shows promising results in reducing viremia and clinical signs in a guinea pig model of Lassa fever, and protects animals from death. Further development of LHF-535 as a therapeutic for Lassa fever is supported by its pharmacokinetics.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Kerry J. Laing, Werner J. D. Ouwendijk, Victoria L. Campbell, Christopher L. McClurkan, Shahin Mortazavi, Michael Elder Waters, Maxwell P. Krist, Richard Tu, Nhi Nguyen, Krithi Basu, Congrong Miao, D. Scott Schmid, Christine Johnston, Georges M. G. M. Verjans, David M. Koelle
Summary: This study reveals that varicella-zoster virus-specific T cells preferentially persist as tissue-resident-memory T cells in the rash-involved skin after recovery from zoster, indicating their importance in controlling skin infections.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, Research & Experimental
Masayuki Kuraoka, Clare Burn Aschner, Ian W. Windsor, Aakash Mahant Mahant, Scott J. Garforth, Susan Luozheng Kong, Jacqueline M. Achkar, Steven C. Almo, Garnett Kelsoe, Betsy C. Herold
Summary: Researchers have discovered that antibodies that protect against herpes simplex virus (HSV) by activating immune cell cytotoxicity may have potential in prevention or treatment of HSV infection. These antibodies do not neutralize the virus, but instead mediate cell killing through activation of Fc gamma receptors. This study highlights the importance of Fc gamma receptor-activating antibodies in protecting against HSV infection.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Weixian Xi, Vishal Hegde, Stephen D. Zoller, Howard Y. Park, Christopher M. Hart, Takeru Kondo, Christopher D. Hamad, Yan Hu, Amanda H. Loftin, Daniel O. Johansen, Zachary Burke, Samuel Clarkson, Chad Ishmael, Kellyn Hori, Zeinab Mamouei, Hiroko Okawa, Ichiro Nishimura, Nicholas M. Bernthal, Tatiana Segura
Summary: The authors present a prophylactic coating technology that can incorporate various antibiotics and be applied in vivo prior to implantation, effectively preventing joint implant infections.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Samuel J. Vidal, Daniel Sellers, Jingyou Yu, Shoko Wakabayashi, Jaimie Sixsmith, Malika Aid, Julia Barrett, Sage F. Stevens, Xiaowen Li, Wenjun Li, Courtney R. Plumlee, Kevin B. Urdahl, Amanda J. Martinot, Dan H. Barouch
Summary: This study found that the live attenuated Mycobacterium tuberculosis vaccine Delta LprG provided better protection compared to BCG in a low-dose murine aerosol challenge model, preventing infection establishment and dissemination and confining the infection to one lung. The protection was partially influenced by certain cytokines.
Article
Pediatrics
Samuel Montenegro Pereira, Rian Vilar Lima, Maria Carolina Rocha Muniz, Marcus Breno Farias Araujo, Luiz de Moraes Ferreira Jr, Juliana Tiburtino de Queiroz Sales Martins, Claudia Faustino Coelho Luz, David Antonio Camelo Cid, Daniel da Rocha Lucena
Summary: Neonatal herpes simplex virus (HSV) infection is a rare disease that commonly presents with mucocutaneous lesions and neurological involvement. This case report describes a rare congenital herpes case with ophthalmologic manifestations and multisystemic involvement.