Review
Orthopedics
Luis M. Salazar, Jose M. Gutierrez-Naranjo, Clarissa Meza, Andrew Gabig, Aaron J. Bois, Christina I. Brady, Anil K. Dutta
Summary: This study conducted a systematic review on the diagnostic value of joint aspiration and serum markers in native shoulder joint sepsis. The results showed that there is no standardized approach to diagnosing septic arthritis of the shoulder, and the methods used are heterogeneous, which may lead to delays or misdiagnosis. The utilization of synovial white cell count is underutilized and may present with lower values than expected.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Orthopedics
Jennifer Bido, Spencer W. Sullivan, James B. Carr, William W. Schairer, Benedict U. Nwachukwu
Summary: This study compared the effectiveness of PROMIS Global-10 and legacy shoulder-specific patient-reported outcome measures in patients undergoing total shoulder arthroplasty for shoulder arthritis. The findings suggest that PROMIS Global-10 has limited correlation with legacy PROMs and is less responsive at 1-year follow-up in patients following TSA.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Orthopedics
Jacobo Rodriguez-Sanz, Carlos Lopez-de-Celis, Cesar Hidalgo-Garcia, Max Canet-Vintro, Pablo Fanlo-Mazas, Albert Perez-Bellmunt
Summary: In this in vitro study, variations in temperature and current flow in shoulder tissues were evaluated during applications of capacitive-resistive electric transfer therapy. The results showed significant differences in superficial temperature changes, with high-power resistive application leading to the greatest temperature increase. However, the effects on supraspinatus tendon and glenohumeral capsule tissues were not statistically significant, suggesting that the application location and power level may impact superficial temperature but not deeper tissue temperatures.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Miwa Okazawa, Takahiro Oyama, Hideaki Abe, Hiroaki Yamazaki, Atsushi Yoshimori, Mitsutoshi Tsukimoto, Kazumi Yoshizawa, Koichi Takao, Yoshiaki Sugita, Takanori Kamiya, Fumiaki Uchiumi, Hiroshi Sakagami, Takehiko Abe, Sei-ichi Tanuma
Summary: In this study, trimebutine was converted to a new small molecule, 7M3TMSC, which effectively suppressed both RAGE and TLR4 signaling pathways in macrophages, showing dual anti-inflammatory activity. The compound may serve as an important scaffold for the development of new anti-inflammatory drugs targeting RAGE/TLR4-ERK1/2 signaling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, General & Internal
Easton J. Bents, Brian C. Werner, Justin W. Griffin, Patric Raiss, Patrick J. Denard
Summary: This study analyzed the intramedullary canal in TSA patients and found a transition point at 73mm distal to the greater tuberosity, indicating that a 90mm stem length is required for predictably reaching a consistent and cylindrical humeral canal diameter.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Michele Mercurio, Erminia Cofano, Filippo Familiari, Katia Corona, Simone Cerciello, Giorgio Gasparini, Olimpio Galasso
Summary: This study investigated the 50 most cited articles on shoulder arthroplasty (SA) and their characteristics. The majority of the articles were clinical studies published in the Journal of Shoulder and Elbow Surgery. Most of the research was conducted in the United States and other countries, with the majority of articles published in the 2000s.
Article
Orthopedics
Yoshihiro Hirakawa, Gabriella E. Ode, Pierre Le Coz, Shinzo Onishi, Laurent Baverel, Mathieu Ferrand, Philippe Collin
Summary: This study reviewed 10 cases of pyrocarbon interposition shoulder arthroplasty (PISA) and found a high clinical failure rate and poor outcomes in younger PISA patients with baseline Walch B glenohumeral osteoarthritis.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Orthopedics
L. T. Jonathan K. Kallevang, L. T. Kyle Wieschhaus, Aaron A. Olsen, Ashton H. Goldman, James Hammond, George C. Balazs
Summary: This study aimed to evaluate the relationship between shoulder instability and patients under 50 undergoing total shoulder arthroplasty (TSA), and found that a higher proportion of patients under 50 had shoulder instability and a history of surgical stabilization. Shoulder instability is a risk factor for TSA in patients under 50.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Review
Orthopedics
John J. Heifner, Anjali D. Kumar, Eric R. Wagner
Summary: Reverse shoulder arthroplasty has shown good outcomes in patients with intact rotator cuff and osteoarthritis, with low complication rates in short-term follow-up. Changes in glenoid morphology may impact treatment outcomes, and reverse arthroplasty may be a more favorable option in managing these difficulties.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Orthopedics
Marc-Olivier Gauci, George S. Athwal, Joaquin Sanchez-Sotelo, Jean Chaoui, Manuel Urvoy, Pascal Boileau, Gilles Walch
Summary: This study aimed to evaluate pathoanatomic parameters of the arthritic glenohumeral joint in shoulders with primary glenohumeral osteoarthritis (PGHOA) to differentiate different glenoid types. By analyzing computed tomography scans and identifying specific numerical threshold values, morphometric differences between various glenoid types were identified.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2021)
Article
Orthopedics
Aaron J. Bois, Andrew M. Gabig, Leah P. Griffin, Charles A. Rockwood Jr, Christina I. Brady, Anil K. Dutta
Summary: This study proposes a comprehensive classification and treatment system for septic arthritis of the shoulder. Age and time between symptom onset and diagnosis were significant risk factors for the development of a more severe infection. Preoperative magnetic resonance imaging can help determine the severity of the disease and aid in surgical decision making. Obesity is a major risk factor for infection recurrence.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Sara E. Till, Anna K. Reinholz, Julia Lee, Jarret M. Woodmass, Isabella T. Wu, Lucas K. Keyt, Aaron J. Krych, Diane L. Dahm, Christopher L. Camp
Summary: This study evaluated a population-based cohort to examine the relationship between posterior shoulder instability (PSI) and osteoarthritis (OA). The results showed that symptomatic glenohumeral arthritis is not commonly seen in patients with PSI, but age older than 30 years and surgical intervention were identified as risk factors for developing symptomatic arthritis.
ORTHOPAEDIC JOURNAL OF SPORTS MEDICINE
(2022)
Review
Orthopedics
Caroline N. Park, Gloria X. Zhang, Jerry Chang, Steven L. Zeng, Lucy E. Meyer, Eoghan T. Hurley, Armodios M. Hatzidakis, Oke Anakwenze, Christopher S. Klifto
Summary: This study evaluated the clinical and radiographic outcomes of shoulder hemiarthroplasty using pyrolytic carbon (PyC). Overall, PyC hemiarthroplasty improves shoulder range of motion and patient-reported outcomes. However, radiographic evaluation shows concern for glenoid erosion at minimum 2-year follow-up. Further long-term follow-up studies with additional radiographic evaluation of the severity of glenoid erosion and its association with functional outcomes and failure risk are needed.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2023)
Article
Orthopedics
Jessica Mowbray, Michael Van Niekerk, Christopher Frampton, Marc Hirner
Summary: This study aimed to compare the outcomes of shoulder surgeries in patients aged >70 years. The results showed that for patients with osteoarthritis as the primary diagnosis, primary total shoulder arthroplasty (TSA) had a higher Oxford Shoulder Score (OSS) compared to primary reverse total shoulder arthroplasty (RSA), with similar revision rates. The outcomes of revision RSA were significantly inferior to primary RSA.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Orthopedics
Robert J. Pettit, Sundeep B. Saini, Richard N. Puzzitiello, Paul-Anthony J. Hart, Glen Ross, Jacob M. Kirsch, Andrew Jawa
Summary: The study aimed to determine whether glenoid morphology is associated with clinical outcomes in patients undergoing reverse total shoulder arthroplasty (RTSA) for primary glenohumeral osteoarthritis (GHOA). The results showed that glenoid morphology had no significant association with treatment outcomes, and primary RTSA provided excellent short-term outcomes in patients with GHOA.
JOURNAL OF SHOULDER AND ELBOW SURGERY
(2022)
Article
Medical Laboratory Technology
Finosh G. Thankam, Sharona Sedighim, Rebecca Kuan, Devendra K. Agrawal
Summary: The study suggests that ischemic insults activate epicardial adipose tissue-derived stem cells (EATDS) to secrete extracellular vesicles (EVs) containing regenerative mediators, which can alter gene expression in cardiac fibroblasts (CF). Results showed that the interaction between ischemia-induced EVs and CF cells led to the upregulation of cardiomyocyte-specific transcription factors and the downregulation of fibroblast and cardiac biomarkers, indicating a cardiomyocyte-like phenotype. The study also identified LGALS1, PRDX2, and CCL2 as potent protein mediators involved in regenerative processes. The findings highlight the potential of EATDS-derived EVs and sub-populations for improved cardiac healing following ischemic injury.
TRANSLATIONAL RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Sharona Sedighim, Yiqing Chen, Changlu Xu, Rohit Mohindra, Huinan Liu, Devendra K. Agrawal, Finosh G. Thankam
Summary: In this study, hydrogel scaffolds for cardiac tissue regeneration following myocardial infarction were developed. Both hydrogels displayed superior physiochemical characteristics and were hemocompatible and biocompatible. The in vitro performance of these hydrogels for cardiac tissue engineering applications was appreciable.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Review
Cell Biology
William H. Fang, Victor Bonavida, Devendra K. Agrawal, Finosh G. Thankam
Summary: Hyperlipidemia is a major risk factor for developing atherosclerosis and cardiovascular disease, and it also contributes to an increased incidence of rotator cuff tendon injury (RCTI). Low-density lipoproteins (LDL) and its oxidized form (ox-LDL) play a crucial role in promoting pro-inflammatory responses in the tendon, leading to tendon matrix disorganization. The exact mechanisms underlying RCTI in hyperlipidemia and the effects of ox-LDL on tendon matrix are currently unknown. This review focuses on the implications and future perspectives of LDL/oxLDL in the increased incidence of RCTI.
CELL AND TISSUE RESEARCH
(2023)
Article
Cell Biology
William Fang, Seerat Sekhon, Darren Teramoto, Cameron Fung, Vy La, Cindy Duong, Christian Doescher, An Thai, Finosh G. G. Thankam, Devendra K. K. Agrawal
Summary: The impact of hyperlipidemia on rotator cuff tendon injury (RCTI) is still unclear. This study found that hyperlipidemia caused changes in major extracellular matrix components in tendon tissues and tenocytes. It also affected the expression levels of certain proteins and promoted lipid uptake and the generation of cellular reactive oxygen radicals. Understanding these mechanisms may provide new approaches for managing RCTI.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Vikrant Rai, Devendra K. Agrawal
Summary: Treatment of nonhealing diabetic foot ulcers is a major challenge and understanding the effects of sexual dimorphism and other related issues is crucial. However, there is a lack of data in this area. It is important to understand these aspects for choosing appropriate animal models and investigating therapeutic options.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Vikrant Rai, Rebecca Moellmer, Devendra K. Agrawal
Summary: Chronic diabetic foot ulcers (DFUs) can lead to amputation, increased morbidity and mortality, and economic stress. Fibroblast plasticity and heterogeneity, hyperglycemia, inflammatory cytokines, and interactions with other cells in the diabetic wound microenvironment play important roles in DFU healing. The different phenotypes of fibroblasts and their effects on angiogenesis in DFUs have not been thoroughly studied. This review aims to address these gaps in the field.
MOLECULAR BIOLOGY REPORTS
(2023)
Correction
Pharmacology & Pharmacy
Gunimat Samra, Vikrant Rai, Devendra K. Agrawal
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Vikrant Rai, Joe Abdo, Devendra K. Agrawal
Summary: Esophageal cancer is a highly fatal disease with limited screening techniques and low survival rates. Non-invasive biomarkers and diagnostic methods are needed for early detection and improved outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sunil K. K. Noothi, Mohamed Radwan Ahmed, Devendra K. K. Agrawal
Summary: Atherosclerotic disease of the coronary and carotid arteries is the leading cause of mortality and morbidity worldwide. Despite advances in treatment and risk factor modification, there is still a residual risk for cardiovascular events. This article discusses the burden of atherosclerotic diseases, highlights the residual risks, and explores the evolving plaques in these arteries using advanced imaging techniques.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Cell Biology
Parth Patel, Vikrant Rai, Devendra K. Agrawal
Summary: Atherosclerosis is a multifactorial inflammatory disease, characterized by plaque formation and hypoxic tissue due to vessel occlusion. Chronic inflammation and altered collagen expression contribute to plaque vulnerability, leading to acute ischemic events. Inflammatory mediators, including TREM-1, TLRs, MMPs, and immune cells, play a critical role in plaque vulnerability.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell Biology
Prathosh Velpuri, Vikrant Rai, Devendra K. Agrawal
Summary: Atherosclerosis is a disease characterized by the formation of plaques in the blood vessels, resulting in reduced blood flow and oxygen deprivation to organs. Chronic inflammation plays a crucial role in plaque instability and rupture, leading to cardiovascular events. Sirtuins have been identified as potential targets for controlling plaque progression and vulnerability due to their involvement in inflammation and oxidative stress.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cell & Tissue Engineering
Pauline Cheng, Ahmad Rashad, Ankit Gangrade, Natan Roberto de Barros, Ali Khademhosseini, Jonathan Tam, Padmini Varadarajan, Devendra K. Agrawal, Finosh G. Thankam
Summary: Myocardial infarction leads to the loss of cardiomyocytes, but stem cell therapy shows promise in restoring cardiac function. This article discusses the application of different stem cell phenotypes and strategies to promote their differentiation into cardiomyocytes.
TISSUE ENGINEERING PART B-REVIEWS
(2023)
Review
Immunology
Armand N. Yazdani, Nathaniel DeMarco, Parth Patel, Arian Abdi, Prathosh Velpuri, Devendra K. Agrawal, Vikrant Rai
Summary: The SARS-CoV-2 virus and the COVID-19 pandemic have had a significant impact on patients with hematological conditions, particularly those who are immunocompromised. Vaccination efforts have increased to protect this vulnerable population, but there are reported side effects and concerns about the vaccine's effectiveness for patients with hematological conditions. This review aims to provide critical hematological information on COVID-19 vaccination for clinicians and to clarify the adverse hematological effects associated with infection and vaccination within the general population.
Article
Pharmacology & Pharmacy
Vikrant Rai, Hoangvi Le, Devendra K. Agrawal
Summary: A non-healing diabetic foot ulcer (DFU) is a significant clinical problem with socioeconomic and psychosocial burdens. Current therapies for DFU, such as wound debridement and growth factors, have limited success in promoting angiogenesis and healing. Poor angiogenesis due to decreased expression of angiogenic mediators and matrix formation leads to nonhealing ulcers and amputation. This article critically reviews existing pro-angiogenic mediators and explores potential novel factors that may enhance angiogenesis and wound healing in DFUs.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Armand N. Yazdani, Michaela Pletsch, Abraham Chorbajian, David Zitser, Vikrant Rai, Devendra K. Agrawal
Summary: To effectively monitor CAD, it is important to identify key biomarkers for assessing disease severity and progression. This review discusses the most relevant markers for monitoring CAD prognosis and highlights the potential of using these markers in therapeutic interventions. By utilizing these markers, healthcare providers can improve patient care, optimize treatment plans, and reduce healthcare costs associated with CAD management.
EXPERT REVIEW OF CARDIOVASCULAR THERAPY
(2023)