A Cinnamon-Derived Procyanidin Compound Displays Anti-HIV-1 Activity by Blocking Heparan Sulfate- and Co-Receptor- Binding Sites on gp120 and Reverses T Cell Exhaustion via Impeding Tim-3 and PD-1 Upregulation

Cinnamon Extract Inhibits Tau Aggregation Associated with Alzheimer's Disease In Vitro

(2017) Dylan W. Peterson et al.   JOURNAL OF ALZHEIMERS DISEASE

Derivation of Cinnamon Blocks Leukocyte Attachment by Interacting with Sialosides

(2015) Wei-Ling Lin et al.   PLoS One

A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry

(2014) Alon Herschhorn et al.   Nature Chemical Biology

Cassia Cinnamon as a Source of Coumarin in Cinnamon-Flavored Food and Food Supplements in the United States

(2013) Yan-Hong Wang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Human Immunodeficiency Virus and Heparan Sulfate: From Attachment to Entry Inhibition

(2013) Bridgette J. Connell et al.   Frontiers in Immunology

A Synthetic Heparan Sulfate-Mimetic Peptide Conjugated to a Mini CD4 Displays Very High Anti- HIV-1 Activity Independently of Coreceptor Usage

(2012) Bridgette Janine Connell et al.   CHEMISTRY & BIOLOGY

Targeting HIV Entry through Interaction with Envelope Glycoprotein 120 (gp120): Synthesis and Antiviral Evaluation of 1,3,5-Triazines with Aromatic Amino Acids

(2011) Virginia Lozano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptidomimetic inhibitors targeting the CCR5-binding site on the human immunodeficiency virus type-1 gp120 glycoprotein complexed to CD4

(2010) Markus Seitz et al.   CHEMICAL COMMUNICATIONS

Cinnamon and Health

(2010) Joerg Gruenwald et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Negative Immune Regulator Tim-3 Is Overexpressed on T Cells in Hepatitis C Virus Infection and Its Blockade Rescues Dysfunctional CD4+ and CD8+ T Cells

(2009) L. Golden-Mason et al.   JOURNAL OF VIROLOGY

A synthetic CD4–heparan sulfate glycoconjugate inhibits CCR5 and CXCR4 HIV-1 attachment and entry

(2009) Françoise Baleux et al.   Nature Chemical Biology

Quantitative Deep Sequencing Reveals Dynamic HIV-1 Escape and Large Population Shifts during CCR5 Antagonist Therapy In Vivo

(2009) Athe M. N. Tsibris et al.   PLoS One

PD-1 and Its Ligands in Tolerance and Immunity

(2008) Mary E. Keir et al.   Annual Review of Immunology

The HIV-1 Envelope Glycoprotein gp120 Features Four Heparan Sulfate Binding Domains, Including the Co-receptor Binding Site

(2008) Elodie Crublet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection

(2008) R. Brad Jones et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

Plant-derived compounds in clinical trials

(2007) A SAKLANI et al.   DRUG DISCOVERY TODAY