Article
Microbiology
Xiushuang Chen, Qinghui Kong, Xiaoxiao Zhao, Chenxi Zhao, Pin Hao, Irfan Irshad, Hongjun Lei, Muhammad Fakhar-e-Alam Kulyar, Zeeshan Ahmad Bhutta, Hassan Ashfaq, Qiang Sha, Kun Li, Yi Wu
Summary: Sodium acetate/sodium butyrate supplementation alleviated LPS-induced diarrhea in mice by enriching beneficial bacterium, reducing pathogens, and regulating oxidative damages and inflammatory responses through the NLRP3/Caspase-1 signaling pathway.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Microbiology
Xin Ma, Yuchen Zhang, Tingting Xu, Mengqi Qian, Zhiren Yang, Xiuan Zhan, Xinyan Han
Summary: The study showed that early-life FMT can alleviate weaning stress in piglets by modifying the intestinal microbiota, leading to decreased diarrhea incidence, improved intestinal morphology, reduced intestinal inflammation, and modified bacterial composition and function in the intestine.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Immunology
Fangyan Wang, Fanyu Qian, Qihao Zhang, Jian Zhao, Jianke Cen, Jiamin Zhang, Jinhui Zhou, Ming Luo, Chang Jia, Xing Rong, Maoping Chu
Summary: Kawasaki disease (KD), a febrile systemic vasculitis in children, is the leading cause of acquired heart disease in developed countries. In a KD mouse model, an altered gut microbiota composition characterized by a reduction in SCFAs-producing bacteria was observed. The use of probiotic Clostridium butyricum increased the abundance of SCFAs-producing bacteria and attenuated coronary lesions with reduced inflammatory markers, but antibiotics depleting gut bacteria worsened the inflammation response. The study suggests a new approach of using probiotics and their metabolites to treat KD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Yan Zhao, Haoming Sun, Yiwei Chen, Qiang Niu, Yiting Dong, Mei Li, Ye Yuan, Xiaojun Yang, Qingzhu Sun
Summary: This study found a relationship between the reduction of butyrate-producing bacteria and MRSA infection, and supplementation of sodium butyrate has been shown to reduce bacterial colonization and pro-inflammatory cytokine expression, as well as improve lung tissue morphology in MRSA-treated mice. Through reducing the abundance of potential pathogenic bacteria in the gut and cell motility-related bacteria in the lung, sodium butyrate reshapes the gut and lung microbiota. Additionally, sodium butyrate increases the levels of butyrate in the gut and circulation, and alters alveolar macrophage polarization, leading to reduced inflammation.
Article
Microbiology
Xuejia He, Ting Zhang, Yubing Zeng, Pei Pei, Yulan Liu, Wenbin Jia, Hongyang Zhao, Meirong Bi, Shan Wang
Summary: Neonatal hypoxic-ischemic encephalopathy (HIE) causes nervous system damage, and its mechanisms require further investigation. This study found that the butanoate metabolism pathway and SCFAs-producing bacteria were decreased in HIE rats, but sodium butyrate treatment could ameliorate pathological damage and restore SCFAs-producing bacteria. Furthermore, histone crotonylation-mediated neurotrophic-related genes were affected by sodium butyrate. This microbiological approach may be important for preventing and treating HIE.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Maria Bernad-Roche, Andrea Belles, Laura Grasa, Alejandro Casanova-Higes, Raul Carlos Mainar-Jaime
Summary: The addition of protected sodium butyrate to the diet of fattening pigs did not change the overall richness of microbiota composition of the pigs at slaughter, but may have caused some significant changes in specific taxa that could be associated with better gut health parameters.
Article
Agriculture, Dairy & Animal Science
Fuli Deng, Shanlong Tang, Huaibao Zhao, Ruqing Zhong, Lei Liu, Qingshi Meng, Hongfu Zhang, Liang Chen
Summary: This study evaluated the individual and combined effects of chemically protected sodium butyrate (CSB) and xylo-oligosaccharide (XOS) on the performance, anti-inflammatory and antioxidant capacity, intestinal morphology, and microbiota of broilers. The results showed that CSB and XOS had positive effects on the growth performance of broilers, and the combined use of both had the best effect.
Article
Food Science & Technology
Huahuan Liu, Zhongbo Bian, Qiuyu Zhang, Zhipeng Xiao, Yu Cao, Xiaodie Sun, Yong Qin, Lianzhi Mao, Xinwei Chu, Wenzhen Liao, Longying Zha, Suxia Sun
Summary: Sodium butyrate (NaB) inhibits colorectal cancer by ameliorating gut microbiota dysbiosis and inhibiting colitis.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Biochemistry & Molecular Biology
Weijun Chen, Kuo Chang, Jialong Chen, Xiaoyu Zhao, Shiyang Gao
Summary: The study found that dietary supplementation of 0.2% NaBT improved intestinal morphology, decreased oxidative stress products, and had a positive impact on intestinal bacterial community structure in largemouth bass fed with high soybean meal diet.
FISH PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Nutrition & Dietetics
Chengzeng Luo, Bing Xia, Ruqing Zhong, Dan Shen, Jiaheng Li, Liang Chen, Hongfu Zhang
Summary: This study explored the effects of early-life nutrition interventions through administration of synthetic milk on growth performance and gut health in piglets. The results showed that early-life nutrition interventions improved growth performance, colonic barrier, and reduced inflammation in the colon by modulating composition of gut microbiota in piglets.
FRONTIERS IN NUTRITION
(2022)
Article
Microbiology
Xiaoyuan Wei, Kristopher A. Bottoms, Hans H. Stein, Laia Blavi, Casey L. Bradley, Jon Bergstrom, Joshua Knapp, Robert Story, Charles Maxwell, Tsungcheng Tsai, Jiangchao Zhao
Summary: The study showed that adding sodium butyrate moderately in a diet containing 0.5% benzoic acid can improve the growth performance of weaning pigs and have potential health benefits on gut microbiota.
Article
Immunology
Gang Du, Wei Dong, Qing Yang, Xueying Yu, Jinghong Ma, Weihong Gu, Yue Huang
Summary: This study investigated alterations in fecal microbiota and inflammatory cytokine responses in Huntington's disease (HD) patients. The results showed that HD patients had changes in microbiota diversity and structure, with some microbial components correlated with clinical characteristics and cytokine levels. The findings provide insight into the pathogenesis of HD and the potential role of gut dysbiosis in the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Laura Schaefer, Humberto Hernandez, Rosalind A. Coats, Zhiyuan Yu, Stephen C. Pflugfelder, Robert A. Britton, Cintia de Paiva
Summary: Dry eye is a common ocular inflammatory disorder characterized by tear film instability and reduced tear production. The interaction between the intestinal microbiota and the ocular surface, mediated by microbially produced small molecules such as butyrate, plays a potential role in maintaining ocular surface homeostasis. In this study, it was found that the SCFA transporter SLC5A8 is expressed in murine conjunctival and corneal epithelium, and pretreatment with phenylbutyrate (PBA) reduced inflammation in corneal epithelial cultures and dendritic cells. The protective effect of PBA requires SLC5A8. Oral treatment with tributyrin, a prodrug form of butyrate, reduced inflammation at the ocular surface in mice undergoing desiccating stress, partially through the involvement of SLC5A8.
SCIENTIFIC REPORTS
(2022)
Article
Veterinary Sciences
Min-Jin Kwak, Sun-Woo Choi, Yong-Soon Choi, Hanbae Lee, Kwang-Youn Whang
Summary: This study demonstrates that adding appropriate SPL supplementation in early-weaned piglets can improve growth performance, histological indices, and gene expression levels related to mucin secretion and local inflammation. Furthermore, SPL supplementation increases the population of beneficial bacteria Prevotella and its short-chain fatty acid production, leading to a reduced occurrence of diarrhea in piglets after weaning.
BMC VETERINARY RESEARCH
(2022)
Review
Microbiology
Mirian Ferrao Maciel-Fiuza, Guilherme Cerutti Muller, Daniel Marques Stuart Campos, Perpetua do Socorro Silva Costa, Juliano Peruzzo, Renan Rangel Bonamigo, Tiago Veit, Fernanda Sales Luiz Vianna
Summary: The gut microbiota is composed of thousands of microorganisms that fight pathogens and regulate immune responses. Imbalance of this microbiota can lead to immune dysregulation and contribute to the development of infectious and inflammatory diseases. Understanding the interaction between the gut microbiota and the host's immune system is crucial for understanding disease mechanisms and developing new treatments.
FRONTIERS IN MICROBIOLOGY
(2023)