Article
Psychiatry
Ana Izquierdo, Maria Cabello, Itziar Leal, Blanca Mellor-Marsa, Miriam Ayora, Maria-Fe Bravo-Ortiz, Roberto Rodriguez-Jimenez, Angela Ibanez, Karina S. MacDowell, Norberto Malpica, Marina Diaz-Marsa, Enrique Baca-Garcia, Natalia E. Fares-Otero, Helena Melero, Pilar Lopez-Garcia, Covadonga M. Diaz-Caneja, Celso Arango, Jose Luis Ayuso-Mateos
Summary: The study used network analysis to examine the relationship between symptoms and functioning dimensions in first-episode psychosis (FEP) patients, identifying specific symptoms and functioning dimensions that should be prioritized in clinical assessment and management. These areas may also be targeted for future early intervention strategies to improve quality of life in this population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Review
Cell Biology
Yu-Yuan Huang, Teng Teng, Xue-Ning Shen, Shi-Dong Chen, Rong-Ze Wang, Rui-Qi Zhang, Kai-Xi Dou, Xiao-Ling Zhong, Jun Wang, Ke-Liang Chen, Qian-Hua Zhao, Lan Tan, Qiang Dong, Xin-Yu Zhou, Jin-Tai Yu
Summary: Psychotic symptoms in dementia are common and have negative impacts on medical outcomes and daily functioning. This study conducted a systematic review and network meta-analysis to explore the efficacy and tolerability of pharmacological treatments in dementia patients. The results suggest that donepezil, memantine, and aripiprazole may be effective treatment options.
AGEING RESEARCH REVIEWS
(2022)
Article
Psychiatry
Ante J. Schlesselmann, Rafaele J. C. Huntjens, Selwyn B. Renard, Richard J. McNally, Casper J. Albers, Vera E. De Vries, G. H. Marieke Pijnenborg
Summary: This study examined the relationship between dissociative experiences and symptoms in schizophrenia spectrum disorders (SSD). The results showed that dissociative symptoms in SSD were mostly independent of other symptoms, but emotional distress bridged between the dissociative and SSD symptom clusters. Furthermore, positive and negative SSD symptoms were associated with trauma through emotional distress, while dissociative symptoms remained relatively isolated.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychiatry
Gregory P. Strauss
Summary: This theoretical paper introduces the bioecosystem theory of negative symptoms, which emphasizes the importance of environmental factors in the genesis and maintenance of negative symptoms. By focusing on four interactive environmental systems, this model provides a novel conceptual framework for exploring environmental contributions to negative symptoms and their interactions with person-level biological and psychological factors. Despite the potential to explain variance in negative symptom severity, environmental contributions to negative symptoms have received minimal empirical attention.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Amy Hardy, Ciaran O'Driscoll, Craig Steel, Mark van der Gaag, David van den Berg
Summary: This study examined the interactions between trauma-related psychological mechanisms and psychotic symptoms using network theory. The results found that trauma-related beliefs had the largest influence in the network, along with hypervigilance, in the pathways from flashbacks to delusions and auditory hallucinations. Further research should explore the role of multiple mediators in trauma-related psychosis.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Adela-Maria Isvoranu, Tim Ziermans, Frederike Schirmbeck, Denny Borsboom, Hilde M. Geurts, Lieuwe de Haan
Summary: This study found a negative association between autistic symptoms and psychotic symptoms, with symptoms potentially reinforcing each other more easily in the PD network. The most central items in strength for the PD network were bizarre experiences, social skills, and paranoia.
SCHIZOPHRENIA BULLETIN
(2022)
Review
Behavioral Sciences
Michel Sabe, Chaomei Chen, Natacha Perez, Marco Solmi, Armida Mucci, Silvana Galderisi, Gregory P. Strauss, Stefan Kaiser
Summary: Research on negative symptoms of schizophrenia has gained renewed attention since the 1980s, but there is a lack of scientometric analysis that objectively maps scientific knowledge and tracks recent trends. We conducted a search in the Web of Science Core Collection using relevant keywords and retrieved 27,568 references published between 1966 and 2022. The analysis revealed a significant increase in scientific interest, with an average annual growth rate of 16.56% from 1990 to 2010. Two major research trends were identified: conceptualization and treatment of negative symptoms. The latest research trends include evidence synthesis, nonpharmacological treatments, and computational psychiatry. Scientometric analyses provide a useful summary of changes in negative symptom research and can inform systematic reviews, meta-analyses, and the generation of novel hypotheses.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychology, Clinical
Yu Jin, Shicun Xu, Yinzhe Wang, Hui Li, Xiaofeng Wang, Xi Sun, Yuanyuan Wang
Summary: This study explores the associations between depression, anxiety, PTSD, and psychosis symptoms among college students who have experienced childhood sexual abuse (CSA) using a network analysis approach. The results show that there are positive correlations between psychosis, depression, anxiety, and PTSD symptoms. Additionally, there is a stronger connection between psychosis and PTSD symptoms.
EUROPEAN JOURNAL OF PSYCHOTRAUMATOLOGY
(2022)
Review
Medicine, General & Internal
Mitchell D. Arnovitz, Andrew J. Spitzberg, Ashkhan J. Davani, Nehal P. Vadhan, Julie Holland, John M. Kane, Timothy Michaels
Summary: The negative symptoms of schizophrenia severely limit daily functioning, and there are currently no FDA-approved treatments for them. 3,4-Methylenedioxy methamphetamine (MDMA) has potential as a novel therapeutic due to its ability to enhance social interactions, generate empathy, and induce a state of metaplasticity in the brain. This review provides a rationale for the use of MDMA in the treatment of negative symptoms by reviewing the literature on negative symptoms, their treatment, MDMA, and MDMA-assisted therapy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Psychiatry
Fabrizia D'Antonio, Lucio Tremolizzo, Marta Zuffi, Simone Pomati, Elisabetta Farina
Summary: This study investigated the perception and treatment strategies for BPSD in Italian dementia centers. The results showed that there are differences in BPSD perception, treatment options, and observed side effects according to the clinical setting. This suggests a need for clear guidelines for the pharmacological treatment of BPSD.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Psychiatry
Saskia M. Cooper, Paolo Fusar-Poli, Peter J. Uhlhaas
Summary: Emerging evidence suggests that the duration of risk symptoms may impact clinical outcomes in clinical high-risk for psychosis (CHR-P) individuals. A meta-analysis was conducted to explore this hypothesis based on studies examining the duration of risk symptoms in relation to clinical outcomes in CHR-P populations. The findings suggest that the duration of risk symptoms is not associated with transition to psychosis at 12 months, but may affect remission. However, further research is needed in this area due to the small database.
SCHIZOPHRENIA RESEARCH
(2023)
Review
Psychiatry
Gonzalo Salazar de Pablo, Ana Catalan, Julio Vaquerizo Serrano, Borja Pedruzo, Luis Alameda, Veronica Sandroni, Alvaro Armendariz, Victoria Rodriguez, Celso Arango, Carmen Moreno, Johnny Downs, Chris Abbott, Jae Il Shin, Marco Solmi, Paolo Fusar-Poli, Christoph U. Correll
Summary: This study aims to provide a comprehensive review and meta-analysis of the diagnosis, prognosis, and treatment of negative symptoms in children and adolescents with early-onset psychosis (EOP) and those at clinical high risk for psychosis (CHR-P). The findings indicate that negative symptoms are common in children and adolescents at early stages of psychosis, particularly in those at CHR-P, and are associated with poor outcomes. Therefore, further intervention research is needed to provide evidence-based treatments.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Oncology
L. K. P. Regli, S. M. H. Huijs, R. C. O. S. Pasmans, C. Leue, J. B. Dijkstra, D. B. P. Eekers, K. E. Hovinga, M. H. M. E. Anten, A. Hoeben, M. P. G. Broen
Summary: This study aims to explore the incidence of clinically relevant psychiatric symptoms during glioblastoma treatment. It found that 11.5% of patients experienced psychiatric symptoms, with mood and behavioral symptoms being the most common. The study concludes that further research is needed to understand the potential impact of these symptoms on survival.
JOURNAL OF NEURO-ONCOLOGY
(2023)
Article
Psychology, Clinical
Or Duek, Tobias Raphael Spiller, Robert H. Pietrzak, Eiko I. Fried, Ilan Harpaz-Rotem
Summary: A new framework for analyzing PTSD, the network approach, has been introduced in recent years. This study utilized a large sample size to conduct network analysis on PTSD symptoms, finding the centrality of certain symptoms in both PTSD and combined network structures. The findings contribute to the understanding of PTSD and help address stability criticisms in network structures.
DEPRESSION AND ANXIETY
(2021)
Article
Psychiatry
Gabriele Lo Buglio, Maria Pontillo, Erika Cerasti, Andrea Polari, Arianna Schiano Lomoriello, Stefano Vicari, Vittorio Lingiardi, Tommaso Boldrini, Marco Solmi
Summary: This study aimed to analyze the network structure of symptom domains, depressive and anxiety symptoms, and general functioning in youths at clinical high risk for psychosis. The results showed a strong association between negative and disorganization symptoms, as well as dense connections among depressive and anxiety symptoms. Physical symptoms of anxiety played a bridging role. Positive symptoms were not associated with other nodes. The findings suggest the importance of targeting negative and disorganization symptoms, as well as depressive and anxiety symptoms, simultaneously.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychology, Clinical
Jim van Os, Lotta-Katrin Pries, Philippe Delespaul, Gunter Kenis, Jurjen J. Luykx, Bochao D. Lin, Alexander L. Richards, Berna Akdede, Tolga Binbay, Vesile Altinyazar, Berna Yalincetin, Guvem Gumus-Akay, Burcin Cihan, Haldun Soyguer, Halis Ulas, Eylem Sahin Cankurtaran, Semra Ulusoy Kaymak, Marina M. Mihaljevic, Sanja Andric Petrovic, Tijana Mirjanic, Miguel Bernardo, Bibiana Cabrera, Julio Bobes, Pilar A. Saiz, Maria Paz Garcia-Portilla, Julio Sanjuan, Eduardo J. Aguilar, Jose Luis Santos, Estela Jimenez-Lopez, Manuel Arrojo, Angel Carracedo, Gonzalo Lopez, Javier Gonzalez-Penas, Mara Parellada, Nadja P. Maric, Cem Atbasoglu, Alp Ucok, Koksal Alptekin, Meram Can Saka, Celso Arango, Michael O'Donovan, Bart P. F. Rutten, Sinan Guloksuz
PSYCHOLOGICAL MEDICINE
(2020)
Article
Psychiatry
Martin Koster Rimvall, Jim van Os, Frank Verhulst, Rasmus Trap Wolf, Janne Tidselbak Larsen, Lars Clemmensen, Anne Mette Skovgaard, Charlotte Ulrikka Rask, Pia Jeppesen
AMERICAN JOURNAL OF PSYCHIATRY
(2020)
Article
Psychiatry
Taciana C. C. Ragazzi, Rosana Shuhama, Jorge Sinval, Joao Maroco, Fabiana Corsi-Zuelli, Daiane L. da Roza, Jim van Os, Paulo R. Menezes, Cristina M. Del-Ben
BRAZILIAN JOURNAL OF PSYCHIATRY
(2020)
Article
Psychology, Developmental
Christian Rauschenberg, Jim van Os, Matthieu Goedhart, Jan N. M. Schieveld, Ulrich Reininghaus
Summary: The study found that exposure to high levels of bullying victimization leads to more intense negative affect and psychotic experiences in response to stress for youth, while the control group showed no significant differences. This suggests that stress sensitivity may be a potential risk and resilience mechanism linking bullying victimization and youth mental health.
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Letter
Psychology, Developmental
Martin Koster Rimvall, Jim van Os, Pia Jeppesen
EUROPEAN CHILD & ADOLESCENT PSYCHIATRY
(2021)
Article
Psychology, Clinical
Christian Rauschenberg, Ulrich Reininghaus, Margreet ten Have, Ron de Graaf, Saskia van Dorsselaer, Claudia J. P. Simons, Nicole Gunther, Cecile Henquet, Lotta-Katrin Pries, Sinan Guloksuz, Maarten Bak, Jim van Os
Summary: This study found that the JTC bias may contribute to psychosis progression and persistence in individuals with affective dysregulation. However, well-powered prospective studies are needed to replicate these findings.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychology, Clinical
Musa Sami, Diego Quattrone, Laura Ferraro, Giada Tripoli, Erika La Cascia, Charlotte Gayer-Anderson, Jean-Paul Selten, Celso Arango, Miguel Bernardo, Ilaria Tarricone, Andrea Tortelli, Giusy Gatto, Simona del Peschio, Cristina Marta Del-Ben, Bart P. Rutten, Peter B. Jones, Jim van Os, Lieuwe de Haan, Craig Morgan, Cathryn Lewis, Sagnik Bhattacharyya, Tom P. Freeman, Michael Lynskey, Robin M. Murray, Marta Di Forti
Summary: The study found that patients with first episode psychosis (FEP) are more likely to experience psychotic-like effects at higher levels of cannabis use compared to controls. This suggests that FEP patients have a specific psychotomimetic response to heavy cannabis use. Clinicians should be aware of this sensitivity and advise on lower levels of cannabis use to reduce psychotic-like experiences.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Psychiatry
Rainald Schmidt-Kastner, Sinan Guloksuz, Thomas Kietzmann, Jim van Os, Bart P. F. Rutten
FRONTIERS IN PSYCHIATRY
(2020)
Article
Biochemistry & Molecular Biology
Johan H. Thygesen, Amelia Presman, Jasmine Harju-Seppanen, Haritz Irizar, Rebecca Jones, Karoline Kuchenbaecker, Kuang Lin, Behrooz Z. Alizadeh, Isabell Austin-Zimmerman, Agna Bartels-Velthuis, Anjali Bhat, Richard Bruggeman, Wiepke Cahn, Stella Calafato, Benedicto Crespo-Facorro, Liewe de Haan, Sonja M. C. de Zwarte, Marta Di Forti, Alvaro Diez-Revuelta, Jeremy Hall, Mei-Hua Hall, Conrad Iyegbe, Assen Jablensky, Rene Kahn, Luba Kalaydjieva, Eugenia Kravariti, Stephen Lawrie, Jurjen J. Luykx, Igancio Mata, Colm McDonald, Andrew M. McIntosh, Andrew McQuillin, Rebecca Muir, Roel Ophoff, Marco Picchioni, Diana P. Prata, Siri Ranlund, Dan Rujescu, Bart P. F. Rutten, Katja Schulze, Madiha Shaikh, Frederike Schirmbeck, Claudia J. P. Simons, Timothea Toulopoulou, Therese van Amelsvoort, Neeltje van Haren, Jim van Os, Ruud van Winkel, Evangelos Vassos, Muriel Walshe, Matthias Weisbrod, Eirini Zartaloudi, Vaughan Bell, John Powell, Cathryn M. Lewis, Robin M. Murray, Elvira Bramon
Summary: The study explored the influence of CNVs on cognition, showing that individuals carrying specific schizophrenia-associated CNVs performed worse in verbal recall. No association was found between CNV burden and cognition.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Maarten Bak, Marjan Drukker, Shauna Cortenraad, Emma Vandenberk, Sinan Guloksuz
Summary: This meta-analysis found that antipsychotics are associated with body weight gain, regardless of psychiatric diagnosis.
Article
Psychiatry
Franck Schurhoff, Baptiste Pignon, Mohamed Lajnef, Romain Denis, Bart Rutten, Craig Morgan, Robin M. Murray, Marion Leboyer, Jim van Os, Andrei Szoke
SCHIZOPHRENIA BULLETIN
(2020)
Article
Pharmacology & Pharmacy
Peter C. Groot, Jim van Os
THERAPEUTIC ADVANCES IN PSYCHOPHARMACOLOGY
(2020)
Article
Psychiatry
Stephanie Menghini-Mueller, Erich Studerus, Sarah Ittig, Lucia R. Valmaggia, Matthew J. Kempton, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Rodrigo A. Bressan, Neus Barrantes-Vidal, Celia Jantac, Merete Nordentoft, Stephan Ruhrmann, Garbiele Sachs, Bart P. Rutten, Jim van Os, Anita Riecher-Roessler
EUROPEAN PSYCHIATRY
(2020)
Article
Psychology, Clinical
Evelyne van Aubel, Jindra Myrthe Bakker, Tim Batink, Stijn Michielse, Liesbet Goossens, Iris Lange, Koen Schruers, Ritsaert Lieverse, Machteld Marcelis, Therese van Amelsvoort, Jim van Os, Marieke Wichers, Thomas Vaessen, Ulrich Reininghaus, Inez Myin-Germeys
BEHAVIOUR RESEARCH AND THERAPY
(2020)
Review
Biochemistry & Molecular Biology
Nadine C. van der Burg, Asmar F. Y. Al Hadithy, Peter N. Van Harten, Jim van Os, P. Roberto Bakker
MOLECULAR PSYCHIATRY
(2020)