Interferon Regulator Factor 8 (IRF8) Limits Ocular Pathology during HSV-1 Infection by Restraining the Activation and Expansion of CD8+ T Cells

Dual Function of the IRF8 Transcription Factor in Autoimmune Uveitis: Loss of IRF8 in T Cells Exacerbates Uveitis, WhereasIrf8Deletion in the Retina Confers Protection

(2015) Sung-Hye Kim et al.   JOURNAL OF IMMUNOLOGY

The Transcription Factor IRF8 Activates Integrin-Mediated TGF-β Signaling and Promotes Neuroinflammation

(2014) Yuko Yoshida et al.   IMMUNITY

Suppressor of Cytokine Signaling 1 (SOCS1) Mitigates Anterior Uveitis and Confers Protection Against Ocular HSV-1 Infection

(2014) Cheng-Rong Yu et al.   INFLAMMATION

Loss of STAT3 in CD4 + T Cells Prevents Development of Experimental Autoimmune Diseases

(2014) Xuebin Liu et al.   JOURNAL OF IMMUNOLOGY

A Reporter Mouse Reveals Lineage-Specific and Heterogeneous Expression of IRF8 during Lymphoid and Myeloid Cell Differentiation

(2014) Hongsheng Wang et al.   JOURNAL OF IMMUNOLOGY

Persistence of skin-resident memory T cells within an epidermal niche

(2014) A. Zaid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis

(2013) Jeremy D. Waight et al.   JOURNAL OF CLINICAL INVESTIGATION

PD-L1/B7-H1 Regulates the Survival but Not the Function of CD8+ T Cells in Herpes Simplex Virus Type 1 Latently Infected Trigeminal Ganglia

(2013) S. Jeon et al.   JOURNAL OF IMMUNOLOGY

Broadening the Repertoire of Functional Herpes Simplex Virus Type 1-Specific CD8+ T Cells Reduces Viral Reactivation from Latency in Sensory Ganglia

(2013) A. J. St. Leger et al.   JOURNAL OF IMMUNOLOGY

Interferon regulatory factor 8/interferon consensus sequence binding protein is a critical transcription factor for the physiological phenotype of microglia

(2012) Makoto Horiuchi et al.   Journal of Neuroinflammation

IFN Regulatory Factor 8 Is a Key Constitutive Determinant of the Morphological and Molecular Properties of Microglia in the CNS

(2012) Carsten Minten et al.   PLoS One

Interferon regulatory factor 8 integrates T-cell receptor and cytokine-signaling pathways and drives effector differentiation of CD8 T cells

(2012) Fumi Miyagawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Herpes keratitis

(2012) A.M. Rowe et al.   PROGRESS IN RETINAL AND EYE RESEARCH

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells

(2011) Weiguo Cui et al.   IMMUNITY

Retinal cells suppress intraocular inflammation (uveitis) through production of interleukin-27 and interleukin-10

(2011) Yun Sang Lee et al.   IMMUNOLOGY

STAT3 Protein Promotes T-cell Survival and Inhibits Interleukin-2 Production through Up-regulation of Class O Forkhead Transcription Factors

(2011) Hyun-Mee Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the Herpes Simplex Virus-Specific CD8 + T Cell Repertoire in C57BL/6 Mice

(2011) Anthony J. St. Leger et al.   JOURNAL OF IMMUNOLOGY

Role of IL-17 and Th17 Cells in Herpes Simplex Virus-Induced Corneal Immunopathology

(2011) A. Suryawanshi et al.   JOURNAL OF IMMUNOLOGY

Transcription factor IRF8 directs a silencing programme for TH17 cell differentiation

(2011) Xinshou Ouyang et al.   Nature Communications

Regulating functional cell fates in CD8 T cells

(2009) Protul A. Shrikant et al.   IMMUNOLOGIC RESEARCH

Early CD4 + T Cell Help Prevents Partial CD8 + T Cell Exhaustion and Promotes Maintenance of Herpes Simplex Virus 1 Latency

(2009) Gregory M. Frank et al.   JOURNAL OF IMMUNOLOGY

The IRF Family Transcription Factors in Immunity and Oncogenesis

(2008) Tomohiko Tamura et al.   Annual Review of Immunology

IRF8 regulates B-cell lineage specification, commitment, and differentiation

(2008) H. Wang et al.   BLOOD

Who (What) Pays Toll for the Development of Herpetic Stromal Keratitis (HSK)

(2008) Kozaburo Hayashi et al.   Seminars in Ophthalmology