Article
Nutrition & Dietetics
Kaimin Lu, Yufei He, Chuanfang Wu, Jinku Bao
Summary: Periplaneta americana, a medicinal and edible insect, has oligosaccharides (PAOS) which exert anti-inflammatory effects through regulating immunity, reducing oxidative stress, and improving gut microbiota. This study found that PAOS had a moderate preventive effect on hyperglycemia in diabetes mice, alleviating symptoms of diabetes, reducing blood glucose, and improving liver and pancreas beta cell function. PAOS downregulated blood glucose levels by activating PI3K/AKT/mTOR and Keap/Nrf2/HO-1 pathways, while inhibiting TLR4/MAPK/NF-kappa B, Beclin1/LC3, and NLRP3/caspase1 pathways. PAOS also balanced the intestinal bacterial communities by promoting SCFAs-producing bacteria and attenuating LPS-producing bacteria, contributing to the improvement of glycemia in diabetes mice.
Article
Biochemistry & Molecular Biology
Kaimin Lu, Jing Zhou, Jie Deng, Yangjun Li, Chuanfang Wu, Jinku Bao
Summary: The study found that oligosaccharides from Periplaneta americana have potent antioxidant activities, significantly alleviate the symptoms of colitis, and protect the integrity of the intestines. OPA exhibited anti-inflammatory activity by regulating Th1/Th2, reducing oxidative stress, preserving intestinal barrier integrity, and increasing microbial diversity to protect the gut.
Article
Biochemistry & Molecular Biology
Shiyi Lu, Shuyi Xu, Lingjun Chen, Yuhang Deng, Jie Feng
Summary: Studies have shown that Periplaneta americana extract (PAE) has therapeutic effects in inflammatory disorders. In this study, the researchers investigated the pre-protective effects of PAE on oxidative stress and inflammation. They found that PAE pretreatment reduced oxidative stress and improved antioxidant systems in the intestine and liver. PAE also reduced liver inflammation and damage by activating anti-inflammatory cytokine mediated signaling pathway. Additionally, PAE maintained intestinal barrier function and increased the abundance of beneficial gut bacteria.
Article
Allergy
Lingyi Wang, Qing Xiong, Nawannaporn Saelim, Lin Wang, Wenyan Nong, Angel Tsz-Yau Wan, Mai Shi, Xiaoyu Liu, Qin Cao, Jerome Ho Lam Hui, Nitat Sookrung, Ting-Fan Leung, Anchalee Tungtrongchitr, Stephen Kwok Wing Tsui
Summary: The study successfully characterized the allergen profile of the American cockroach at the molecular level, identifying seven novel allergen groups and one isoallergen. The research also revealed the possibility of cross-reaction with closely related species.
Article
Entomology
Shiming Zhu, Xiaoyi Chen, Sishi Xia, Qin Li, Ziqi Ye, Shaoting Zhao, Kexin Liu, Fangfang Liu
Summary: Reproduction is crucial for the continuation of insect species. Storage proteins, hexamerin and allergen, have been identified in the fat bodies of female American cockroaches, and they play an essential role in promoting vitellogenesis and ovarian maturation. The expression of these proteins is regulated by the juvenile hormone (JH) signaling, with the JH receptor gene Met and the primary response gene Kr-h1 acting as repressors and methoprene, a JH analog, inducing their expression.
Article
Environmental Sciences
Lamia M. El-Samad, Mohamed S. El-Gerbed, Hanaa S. Hussein, Justin Flaven-Pouchon, Abeer El Wakil, Bernard Moussian
Summary: The effects of the neonicotinoid imidacloprid on the midgut of pest insect Locusta migratoria caught in the field were studied. Imidacloprid induced oxidative stress in the locust midgut, resulting in disorganized midgut epithelium and compromised physiological function.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Fangfang Liu, Yingying Cui, Huna Lu, Xiaoyi Chen, Qin Li, Ziqi Ye, Wanyi Chen, Shiming Zhu
Summary: The expansion of wings and maintenance of genital morphology in insects are regulated by myofilament genes. Inhibiting the expression of four myofilament genes during early nymph stage leads to curled wings and abnormal genitalia. The expression of myofilament genes is induced by juvenile hormone analogue.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Agronomy
Vincent L. Salgado
Summary: The study demonstrates that different types of nicotinic insecticides have distinct mechanisms of action and selectivity towards insect desensitizing and non-desensitizing nicotinic acetylcholine receptors.
PEST MANAGEMENT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Milena Jankowska, Angelika Klimek, Chiara Valsecchi, Maria Stankiewicz, Joanna Wyszkowska, Justyna Rogalska
Summary: The study evaluated compensatory plasticity in the cockroach nervous system after sensory nerve injury, finding that exposure to electromagnetic fields and TGF-beta can enhance the insect's ability to recognize stimuli. Data showed positive effects of EMF and TGF-beta on insect recovery, highlighting the importance of further research in this area.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Jovana M. Jasso-Martinez, Alexander Donath, Dieter Schulten, Alejandro Zaldivar-Riveron, Manuela Sann
Summary: The study identified a variety of gut-biased genes related to digestion and detoxification in the midgut of the emerald jewel wasp A. compressa, with significant differences in gene expression levels between adults and larvae, suggesting a transcriptional versatility between life stages. Key enzymes such as carbohydrases and proteinases were found to exhibit high gene diversity, while detoxification-related genes such as glutathione S-transferase and cytochrome P450s were also identified. These findings provide a foundation for future comparative genomic and proteomic studies on dietary transitions in Hymenoptera.
Article
Biochemistry & Molecular Biology
Kaizun Xu, Huangli Lan, Chunhui He, Yuting Wei, Qingyu Lu, Kunpei Cai, Dongliang Yu, Xingcan Yin, Yizhe Li, Jiachen Lv
Summary: Pyriproxyfen has significant toxic effects on silkworms, damaging their midgut microvilli, goblet cells, and nuclei, while increasing their body weight and digestibility. It also inhibits ecdysone synthesis and prolongs the larval stage, and activates the transcription of detoxification enzyme-related genes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
In-Woo Kim, Ra-Yeong Choi, Joon Ha Lee, Minchul Seo, Hwa Jeong Lee, Mi-Ae Kim, Seong Hyun Kim, Iksoo Kim, Jae Sam Hwang
Summary: Periplanetasin-5 demonstrated anticancer activity against human leukemia cells by inducing apoptosis and necrosis. The compound was found to modulate protein expression and activate caspases, leading to cell death through both intrinsic and extrinsic pathways.
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaofeng Zheng, Lei Wang, Yi Liu, Zhen Yang, Fengjun Li, Lin Yan, Yongmei Shen, Bisong Yue, Chuang Zhou
Summary: This study de novo assembled the whole genome of the American cockroach and investigated the genetic mechanisms of its environmental adaptation. It identified expanded gene families associated with chemoreception, bitter taste receptors, and detoxification enzymes in the cockroach, providing valuable information for functional characterization and pest management strategies.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Esraa A. Arafat, Doaa S. El-Sayed, Hussein K. Hussein, Justin Flaven-Pouchon, Bernard Moussian, Lamia M. El-Samad, Abeer El Wakil, Mohamed A. Hassan
Summary: This study revealed the use of migratory locusts as an insect model to investigate the toxic effects of aluminum oxide nanoparticles on testes and the potential of American cockroach extract to mitigate this toxicity. The accumulation of aluminum in testicular tissues due to the nanoparticles' penetration into the blood-testis barrier was observed. Toxicity induced by aluminum resulted in antioxidant and stress biomarker disorders, DNA damage, and cell apoptosis. However, pretreatment with the cockroach extract counteracted the detrimental effects, demonstrating antioxidant properties and preventing DNA impairment and cell apoptosis.
Article
Biochemistry & Molecular Biology
Yanzheng Lin, Yuting Huang, Jiafu Liu, Luyang Liu, Xueming Cai, Jintian Lin, Benshui Shu
Summary: This study analyzed the effects of the insecticide toosendanin on the larval midguts of the fall armyworm. The results showed that toosendanin changed the activity of digestive enzymes and detoxification enzymes, as well as the structure of the midgut. Furthermore, gene sequencing revealed the impact of toosendanin on gene expression in the larval midguts. These findings provide a preliminary rationale for using toosendanin to control the fall armyworm in the field.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)